RU2004127136A - Способ получения гамма-амидов глутамовой кислоты - Google Patents

Способ получения гамма-амидов глутамовой кислоты Download PDF

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Publication number
RU2004127136A
RU2004127136A RU2004127136/15A RU2004127136A RU2004127136A RU 2004127136 A RU2004127136 A RU 2004127136A RU 2004127136/15 A RU2004127136/15 A RU 2004127136/15A RU 2004127136 A RU2004127136 A RU 2004127136A RU 2004127136 A RU2004127136 A RU 2004127136A
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RU
Russia
Prior art keywords
amides
glutamic acid
acid gamma
producing glutamic
producing
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RU2004127136/15A
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English (en)
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RU2395490C2 (ru
Inventor
Пьер Лучио АНЕЛЛИ (IT)
Пьер Лучио АНЕЛЛИ
Марино БРОККЕТТА (IT)
Марино БРОККЕТТА
ХАЕН Кристоф ДЕ (IT)
ХАЕН Кристоф ДЕ
Орнелла ГАЦЦОТТИ (IT)
Орнелла ГАЦЦОТТИ
Лучано ЛАТТУАДА (IT)
Лучано ЛАТТУАДА
Джованна ЛУКС (IT)
Джованна ЛУКС
Джузеппе МАНФРЕДИ (IT)
Джузеппе МАНФРЕДИ
Пьерфранческо МОРОЗИНИ (IT)
Пьерфранческо МОРОЗИНИ
Даниела ПАЛАНО (IT)
Даниела ПАЛАНО
Микеле СЕРЛЕТИ (IT)
Микеле СЕРЛЕТИ
Фульвио УГГЕРИ (IT)
Фульвио УГГЕРИ
Массимо ВИЗИГАЛЛИ (IT)
Массимо ВИЗИГАЛЛИ
Original Assignee
Бракко Имэджинг С.П.А. (It)
Бракко Имэджинг С.П.А.
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Publication of RU2004127136A publication Critical patent/RU2004127136A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (1)

1. Способ получения γ-амидов глутамовой кислоты в соответствии со следующей схемой:
Figure 00000001
где R4 представляет аминозащитную группу;
R5 представляет неразветвленный или разветвленный С1-С10 алкил или арил;
R2 и R3 независимо представляют атом водорода, разветвленный или неразветвленный С1-С20 алкил, незамещенный или замещенный арильными группами, или указанные группы образуют С3-С10 цикл.
RU2004127136/04A 1998-12-23 1999-12-16 Способ получения гамма-амидов глутамовой кислоты RU2395490C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI98A002802 1998-12-23
IT1998MI002802A IT1304501B1 (it) 1998-12-23 1998-12-23 Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza

Related Parent Applications (1)

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RU2001120351/15A Division RU2250765C2 (ru) 1998-12-23 1999-12-16 Агенты для кровяного депо для диагностики с помощью ядерного магнитного резонанса

Publications (2)

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RU2004127136A true RU2004127136A (ru) 2006-02-27
RU2395490C2 RU2395490C2 (ru) 2010-07-27

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RU2001120351/15A RU2250765C2 (ru) 1998-12-23 1999-12-16 Агенты для кровяного депо для диагностики с помощью ядерного магнитного резонанса
RU2004127136/04A RU2395490C2 (ru) 1998-12-23 1999-12-16 Способ получения гамма-амидов глутамовой кислоты

