JP2004525896A5 - - Google Patents
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- Publication number
- JP2004525896A5 JP2004525896A5 JP2002564525A JP2002564525A JP2004525896A5 JP 2004525896 A5 JP2004525896 A5 JP 2004525896A5 JP 2002564525 A JP2002564525 A JP 2002564525A JP 2002564525 A JP2002564525 A JP 2002564525A JP 2004525896 A5 JP2004525896 A5 JP 2004525896A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- cycloalkyl
- heteroalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 57
- 229910052739 hydrogen Inorganic materials 0.000 claims 41
- 239000001257 hydrogen Substances 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000000753 cycloalkyl group Chemical group 0.000 claims 25
- -1 monoalkylamino Chemical group 0.000 claims 25
- 150000002431 hydrogen Chemical class 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 23
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 21
- 125000004404 heteroalkyl group Chemical group 0.000 claims 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 17
- 125000003710 aryl alkyl group Chemical group 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 125000004663 dialkyl amino group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000002252 acyl group Chemical group 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000001404 mediated effect Effects 0.000 claims 6
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 6
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000001769 aryl amino group Chemical group 0.000 claims 3
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 claims 1
- CQBKXXDWVJIDMM-UHFFFAOYSA-N 6-(2,4-difluorophenoxy)-2-[(4-hydroxy-4-methylpentan-2-yl)amino]-8-methylpyrido[2,3-d]pyrimidin-7-one Chemical compound O=C1N(C)C2=NC(NC(CC(C)(C)O)C)=NC=C2C=C1OC1=CC=C(F)C=C1F CQBKXXDWVJIDMM-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052702 rhenium Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26837501P | 2001-02-12 | 2001-02-12 | |
| US33465401P | 2001-11-30 | 2001-11-30 | |
| PCT/EP2002/001106 WO2002064594A2 (en) | 2001-02-12 | 2002-02-04 | 6-substituted pyrido-pyrimidines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525896A JP2004525896A (ja) | 2004-08-26 |
| JP2004525896A5 true JP2004525896A5 (https=) | 2005-06-09 |
| JP4064818B2 JP4064818B2 (ja) | 2008-03-19 |
Family
ID=26953040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002564525A Expired - Lifetime JP4064818B2 (ja) | 2001-02-12 | 2002-02-04 | ６−置換ピリド−ピリミジン類 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US6696566B2 (https=) |
| EP (1) | EP1361880B1 (https=) |
| JP (1) | JP4064818B2 (https=) |
| KR (1) | KR100639772B1 (https=) |
| CN (1) | CN100376571C (https=) |
| AR (1) | AR035854A1 (https=) |
| AT (1) | ATE305303T1 (https=) |
| AU (1) | AU2002256615B2 (https=) |
| BR (1) | BRPI0207172B8 (https=) |
| CA (1) | CA2434834C (https=) |
| CZ (1) | CZ20032416A3 (https=) |
| DE (1) | DE60206363T2 (https=) |
| DK (1) | DK1361880T3 (https=) |
| ES (1) | ES2249574T3 (https=) |
| HR (1) | HRP20030624B1 (https=) |
| HU (1) | HU229604B1 (https=) |
| IL (2) | IL156872A0 (https=) |
| JO (1) | JO2410B1 (https=) |
| MA (1) | MA26993A1 (https=) |
| MX (1) | MXPA03007166A (https=) |
| MY (1) | MY131518A (https=) |
| NO (1) | NO326133B1 (https=) |
| NZ (1) | NZ526961A (https=) |
| PA (1) | PA8539201A1 (https=) |
