PE20040759A1 - Imidazo-piridinonas sustituidas como inhibidores de la actividad de la enzima dipeptidilpeptidasa-iv - Google Patents

Imidazo-piridinonas sustituidas como inhibidores de la actividad de la enzima dipeptidilpeptidasa-iv

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Publication number
PE20040759A1
PE20040759A1 PE2003001222A PE2003001222A PE20040759A1 PE 20040759 A1 PE20040759 A1 PE 20040759A1 PE 2003001222 A PE2003001222 A PE 2003001222A PE 2003001222 A PE2003001222 A PE 2003001222A PE 20040759 A1 PE20040759 A1 PE 20040759A1
Authority
PE
Peru
Prior art keywords
imidazo
inhibitors
activity
ilmetil
inyl
Prior art date
Application number
PE2003001222A
Other languages
English (en)
Inventor
Norbert Hauel
Frank Himmlsbach
Elke Langkopf
Matthias Eckhardt
Roland Maier
Michael Mark
Mohammad Tadayyon
Iris Kauffmann-Hefner
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002156264 external-priority patent/DE10256264A1/de
Priority claimed from DE2003109927 external-priority patent/DE10309927A1/de
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20040759A1 publication Critical patent/PE20040759A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Dispersion Chemistry (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A IMIDAZO-PIRIDINONAS E IMIDAZO-PIRIDAZINONAS SUSTITUIDAS DE FORMULA I DONDE X ES N, C-R5 DONDE R5 ES H, METILO; R1 ES CICLOALQUILENIMINO DE 5 A 7 MIEMBROS, UN GRUPO CICLOALQUILENIMINO DE 6 A 7 MIEMBROS EN EL QU EEL GRUPO METILENO EN POSICION 4 ESTA REEMPLAZADO POR UN GRUPO NH, ENTRE OTROS; R2 ES BENCILO CON HALO, UN GRUPO ALQUENILO C3-C8, ALQUINILO C3-C5, ENTRE OTROS; 3 ES ALQUILO C1-C6, FENILALQUILO C1-C3, NAFTIL-ALQUILO C1-C3, 2-FENIL-2-HIDROXI-ETILO, ENTRE OTROS; R4 ES H, ALQUILO C1-C3. SON COMPUESTOS PREFERIDOS 2-(3-AMINO-PIPERIDIN-1-IL)-3-(BUT-2-INIL)-5-(NAFTALIN-1-ILMETIL)-3,5-DIHIDRO-IMIDAZO[4,5-d]PIRIDAZIN-4-ONA, 2-(3-AMINO-PIPERIDIN-1-IL)-3-(BUT-2-INIL)-5-(3-METIL-ISOQUINOLIN-1-ILMETIL)-3,5-DIHIDRO-IMIDAZO[4,5-d]PIRIDAZIN-4-ONA, 2-(3-AMINO-PIPERIDIN-1-IL)-3-(BUT-2-INIL)-5-(QUINAZOLIN-2-ILMETIL)-3,5-DIHIDRO-IMIDAZO[4,5-d]PIRIDAZIN-4-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA ACTIVIDAD DE LA ENZIMA DIPEPTIDILPEPTIDASA-IV (DDP-IV) UTIL PARA EL TRATAMIENTO DE DIABETES MELLITUS, ARTRITIS, OSTEOPOROSIS
PE2003001222A 2002-12-03 2003-12-01 Imidazo-piridinonas sustituidas como inhibidores de la actividad de la enzima dipeptidilpeptidasa-iv PE20040759A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2002156264 DE10256264A1 (de) 2002-12-03 2002-12-03 Neue substituierte Imidazo-pyridinone und Imidazo-pyridazinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE2003109927 DE10309927A1 (de) 2003-03-07 2003-03-07 Neue substituierte Imidazo-pyridinone und Imidazo-pyridazinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PE20040759A1 true PE20040759A1 (es) 2004-12-10

Family

ID=32471489

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001222A PE20040759A1 (es) 2002-12-03 2003-12-01 Imidazo-piridinonas sustituidas como inhibidores de la actividad de la enzima dipeptidilpeptidasa-iv

Country Status (12)

Country Link
EP (1) EP1569936B1 (es)
JP (1) JP4726493B2 (es)
AR (1) AR042275A1 (es)
AT (1) ATE425979T1 (es)
AU (1) AU2003293757A1 (es)
CA (1) CA2508233C (es)
DE (1) DE50311318D1 (es)
ES (1) ES2324294T3 (es)
PE (1) PE20040759A1 (es)
TW (1) TW200504067A (es)
UY (1) UY28103A1 (es)
WO (1) WO2004050658A1 (es)

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