BR0010752A - Deidrogenase de 1,3-propanodiol mutante - Google Patents

Deidrogenase de 1,3-propanodiol mutante

Info

Publication number
BR0010752A
BR0010752A BR0010752-2A BR0010752A BR0010752A BR 0010752 A BR0010752 A BR 0010752A BR 0010752 A BR0010752 A BR 0010752A BR 0010752 A BR0010752 A BR 0010752A
Authority
BR
Brazil
Prior art keywords
mutant
propanediol
propanediol dehydrogenase
dehydrogenase
present
Prior art date
Application number
BR0010752-2A
Other languages
English (en)
Inventor
Donald E Trimbur
Gregory M Whited
Olga V Selifonova
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int filed Critical Genencor Int
Publication of BR0010752A publication Critical patent/BR0010752A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Patente de Invenção: "DEIDROGENASE DE 1,3-PROPANODIOL MUTANTE". A presente invenção refere-se a deidrogenase de 1,3-propanodiol mutante e a um novo microorganismo que é capaz de se desenvolver em concentrações de pelo menos 105 g/l de 1,3-propanodiol, níveis normalmente tóxicos aos microorganismos do tipo silvestre. A presente invenção também proporciona vetores de expressão e células hospedeiras compreendendo a deidrogenase de 1,3-propanodiol mutante, bem como a métodos para a produção de 1,3-propanodiol compreendendo o uso da deidrogenase de 1,3-propanodiol mutante.
BR0010752-2A 1999-05-19 2000-05-16 Deidrogenase de 1,3-propanodiol mutante BR0010752A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13486899P 1999-05-19 1999-05-19
PCT/US2000/013286 WO2000070057A2 (en) 1999-05-19 2000-05-16 Mutant 1,3-propanediol dehydrogenase

Publications (1)

Publication Number Publication Date
BR0010752A true BR0010752A (pt) 2002-02-26

Family

ID=22465381

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010752-2A BR0010752A (pt) 1999-05-19 2000-05-16 Deidrogenase de 1,3-propanodiol mutante

Country Status (12)

Country Link
US (2) US6468773B1 (pt)
EP (1) EP1185667B1 (pt)
JP (1) JP4646411B2 (pt)
CN (1) CN1187448C (pt)
AT (1) ATE485378T1 (pt)
AU (1) AU777718B2 (pt)
BR (1) BR0010752A (pt)
CA (1) CA2373312C (pt)
DE (1) DE60045125D1 (pt)
IL (1) IL146172A0 (pt)
MX (1) MXPA01011766A (pt)
WO (1) WO2000070057A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5751000A (en) * 1999-06-18 2001-01-09 Brook Biotechnologies, Inc. Groups of borrelia burgdorferi and borrelia afzelii that cause lyme disease in humans
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
CN101528936A (zh) * 2006-10-31 2009-09-09 代谢探索者公司 以高产率从甘油生物产生1，3-丙二醇的方法
US20110229942A1 (en) * 2007-12-13 2011-09-22 Glycos Biotechnologies, Incorporated Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals
US9605283B2 (en) 2012-07-11 2017-03-28 Institut National Des Sciences Appliquées Microorganism modified for the production of 1,3-propanediol
CA2925699A1 (en) 2013-10-04 2015-04-09 Genomatica, Inc. Alchohol dehydrogenase variants having increased substrate conversion
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
CN106609249B (zh) * 2015-10-22 2019-07-23 中国科学院上海高等研究院 克雷伯氏肺炎杆菌突变菌及其生产1,3-丙二醇的应用
CN115322261A (zh) 2015-10-30 2022-11-11 基因组股份公司 甲醇脱氢酶融合蛋白
CN116622657B (zh) * 2023-07-17 2023-10-24 花安堂生物科技集团有限公司 一种1，3-丙二醇氧化还原酶突变体及含其融合蛋白与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686276A (en) * 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
ID21487A (id) * 1996-11-13 1999-06-17 Du Pont Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan

Also Published As

Publication number Publication date
CA2373312A1 (en) 2000-11-23
CA2373312C (en) 2010-07-20
WO2000070057A2 (en) 2000-11-23
ATE485378T1 (de) 2010-11-15
US20030040091A1 (en) 2003-02-27
US6558933B2 (en) 2003-05-06
CN1352688A (zh) 2002-06-05
EP1185667B1 (en) 2010-10-20
US6468773B1 (en) 2002-10-22
AU777718B2 (en) 2004-10-28
EP1185667A2 (en) 2002-03-13
JP2002543843A (ja) 2002-12-24
WO2000070057A3 (en) 2001-02-08
DE60045125D1 (en) 2010-12-02
MXPA01011766A (es) 2002-05-14
CN1187448C (zh) 2005-02-02
IL146172A0 (en) 2002-07-25
JP4646411B2 (ja) 2011-03-09
AU5015500A (en) 2000-12-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1927 DE 11/12/2007.