RU2395490C2 - Способ получения гамма-амидов глутамовой кислоты - Google Patents

Способ получения гамма-амидов глутамовой кислоты Download PDF

Info

Publication number
RU2395490C2
RU2395490C2 RU2004127136/04A RU2004127136A RU2395490C2 RU 2395490 C2 RU2395490 C2 RU 2395490C2 RU 2004127136/04 A RU2004127136/04 A RU 2004127136/04A RU 2004127136 A RU2004127136 A RU 2004127136A RU 2395490 C2 RU2395490 C2 RU 2395490C2
Authority
RU
Russia
Prior art keywords
amino
bis
mmol
solution
ethyl
Prior art date
Application number
RU2004127136/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2004127136A (ru
Inventor
Пьер Лучио АНЕЛЛИ (IT)
Пьер Лучио АНЕЛЛИ
Марино БРОККЕТТА (IT)
Марино БРОККЕТТА
ХАЕН Кристоф ДЕ (IT)
ХАЕН Кристоф ДЕ
Орнелла ГАЦЦОТТИ (IT)
Орнелла ГАЦЦОТТИ
Лучано ЛАТТУАДА (IT)
Лучано ЛАТТУАДА
Джованна ЛУКС (IT)
Джованна ЛУКС
Джузеппе МАНФРЕДИ (IT)
Джузеппе МАНФРЕДИ
Пьерфранческо МОРОЗИНИ (IT)
Пьерфранческо МОРОЗИНИ
Даниела ПАЛАНО (IT)
Даниела ПАЛАНО
Микеле СЕРЛЕТИ (IT)
Микеле СЕРЛЕТИ
Фульвио УГГЕРИ (IT)
Фульвио УГГЕРИ
Массимо ВИЗИГАЛЛИ (IT)
Массимо ВИЗИГАЛЛИ
Original Assignee
Бракко Имэджинг С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бракко Имэджинг С.П.А. filed Critical Бракко Имэджинг С.П.А.
Publication of RU2004127136A publication Critical patent/RU2004127136A/ru
Application granted granted Critical
Publication of RU2395490C2 publication Critical patent/RU2395490C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2004127136/04A 1998-12-23 1999-12-16 Способ получения гамма-амидов глутамовой кислоты RU2395490C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI98A002802 1998-12-23
IT1998MI002802A IT1304501B1 (it) 1998-12-23 1998-12-23 Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2001120351/15A Division RU2250765C2 (ru) 1998-12-23 1999-12-16 Агенты для кровяного депо для диагностики с помощью ядерного магнитного резонанса

Publications (2)

Publication Number Publication Date
RU2004127136A RU2004127136A (ru) 2006-02-27
RU2395490C2 true RU2395490C2 (ru) 2010-07-27

Family

ID=11381326

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2004127136/04A RU2395490C2 (ru) 1998-12-23 1999-12-16 Способ получения гамма-амидов глутамовой кислоты
RU2001120351/15A RU2250765C2 (ru) 1998-12-23 1999-12-16 Агенты для кровяного депо для диагностики с помощью ядерного магнитного резонанса

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2001120351/15A RU2250765C2 (ru) 1998-12-23 1999-12-16 Агенты для кровяного депо для диагностики с помощью ядерного магнитного резонанса

Country Status (20)

Country Link
US (1) US6461588B1 (https=)
EP (2) EP1935435B1 (https=)
JP (1) JP4733271B2 (https=)
KR (1) KR100736298B1 (https=)
CN (2) CN100450996C (https=)
AT (1) ATE405296T1 (https=)
AU (1) AU773876B2 (https=)
CA (1) CA2355888C (https=)
CZ (1) CZ302195B6 (https=)
DE (1) DE69939398D1 (https=)
HK (1) HK1042432B (https=)
HU (1) HU228048B1 (https=)
IL (2) IL143730A0 (https=)
IT (1) IT1304501B1 (https=)
MX (1) MXPA01006344A (https=)
NO (1) NO322551B1 (https=)
PL (1) PL196474B1 (https=)
RU (2) RU2395490C2 (https=)
WO (1) WO2000038738A1 (https=)
ZA (1) ZA200104820B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (https=) * 1995-02-01 1997-11-11 Epix Medical Inc
KR20010030854A (ko) 1997-10-02 2001-04-16 로퍼, 랜달 비. 인터벤셔날 요법을 모니터하기 위한 콘트라스트 강화된진단 영상화 방법
IT1317862B1 (it) * 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
EP1361847A2 (en) * 2000-10-06 2003-11-19 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
EP1229041A1 (en) * 2001-02-05 2002-08-07 Bracco Imaging S.p.A. A process for the preparation of 3-Glutamido bile ester derivatives using N-tBoc methyl pyroglutamate
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2512310C (en) * 2003-01-13 2012-09-25 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2549318A1 (en) * 2003-12-24 2005-07-28 Enrico Cappelletti Improved gastrin releasing peptide compounds
RU2425831C2 (ru) * 2005-12-02 2011-08-10 Джи-И Хелткер АС Мультимерные контрастные агенты для магнитного резонанса
WO2009009760A1 (en) 2007-07-11 2009-01-15 Board Of Regents, The University Of Texas System Seeds and markers for use in imaging
CN101845112B (zh) * 2010-06-02 2011-09-14 华东理工大学 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法
CN103442737B (zh) 2011-01-20 2017-03-29 得克萨斯系统大学董事会 Mri标记、递送和提取系统及其制造方法和用途
AU2013229631B2 (en) 2012-03-05 2017-09-14 Bracco Imaging Spa Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues
CN102766188B (zh) * 2012-07-24 2016-01-13 上海交通大学 胆固醇衍生物、螯合物、重组高密度脂蛋白及其用途
GB201421163D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Formulations of metal complexes
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
KR102612882B1 (ko) 2017-05-05 2023-12-11 센터 포 프로브 디벨롭먼트 앤드 커머셜리제이션 이관능성 킬레이트 및 그의 용도의 약동학적 증진
CA3062538A1 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
JP7463006B2 (ja) * 2018-05-30 2024-04-08 トランスレイト バイオ， インコーポレイテッド ステロイド性部分を含むカチオン性脂質
EP4377323B1 (en) * 2021-07-27 2025-07-02 Bracco Imaging SPA Manufacturing of dimeric contrast agents
WO2025163025A1 (en) 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2059642C1 (ru) * 1987-12-24 1996-05-10 Бракко Индустрия Кимика С.п.А Хелаты гадолиния и способ их получения

