JP4646411B2 - 変異体プロパンジオールデヒドロゲナーゼ - Google Patents

変異体プロパンジオールデヒドロゲナーゼ Download PDF

Info

Publication number
JP4646411B2
JP4646411B2 JP2000618463A JP2000618463A JP4646411B2 JP 4646411 B2 JP4646411 B2 JP 4646411B2 JP 2000618463 A JP2000618463 A JP 2000618463A JP 2000618463 A JP2000618463 A JP 2000618463A JP 4646411 B2 JP4646411 B2 JP 4646411B2
Authority
JP
Japan
Prior art keywords
propanediol
mutant
dehydrogenase
propanediol dehydrogenase
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000618463A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002543843A5 (enExample
JP2002543843A (ja
Inventor
トリムバー，ドナルド・イー
ホワイテッド，グレゴリー・エム
セリフォノバ，オルガ・ブイ
Original Assignee
ジェネンコア インターナショナル インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジェネンコア インターナショナル インコーポレーテッド filed Critical ジェネンコア インターナショナル インコーポレーテッド
Publication of JP2002543843A publication Critical patent/JP2002543843A/ja
Publication of JP2002543843A5 publication Critical patent/JP2002543843A5/ja
Application granted granted Critical
Publication of JP4646411B2 publication Critical patent/JP4646411B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2000618463A 1999-05-19 2000-05-16 変異体プロパンジオールデヒドロゲナーゼ Expired - Lifetime JP4646411B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13486899P 1999-05-19 1999-05-19
US60/134,868 1999-05-19
PCT/US2000/013286 WO2000070057A2 (en) 1999-05-19 2000-05-16 Mutant 1,3-propanediol dehydrogenase

Publications (3)

Publication Number Publication Date
JP2002543843A JP2002543843A (ja) 2002-12-24
JP2002543843A5 JP2002543843A5 (enExample) 2010-10-07
JP4646411B2 true JP4646411B2 (ja) 2011-03-09

Family

ID=22465381

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000618463A Expired - Lifetime JP4646411B2 (ja) 1999-05-19 2000-05-16 変異体プロパンジオールデヒドロゲナーゼ

Country Status (12)

Country Link
US (2) US6468773B1 (enExample)
EP (1) EP1185667B1 (enExample)
JP (1) JP4646411B2 (enExample)
CN (1) CN1187448C (enExample)
AT (1) ATE485378T1 (enExample)
AU (1) AU777718B2 (enExample)
BR (1) BR0010752A (enExample)
CA (1) CA2373312C (enExample)
DE (1) DE60045125D1 (enExample)
IL (1) IL146172A0 (enExample)
MX (1) MXPA01011766A (enExample)
WO (1) WO2000070057A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60030859T2 (de) * 1999-06-18 2007-06-14 The Research Foundation Of State University Of New York Gruppen von borrelia burgdorferi, die lyme krankheit verursachen
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
CA2665448A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
EP2225373A4 (en) * 2007-12-13 2014-04-30 Glycos Biotechnologies Inc MICROBIAL CONVERSION OF OILS AND FATTY ACIDS IN HIGH-VALUE CHEMICALS
EP2872639B1 (en) * 2012-07-11 2018-03-14 Institut National Des Sciences Appliquees A microorganism modified for the production of 1,3-propanediol
CN106211783A (zh) 2013-10-04 2016-12-07 基因组股份公司 醇脱氢酶变体
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
CN106609249B (zh) * 2015-10-22 2019-07-23 中国科学院上海高等研究院 克雷伯氏肺炎杆菌突变菌及其生产1,3-丙二醇的应用
CN115322261A (zh) 2015-10-30 2022-11-11 基因组股份公司 甲醇脱氢酶融合蛋白
CN116622657B (zh) * 2023-07-17 2023-10-24 花安堂生物科技集团有限公司 一种1，3-丙二醇氧化还原酶突变体及含其融合蛋白与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686276A (en) * 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
ID21487A (id) * 1996-11-13 1999-06-17 Du Pont Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan

