CZ302195B6 - Použití chelatovaných komplexu - Google Patents

Použití chelatovaných komplexu Download PDF

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Publication number
CZ302195B6
CZ302195B6 CZ20012330A CZ20012330A CZ302195B6 CZ 302195 B6 CZ302195 B6 CZ 302195B6 CZ 20012330 A CZ20012330 A CZ 20012330A CZ 20012330 A CZ20012330 A CZ 20012330A CZ 302195 B6 CZ302195 B6 CZ 302195B6
Authority
CZ
Czechia
Prior art keywords
amino
bis
carboxymethyl
ethyl
acid
Prior art date
Application number
CZ20012330A
Other languages
Czech (cs)
English (en)
Other versions
CZ20012330A3 (cs
Inventor
Lucio Anelli@Pier
Brocchetta@Marino
Haën@Christoph De
Gazzotti@Ornella
Lattuada@Luciano
Lux@Giovanna
Manfredi@Giuseppe
Morosini@Pierfrancesco
Palano@Daniela
Serleti@Michele
Uggeri@Fulvio
Visigalli@Massimo
Original Assignee
Bracco Imaging S. P. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging S. P. A. filed Critical Bracco Imaging S. P. A.
Publication of CZ20012330A3 publication Critical patent/CZ20012330A3/cs
Publication of CZ302195B6 publication Critical patent/CZ302195B6/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CZ20012330A 1998-12-23 1999-12-16 Použití chelatovaných komplexu CZ302195B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002802A IT1304501B1 (it) 1998-12-23 1998-12-23 Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza

Publications (2)

Publication Number Publication Date
CZ20012330A3 CZ20012330A3 (cs) 2002-01-16
CZ302195B6 true CZ302195B6 (cs) 2010-12-08

Family

ID=11381326

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20012330A CZ302195B6 (cs) 1998-12-23 1999-12-16 Použití chelatovaných komplexu

Country Status (20)

Country Link
US (1) US6461588B1 (https=)
EP (2) EP1935435B1 (https=)
JP (1) JP4733271B2 (https=)
KR (1) KR100736298B1 (https=)
CN (2) CN100450996C (https=)
AT (1) ATE405296T1 (https=)
AU (1) AU773876B2 (https=)
CA (1) CA2355888C (https=)
CZ (1) CZ302195B6 (https=)
DE (1) DE69939398D1 (https=)
HK (1) HK1042432B (https=)
HU (1) HU228048B1 (https=)
IL (2) IL143730A0 (https=)
IT (1) IT1304501B1 (https=)
MX (1) MXPA01006344A (https=)
NO (1) NO322551B1 (https=)
PL (1) PL196474B1 (https=)
RU (2) RU2395490C2 (https=)
WO (1) WO2000038738A1 (https=)
ZA (1) ZA200104820B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (https=) * 1995-02-01 1997-11-11 Epix Medical Inc
KR20010030854A (ko) 1997-10-02 2001-04-16 로퍼, 랜달 비. 인터벤셔날 요법을 모니터하기 위한 콘트라스트 강화된진단 영상화 방법
IT1317862B1 (it) * 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
EP1361847A2 (en) * 2000-10-06 2003-11-19 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
EP1229041A1 (en) * 2001-02-05 2002-08-07 Bracco Imaging S.p.A. A process for the preparation of 3-Glutamido bile ester derivatives using N-tBoc methyl pyroglutamate
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2512310C (en) * 2003-01-13 2012-09-25 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2549318A1 (en) * 2003-12-24 2005-07-28 Enrico Cappelletti Improved gastrin releasing peptide compounds
RU2425831C2 (ru) * 2005-12-02 2011-08-10 Джи-И Хелткер АС Мультимерные контрастные агенты для магнитного резонанса
WO2009009760A1 (en) 2007-07-11 2009-01-15 Board Of Regents, The University Of Texas System Seeds and markers for use in imaging
CN101845112B (zh) * 2010-06-02 2011-09-14 华东理工大学 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法
CN103442737B (zh) 2011-01-20 2017-03-29 得克萨斯系统大学董事会 Mri标记、递送和提取系统及其制造方法和用途
AU2013229631B2 (en) 2012-03-05 2017-09-14 Bracco Imaging Spa Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues
CN102766188B (zh) * 2012-07-24 2016-01-13 上海交通大学 胆固醇衍生物、螯合物、重组高密度脂蛋白及其用途
GB201421163D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Formulations of metal complexes
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
KR102612882B1 (ko) 2017-05-05 2023-12-11 센터 포 프로브 디벨롭먼트 앤드 커머셜리제이션 이관능성 킬레이트 및 그의 용도의 약동학적 증진
CA3062538A1 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
JP7463006B2 (ja) * 2018-05-30 2024-04-08 トランスレイト バイオ， インコーポレイテッド ステロイド性部分を含むカチオン性脂質
EP4377323B1 (en) * 2021-07-27 2025-07-02 Bracco Imaging SPA Manufacturing of dimeric contrast agents
WO2025163025A1 (en) 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279307A2 (en) * 1987-02-13 1988-08-24 Abbott Laboratories Bifunctional chelating agents
EP0417725A2 (de) * 1989-09-14 1991-03-20 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung, Verwendung als Arzneimittel
WO1995019186A2 (en) * 1994-01-13 1995-07-20 Nycomed Imaging A/S Contrast media for x-ray and magnetic resonance imaging
WO1995032741A1 (en) * 1994-05-26 1995-12-07 Bracco S.P.A. Bile acid conjugates, derivatives thereof with metal complexes and related uses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
DE440606T1 (de) * 1987-12-24 1992-02-27 Bracco Industria Chimica S.P.A., Mailand / Milano Macrocyclische chelatisierungsmittel und daraus hergestellte chelate.
JPH09512265A (ja) * 1994-04-20 1997-12-09 ニコムド サルター アイエヌシー コントラスト剤
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
JPH11116542A (ja) * 1997-10-06 1999-04-27 Sogo Pharmaceut Co Ltd γ−グルタミン酸アミド類の製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279307A2 (en) * 1987-02-13 1988-08-24 Abbott Laboratories Bifunctional chelating agents
EP0417725A2 (de) * 1989-09-14 1991-03-20 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung, Verwendung als Arzneimittel
WO1995019186A2 (en) * 1994-01-13 1995-07-20 Nycomed Imaging A/S Contrast media for x-ray and magnetic resonance imaging
WO1995032741A1 (en) * 1994-05-26 1995-12-07 Bracco S.P.A. Bile acid conjugates, derivatives thereof with metal complexes and related uses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bioconjug. Chem. 1991 2 (2) s. 117-123 (abstrakt) *

