HRP20030624B1 - 6-substituted pyrido-pyrimidines - Google Patents

6-substituted pyrido-pyrimidines

Info

Publication number
HRP20030624B1
HRP20030624B1 HR20030624A HRP20030624A HRP20030624B1 HR P20030624 B1 HRP20030624 B1 HR P20030624B1 HR 20030624 A HR20030624 A HR 20030624A HR P20030624 A HRP20030624 A HR P20030624A HR P20030624 B1 HRP20030624 B1 HR P20030624B1
Authority
HR
Croatia
Prior art keywords
alkyl
cycloalkyl
hydrogen
aryl
heteroalkyl
Prior art date
Application number
HR20030624A
Other languages
English (en)
Croatian (hr)
Inventor
Jeffrey Chen Jian
Patrick Dunn James
Michael Goldstein David
Martin Stahl Christoph
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20030624A2 publication Critical patent/HRP20030624A2/hr
Publication of HRP20030624B1 publication Critical patent/HRP20030624B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20030624A 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines HRP20030624B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30
PCT/EP2002/001106 WO2002064594A2 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines

Publications (2)

Publication Number Publication Date
HRP20030624A2 HRP20030624A2 (en) 2005-06-30
HRP20030624B1 true HRP20030624B1 (en) 2007-03-31

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030624A HRP20030624B1 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines

Country Status (31)

Country Link
US (3) US6696566B2 (https=)
EP (1) EP1361880B1 (https=)
JP (1) JP4064818B2 (https=)
KR (1) KR100639772B1 (https=)
CN (1) CN100376571C (https=)
AR (1) AR035854A1 (https=)
AT (1) ATE305303T1 (https=)
AU (1) AU2002256615B2 (https=)
BR (1) BRPI0207172B8 (https=)
CA (1) CA2434834C (https=)
CZ (1) CZ20032416A3 (https=)
DE (1) DE60206363T2 (https=)
DK (1) DK1361880T3 (https=)
ES (1) ES2249574T3 (https=)
HR (1) HRP20030624B1 (https=)
HU (1) HU229604B1 (https=)
IL (2) IL156872A0 (https=)
JO (1) JO2410B1 (https=)
MA (1) MA26993A1 (https=)
MX (1) MXPA03007166A (https=)
MY (1) MY131518A (https=)
NO (1) NO326133B1 (https=)
NZ (1) NZ526961A (https=)
PA (1) PA8539201A1 (https=)
PE (1) PE20020976A1 (https=)
PL (1) PL366918A1 (https=)
RU (1) RU2269527C2 (https=)
SK (1) SK11322003A3 (https=)
WO (1) WO2002064594A2 (https=)
YU (1) YU63703A (https=)
ZA (1) ZA200305938B (https=)

