HUP0102599A2 - Artemizinin-származékok, eljárás a vegyületek előállítására, és a vegyületeket tartalmazó gyógyszerészeti készítmények - Google Patents
Artemizinin-származékok, eljárás a vegyületek előállítására, és a vegyületeket tartalmazó gyógyszerészeti készítményekInfo
- Publication number
- HUP0102599A2 HUP0102599A2 HU0102599A HUP0102599A HUP0102599A2 HU P0102599 A2 HUP0102599 A2 HU P0102599A2 HU 0102599 A HU0102599 A HU 0102599A HU P0102599 A HUP0102599 A HU P0102599A HU P0102599 A2 HUP0102599 A2 HU P0102599A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- straight
- general formula
- optionally substituted
- substituted
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical class C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005156 substituted alkylene group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005760 substituted naphthylene group Chemical group 0.000 abstract 1
- 125000005650 substituted phenylene group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya (I) általános képletű vegyületek, ahol R jelentése(II) képletű csoport, A jelentése (III) általános képletű csoport,amelyben R1 jelentése aril-, szubsztituált aril-, heteroaril- vagyszubsztituált heteroarilcsoport, R2 jelentése hidrogénatom, egyenesvagy elágazó láncú, adott esetben szubsztituált 1-6 szénatomosalkilcsoport, vagy A jelentése (IV) általános képletű csoport, ahol Yjelentése 2-14 szénatomos egyenes vagy elágazó láncú, adott esetbenszubsztituált alkiléncsoport, 2-14 szénatomos egyenes vagy elágazóláncú, adott esetben szubsztituált alkeniléncsoport, 2-14 szénatomosegyenes vagy elágazó láncú, adott esetben szubsztituáltalkiniléncsoport, feniléncsoport, szubsztituált fenilén-, naftilén-vagy szubsztituált naftiléncsoport, Z jelentése oxigén- vagy kénatom,vagy NR'2 általános képletű csoport, amelyben R'2 jelentése megegyezikR2 jelentésével, R3 jelentése (III) általános képletű csoport,amelyben a szubsztituensek jelentése a fenti, enantiomerjeik ésdiasztereoizomerjeik, valamint gyógyszerészetileg alkalmazható savvalvagy bázissal alkotott addíciós sóik. A találmány a vegyületekelőállítására szolgáló eljárást és a vegyületeket tartalmazógyógyszerészeti készítményeket is magában foglalja. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN98114788A CN1084333C (zh) | 1998-06-17 | 1998-06-17 | 新的青蒿素化合物,其制备方法以及含有它们的药物组合物 |
PCT/FR1999/001359 WO1999065914A1 (fr) | 1998-06-17 | 1999-06-09 | Derives de l'artemisinine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0102599A2 true HUP0102599A2 (hu) | 2001-11-28 |
HUP0102599A3 HUP0102599A3 (en) | 2003-03-28 |
Family
ID=5224325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102599A HUP0102599A3 (en) | 1998-06-17 | 1999-06-09 | Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (14)
Country | Link |
---|---|
US (1) | US6307068B1 (hu) |
EP (1) | EP1086107A1 (hu) |
JP (1) | JP2002518398A (hu) |
CN (2) | CN1084333C (hu) |
AU (1) | AU748798B2 (hu) |
BR (1) | BR9911274A (hu) |
CA (1) | CA2342990A1 (hu) |
HK (1) | HK1036985A1 (hu) |
HU (1) | HUP0102599A3 (hu) |
NO (1) | NO20006257L (hu) |
NZ (1) | NZ508388A (hu) |
PL (1) | PL344984A1 (hu) |
WO (1) | WO1999065914A1 (hu) |
ZA (1) | ZA200007070B (hu) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0129215D0 (en) * | 2001-12-06 | 2002-01-23 | Ufc Ltd | Trioxane derivatives |
AU2002350910A1 (en) * | 2001-12-06 | 2003-06-17 | Ufc Limited | Trioxane derivatives as antimalaria or anticancer compounds |
AU2002352357A1 (en) * | 2001-12-06 | 2003-06-17 | Ufc Limited | Trioxane derivatives |