Also Published As

Publication number Publication date
WO2000038738A1 (en) 2000-07-06
RU2250765C2 (ru) 2005-04-27
RU2395490C2 (ru) 2010-07-27
EP1935435A3 (en) 2009-01-21
IL143730A0 (en) 2002-04-21
PL196474B1 (pl) 2008-01-31
EP1140209A1 (en) 2001-10-10
CA2355888C (en) 2009-02-24
AU773876B2 (en) 2004-06-10
ATE405296T1 (de) 2008-09-15
HK1042432B (zh) 2007-01-26
ITMI982802A1 (it) 2000-06-23
NO20013154D0 (no) 2001-06-22
HK1042432A1 (zh) 2002-08-16
KR20010099889A (ko) 2001-11-09
AU1980700A (en) 2000-07-31
CZ20012330A3 (cs) 2002-01-16
CN1263515C (zh) 2006-07-12
NO20013154L (no) 2001-08-23
HU228048B1 (en) 2012-09-28
ZA200104820B (en) 2002-06-13
RU2004127136A (ru) 2006-02-27
HUP0104715A2 (hu) 2002-04-29
EP1140209B1 (en) 2008-08-20
KR100736298B1 (ko) 2007-07-06
NO322551B1 (no) 2006-10-23
CN1854122A (zh) 2006-11-01
EP1935435A2 (en) 2008-06-25
IT1304501B1 (it) 2001-03-19
EP1935435B1 (en) 2017-09-06
HUP0104715A3 (en) 2005-11-28
CA2355888A1 (en) 2000-07-06
IL143730A (en) 2007-09-20
CN1333695A (zh) 2002-01-30
CN100450996C (zh) 2009-01-14
US6461588B1 (en) 2002-10-08
MXPA01006344A (es) 2002-06-04
JP4733271B2 (ja) 2011-07-27
PL349488A1 (en) 2002-07-29
JP2002533420A (ja) 2002-10-08
DE69939398D1 (de) 2008-10-02

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MM4A Patent lapsed due to non-payment of fee

Effective date: 20171216