Also Published As

Publication number Publication date
WO2000070057A2 (en) 2000-11-23
CA2373312C (en) 2010-07-20
AU5015500A (en) 2000-12-05
MXPA01011766A (es) 2002-05-14
EP1185667B1 (en) 2010-10-20
JP2002543843A (ja) 2002-12-24
EP1185667A2 (en) 2002-03-13
US6468773B1 (en) 2002-10-22
IL146172A0 (en) 2002-07-25
DE60045125D1 (en) 2010-12-02
ATE485378T1 (de) 2010-11-15
WO2000070057A3 (en) 2001-02-08
US6558933B2 (en) 2003-05-06
CA2373312A1 (en) 2000-11-23
US20030040091A1 (en) 2003-02-27
CN1187448C (zh) 2005-02-02
AU777718B2 (en) 2004-10-28
CN1352688A (zh) 2002-06-05
BR0010752A (pt) 2002-02-26

Similar Documents

Publication Publication Date Title
JP4570775B2 (ja) 組換え生物によるグリセロールの産生方法
JP4592418B2 (ja) 高収率での１，３−プロパンジオールの生物生産のための方法
JP4716634B2 (ja) 高力価を有する１，３−プロパンジオールの生物的生産法
JP3403412B2 (ja) 単一微生物による発酵性炭素源の１，３−プロパンジオールへの生物転化
Kataoka et al. Cloning and overexpression of the old yellow enzyme gene of Candida macedoniensis, and its application to the production of a chiral compound
KR20080036617A (ko) 케토 화합물의 입체구조 선택적인 환원을 위한산화환원효소
JP4646411B2 (ja) 変異体プロパンジオールデヒドロゲナーゼ
Povelainen et al. Production of xylitol by metabolically engineered strains of Bacillus subtilis
AU2015293864A1 (en) Method for producing acetoin
KR20150110144A (ko) 글리세롤, 3-hp, 또는 아크릴산 생산능을 갖는 재조합 미생물 및 그를 이용하여 글리세롤, 3-hp, 또는 아크릴산을 생산하는 방법
EP2336295B1 (en) Method for producing lactic acid from plant-derived raw material, and lactic-acid-producing bacterium
KR20190097250A (ko) 신규한 효소를 사용한 메틸글리옥살의 히드록시아세톤으로의 전환 및 그의 적용
KR101627921B1 (ko) 알돌레이즈 돌연변이체 및 이를 이용한 타가토스 생산 방법
JP2002543843A5 (enExample)
KR20140003258A (ko) 3-하이드록시프로피온산을 생산하는 재조합 미생물 및 이를 이용한 3-하이드록시프로피온산의 생산방법
US11814663B2 (en) Microorganisms with improved 1,3-propanediol and butyric acid production
KR20140003262A (ko) 재조합 미생물을 이용한 3-하이드록시프로피온산의 생산방법 및 그에 사용되는 재조합 미생물
JPH0556789A (ja) テルムス アクアテイカスのキシロースイソメラーゼ遺伝子、キシロースイソメラーゼ及びそれを用いたフラクトースの製造方法
KR20040104165A (ko) 캔디다 알비칸스 유래의 글리세롤-3-포스페이트포스파타제 및 글리세롤-3-포스페이트 디히드로게나제,이를 코딩하는 유전자, 상기 유전자를 포함하는 벡터 및숙주 세포, 및 상기 숙주세포를 이용한 글리세롤의 생산방법
CN112877305B (zh) 对辅酶亲和力提高的葡萄糖脱氢酶突变体
WO2024229190A1 (en) Genetically modified yeast and fermentation processes for the production of arabitol
JP2016517690A (ja) （ｒ）−３−キヌクリジノールの製造のための生体触媒法
JP2005304306A (ja) 新規な糖質酸化酵素
KR20040074506A (ko) 에머리셀라 니듈란스 유래의 글리세롤-3-포스페이트포스파타제, 이를 코드하는 폴리뉴클레오티드, 상기폴리뉴클레오티드를 포함하는 벡터, 및 상기 벡터를이용한 글리세롤의 생산방법

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070510

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100514

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100521

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20100817

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20101109

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20101207

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131217

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4646411

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term