NZ537113A (en) * | 2002-06-06 | 2007-01-26 | Univ Washington | Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer |
ATE536887T1 (de) * | 2002-06-06 | 2011-12-15 | Univ Washington | Kovalente konjugate zwischen mit artemisinin verwandten endoperoxiden und eisentragenden proteinen und anwendungsverfahren |
US6677463B1 (en) * | 2002-12-10 | 2004-01-13 | Council Of Scientific And Industrial Research | Single pot conversion of artemisinin to artesunic acid |
CN1327842C (zh) * | 2003-02-12 | 2007-07-25 | 沈恒 | 一种新型的抗肿瘤药物复方制备方法 |
JP5140416B2 (ja) | 2004-06-21 | 2013-02-06 | ユニヴァーシティー オブ ミシシッピ | 望ましい化学的官能基を有する抗がん及び抗原虫ジヒドロアーテミシニン及びジヒドロアーテミシテンダイマー |
CN1814601A (zh) * | 2005-02-04 | 2006-08-09 | 中国科学院上海药物研究所 | 具有免疫抑制作用的青蒿素衍生物及药物组合物 |
FR2899586B1 (fr) | 2006-04-11 | 2008-06-20 | Sanofi Aventis Sa | Dimeres de derives d'artemisinine, leur preparation et leur application en therapeutique |
ITMI20071915A1 (it) * | 2007-10-04 | 2009-04-05 | Lachifarma Srl Lab Chimico Far | Derivati dell'artemisinina per il trattamento del melanoma |
GB0720967D0 (en) * | 2007-10-25 | 2007-12-05 | Protophama Ltd | Anti-material pharmaceutical composition |
GB2469791B (en) * | 2009-04-23 | 2011-12-14 | Londonpharma Ltd | Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease |
US8815942B2 (en) | 2010-10-20 | 2014-08-26 | The Royal Institution For The Advancement Of Learning/Mcgill University | Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease |
WO2014023081A1 (zh) * | 2012-08-07 | 2014-02-13 | 中国科学院上海生命科学研究院 | 青嵩素衍生物及其制法和应用 |
WO2014070673A1 (en) | 2012-10-29 | 2014-05-08 | University Of Rochester | Artemisinin derivatives, methods for their preparation and their use as antimalarial agents |
CN117695222B (zh) * | 2024-02-06 | 2024-04-26 | 山东百奥生物医药有限公司 | 一种用于改善皮肤问题的青蒿素壬二酸酯-聚乙二醇二胺胶束及制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4916204A (en) | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
CN1049435A (zh) * | 1990-08-16 | 1991-02-20 | 中国对外贸易运输总公司 | 电传线路自动转换开关 |
US5219880A (en) * | 1991-03-29 | 1993-06-15 | Dermatologic Research Corporation | Treatment of viral tumors and hemorrhoids with artemisinin and derivatives |
CN1038416C (zh) * | 1992-12-04 | 1998-05-20 | 中国科学院上海药物研究所 | 新型青蒿素衍生物及其制备方法 |
CN1049435C (zh) * | 1994-11-09 | 2000-02-16 | 中国科学院上海药物研究所 | 含苯基和杂环基的青蒿素衍生物及其制备方法 |
US5578637A (en) * | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
US5677468A (en) * | 1995-06-29 | 1997-10-14 | Hauser, Inc. | Artemisinin dimer compounds having anticancer activity |
-
1998
- 1998-06-17 CN CN98114788A patent/CN1084333C/zh not_active Expired - Fee Related
-
1999
- 1999-06-09 WO PCT/FR1999/001359 patent/WO1999065914A1/fr not_active Application Discontinuation
- 1999-06-09 AU AU40474/99A patent/AU748798B2/en not_active Ceased
- 1999-06-09 EP EP99923702A patent/EP1086107A1/fr not_active Withdrawn
- 1999-06-09 NZ NZ508388A patent/NZ508388A/en unknown
- 1999-06-09 CA CA002342990A patent/CA2342990A1/fr not_active Abandoned
- 1999-06-09 US US09/719,767 patent/US6307068B1/en not_active Expired - Fee Related
- 1999-06-09 PL PL99344984A patent/PL344984A1/xx not_active Application Discontinuation
- 1999-06-09 HU HU0102599A patent/HUP0102599A3/hu unknown
- 1999-06-09 JP JP2000554739A patent/JP2002518398A/ja active Pending
- 1999-06-09 BR BR9911274-4A patent/BR9911274A/pt not_active IP Right Cessation
- 1999-06-09 CN CN99807416A patent/CN1111162C/zh not_active Expired - Fee Related
-
2000
- 2000-11-30 ZA ZA200007070A patent/ZA200007070B/en unknown
