DE60045125D1 - 1,3-propanediol dehydrogenase mutant - Google Patents

1,3-propanediol dehydrogenase mutant

Info

Publication number
DE60045125D1
DE60045125D1 DE60045125T DE60045125T DE60045125D1 DE 60045125 D1 DE60045125 D1 DE 60045125D1 DE 60045125 T DE60045125 T DE 60045125T DE 60045125 T DE60045125 T DE 60045125T DE 60045125 D1 DE60045125 D1 DE 60045125D1
Authority
DE
Germany
Prior art keywords
propanediol
mutant
propanediol dehydrogenase
dehydrogenase mutant
dehydrogenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60045125T
Other languages
German (de)
English (en)
Inventor
Donald E Trimbur
Gregory M Whited
Olga V Selifonova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Danisco US Inc
Original Assignee
Genencor International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor International Inc filed Critical Genencor International Inc
Application granted granted Critical
Publication of DE60045125D1 publication Critical patent/DE60045125D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE60045125T 1999-05-19 2000-05-16 1,3-propanediol dehydrogenase mutant Expired - Lifetime DE60045125D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13486899P 1999-05-19 1999-05-19
PCT/US2000/013286 WO2000070057A2 (en) 1999-05-19 2000-05-16 Mutant 1,3-propanediol dehydrogenase

Publications (1)

Publication Number Publication Date
DE60045125D1 true DE60045125D1 (en) 2010-12-02

Family

ID=22465381

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60045125T Expired - Lifetime DE60045125D1 (en) 1999-05-19 2000-05-16 1,3-propanediol dehydrogenase mutant

Country Status (12)

Country Link
US (2) US6468773B1 (enExample)
EP (1) EP1185667B1 (enExample)
JP (1) JP4646411B2 (enExample)
CN (1) CN1187448C (enExample)
AT (1) ATE485378T1 (enExample)
AU (1) AU777718B2 (enExample)
BR (1) BR0010752A (enExample)
CA (1) CA2373312C (enExample)
DE (1) DE60045125D1 (enExample)
IL (1) IL146172A0 (enExample)
MX (1) MXPA01011766A (enExample)
WO (1) WO2000070057A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1683867B1 (en) * 1999-06-18 2014-04-09 Research Foundation Of State University Of New York Groups of Borrelia burgdorferi and Borrelia afzelii that cause lyme disease in humans
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
JP2010508013A (ja) * 2006-10-31 2010-03-18 メタボリック エクスプローラー グリセロールから１，３−プロパンジオールを高収量で生物学的に製造する方法
WO2009078973A2 (en) * 2007-12-13 2009-06-25 Glycos Biotechnologies, Incorporated Microbial conversion of oils and fatty acids to high-value chemicals
US9605283B2 (en) 2012-07-11 2017-03-28 Institut National Des Sciences Appliquées Microorganism modified for the production of 1,3-propanediol
CA2925699A1 (en) 2013-10-04 2015-04-09 Genomatica, Inc. Alchohol dehydrogenase variants having increased substrate conversion
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
CN106609249B (zh) * 2015-10-22 2019-07-23 中国科学院上海高等研究院 克雷伯氏肺炎杆菌突变菌及其生产1,3-丙二醇的应用
SG11201803164SA (en) 2015-10-30 2018-05-30 Genomatica Inc Methanol dehydrogenase fusion proteins
CN116622657B (zh) * 2023-07-17 2023-10-24 花安堂生物科技集团有限公司 一种1，3-丙二醇氧化还原酶突变体及含其融合蛋白与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686276A (en) * 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
ID21487A (id) * 1996-11-13 1999-06-17 Du Pont Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan

Also Published As

Publication number Publication date
CN1187448C (zh) 2005-02-02
AU5015500A (en) 2000-12-05
EP1185667A2 (en) 2002-03-13
WO2000070057A2 (en) 2000-11-23
AU777718B2 (en) 2004-10-28
JP2002543843A (ja) 2002-12-24
US20030040091A1 (en) 2003-02-27
CA2373312C (en) 2010-07-20
US6468773B1 (en) 2002-10-22
CN1352688A (zh) 2002-06-05
US6558933B2 (en) 2003-05-06
BR0010752A (pt) 2002-02-26
WO2000070057A3 (en) 2001-02-08
JP4646411B2 (ja) 2011-03-09
IL146172A0 (en) 2002-07-25
EP1185667B1 (en) 2010-10-20
MXPA01011766A (es) 2002-05-14
ATE485378T1 (de) 2010-11-15
CA2373312A1 (en) 2000-11-23

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