JP4733271B2 - 核磁気共鳴診断用の血液プール剤 - Google Patents

核磁気共鳴診断用の血液プール剤 Download PDF

Info

Publication number
JP4733271B2
JP4733271B2 JP2000590689A JP2000590689A JP4733271B2 JP 4733271 B2 JP4733271 B2 JP 4733271B2 JP 2000590689 A JP2000590689 A JP 2000590689A JP 2000590689 A JP2000590689 A JP 2000590689A JP 4733271 B2 JP4733271 B2 JP 4733271B2
Authority
JP
Japan
Prior art keywords
amino
acid
bis
carboxymethyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000590689A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002533420A (ja
JP2002533420A5 (https=
Inventor
アネリ，ピエル・ルチオ
ブロチェッタ，マリノ
デ・ハエン，クリストフ
ガツォッティ，オルネラ
ラットゥアダ，ルチアーノ
ルクス，ジョヴァンナ
マンフレディ，ジュセッペ
モロシニ，ピエルフランチェスコ
パラノ，ダニエラ
セルレティ，ミケレ
ウッゲリ，フルヴィオ
ヴィジガッリ，マッシモ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of JP2002533420A publication Critical patent/JP2002533420A/ja
Publication of JP2002533420A5 publication Critical patent/JP2002533420A5/ja
Application granted granted Critical
Publication of JP4733271B2 publication Critical patent/JP4733271B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2000590689A 1998-12-23 1999-12-16 核磁気共鳴診断用の血液プール剤 Expired - Fee Related JP4733271B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT98A002802 1998-12-23
ITMI98A002802 1998-12-23
IT1998MI002802A IT1304501B1 (it) 1998-12-23 1998-12-23 Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
PCT/EP1999/010002 WO2000038738A1 (en) 1998-12-23 1999-12-16 Blood pool agents for nuclear magnetic resonance diagnostics

Publications (3)

Publication Number Publication Date
JP2002533420A JP2002533420A (ja) 2002-10-08
JP2002533420A5 JP2002533420A5 (https=) 2007-02-08
JP4733271B2 true JP4733271B2 (ja) 2011-07-27

Family

ID=11381326

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000590689A Expired - Fee Related JP4733271B2 (ja) 1998-12-23 1999-12-16 核磁気共鳴診断用の血液プール剤

Country Status (20)

Country Link
US (1) US6461588B1 (https=)
EP (2) EP1935435B1 (https=)
JP (1) JP4733271B2 (https=)
KR (1) KR100736298B1 (https=)
CN (2) CN100450996C (https=)
AT (1) ATE405296T1 (https=)
AU (1) AU773876B2 (https=)
CA (1) CA2355888C (https=)
CZ (1) CZ302195B6 (https=)
DE (1) DE69939398D1 (https=)
HK (1) HK1042432B (https=)
HU (1) HU228048B1 (https=)
IL (2) IL143730A0 (https=)
IT (1) IT1304501B1 (https=)
MX (1) MXPA01006344A (https=)
NO (1) NO322551B1 (https=)
PL (1) PL196474B1 (https=)
RU (2) RU2395490C2 (https=)
WO (1) WO2000038738A1 (https=)
ZA (1) ZA200104820B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240269330A1 (en) * 2021-07-27 2024-08-15 Bracco Imaging S.P.A. Manufacturing of dimeric contrast agents