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
NO940115D0 (no) * 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
JPH09512265A (ja) * 1994-04-20 1997-12-09 ニコムド サルター アイエヌシー コントラスト剤
IT1269839B (it) * 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
JPH11116542A (ja) * 1997-10-06 1999-04-27 Sogo Pharmaceut Co Ltd γ−グルタミン酸アミド類の製造法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2059642C1 (ru) * 1987-12-24 1996-05-10 Бракко Индустрия Кимика С.п.А Хелаты гадолиния и способ их получения

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Y.S.Lee et al. «Chiral synthesis of trans-1-Aminoindolo[2,3-α]quinolizidine and trans-l-Aminobenzol[α]quinolizidine Derivatives from L-Pyroglutamic Acid», The Journal of Organic Chemistry 1999, 64 (26), p.9727-9730. C.M.Acevedo et al. Synthesis and analysis of the sterically constrained L-glutamine analogues (3S,4R)-3,4-dimethyl-L-glutamine and (3S,4R)-3,4-dimethyl-L-pyroglutamic acid, TETRAHEDRON 2001, 57, p.6353-6359. *

Also Published As

Publication number Publication date
WO2000038738A1 (en) 2000-07-06
RU2250765C2 (ru) 2005-04-27
EP1935435A3 (en) 2009-01-21
IL143730A0 (en) 2002-04-21
PL196474B1 (pl) 2008-01-31
EP1140209A1 (en) 2001-10-10
CA2355888C (en) 2009-02-24
AU773876B2 (en) 2004-06-10
ATE405296T1 (de) 2008-09-15
HK1042432B (zh) 2007-01-26
ITMI982802A1 (it) 2000-06-23
CZ302195B6 (cs) 2010-12-08
NO20013154D0 (no) 2001-06-22
HK1042432A1 (zh) 2002-08-16
KR20010099889A (ko) 2001-11-09
AU1980700A (en) 2000-07-31
CZ20012330A3 (cs) 2002-01-16
CN1263515C (zh) 2006-07-12
NO20013154L (no) 2001-08-23
HU228048B1 (en) 2012-09-28
ZA200104820B (en) 2002-06-13
RU2004127136A (ru) 2006-02-27
HUP0104715A2 (hu) 2002-04-29
EP1140209B1 (en) 2008-08-20
KR100736298B1 (ko) 2007-07-06
NO322551B1 (no) 2006-10-23
CN1854122A (zh) 2006-11-01
EP1935435A2 (en) 2008-06-25
IT1304501B1 (it) 2001-03-19
EP1935435B1 (en) 2017-09-06
HUP0104715A3 (en) 2005-11-28
CA2355888A1 (en) 2000-07-06
IL143730A (en) 2007-09-20
CN1333695A (zh) 2002-01-30
CN100450996C (zh) 2009-01-14
US6461588B1 (en) 2002-10-08
MXPA01006344A (es) 2002-06-04
JP4733271B2 (ja) 2011-07-27
PL349488A1 (en) 2002-07-29
JP2002533420A (ja) 2002-10-08
DE69939398D1 (de) 2008-10-02

Similar Documents

Publication Publication Date Title
RU2395490C2 (ru) Способ получения гамма-амидов глутамовой кислоты
JP4108120B2 (ja) 胆汁酸抱合体、それらの金属錯体との誘導体、及び関連する使用方法
EP1259532B1 (en) Bile acids conjugates with metal ion chelates and the use thereof
JPH08510458A (ja) 沃素化された常磁性キレートおよびそれらの造影剤としての使用法
AU691024B2 (en) Macrocyclic chelants, their chelates and uses thereof in the diagnostic field

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20171217