| PE (1) | PE20020976A1 (https=) |
| PL (1) | PL366918A1 (https=) |
| RU (1) | RU2269527C2 (https=) |
| SK (1) | SK11322003A3 (https=) |
| WO (1) | WO2002064594A2 (https=) |
| YU (1) | YU63703A (https=) |
| ZA (1) | ZA200305938B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
| DE60206363T2 (de) | 2001-02-12 | 2006-07-06 | F. Hoffmann-La Roche Ag | 6-substituierte pyridopyrimidine |
| ES2251677T3 (es) * | 2002-01-22 | 2006-05-01 | Warner-Lambert Company Llc | 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-onas. |
| EP1492790A1 (en) | 2002-04-03 | 2005-01-05 | F. Hoffmann-La Roche Ag | Imidazo fused compounds |
| CA2492112A1 (en) * | 2002-08-06 | 2004-02-19 | F. Hoffmann-La Roche Ag | 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors |
| EP2181704B1 (en) | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| CA2517256C (en) * | 2003-02-26 | 2013-04-30 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
| AU2004229163A1 (en) * | 2003-04-16 | 2004-10-28 | F. Hoffmann-La Roche Ag | (6-(phenoxy)-pyrido`3,4-d! PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORYY CONDITIONS SUCH AS RHEUMATOIS ARTRITIS |
| WO2005047284A1 (en) * | 2003-11-13 | 2005-05-26 | F. Hoffmann-La Roche Ag | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones |
| EP1831215A1 (en) * | 2004-11-23 | 2007-09-12 | Ranbaxy Laboratories Limited | Pyrido[2,3-d]pyrimidines as anti-inflamatory agents |
| US20060142312A1 (en) * | 2004-12-23 | 2006-06-29 | Pfizer Inc | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones |
| EP1846403A1 (en) * | 2005-02-02 | 2007-10-24 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
| MX2007013595A (es) * | 2005-05-04 | 2008-01-24 | Renovis Inc | Compuestos heterociclicos fusionados y composiciones y usos de estos. |
| WO2007009911A1 (en) * | 2005-07-21 | 2007-01-25 | F. Hoffmann-La Roche Ag | PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS |
| ATE482958T1 (de) * | 2005-08-09 | 2010-10-15 | Irm Llc | Verbindungen und zusammensetzungen als proteinkinaseinhibitoren |
| WO2007022946A1 (de) | 2005-08-21 | 2007-03-01 | Abbott Gmbh & Co. Kg | Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| JO2783B1 (en) * | 2005-09-30 | 2014-03-15 | نوفارتيس ايه جي | Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones |
| CN101454319B (zh) * | 2006-05-26 | 2012-06-27 | 富山化学工业株式会社 | 新杂环化合物或其盐及其中间体 |
| WO2008150260A1 (en) * | 2007-06-06 | 2008-12-11 | Gpc Biotech, Inc. | 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents |
| WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
| US8022085B2 (en) | 2007-05-07 | 2011-09-20 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof |
| CA2690327A1 (en) | 2007-06-15 | 2008-12-18 | Thomas P. Cleary | A novel process for the preparation of 3-amino-pentan-1,5-diol |
| US8367671B2 (en) | 2008-03-21 | 2013-02-05 | Amgen Inc. | Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| JP2012505927A (ja) * | 2008-10-22 | 2012-03-08 | エフ．ホフマン−ラ ロシュ アーゲー | Ｊｎｋのピリミジニルピリドン阻害剤 |
| WO2010071846A2 (en) | 2008-12-19 | 2010-06-24 | Afraxis, Inc. | Compounds for treating neuropsychiatric conditions |
| JP2013507395A (ja) | 2009-10-09 | 2013-03-04 | アフラクシス・インコーポレイテッド | Ｃｎｓ障害治療用の８−エチル−６−（アリール）ピリド［２，３−ｄ］ピリミジン−７（８ｈ）−オン |
| US8889696B2 (en) * | 2009-12-18 | 2014-11-18 | Temple University—Of the Commonwealth System of Higher Education | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof |
