CN1187448C - 1,3－丙二醇脱氢酶突变体 - Google Patents

1,3－丙二醇脱氢酶突变体 Download PDF

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Publication number
CN1187448C
CN1187448C CNB008077436A CN00807743A CN1187448C CN 1187448 C CN1187448 C CN 1187448C CN B008077436 A CNB008077436 A CN B008077436A CN 00807743 A CN00807743 A CN 00807743A CN 1187448 C CN1187448 C CN 1187448C
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China
Prior art keywords
ammediol
sudden change
desaturase
pdd
escherichia
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Expired - Lifetime
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CNB008077436A
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English (en)
Chinese (zh)
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CN1352688A (zh
Inventor
D·E·特林伯
G·M·威蒂德
O·V·塞里弗诺瓦
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Danisco US Inc
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Genencor International Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CNB008077436A 1999-05-19 2000-05-16 1,3－丙二醇脱氢酶突变体 Expired - Lifetime CN1187448C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13486899P 1999-05-19 1999-05-19
US60/134,868 1999-05-19

Publications (2)

Publication Number Publication Date
CN1352688A CN1352688A (zh) 2002-06-05
CN1187448C true CN1187448C (zh) 2005-02-02

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ID=22465381

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CNB008077436A Expired - Lifetime CN1187448C (zh) 1999-05-19 2000-05-16 1,3－丙二醇脱氢酶突变体

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US (2) US6468773B1 (enExample)
EP (1) EP1185667B1 (enExample)
JP (1) JP4646411B2 (enExample)
CN (1) CN1187448C (enExample)
AT (1) ATE485378T1 (enExample)
AU (1) AU777718B2 (enExample)
BR (1) BR0010752A (enExample)
CA (1) CA2373312C (enExample)
DE (1) DE60045125D1 (enExample)
IL (1) IL146172A0 (enExample)
MX (1) MXPA01011766A (enExample)
WO (1) WO2000070057A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60030859T2 (de) * 1999-06-18 2007-06-14 The Research Foundation Of State University Of New York Gruppen von borrelia burgdorferi, die lyme krankheit verursachen
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
CA2665448A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
EP2225373A4 (en) * 2007-12-13 2014-04-30 Glycos Biotechnologies Inc MICROBIAL CONVERSION OF OILS AND FATTY ACIDS IN HIGH-VALUE CHEMICALS
EP2872639B1 (en) * 2012-07-11 2018-03-14 Institut National Des Sciences Appliquees A microorganism modified for the production of 1,3-propanediol
CN106211783A (zh) 2013-10-04 2016-12-07 基因组股份公司 醇脱氢酶变体
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
CN106609249B (zh) * 2015-10-22 2019-07-23 中国科学院上海高等研究院 克雷伯氏肺炎杆菌突变菌及其生产1,3-丙二醇的应用
CN115322261A (zh) 2015-10-30 2022-11-11 基因组股份公司 甲醇脱氢酶融合蛋白
CN116622657B (zh) * 2023-07-17 2023-10-24 花安堂生物科技集团有限公司 一种1，3-丙二醇氧化还原酶突变体及含其融合蛋白与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686276A (en) * 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
ID21487A (id) * 1996-11-13 1999-06-17 Du Pont Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan

Also Published As

Publication number Publication date
WO2000070057A2 (en) 2000-11-23
CA2373312C (en) 2010-07-20
AU5015500A (en) 2000-12-05
MXPA01011766A (es) 2002-05-14
EP1185667B1 (en) 2010-10-20
JP2002543843A (ja) 2002-12-24
JP4646411B2 (ja) 2011-03-09
EP1185667A2 (en) 2002-03-13
US6468773B1 (en) 2002-10-22
IL146172A0 (en) 2002-07-25
DE60045125D1 (en) 2010-12-02
ATE485378T1 (de) 2010-11-15
WO2000070057A3 (en) 2001-02-08
US6558933B2 (en) 2003-05-06
CA2373312A1 (en) 2000-11-23
US20030040091A1 (en) 2003-02-27
AU777718B2 (en) 2004-10-28
CN1352688A (zh) 2002-06-05
BR0010752A (pt) 2002-02-26

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Granted publication date: 20050202