AU2007310624B2 - Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators - Google Patents

Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators Download PDF

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Publication number
AU2007310624B2
AU2007310624B2 AU2007310624A AU2007310624A AU2007310624B2 AU 2007310624 B2 AU2007310624 B2 AU 2007310624B2 AU 2007310624 A AU2007310624 A AU 2007310624A AU 2007310624 A AU2007310624 A AU 2007310624A AU 2007310624 B2 AU2007310624 B2 AU 2007310624B2
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AU
Australia
Prior art keywords
oxy
propan
difluoromethoxy
formula
glk
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Ceased
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AU2007310624A
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AU2007310624A1 (en
AU2007310624A8 (en
Inventor
Nathaniel George Martin
Darren Mckerrecher
Kurt Gordon Pike
Michael James Waring
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AstraZeneca AB
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AstraZeneca AB
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Publication of AU2007310624A1 publication Critical patent/AU2007310624A1/en
Publication of AU2007310624A8 publication Critical patent/AU2007310624A8/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2007310624A 2006-10-26 2007-10-25 Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators Ceased AU2007310624B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86305606P 2006-10-26 2006-10-26
US60/863,056 2006-10-26
US95737007P 2007-08-22 2007-08-22
US60/957,370 2007-08-22
PCT/GB2007/004057 WO2008050117A1 (en) 2006-10-26 2007-10-25 Benzoyl amino heterocyclyl compounds as glucokinase (glk) activators

Publications (3)

Publication Number Publication Date
AU2007310624A1 AU2007310624A1 (en) 2008-05-02
AU2007310624A8 AU2007310624A8 (en) 2009-05-14
AU2007310624B2 true AU2007310624B2 (en) 2011-09-01

Family

ID=38925536

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007310624A Ceased AU2007310624B2 (en) 2006-10-26 2007-10-25 Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators

Country Status (20)

Country Link
US (2) US7671060B2 (enExample)
EP (2) EP2078000A1 (enExample)
JP (2) JP4673429B2 (enExample)
KR (1) KR20090084880A (enExample)
CN (1) CN101805299A (enExample)
AR (1) AR063393A1 (enExample)
AU (1) AU2007310624B2 (enExample)
BR (1) BRPI0718155A2 (enExample)
CA (1) CA2667316A1 (enExample)
CL (1) CL2007003061A1 (enExample)
CO (1) CO6160314A2 (enExample)
IL (1) IL198143A0 (enExample)
MX (1) MX2009004467A (enExample)
NO (1) NO20091596L (enExample)
PE (1) PE20080927A1 (enExample)
RU (1) RU2440992C2 (enExample)
SA (1) SA07280576B1 (enExample)
TW (1) TW200825060A (enExample)
UY (1) UY30659A1 (enExample)
WO (1) WO2008050117A1 (enExample)

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NZ564608A (en) 2005-07-09 2009-09-25 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
SA07280576B1 (ar) * 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
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UA101166C2 (ru) 2007-09-21 2013-03-11 Аррей Биофарма Инк. Производные пиридин-2-иламино-1,2,4-тиадиазола как активаторы глюкокиназы для лечения сахарного диабета
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US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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CN110128352A (zh) 2018-02-02 2019-08-16 青岛清原化合物有限公司 哒嗪醇类化合物及其衍生物、制备方法、除草组合物和应用

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EP2078000A1 (en) 2009-07-15
UY30659A1 (es) 2008-05-31
NO20091596L (no) 2009-06-30
WO2008050117A1 (en) 2008-05-02
JP2011046724A (ja) 2011-03-10
RU2009114802A (ru) 2010-12-10
US20100173825A1 (en) 2010-07-08
AR063393A1 (es) 2009-01-28
US20080318968A1 (en) 2008-12-25
MX2009004467A (es) 2009-07-27
BRPI0718155A2 (pt) 2013-11-19
CA2667316A1 (en) 2008-05-02
CN101805299A (zh) 2010-08-18
IL198143A0 (en) 2009-12-24
PE20080927A1 (es) 2008-09-20
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AU2007310624A1 (en) 2008-05-02
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JP2010507641A (ja) 2010-03-11
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AU2007310624A8 (en) 2009-05-14

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