CN100450996C - 用于核磁共振诊断的血池剂 - Google Patents

用于核磁共振诊断的血池剂 Download PDF

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Publication number
CN100450996C
CN100450996C CNB2006100676912A CN200610067691A CN100450996C CN 100450996 C CN100450996 C CN 100450996C CN B2006100676912 A CNB2006100676912 A CN B2006100676912A CN 200610067691 A CN200610067691 A CN 200610067691A CN 100450996 C CN100450996 C CN 100450996C
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CN
China
Prior art keywords
amino
bis
mmol
acid
ethyl
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Expired - Fee Related
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CNB2006100676912A
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English (en)
Chinese (zh)
Other versions
CN1854122A (zh
Inventor
P·L·阿奈里
M·布洛柴塔
C·德汉恩
O·加佐蒂
L·拉图尔达
G·拉克斯
G·曼弗莱迪
P·莫洛希尼
D·帕拉诺
M·瑟莱提
F·尤吉里
M·维希加里
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Bracco Imaging SpA
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Bracco Imaging SpA
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Publication of CN1854122A publication Critical patent/CN1854122A/zh
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Publication of CN100450996C publication Critical patent/CN100450996C/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB2006100676912A 1998-12-23 1999-12-16 用于核磁共振诊断的血池剂 Expired - Fee Related CN100450996C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI98A002802 1998-12-23
IT1998MI002802A IT1304501B1 (it) 1998-12-23 1998-12-23 Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB998157929A Division CN1263515C (zh) 1998-12-23 1999-12-16 用于核磁共振诊断的血池剂

Publications (2)

Publication Number Publication Date
CN1854122A CN1854122A (zh) 2006-11-01
CN100450996C true CN100450996C (zh) 2009-01-14

Family

ID=11381326

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB2006100676912A Expired - Fee Related CN100450996C (zh) 1998-12-23 1999-12-16 用于核磁共振诊断的血池剂
CNB998157929A Expired - Fee Related CN1263515C (zh) 1998-12-23 1999-12-16 用于核磁共振诊断的血池剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB998157929A Expired - Fee Related CN1263515C (zh) 1998-12-23 1999-12-16 用于核磁共振诊断的血池剂

Country Status (20)