| KR20170032244A (ko) | 2014-07-26 | 2017-03-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Cdk 저해제로서 2-아미노-피리도[2,3-d]피리미딘-7(8h)-온 유도체 및 그 용도 |
| ES2866883T3 (es) * | 2016-06-08 | 2021-10-20 | Support Venture Gmbh | Combinaciones farmacéuticas para el tratamiento del cáncer |
| CN109803968A (zh) | 2016-08-15 | 2019-05-24 | 辉瑞公司 | 吡啶并嘧啶酮cdk2/4/6抑制剂 |
| CA3033887A1 (en) * | 2016-08-17 | 2018-02-22 | Support-Venture Gmbh | Method of preventing or treating hearing loss |
| US11117858B2 (en) | 2017-01-11 | 2021-09-14 | The General Hospital Corporation | Voltage gated sodium channel imaging agents |
| CN110636840A (zh) | 2017-04-04 | 2019-12-31 | 斯特里金股份公司 | 预防或治疗眼科疾病的方法 |
| CN111032655B (zh) * | 2017-08-31 | 2022-09-02 | 达纳-法伯癌症研究所股份有限公司 | Egfr和/或her2抑制剂和使用方法 |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2020006210A1 (en) * | 2018-06-27 | 2020-01-02 | Tufts Medical Center, Inc. | Pyridopyrimidine compounds and methods of their use |
| SG11202012775SA (en) | 2018-07-13 | 2021-02-25 | Kinarus Ag | Combinations of ppar agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases |
| TW202112368A (zh) | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
| WO2022034031A1 (en) | 2020-08-11 | 2022-02-17 | Kinarus Ag | Methods of preventing or treating covid-19 and related viral diseases or disorders |
| CN120247910A (zh) * | 2025-04-01 | 2025-07-04 | 赣南师范大学 | 一种杂环类化合物及其制备方法、应用和防治肿瘤的药物组合物 |
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| US4215216A (en) | 1979-04-18 | 1980-07-29 | American Home Products Corporation | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives |
| US5037826A (en) | 1986-10-15 | 1991-08-06 | Schering Corporation | 1-substituted naphthyridine and pyridopyrazine derivatives |
| GB8702758D0 (en) * | 1987-02-06 | 1987-03-11 | Wellcome Found | Treatment of disease |
| AU598093B2 (en) | 1987-02-07 | 1990-06-14 | Wellcome Foundation Limited, The | Pyridopyrimidines, methods for their preparation and pharmaceutical formulations thereof |
| ATE194985T1 (de) * | 1990-11-06 | 2000-08-15 | Yamanouchi Pharma Co Ltd | Kondensiertes pyrazinderivat |
| WO1993017682A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| TW299333B (https=) * | 1992-12-29 | 1997-03-01 | Takeda Pharm Industry Co Ltd | |
| HUT76853A (en) * | 1994-11-14 | 1997-12-29 | Warner Lambert Co | 6-aryl pyrido[2,3-d]pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation and pharmaceutical compositions containing the same |
| IL115256A0 (en) * | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
| US5620981A (en) | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| ES2301194T3 (es) | 1997-02-05 | 2008-06-16 | Warner-Lambert Company Llc | Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular. |
| US5945422A (en) | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| AU7108398A (en) | 1997-04-16 | 1998-11-11 | Abbott Laboratories | 5,7-disubstituted 4-aminopyrido{2,3-d}pyrimidine compounds and their use as adenosine kinase inhibitors |
| TR199902550T2 (xx) | 1997-04-16 | 2000-04-21 | Abbott Laboratories | 5, 6, 7-Tris�bstit�e -4-aminopirido $2,3-D] pirimidin bile�ikleri. |
| TW458977B (en) * | 1997-04-16 | 2001-10-11 | Abbott Lab | 6,7-disubstituted-4-aminopyrido[2,3-D] pyrimidine compounds |
