JP4726493B2 - 新規な置換イミダゾ−ピリジノン及びイミダゾ−ピリダジノン、それらの製法並びにそれらの医薬組成物としての使用 - Google Patents
新規な置換イミダゾ−ピリジノン及びイミダゾ−ピリダジノン、それらの製法並びにそれらの医薬組成物としての使用 Download PDFInfo
- Publication number
- JP4726493B2 JP4726493B2 JP2004570687A JP2004570687A JP4726493B2 JP 4726493 B2 JP4726493 B2 JP 4726493B2 JP 2004570687 A JP2004570687 A JP 2004570687A JP 2004570687 A JP2004570687 A JP 2004570687A JP 4726493 B2 JP4726493 B2 JP 4726493B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- amino
- imidazo
- dihydro
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GAPCRUXXQCVWDJ-UHFFFAOYSA-N CCc1nnc2[n]1cccc2 Chemical compound CCc1nnc2[n]1cccc2 GAPCRUXXQCVWDJ-UHFFFAOYSA-N 0.000 description 2
- VODPGFNLEVQMFN-UHFFFAOYSA-N CC#CC[n]1c(Br)nc(C(OC)=O)c1C(OC)=O Chemical compound CC#CC[n]1c(Br)nc(C(OC)=O)c1C(OC)=O VODPGFNLEVQMFN-UHFFFAOYSA-N 0.000 description 1
- AWBRGPKFAOVXNJ-UHFFFAOYSA-N CC#CC[n]1c(N(CCC2)CC2N)nc(C=NN2Cc3nc(cccc4)c4cn3)c1C2=O Chemical compound CC#CC[n]1c(N(CCC2)CC2N)nc(C=NN2Cc3nc(cccc4)c4cn3)c1C2=O AWBRGPKFAOVXNJ-UHFFFAOYSA-N 0.000 description 1
- DCAKSIWUXGMRFT-GOSISDBHSA-N CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc(cc3)c(cccc4)c4c3Br)c1C2=O Chemical compound CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc(cc3)c(cccc4)c4c3Br)c1C2=O DCAKSIWUXGMRFT-GOSISDBHSA-N 0.000 description 1
- MDWBUHINFWRARY-QGZVFWFLSA-N CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3c(cn[n]4C)c4ccc3)c1C2=O Chemical compound CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3c(cn[n]4C)c4ccc3)c1C2=O MDWBUHINFWRARY-QGZVFWFLSA-N 0.000 description 1
- LTYFBZKPWVJWBJ-OAHLLOKOSA-N CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3cc4n[s]nc4cc3)c1C2=O Chemical compound CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3cc4n[s]nc4cc3)c1C2=O LTYFBZKPWVJWBJ-OAHLLOKOSA-N 0.000 description 1
- AHUSIZOKEFDUCL-OAHLLOKOSA-N CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3n[s]c4c3cccc4)c1C2=O Chemical compound CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3n[s]c4c3cccc4)c1C2=O AHUSIZOKEFDUCL-OAHLLOKOSA-N 0.000 description 1
- RRYUVOSBAKYTCM-MRXNPFEDSA-N CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3nc(cccc4)c4nc3)c1C2=O Chemical compound CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3nc(cccc4)c4nc3)c1C2=O RRYUVOSBAKYTCM-MRXNPFEDSA-N 0.000 description 1
- VRSPOJFPOCQMBF-OAHLLOKOSA-N CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3nnc4[n]3cccc4)c1C2=O Chemical compound CC#CC[n]1c(N(CCC2)C[C@@H]2N)nc(C=NN2Cc3nnc4[n]3cccc4)c1C2=O VRSPOJFPOCQMBF-OAHLLOKOSA-N 0.000 description 1
- AXUAPERHJCQRCF-OAQYLSRUSA-N CC(c1c2[n](CC#CC)c(N(CCC3)C[C@@H]3N)n1)=NN(Cc(c1c3cccc1)ccc3C#N)C2=O Chemical compound CC(c1c2[n](CC#CC)c(N(CCC3)C[C@@H]3N)n1)=NN(Cc(c1c3cccc1)ccc3C#N)C2=O AXUAPERHJCQRCF-OAQYLSRUSA-N 0.000 description 1
- JOAPVBJGWDLSMU-GOSISDBHSA-N CC(c1c2[n](CC#CC)c(N(CCC3)C[C@@H]3N)n1)=NN(Cc1nc3ccccc3c(C)n1)C2=O Chemical compound CC(c1c2[n](CC#CC)c(N(CCC3)C[C@@H]3N)n1)=NN(Cc1nc3ccccc3c(C)n1)C2=O JOAPVBJGWDLSMU-GOSISDBHSA-N 0.000 description 1
- ZHFBLXGACDANJJ-UHFFFAOYSA-N CC(c1c[n]2c(C)cccc2n1)I Chemical compound CC(c1c[n]2c(C)cccc2n1)I ZHFBLXGACDANJJ-UHFFFAOYSA-N 0.000 description 1
- JUXOEPCCCLDEPV-UHFFFAOYSA-N CCc(cc1)nc2c1nccc2 Chemical compound CCc(cc1)nc2c1nccc2 JUXOEPCCCLDEPV-UHFFFAOYSA-N 0.000 description 1