- 2000-12-08 NO NO20006257A patent/NO20006257L/no not_active Application Discontinuation
-
2001
- 2001-11-12 HK HK01107929A patent/HK1036985A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU748798B2 (en) | 2002-06-13 |
CN1239097A (zh) | 1999-12-22 |
AU4047499A (en) | 2000-01-05 |
WO1999065914A1 (fr) | 1999-12-23 |
CA2342990A1 (fr) | 1999-12-23 |
BR9911274A (pt) | 2001-10-23 |
NO20006257D0 (no) | 2000-12-08 |
PL344984A1 (en) | 2001-11-19 |
CN1084333C (zh) | 2002-05-08 |
NO20006257L (no) | 2001-02-19 |
HK1036985A1 (en) | 2002-01-25 |
EP1086107A1 (fr) | 2001-03-28 |
US6307068B1 (en) | 2001-10-23 |
JP2002518398A (ja) | 2002-06-25 |
ZA200007070B (en) | 2001-10-18 |
NZ508388A (en) | 2003-07-25 |
CN1305482A (zh) | 2001-07-25 |
CN1111162C (zh) | 2003-06-11 |
HUP0102599A3 (en) | 2003-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0102599A2 (hu) | Artemizinin-származékok, eljárás a vegyületek előállítására, és a vegyületeket tartalmazó gyógyszerészeti készítmények | |
EP2308846A3 (en) | Caspase inhibitors and uses thereof | |
IL148631A0 (en) | Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof | |
HUP0001607A2 (hu) | Tienopirimidinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás ezek előállítására, valamint e vegyületek alkalmazása | |
BRPI0508072A (pt) | derivados de piperidinilalquicarbamatos, o respectivo preparo e a respectiva aplicação como inibidores da enzima faah | |
EA200601512A1 (ru) | Новые азабициклические соединения, способ их получения и фармацевтические композиции, которые их содержат | |
IE810485L (en) | Imidazo compounds | |
CA2195924A1 (en) | 3-Aza and 3-Oxa-Piperidone Tachykinin Antagonists | |
AU1414900A (en) | Novel compound, polymer prepared from the compound, and composition comprising the polymer | |
DE60223904D1 (de) | Benzylaminanalogen | |
BG105123A (en) | Tetrahydroquinaline derivatives as glycine antagonists | |
AU639154B2 (en) | New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them | |
ATE215080T1 (de) | 1,2-dithiolan derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen | |
HUP0102350A2 (hu) | Propenil-cefalosporin-származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek | |
ATE251177T1 (de) | Bizyklische amino-pyrazinon-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen die diese enthalten | |
HUP0202663A2 (hu) | 7-acilamino-3-heteroariltio-3-cefémkarbonsav antibiotikumok és prodrogjaik, előállításuk és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
DE60040653D1 (de) | Carbonsäurederivate und verfahren zu ihrer herstellung | |
RU96120092A (ru) | Новые производные пиперазина и способы их получения и содержащие их композиции | |
ATE315561T1 (de) | Carbamatderivate, verfahren zu deren herstellung und deren verwendung | |
FI903511A0 (fi) | Pyrrolo (2,1-b) tiazolderivat. | |
DE69904940D1 (de) | 6-deoxy-erythromycin-derivate, ihrer herstellung, und ihrer verwendung als arzneimitteln | |
BG100704A (en) | New piperazine derivatives and methods for their preparation as well as of the compounds containing them | |
MXPA04005839A (es) | Nuevos compuestos de benzotiazina y benzotiadiazina un proceso para su preparacion y las composiciones farmaceuticas que los contienen. | |
AU7932100A (en) | N-substituted 3-amino-2,2-di-c-alkyl-1,4-butyrolactones and 1,4-thiobutyrolactones for use as promoter of gamma-aminobutyric acid activity and for treating nervous disorders and preparation method | |
DE68928558D1 (de) | Verfahren zur Herstellung von heterocyclischen Derivaten |