JP4064818B2 - ６−置換ピリド−ピリミジン類 - Google Patents

６−置換ピリド−ピリミジン類 Download PDF

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Publication number
JP4064818B2
JP4064818B2 JP2002564525A JP2002564525A JP4064818B2 JP 4064818 B2 JP4064818 B2 JP 4064818B2 JP 2002564525 A JP2002564525 A JP 2002564525A JP 2002564525 A JP2002564525 A JP 2002564525A JP 4064818 B2 JP4064818 B2 JP 4064818B2
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JP
Japan
Prior art keywords
alkyl
mmol
cycloalkyl
hydrogen
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2002564525A
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English (en)
Japanese (ja)
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JP2004525896A (ja
JP2004525896A5 (https=
Inventor
チェン，チエン・ジェフリー
ダン，ジェームズ・パトリック
ゴールドスタイン，デービッド・マイケル
シュタール，クリストフ・マルティン
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Filing date
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2004525896A publication Critical patent/JP2004525896A/ja
Publication of JP2004525896A5 publication Critical patent/JP2004525896A5/ja
Application granted granted Critical
Publication of JP4064818B2 publication Critical patent/JP4064818B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2002564525A 2001-02-12 2002-02-04 ６−置換ピリド−ピリミジン類 Expired - Lifetime JP4064818B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30
PCT/EP2002/001106 WO2002064594A2 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines

Publications (3)

Publication Number Publication Date
JP2004525896A JP2004525896A (ja) 2004-08-26
JP2004525896A5 JP2004525896A5 (https=) 2005-06-09
JP4064818B2 true JP4064818B2 (ja) 2008-03-19

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002564525A Expired - Lifetime JP4064818B2 (ja) 2001-02-12 2002-02-04 ６−置換ピリド−ピリミジン類

Country Status (31)

Country Link
US (3) US6696566B2 (https=)
EP (1) EP1361880B1 (https=)
JP (1) JP4064818B2 (https=)
KR (1) KR100639772B1 (https=)
CN (1) CN100376571C (https=)
AR (1) AR035854A1 (https=)
AT (1) ATE305303T1 (https=)
AU (1) AU2002256615B2 (https=)
BR (1) BRPI0207172B8 (https=)
CA (1) CA2434834C (https=)
CZ (1) CZ20032416A3 (https=)
DE (1) DE60206363T2 (https=)
DK (1) DK1361880T3 (https=)
ES (1) ES2249574T3 (https=)
HR (1) HRP20030624B1 (https=)
HU (1) HU229604B1 (https=)
IL (2) IL156872A0 (https=)
JO (1) JO2410B1 (https=)
MA (1) MA26993A1 (https=)
MX (1) MXPA03007166A (https=)
MY (1) MY131518A (https=)
NO (1) NO326133B1 (https=)
NZ (1) NZ526961A (https=)
PA (1) PA8539201A1 (https=)
PE (1) PE20020976A1 (https=)
PL (1) PL366918A1 (https=)
RU (1) RU2269527C2 (https=)
SK (1) SK11322003A3 (https=)
WO (1) WO2002064594A2 (https=)
YU (1) YU63703A (https=)
ZA (1) ZA200305938B (https=)

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MXPA04005939A (es) 2002-01-22 2005-01-25 Warner Lambert Co 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas.
JP2006503802A (ja) 2002-04-03 2006-02-02 エフ．ホフマン−ラ　ロシュ　アーゲー イミダゾ縮合化合物
AU2003251661A1 (en) 2002-08-06 2004-02-25 F. Hoffmann-La Roche Ag 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
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CA2520785A1 (en) * 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag Substituted 7-aza-quinazoline compounds
RU2348632C2 (ru) * 2003-11-13 2009-03-10 Ф.Хоффманн-Ля Рош Аг Гидроксиалкилзамещенные пиридо-7-пиримидин-7-оны
WO2006056863A1 (en) * 2004-11-23 2006-06-01 Ranbaxy Laboratories Limited Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
WO2006082492A1 (en) * 2005-02-02 2006-08-10 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
MX2007013595A (es) * 2005-05-04 2008-01-24 Renovis Inc Compuestos heterociclicos fusionados y composiciones y usos de estos.
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WO2007022946A1 (de) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
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US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
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US8372970B2 (en) 2009-10-09 2013-02-12 Afraxis, Inc. 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders
JP5797664B2 (ja) * 2009-12-18 2015-10-21 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ 置換ピリド［２，３−ｄ］ピリミジン−７（８Ｈ）−オン及びそれらの治療用の使用
CN105294682B (zh) 2014-07-26 2017-07-07 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
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Also Published As

Publication number Publication date
BR0207172A (pt) 2004-03-30
AR035854A1 (es) 2004-07-21
WO2002064594A3 (en) 2003-01-09
DK1361880T3 (da) 2006-01-23
CA2434834C (en) 2010-09-14
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
PA8539201A1 (es) 2004-08-31
US20030171584A1 (en) 2003-09-11
ATE305303T1 (de) 2005-10-15
HUP0303458A3 (en) 2012-12-28
NO20033540L (no) 2003-08-11
ZA200305938B (en) 2005-01-26
PL366918A1 (en) 2005-02-07
WO2002064594A2 (en) 2002-08-22
EP1361880B1 (en) 2005-09-28
YU63703A (sh) 2006-05-25
US20040116698A1 (en) 2004-06-17
SK11322003A3 (en) 2004-10-05
US6696566B2 (en) 2004-02-24
AU2002256615B2 (en) 2007-09-13
CN100376571C (zh) 2008-03-26
RU2269527C2 (ru) 2006-02-10
DE60206363D1 (de) 2006-02-09
US20070135458A1 (en) 2007-06-14
MY131518A (en) 2007-08-30
KR100639772B1 (ko) 2006-10-30
US7449581B2 (en) 2008-11-11
HRP20030624A2 (en) 2005-06-30
HRP20030624B1 (en) 2007-03-31
ES2249574T3 (es) 2006-04-01
EP1361880A2 (en) 2003-11-19
HU229604B1 (en) 2014-02-28
JO2410B1 (en) 2007-06-17
HK1066170A1 (en) 2005-03-18
CA2434834A1 (en) 2002-08-22
NZ526961A (en) 2005-03-24
DE60206363T2 (de) 2006-07-06
RU2003125887A (ru) 2005-03-20
NO326133B1 (no) 2008-10-06
HUP0303458A2 (hu) 2004-01-28
CZ20032416A3 (cs) 2004-07-14
CN1503672A (zh) 2004-06-09
US7169794B2 (en) 2007-01-30
KR20040018254A (ko) 2004-03-02
IL156872A0 (en) 2004-02-08
NO20033540D0 (no) 2003-08-11
JP2004525896A (ja) 2004-08-26
BRPI0207172B1 (pt) 2019-04-09
MXPA03007166A (es) 2003-11-18
BRPI0207172B8 (pt) 2021-05-25
IL156872A (en) 2009-07-20

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