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US (1) US6461588B1 (ru)
EP (2) EP1935435B1 (ru)
JP (1) JP4733271B2 (ru)
KR (1) KR100736298B1 (ru)
CN (2) CN1263515C (ru)
AT (1) ATE405296T1 (ru)
AU (1) AU773876B2 (ru)
CA (1) CA2355888C (ru)
CZ (1) CZ302195B6 (ru)
DE (1) DE69939398D1 (ru)
HK (1) HK1042432B (ru)
HU (1) HU228048B1 (ru)
IL (2) IL143730A0 (ru)
IT (1) IT1304501B1 (ru)
MX (1) MXPA01006344A (ru)
NO (1) NO322551B1 (ru)
PL (1) PL196474B1 (ru)
RU (2) RU2250765C2 (ru)
WO (1) WO2000038738A1 (ru)
ZA (1) ZA200104820B (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (ru) * 1995-02-01 1997-11-11 Epix Medical Inc
HUP0101245A3 (en) 1997-10-02 2003-10-28 Epix Pharmaceuticals Inc Cambr Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
IT1317862B1 (it) * 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
WO2002032376A2 (en) * 2000-10-06 2002-04-25 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
EP1229041A1 (en) * 2001-02-05 2002-08-07 Bracco Imaging S.p.A. A process for the preparation of 3-Glutamido bile ester derivatives using N-tBoc methyl pyroglutamate
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1302465A1 (en) * 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7989417B2 (en) * 2003-01-13 2011-08-02 Bracco Imaging S.P.A. Linkers for radiopharmaceutical compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
JP2008501627A (ja) * 2003-12-24 2008-01-24 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 改善されたガストリン関連ペプチド化合物
WO2009009760A1 (en) 2007-07-11 2009-01-15 Board Of Regents, The University Of Texas System Seeds and markers for use in imaging
CN101845112B (zh) * 2010-06-02 2011-09-14 华东理工大学 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法
CA2824521C (en) 2011-01-20 2016-06-28 Board Of Regents, The University Of Texas System Mri markers, delivery and extraction systems, and related methods
EP2822605A1 (en) 2012-03-05 2015-01-14 Bracco Imaging S.p.A Dynamic contrast enhanced mri method and agents for the assessment of the macromolecular transport within pathologic tissues
CN102766188B (zh) * 2012-07-24 2016-01-13 上海交通大学 胆固醇衍生物、螯合物、重组高密度脂蛋白及其用途
GB201421163D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Formulations of metal complexes
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
KR20200004861A (ko) 2017-05-05 2020-01-14 퓨전 파마슈티칼즈 인크. Igf-1r 모노클로날 항체 및 그의 용도
KR102612882B1 (ko) 2017-05-05 2023-12-11 센터 포 프로브 디벨롭먼트 앤드 커머셜리제이션 이관능성 킬레이트 및 그의 용도의 약동학적 증진
EP3802558A1 (en) * 2018-05-30 2021-04-14 Translate Bio, Inc. Cationic lipids comprising a steroidal moiety

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
NO940115D0 (no) * 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
DE69534990T2 (de) * 1994-04-20 2006-10-05 Amersham Health Salutar Inc. Kontrastmittel
IT1269839B (it) * 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
JPH11116542A (ja) * 1997-10-06 1999-04-27 Sogo Pharmaceut Co Ltd γ−グルタミン酸アミド類の製造法

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AU773876B2 (en) 2004-06-10
CN100450996C (zh) 2009-01-14
RU2250765C2 (ru) 2005-04-27
CN1854122A (zh) 2006-11-01
NO20013154L (no) 2001-08-23
KR20010099889A (ko) 2001-11-09
IT1304501B1 (it) 2001-03-19
MXPA01006344A (es) 2002-06-04
EP1935435A2 (en) 2008-06-25
CA2355888A1 (en) 2000-07-06
ZA200104820B (en) 2002-06-13
DE69939398D1 (de) 2008-10-02
CZ20012330A3 (cs) 2002-01-16
CN1263515C (zh) 2006-07-12
PL196474B1 (pl) 2008-01-31
HUP0104715A3 (en) 2005-11-28
HU228048B1 (en) 2012-09-28
RU2395490C2 (ru) 2010-07-27
EP1935435A3 (en) 2009-01-21
AU1980700A (en) 2000-07-31
US6461588B1 (en) 2002-10-08
WO2000038738A1 (en) 2000-07-06
EP1140209B1 (en) 2008-08-20
EP1935435B1 (en) 2017-09-06
IL143730A0 (en) 2002-04-21
HK1042432B (zh) 2007-01-26
EP1140209A1 (en) 2001-10-10
CN1333695A (zh) 2002-01-30
IL143730A (en) 2007-09-20
JP4733271B2 (ja) 2011-07-27
ITMI982802A1 (it) 2000-06-23
KR100736298B1 (ko) 2007-07-06
CZ302195B6 (cs) 2010-12-08
NO322551B1 (no) 2006-10-23
HK1042432A1 (en) 2002-08-16
CA2355888C (en) 2009-02-24
NO20013154D0 (no) 2001-06-22
PL349488A1 (en) 2002-07-29
ATE405296T1 (de) 2008-09-15
HUP0104715A2 (hu) 2002-04-29
JP2002533420A (ja) 2002-10-08

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