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (https=) * 1995-02-01 1997-11-11 Epix Medical Inc
KR20010030854A (ko) 1997-10-02 2001-04-16 로퍼, 랜달 비. 인터벤셔날 요법을 모니터하기 위한 콘트라스트 강화된진단 영상화 방법
IT1317862B1 (it) * 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
EP1361847A2 (en) * 2000-10-06 2003-11-19 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
EP1229041A1 (en) * 2001-02-05 2002-08-07 Bracco Imaging S.p.A. A process for the preparation of 3-Glutamido bile ester derivatives using N-tBoc methyl pyroglutamate
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2512310C (en) * 2003-01-13 2012-09-25 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2549318A1 (en) * 2003-12-24 2005-07-28 Enrico Cappelletti Improved gastrin releasing peptide compounds
RU2425831C2 (ru) * 2005-12-02 2011-08-10 Джи-И Хелткер АС Мультимерные контрастные агенты для магнитного резонанса
WO2009009760A1 (en) 2007-07-11 2009-01-15 Board Of Regents, The University Of Texas System Seeds and markers for use in imaging
CN101845112B (zh) * 2010-06-02 2011-09-14 华东理工大学 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法
CN103442737B (zh) 2011-01-20 2017-03-29 得克萨斯系统大学董事会 Mri标记、递送和提取系统及其制造方法和用途
AU2013229631B2 (en) 2012-03-05 2017-09-14 Bracco Imaging Spa Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues
CN102766188B (zh) * 2012-07-24 2016-01-13 上海交通大学 胆固醇衍生物、螯合物、重组高密度脂蛋白及其用途
GB201421163D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Formulations of metal complexes
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
KR102612882B1 (ko) 2017-05-05 2023-12-11 센터 포 프로브 디벨롭먼트 앤드 커머셜리제이션 이관능성 킬레이트 및 그의 용도의 약동학적 증진
CA3062538A1 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
JP7463006B2 (ja) * 2018-05-30 2024-04-08 トランスレイト バイオ， インコーポレイテッド ステロイド性部分を含むカチオン性脂質
WO2025163025A1 (en) 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
DE440606T1 (de) * 1987-12-24 1992-02-27 Bracco Industria Chimica S.P.A., Mailand / Milano Macrocyclische chelatisierungsmittel und daraus hergestellte chelate.
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
NO940115D0 (no) * 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
JPH09512265A (ja) * 1994-04-20 1997-12-09 ニコムド サルター アイエヌシー コントラスト剤
IT1269839B (it) * 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
JPH11116542A (ja) * 1997-10-06 1999-04-27 Sogo Pharmaceut Co Ltd γ−グルタミン酸アミド類の製造法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240269330A1 (en) * 2021-07-27 2024-08-15 Bracco Imaging S.P.A. Manufacturing of dimeric contrast agents
US12290576B2 (en) * 2021-07-27 2025-05-06 Bracco Imaging S.P.A. Manufacturing of dimeric contrast agents

Also Published As

Publication number Publication date
WO2000038738A1 (en) 2000-07-06
RU2250765C2 (ru) 2005-04-27
RU2395490C2 (ru) 2010-07-27
EP1935435A3 (en) 2009-01-21
IL143730A0 (en) 2002-04-21
PL196474B1 (pl) 2008-01-31
EP1140209A1 (en) 2001-10-10
CA2355888C (en) 2009-02-24
AU773876B2 (en) 2004-06-10
ATE405296T1 (de) 2008-09-15
HK1042432B (zh) 2007-01-26
ITMI982802A1 (it) 2000-06-23
CZ302195B6 (cs) 2010-12-08
NO20013154D0 (no) 2001-06-22
HK1042432A1 (zh) 2002-08-16
KR20010099889A (ko) 2001-11-09
AU1980700A (en) 2000-07-31
CZ20012330A3 (cs) 2002-01-16
CN1263515C (zh) 2006-07-12
NO20013154L (no) 2001-08-23
HU228048B1 (en) 2012-09-28
ZA200104820B (en) 2002-06-13
RU2004127136A (ru) 2006-02-27
HUP0104715A2 (hu) 2002-04-29
EP1140209B1 (en) 2008-08-20
KR100736298B1 (ko) 2007-07-06
NO322551B1 (no) 2006-10-23
CN1854122A (zh) 2006-11-01
EP1935435A2 (en) 2008-06-25
IT1304501B1 (it) 2001-03-19
EP1935435B1 (en) 2017-09-06
HUP0104715A3 (en) 2005-11-28
CA2355888A1 (en) 2000-07-06
IL143730A (en) 2007-09-20
CN1333695A (zh) 2002-01-30
CN100450996C (zh) 2009-01-14
US6461588B1 (en) 2002-10-08
MXPA01006344A (es) 2002-06-04
PL349488A1 (en) 2002-07-29
JP2002533420A (ja) 2002-10-08
DE69939398D1 (de) 2008-10-02

Similar Documents

Publication Publication Date Title
JP4733271B2 (ja) 核磁気共鳴診断用の血液プール剤
JP4108120B2 (ja) 胆汁酸抱合体、それらの金属錯体との誘導体、及び関連する使用方法
JP5052726B2 (ja) 金属イオンキレートとの胆汁酸複合体及びその使用
WO2000030688A2 (en) Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as mri contrast agents
RU2001120351A (ru) Агенты для кровяного депо для диагностики с помощью ядерного магнитного резонанса
JPH08510458A (ja) 沃素化された常磁性キレートおよびそれらの造影剤としての使用法
KR100376950B1 (ko) 대환식킬레이트제,이들의킬레이트및진단분야에서의이의용도

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061214

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061214

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100914

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101213

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101220

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110113

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110120

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110210

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110311

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110405

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110422

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140428

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees