JP4673429B2 - グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物 - Google Patents

グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物 Download PDF

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Publication number
JP4673429B2
JP4673429B2 JP2009533939A JP2009533939A JP4673429B2 JP 4673429 B2 JP4673429 B2 JP 4673429B2 JP 2009533939 A JP2009533939 A JP 2009533939A JP 2009533939 A JP2009533939 A JP 2009533939A JP 4673429 B2 JP4673429 B2 JP 4673429B2
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oxy
formula
propan
difluoromethoxy
alkyl
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JP2010507641A5 (enExample
JP2010507641A (ja
Inventor
マーティン，ナサニエル・ジョージ
マッカレッシャー，ダレン
パイク，カート・ゴードン
ワリング，マイケル・ジェイムズ
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009533939A 2006-10-26 2007-10-25 グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物 Expired - Fee Related JP4673429B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86305606P 2006-10-26 2006-10-26
US95737007P 2007-08-22 2007-08-22
PCT/GB2007/004057 WO2008050117A1 (en) 2006-10-26 2007-10-25 Benzoyl amino heterocyclyl compounds as glucokinase (glk) activators

Related Child Applications (1)

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JP2010228109A Division JP2011046724A (ja) 2006-10-26 2010-10-08 グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物

Publications (3)

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JP2010507641A JP2010507641A (ja) 2010-03-11
JP2010507641A5 JP2010507641A5 (enExample) 2010-11-25
JP4673429B2 true JP4673429B2 (ja) 2011-04-20

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JP2009533939A Expired - Fee Related JP4673429B2 (ja) 2006-10-26 2007-10-25 グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物
JP2010228109A Withdrawn JP2011046724A (ja) 2006-10-26 2010-10-08 グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物

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JP2010228109A Withdrawn JP2011046724A (ja) 2006-10-26 2010-10-08 グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物

Country Status (20)

Country Link
US (2) US7671060B2 (enExample)
EP (2) EP2078000A1 (enExample)
JP (2) JP4673429B2 (enExample)
KR (1) KR20090084880A (enExample)
CN (1) CN101805299A (enExample)
AR (1) AR063393A1 (enExample)
AU (1) AU2007310624B2 (enExample)
BR (1) BRPI0718155A2 (enExample)
CA (1) CA2667316A1 (enExample)
CL (1) CL2007003061A1 (enExample)
CO (1) CO6160314A2 (enExample)
IL (1) IL198143A0 (enExample)
MX (1) MX2009004467A (enExample)
NO (1) NO20091596L (enExample)
PE (1) PE20080927A1 (enExample)
RU (1) RU2440992C2 (enExample)
SA (1) SA07280576B1 (enExample)
TW (1) TW200825060A (enExample)
UY (1) UY30659A1 (enExample)
WO (1) WO2008050117A1 (enExample)

Families Citing this family (25)

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BRPI0507746A (pt) * 2004-02-18 2007-07-10 Astrazeneca Ab composto ou um sal, pró-droga ou solvato do mesmo, composição farmacêutica, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
KR101346902B1 (ko) * 2005-07-09 2014-01-02 아스트라제네카 아베 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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CN110128352A (zh) 2018-02-02 2019-08-16 青岛清原化合物有限公司 哒嗪醇类化合物及其衍生物、制备方法、除草组合物和应用

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RU2440992C2 (ru) 2012-01-27
US7671060B2 (en) 2010-03-02
MX2009004467A (es) 2009-07-27
EP2272834A1 (en) 2011-01-12
CL2007003061A1 (es) 2008-08-01
AU2007310624A1 (en) 2008-05-02
RU2009114802A (ru) 2010-12-10
SA07280576B1 (ar) 2011-06-22
US7964725B2 (en) 2011-06-21
AU2007310624A8 (en) 2009-05-14
TW200825060A (en) 2008-06-16
KR20090084880A (ko) 2009-08-05
PE20080927A1 (es) 2008-09-20
JP2010507641A (ja) 2010-03-11
BRPI0718155A2 (pt) 2013-11-19
CA2667316A1 (en) 2008-05-02
UY30659A1 (es) 2008-05-31
WO2008050117A1 (en) 2008-05-02
IL198143A0 (en) 2009-12-24
EP2078000A1 (en) 2009-07-15
AU2007310624B2 (en) 2011-09-01
NO20091596L (no) 2009-06-30
US20100173825A1 (en) 2010-07-08
CO6160314A2 (es) 2010-05-20
JP2011046724A (ja) 2011-03-10
US20080318968A1 (en) 2008-12-25
AR063393A1 (es) 2009-01-28

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