Country Link
US (1) US6461588B1 (https=)
EP (2) EP1935435B1 (https=)
JP (1) JP4733271B2 (https=)
KR (1) KR100736298B1 (https=)
CN (2) CN100450996C (https=)
AT (1) ATE405296T1 (https=)
AU (1) AU773876B2 (https=)
CA (1) CA2355888C (https=)
CZ (1) CZ302195B6 (https=)
DE (1) DE69939398D1 (https=)
HK (1) HK1042432B (https=)
HU (1) HU228048B1 (https=)
IL (2) IL143730A0 (https=)
IT (1) IT1304501B1 (https=)
MX (1) MXPA01006344A (https=)
NO (1) NO322551B1 (https=)
PL (1) PL196474B1 (https=)
RU (2) RU2395490C2 (https=)
WO (1) WO2000038738A1 (https=)
ZA (1) ZA200104820B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (https=) * 1995-02-01 1997-11-11 Epix Medical Inc
AU742438C (en) 1997-10-02 2003-05-22 Lantheus Medical Imaging, Inc. Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
IT1317862B1 (it) * 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
AU2002230398A1 (en) * 2000-10-06 2002-04-29 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
EP1229041A1 (en) * 2001-02-05 2002-08-07 Bracco Imaging S.p.A. A process for the preparation of 3-Glutamido bile ester derivatives using N-tBoc methyl pyroglutamate
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1302465A1 (en) * 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
AU2003303714B2 (en) * 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) * 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
BRPI0418194A (pt) * 2003-12-24 2007-04-27 Bracco Imaging Spa compostos peptìdeos liberadores de gastrina aperfeiçoados
RU2425831C2 (ru) * 2005-12-02 2011-08-10 Джи-И Хелткер АС Мультимерные контрастные агенты для магнитного резонанса
JP5577245B2 (ja) 2007-07-11 2014-08-20 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 画像化での使用を目的としたシードおよびマーカー
CN101845112B (zh) * 2010-06-02 2011-09-14 华东理工大学 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法
JP5889337B2 (ja) 2011-01-20 2016-03-22 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｍｒｉマーカー、送達および抜取りシステムならびにこれらの製造方法および使用方法
CA2862760A1 (en) 2012-03-05 2013-09-12 Bracco Imaging Spa Dynamic contrast enhanced-mri method and agents for the assessment of the macromolecular transport within pathologic tissues
CN102766188B (zh) * 2012-07-24 2016-01-13 上海交通大学 胆固醇衍生物、螯合物、重组高密度脂蛋白及其用途
GB201421163D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Formulations of metal complexes
MA48861A (fr) 2017-05-05 2020-04-01 Fusion Pharmaceuticals Inc Améliorations pharmacocinétiques de chélates bifonctionnels et leurs utilisations
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
WO2018204872A2 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
WO2019232208A1 (en) * 2018-05-30 2019-12-05 Translate Bio, Inc. Cationic lipids comprising a steroidal moiety
US12290576B2 (en) * 2021-07-27 2025-05-06 Bracco Imaging S.P.A. Manufacturing of dimeric contrast agents
WO2025163025A1 (en) 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
US5462933A (en) * 1989-09-14 1995-10-31 Hoechst Aktiengesellschaft Modified bile acid conjugates, and their use as pharmaceuticals
US5649537A (en) * 1994-05-26 1997-07-22 Dibra S.P.A. Paramagnetic metal icon chelates and use thereof as contrast agents in magnetic resonance imaging
US5725840A (en) * 1994-01-13 1998-03-10 Nycomed Imaging As Steroidal ester contrast media for x-ray and magnetic resonance imaging
JPH11116542A (ja) * 1997-10-06 1999-04-27 Sogo Pharmaceut Co Ltd γ−グルタミン酸アミド類の製造法
US6010681A (en) * 1994-04-20 2000-01-04 Nycomed Salutar, Inc. Biodegradable blood-pool contrast agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
RU2059642C1 (ru) * 1987-12-24 1996-05-10 Бракко Индустрия Кимика С.п.А Хелаты гадолиния и способ их получения
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
US5462933A (en) * 1989-09-14 1995-10-31 Hoechst Aktiengesellschaft Modified bile acid conjugates, and their use as pharmaceuticals
US5725840A (en) * 1994-01-13 1998-03-10 Nycomed Imaging As Steroidal ester contrast media for x-ray and magnetic resonance imaging
US6010681A (en) * 1994-04-20 2000-01-04 Nycomed Salutar, Inc. Biodegradable blood-pool contrast agents
US5649537A (en) * 1994-05-26 1997-07-22 Dibra S.P.A. Paramagnetic metal icon chelates and use thereof as contrast agents in magnetic resonance imaging
JPH11116542A (ja) * 1997-10-06 1999-04-27 Sogo Pharmaceut Co Ltd γ−グルタミン酸アミド類の製造法

Also Published As

Publication number Publication date
HUP0104715A2 (hu) 2002-04-29
JP2002533420A (ja) 2002-10-08
IL143730A0 (en) 2002-04-21
RU2250765C2 (ru) 2005-04-27
JP4733271B2 (ja) 2011-07-27
EP1140209B1 (en) 2008-08-20
KR20010099889A (ko) 2001-11-09
MXPA01006344A (es) 2002-06-04
NO20013154L (no) 2001-08-23
CA2355888C (en) 2009-02-24
CA2355888A1 (en) 2000-07-06
PL196474B1 (pl) 2008-01-31
KR100736298B1 (ko) 2007-07-06
HU228048B1 (en) 2012-09-28
CZ302195B6 (cs) 2010-12-08
DE69939398D1 (de) 2008-10-02
EP1140209A1 (en) 2001-10-10
ITMI982802A1 (it) 2000-06-23
HUP0104715A3 (en) 2005-11-28
CN1263515C (zh) 2006-07-12
HK1042432B (zh) 2007-01-26
NO20013154D0 (no) 2001-06-22
EP1935435B1 (en) 2017-09-06
ATE405296T1 (de) 2008-09-15
ZA200104820B (en) 2002-06-13
AU1980700A (en) 2000-07-31
HK1042432A1 (zh) 2002-08-16
RU2395490C2 (ru) 2010-07-27
IL143730A (en) 2007-09-20
EP1935435A2 (en) 2008-06-25
NO322551B1 (no) 2006-10-23
EP1935435A3 (en) 2009-01-21
CN1333695A (zh) 2002-01-30
WO2000038738A1 (en) 2000-07-06
RU2004127136A (ru) 2006-02-27
IT1304501B1 (it) 2001-03-19
US6461588B1 (en) 2002-10-08
PL349488A1 (en) 2002-07-29
AU773876B2 (en) 2004-06-10
CN1854122A (zh) 2006-11-01
CZ20012330A3 (cs) 2002-01-16

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