CA2373312C - Mutant 1,3-propanediol dehydrogenase - Google Patents
Mutant 1,3-propanediol dehydrogenase Download PDFInfo
- Publication number
- CA2373312C CA2373312C CA2373312A CA2373312A CA2373312C CA 2373312 C CA2373312 C CA 2373312C CA 2373312 A CA2373312 A CA 2373312A CA 2373312 A CA2373312 A CA 2373312A CA 2373312 C CA2373312 C CA 2373312C
- Authority
- CA
- Canada
- Prior art keywords
- propanediol
- mutant
- propanediol dehydrogenase
- dehydrogenase
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13486899P | 1999-05-19 | 1999-05-19 | |
| US60/134,868 | 1999-05-19 | ||
| PCT/US2000/013286 WO2000070057A2 (en) | 1999-05-19 | 2000-05-16 | Mutant 1,3-propanediol dehydrogenase |
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| CA2373312A1 CA2373312A1 (en) | 2000-11-23 |
| CA2373312C true CA2373312C (en) | 2010-07-20 |
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| DE60030859T2 (de) * | 1999-06-18 | 2007-06-14 | The Research Foundation Of State University Of New York | Gruppen von borrelia burgdorferi, die lyme krankheit verursachen |
| WO2008052596A1 (en) * | 2006-10-31 | 2008-05-08 | Metabolic Explorer | Process for the biological production of n-butanol with high yield |
| CA2665448A1 (en) * | 2006-10-31 | 2008-05-08 | Metabolic Explorer | Process for the biological production of 1,3-propanediol from glycerol with high yield |
| EP2225373A4 (en) * | 2007-12-13 | 2014-04-30 | Glycos Biotechnologies Inc | MICROBIAL CONVERSION OF OILS AND FATTY ACIDS IN HIGH-VALUE CHEMICALS |
| EP2872639B1 (en) * | 2012-07-11 | 2018-03-14 | Institut National Des Sciences Appliquees | A microorganism modified for the production of 1,3-propanediol |
| CN106211783A (zh) | 2013-10-04 | 2016-12-07 | 基因组股份公司 | 醇脱氢酶变体 |
| CN103642765B (zh) * | 2013-12-25 | 2015-11-18 | 南京工业大学 | 醇脱氢酶突变体及其应用 |
| CN106609249B (zh) * | 2015-10-22 | 2019-07-23 | 中国科学院上海高等研究院 | 克雷伯氏肺炎杆菌突变菌及其生产1,3-丙二醇的应用 |
| CN115322261A (zh) | 2015-10-30 | 2022-11-11 | 基因组股份公司 | 甲醇脱氢酶融合蛋白 |
| CN116622657B (zh) * | 2023-07-17 | 2023-10-24 | 花安堂生物科技集团有限公司 | 一种1，3-丙二醇氧化还原酶突变体及含其融合蛋白与应用 |
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| US5686276A (en) * | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| ID21487A (id) * | 1996-11-13 | 1999-06-17 | Du Pont | Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan |
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| AU5015500A (en) | 2000-12-05 |
| MXPA01011766A (es) | 2002-05-14 |
| EP1185667B1 (en) | 2010-10-20 |
| JP2002543843A (ja) | 2002-12-24 |
| JP4646411B2 (ja) | 2011-03-09 |
| EP1185667A2 (en) | 2002-03-13 |
| US6468773B1 (en) | 2002-10-22 |
| IL146172A0 (en) | 2002-07-25 |
| DE60045125D1 (en) | 2010-12-02 |
| ATE485378T1 (de) | 2010-11-15 |
| WO2000070057A3 (en) | 2001-02-08 |
| US6558933B2 (en) | 2003-05-06 |
| CA2373312A1 (en) | 2000-11-23 |
| US20030040091A1 (en) | 2003-02-27 |
| CN1187448C (zh) | 2005-02-02 |
| AU777718B2 (en) | 2004-10-28 |
| CN1352688A (zh) | 2002-06-05 |
| BR0010752A (pt) | 2002-02-26 |
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