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DE60206363T2 (de) 2001-02-12 2006-07-06 F. Hoffmann-La Roche Ag 6-substituierte pyridopyrimidine
ES2251677T3 (es) * 2002-01-22 2006-05-01 Warner-Lambert Company Llc 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-onas.
EP1492790A1 (en) 2002-04-03 2005-01-05 F. Hoffmann-La Roche Ag Imidazo fused compounds
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CA2517256C (en) * 2003-02-26 2013-04-30 Sugen, Inc. Aminoheteroaryl compounds as protein kinase inhibitors
AU2004229163A1 (en) * 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag (6-(phenoxy)-pyrido`3,4-d! PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORYY CONDITIONS SUCH AS RHEUMATOIS ARTRITIS
WO2005047284A1 (en) * 2003-11-13 2005-05-26 F. Hoffmann-La Roche Ag Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
EP1831215A1 (en) * 2004-11-23 2007-09-12 Ranbaxy Laboratories Limited Pyrido[2,3-d]pyrimidines as anti-inflamatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (en) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
MX2007013595A (es) * 2005-05-04 2008-01-24 Renovis Inc Compuestos heterociclicos fusionados y composiciones y usos de estos.
WO2007009911A1 (en) * 2005-07-21 2007-01-25 F. Hoffmann-La Roche Ag PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
ATE482958T1 (de) * 2005-08-09 2010-10-15 Irm Llc Verbindungen und zusammensetzungen als proteinkinaseinhibitoren
WO2007022946A1 (de) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
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WO2008150260A1 (en) * 2007-06-06 2008-12-11 Gpc Biotech, Inc. 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents
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US8022085B2 (en) 2007-05-07 2011-09-20 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof
CA2690327A1 (en) 2007-06-15 2008-12-18 Thomas P. Cleary A novel process for the preparation of 3-amino-pentan-1,5-diol
US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
JP2012505927A (ja) * 2008-10-22 2012-03-08 エフ.ホフマン−ラ ロシュ アーゲー Jnkのピリミジニルピリドン阻害剤
WO2010071846A2 (en) 2008-12-19 2010-06-24 Afraxis, Inc. Compounds for treating neuropsychiatric conditions
JP2013507395A (ja) 2009-10-09 2013-03-04 アフラクシス・インコーポレイテッド Cns障害治療用の8−エチル−6−(アリール)ピリド[2,3−d]ピリミジン−7(8h)−オン
US8889696B2 (en) * 2009-12-18 2014-11-18 Temple University—Of the Commonwealth System of Higher Education Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
KR20170032244A (ko) 2014-07-26 2017-03-22 선샤인 레이크 파르마 컴퍼니 리미티드 Cdk 저해제로서 2-아미노-피리도[2,3-d]피리미딘-7(8h)-온 유도체 및 그 용도
ES2866883T3 (es) * 2016-06-08 2021-10-20 Support Venture Gmbh Combinaciones farmacéuticas para el tratamiento del cáncer
CN109803968A (zh) 2016-08-15 2019-05-24 辉瑞公司 吡啶并嘧啶酮cdk2/4/6抑制剂
CA3033887A1 (en) * 2016-08-17 2018-02-22 Support-Venture Gmbh Method of preventing or treating hearing loss
US11117858B2 (en) 2017-01-11 2021-09-14 The General Hospital Corporation Voltage gated sodium channel imaging agents
CN110636840A (zh) 2017-04-04 2019-12-31 斯特里金股份公司 预防或治疗眼科疾病的方法
CN111032655B (zh) * 2017-08-31 2022-09-02 达纳-法伯癌症研究所股份有限公司 Egfr和/或her2抑制剂和使用方法
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Also Published As

Publication number Publication date
ES2249574T3 (es) 2006-04-01
JO2410B1 (en) 2007-06-17
DE60206363T2 (de) 2006-07-06
NO326133B1 (no) 2008-10-06
HK1066170A1 (en) 2005-03-18
ZA200305938B (en) 2005-01-26
YU63703A (sh) 2006-05-25
SK11322003A3 (en) 2004-10-05
MXPA03007166A (es) 2003-11-18
MY131518A (en) 2007-08-30
PL366918A1 (en) 2005-02-07
CN1503672A (zh) 2004-06-09
US20070135458A1 (en) 2007-06-14
NZ526961A (en) 2005-03-24
KR20040018254A (ko) 2004-03-02
IL156872A0 (en) 2004-02-08
HUP0303458A2 (hu) 2004-01-28
HU229604B1 (en) 2014-02-28
BRPI0207172B8 (pt) 2021-05-25
JP4064818B2 (ja) 2008-03-19
US20040116698A1 (en) 2004-06-17
DE60206363D1 (de) 2006-02-09
CN100376571C (zh) 2008-03-26
CA2434834A1 (en) 2002-08-22
PA8539201A1 (es) 2004-08-31
BR0207172A (pt) 2004-03-30
EP1361880B1 (en) 2005-09-28
JP2004525896A (ja) 2004-08-26
RU2269527C2 (ru) 2006-02-10
ATE305303T1 (de) 2005-10-15
HRP20030624A2 (en) 2005-06-30
RU2003125887A (ru) 2005-03-20
US7169794B2 (en) 2007-01-30
US7449581B2 (en) 2008-11-11
WO2002064594A2 (en) 2002-08-22
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
KR100639772B1 (ko) 2006-10-30
CA2434834C (en) 2010-09-14
AR035854A1 (es) 2004-07-21
HUP0303458A3 (en) 2012-12-28
CZ20032416A3 (cs) 2004-07-14
AU2002256615B2 (en) 2007-09-13
NO20033540D0 (no) 2003-08-11
NO20033540L (no) 2003-08-11
WO2002064594A3 (en) 2003-01-09
EP1361880A2 (en) 2003-11-19
US6696566B2 (en) 2004-02-24
IL156872A (en) 2009-07-20
DK1361880T3 (da) 2006-01-23
US20030171584A1 (en) 2003-09-11
BRPI0207172B1 (pt) 2019-04-09

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