| AU763839B2 (en) | 1998-05-26 | 2003-07-31 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| BR9911365A (pt) | 1998-06-19 | 2001-03-13 | Pfizer Prod Inc | Compostos pirrolo[2,3-d]pirimidina |
| EP1078923B1 (en) | 1999-08-02 | 2006-03-08 | F. Hoffmann-La Roche Ag | Process for the preparation of benzothiophene derivatives |
| US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
| PL358271A1 (pl) * | 2000-03-06 | 2004-08-09 | Warner-Lambert Company | 5-alkilopirydo[2,3-D]pirymidyny jako inhibitory kinazy tyrozyny |
| US6518276B2 (en) * | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| DE60206363T2 (de) | 2001-02-12 | 2006-07-06 | F. Hoffmann-La Roche Ag | 6-substituierte pyridopyrimidine |
| ES2251677T3 (es) * | 2002-01-22 | 2006-05-01 | Warner-Lambert Company Llc | 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-onas. |
-
2002
- 2002-02-04 DE DE60206363T patent/DE60206363T2/de not_active Expired - Lifetime
- 2002-02-04 HR HR20030624A patent/HRP20030624B1/xx not_active IP Right Cessation
- 2002-02-04 ES ES02726103T patent/ES2249574T3/es not_active Expired - Lifetime
- 2002-02-04 EP EP02726103A patent/EP1361880B1/en not_active Expired - Lifetime
- 2002-02-04 MX MXPA03007166A patent/MXPA03007166A/es active IP Right Grant
- 2002-02-04 BR BRPI0207172-0 patent/BRPI0207172B8/pt not_active IP Right Cessation
- 2002-02-04 AU AU2002256615A patent/AU2002256615B2/en not_active Expired
- 2002-02-04 PL PL02366918A patent/PL366918A1/xx not_active Application Discontinuation
- 2002-02-04 JP JP2002564525A patent/JP4064818B2/ja not_active Expired - Lifetime
- 2002-02-04 YU YU63703A patent/YU63703A/sh unknown
- 2002-02-04 HU HU0303458A patent/HU229604B1/hu unknown
- 2002-02-04 WO PCT/EP2002/001106 patent/WO2002064594A2/en not_active Ceased
- 2002-02-04 CA CA2434834A patent/CA2434834C/en not_active Expired - Lifetime
- 2002-02-04 AT AT02726103T patent/ATE305303T1/de active
- 2002-02-04 CN CNB028048342A patent/CN100376571C/zh not_active Expired - Lifetime
- 2002-02-04 RU RU2003125887/04A patent/RU2269527C2/ru not_active IP Right Cessation
- 2002-02-04 SK SK11322003A patent/SK11322003A3/sk unknown
- 2002-02-04 KR KR1020037010562A patent/KR100639772B1/ko not_active Expired - Lifetime
- 2002-02-04 CZ CZ20032416A patent/CZ20032416A3/cs unknown
- 2002-02-04 IL IL15687202A patent/IL156872A0/xx unknown
- 2002-02-04 NZ NZ526961A patent/NZ526961A/en unknown
- 2002-02-04 DK DK02726103T patent/DK1361880T3/da active
- 2002-02-06 JO JO200212A patent/JO2410B1/en active
- 2002-02-08 PE PE2002000097A patent/PE20020976A1/es not_active Application Discontinuation
- 2002-02-08 PA PA20028539201A patent/PA8539201A1/es unknown
- 2002-02-11 AR ARP020100430A patent/AR035854A1/es unknown
- 2002-02-11 MY MYPI20020491A patent/MY131518A/en unknown
- 2002-02-11 US US10/073,845 patent/US6696566B2/en not_active Expired - Lifetime
-
2003
- 2003-07-10 IL IL156872A patent/IL156872A/en unknown
- 2003-07-31 ZA ZA2003/05938A patent/ZA200305938B/en unknown
- 2003-08-11 MA MA27273A patent/MA26993A1/fr unknown
- 2003-08-11 NO NO20033540A patent/NO326133B1/no not_active IP Right Cessation
- 2003-11-25 US US10/722,703 patent/US7169794B2/en not_active Expired - Lifetime
-
2007
- 2007-01-09 US US11/651,302 patent/US7449581B2/en not_active Expired - Lifetime
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