- NKGQMTMAJFEXID-UHFFFAOYSA-N CCc1c[n](cccc2)c2n1 Chemical compound CCc1c[n](cccc2)c2n1 NKGQMTMAJFEXID-UHFFFAOYSA-N 0.000 description 1
- MPNRXGDZOJLFSJ-UHFFFAOYSA-N CSc1nc(C=CN(Cc2ccccc2)C2=O)c2[n]1Cc1ccccc1 Chemical compound CSc1nc(C=CN(Cc2ccccc2)C2=O)c2[n]1Cc1ccccc1 MPNRXGDZOJLFSJ-UHFFFAOYSA-N 0.000 description 1
- PVSRBIIBKNTKNU-UHFFFAOYSA-N Cc1c(cccc2)c2nc(CN(C2=O)N=Cc3c2[n](CC#CC)c(Br)n3)n1 Chemical compound Cc1c(cccc2)c2nc(CN(C2=O)N=Cc3c2[n](CC#CC)c(Br)n3)n1 PVSRBIIBKNTKNU-UHFFFAOYSA-N 0.000 description 1
- IXVARICGYAWRCV-HXUWFJFHSA-N Cc1cc(CN(C2=O)N=Cc3c2[n](CC#CC)c(N(CCC2)C[C@@H]2N)n3)cc2nc(C)c(C)nc12 Chemical compound Cc1cc(CN(C2=O)N=Cc3c2[n](CC#CC)c(N(CCC2)C[C@@H]2N)n3)cc2nc(C)c(C)nc12 IXVARICGYAWRCV-HXUWFJFHSA-N 0.000 description 1
- IZISCGFIOLCUSQ-UHFFFAOYSA-N Cc1nc(CN(C2=O)N=Cc3c2[n](CC#CC)c(N(CCC2)CC2N)n3)c(cccc2)c2c1 Chemical compound Cc1nc(CN(C2=O)N=Cc3c2[n](CC#CC)c(N(CCC2)CC2N)n3)c(cccc2)c2c1 IZISCGFIOLCUSQ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
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- Transplantation (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10256264.4 | 2002-12-03 | ||
| DE2002156264 DE10256264A1 (de) | 2002-12-03 | 2002-12-03 | Neue substituierte Imidazo-pyridinone und Imidazo-pyridazinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE2003109927 DE10309927A1 (de) | 2003-03-07 | 2003-03-07 | Neue substituierte Imidazo-pyridinone und Imidazo-pyridazinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE10309927.1 | 2003-03-07 | ||
| PCT/EP2003/013648 WO2004050658A1 (de) | 2002-12-03 | 2003-12-03 | Neue substituierte imidazo-pyridinone und imidazo-pyridazinone, ihre herstellung und ihre verwendung als arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514980A JP2006514980A (ja) | 2006-05-18 |
| JP2006514980A5 JP2006514980A5 (enExample) | 2010-09-30 |
| JP4726493B2 true JP4726493B2 (ja) | 2011-07-20 |
Family
ID=32471489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004570687A Expired - Lifetime JP4726493B2 (ja) | 2002-12-03 | 2003-12-03 | 新規な置換イミダゾ−ピリジノン及びイミダゾ−ピリダジノン、それらの製法並びにそれらの医薬組成物としての使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1569936B1 (enExample) |
| JP (1) | JP4726493B2 (enExample) |
| AR (1) | AR042275A1 (enExample) |
| AT (1) | ATE425979T1 (enExample) |
| AU (1) | AU2003293757A1 (enExample) |
| CA (1) | CA2508233C (enExample) |
| DE (1) | DE50311318D1 (enExample) |
| ES (1) | ES2324294T3 (enExample) |
| PE (1) | PE20040759A1 (enExample) |
| TW (1) | TW200504067A (enExample) |
| UY (1) | UY28103A1 (enExample) |
| WO (1) | WO2004050658A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190124536A (ko) * | 2018-04-26 | 2019-11-05 | 주식회사 경보제약 | 신규한 리나글립틴 염 화합물, 이의 제조 방법 및 신규한 리나글립틴 염 화합물로부터 제조된 리나글립틴 |
Families Citing this family (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
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| CN110075098A (zh) | 2013-03-15 | 2019-08-02 | 勃林格殷格翰国际有限公司 | 利格列汀在心脏和肾脏保护性抗糖尿病治疗中的用途 |
| CA2906624A1 (en) | 2013-03-15 | 2014-09-25 | Dyax Corp. | Anti-plasma kallikrein antibodies |
