WO1995011908B1 - Novel phosphorus-containing spin-trap compositions - Google Patents
Novel phosphorus-containing spin-trap compositionsInfo
- Publication number
- WO1995011908B1 WO1995011908B1 PCT/US1994/012109 US9412109W WO9511908B1 WO 1995011908 B1 WO1995011908 B1 WO 1995011908B1 US 9412109 W US9412109 W US 9412109W WO 9511908 B1 WO9511908 B1 WO 9511908B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- alkyl
- metal ions
- coor
- aryl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 3
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
- 229910052698 phosphorus Inorganic materials 0.000 title 1
- 239000011574 phosphorus Substances 0.000 title 1
- VCUVETGKTILCLC-UHFFFAOYSA-N 2,2-dimethyl-1-oxido-3,4-dihydropyrrol-1-ium Chemical compound CC1(C)CCC=[N+]1[O-] VCUVETGKTILCLC-UHFFFAOYSA-N 0.000 claims abstract 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 239000002184 metal Substances 0.000 claims 8
- 229910052751 metal Inorganic materials 0.000 claims 8
- 150000002500 ions Chemical class 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000002739 metals Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000002194 synthesizing Effects 0.000 claims 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Abstract
Novel spin traps comprising phosphorous containing DMPO and PBN derivatives are disclosed. Effective synthesis methods for these spin traps is also disclosed.
Claims
AMENDED CLAIMS
[received by the International Bureau on 18 April 1995 (18.04.95); original claims 1 and 7 amended; remaining claims unchanged (2 pages)]
1. A chemical composition of the formula:
where R4 is H; alkyl (CH2)nH where n = (1, 2 . . . .18); aryl; (CH2)n COOR where n = (0, 1, 2 . . . .18) and R = H, CH3, CH3-CH2, or Group IA metal ions; (CH2)n P(O) (OR)2 where n = (0, 1, 2, . . . .18), R = H, CH3, CH3-CH2, or Group IA metal ions;
and R5 is H; alkyl (CH2)nH where n = (1, 2 . . .
18); aryl; (CH2)n COOR where n = (0, 1, 2 . . . .18) and R = H, CH3, CH3-CH2, or Group IA metals; (CH2)n P(O) (OR)2 where n = (0, 1, 2, . . . .18), R = H, CH3, CH3-CH2, or Group IA metal ions; wherein
R4 can be the same or different from R5 in a given molecule.
2. A chemical composition of the formula:
7. A method for synthesizing phosphorous-containing derivatives of DMPO, comprising the steps of:
(a) providing
to
where R4 is H; alkyl (CH2)nH where n = (1, 2 . . . .18); aryl; (CH2)n COOR where n = (0, 1, 2 . . . .18) and R = H, CH3, CH3-CH2, or Group IA metal ions; (CH2)n P(O) (OR)2 where n = (0, 1, 2, . . . .18), R = H, CH3, CH3-CH2, or Group IA metal ions;
and R5 is H; alkyl (CH2)nH where n = (1, 2 . . .
.18); aryl; (CH2)n COOR where n = (0, 1, 2 . . . .18) and R = H, CH3, CH3-CH2, or Group IA metals; (CH2)n P(O) (OR)2 where n - (0, 1, 2, . . . .18), R = H, CH3, CH3-CH2, or Group IA metal ions; and wherein
R4 can be the same or different from R5 in a given molecule;
to form an addition product;
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7512737A JPH08505406A (en) | 1993-10-25 | 1994-10-20 | Novel phosphorus-containing spin-trapping composition |
| EP94931432A EP0675892A1 (en) | 1993-10-25 | 1994-10-20 | Novel phosphorus-containing spin-trap compositions |
| AU80518/94A AU8051894A (en) | 1993-10-25 | 1994-10-20 | Novel phosphorus-containing spin-trap compositions |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14123193A | 1993-10-25 | 1993-10-25 | |
| US08/141,231 | 1993-10-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995011908A1 WO1995011908A1 (en) | 1995-05-04 |
| WO1995011908B1 true WO1995011908B1 (en) | 1995-05-18 |
Family
ID=22494771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/012109 WO1995011908A1 (en) | 1993-10-25 | 1994-10-20 | Novel phosphorus-containing spin-trap compositions |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0675892A1 (en) |
| JP (1) | JPH08505406A (en) |
| AU (1) | AU8051894A (en) |
| CA (1) | CA2152363A1 (en) |
| WO (1) | WO1995011908A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2731428B1 (en) * | 1995-03-06 | 1997-06-06 | Centre Nat Rech Scient | PHOSPHORYLATED NITRON DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM |
| DK0863878T3 (en) * | 1995-09-11 | 2003-04-22 | Aventis Pharma Inc | Cyclic nitrons and pharmaceutical preparations containing them |
| JP2011098910A (en) * | 2009-11-06 | 2011-05-19 | Mikuni Seiyaku Kogyo Kk | Novel pyrrolidine compound or salt thereof, process for producing the same and process for producing nitrone compound having pyrroline ring using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2639350B1 (en) * | 1988-11-21 | 1990-12-21 | Commissariat Energie Atomique | RADICAL NITROXIDE, ITS MANUFACTURING PROCESS AND ITS APPLICATION IN MAGNETOMETRY |
| ES2044829T3 (en) * | 1989-10-17 | 1995-01-16 | Oklahoma Med Res Found | METHOD AND COMPOSITIONS FOR THE INHIBITION OF ALTERATIONS ASSOCIATED WITH OXIDATIVE INJURIES OF TISSUES. |
| FR2707990B1 (en) * | 1993-07-20 | 1995-10-20 | Centre Nat Rech Scient | New nitrones usable for trapping free radicals. |
-
1994
- 1994-10-20 AU AU80518/94A patent/AU8051894A/en not_active Abandoned
- 1994-10-20 WO PCT/US1994/012109 patent/WO1995011908A1/en not_active Application Discontinuation
- 1994-10-20 EP EP94931432A patent/EP0675892A1/en not_active Withdrawn
- 1994-10-20 CA CA002152363A patent/CA2152363A1/en not_active Abandoned
- 1994-10-20 JP JP7512737A patent/JPH08505406A/en active Pending
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