| CN103435540A (zh) * | 2013-08-22 | 2013-12-11 | 南京华安药业有限公司 | 一种3,4-二氨基-2-羟基吡啶的合成方法 |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2015128453A1 (en) | 2014-02-28 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Medical use of a dpp-4 inhibitor |
| GB201415598D0 (en) | 2014-09-03 | 2014-10-15 | Univ Birmingham | Elavated Itercranial Pressure Treatment |
| AU2016229982B2 (en) | 2015-03-09 | 2020-06-18 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
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| US10155000B2 (en) | 2016-06-10 | 2018-12-18 | Boehringer Ingelheim International Gmbh | Medical use of pharmaceutical combination or composition |
| WO2018104263A1 (en) | 2016-12-06 | 2018-06-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of enhancing the potency of incretin-based drugs in subjects in need thereof |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
| JP2020515639A (ja) | 2017-04-03 | 2020-05-28 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 進行性核上性麻痺の処置のためのPPARγアゴニスト |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1301187B1 (en) * | 2000-07-04 | 2005-07-06 | Novo Nordisk A/S | Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv) |
| CA2418656C (en) * | 2000-08-10 | 2011-02-01 | Mitsubishi Pharma Corporation | Proline derivatives and use thereof as drugs |
| CZ305402B6 (cs) * | 2001-02-24 | 2015-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthinové deriváty, jejich výroba a použití v kombinační terapii |
| PL374007A1 (en) * | 2002-06-06 | 2005-09-19 | Eisai Co, Ltd. | Novel fused imidazole derivative |
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2003
- 2003-11-28 UY UY28103A patent/UY28103A1/es not_active Application Discontinuation
- 2003-12-01 PE PE2003001222A patent/PE20040759A1/es not_active Application Discontinuation
- 2003-12-02 TW TW092133830A patent/TW200504067A/zh unknown
- 2003-12-03 AU AU2003293757A patent/AU2003293757A1/en not_active Abandoned
- 2003-12-03 AR ARP030104444A patent/AR042275A1/es unknown
- 2003-12-03 EP EP03789123A patent/EP1569936B1/de not_active Expired - Lifetime
- 2003-12-03 ES ES03789123T patent/ES2324294T3/es not_active Expired - Lifetime
- 2003-12-03 WO PCT/EP2003/013648 patent/WO2004050658A1/de not_active Ceased
- 2003-12-03 DE DE50311318T patent/DE50311318D1/de not_active Expired - Lifetime
- 2003-12-03 JP JP2004570687A patent/JP4726493B2/ja not_active Expired - Lifetime
- 2003-12-03 AT AT03789123T patent/ATE425979T1/de active
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190124536A (ko) * | 2018-04-26 | 2019-11-05 | 주식회사 경보제약 | 신규한 리나글립틴 염 화합물, 이의 제조 방법 및 신규한 리나글립틴 염 화합물로부터 제조된 리나글립틴 |
| KR102208009B1 (ko) * | 2018-04-26 | 2021-01-28 | 주식회사 경보제약 | 신규한 리나글립틴 염 화합물, 이의 제조 방법 및 신규한 리나글립틴 염 화합물로부터 제조된 리나글립틴 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE50311318D1 (de) | 2009-04-30 |
| CA2508233A1 (en) | 2004-06-17 |
| PE20040759A1 (es) | 2004-12-10 |
| WO2004050658A1 (de) | 2004-06-17 |
| CA2508233C (en) | 2012-01-31 |
| TW200504067A (en) | 2005-02-01 |
| ES2324294T3 (es) | 2009-08-04 |
| JP2006514980A (ja) | 2006-05-18 |
| AU2003293757A1 (en) | 2004-06-23 |
| ATE425979T1 (de) | 2009-04-15 |
| EP1569936B1 (de) | 2009-03-18 |
| EP1569936A1 (de) | 2005-09-07 |
| AR042275A1 (es) | 2005-06-15 |
| UY28103A1 (es) | 2004-06-30 |
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