JP4064458B2 - 延長された血液保持を有する診断画像造影剤 - Google Patents

延長された血液保持を有する診断画像造影剤 Download PDF

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Publication number
JP4064458B2
JP4064458B2 JP52354396A JP52354396A JP4064458B2 JP 4064458 B2 JP4064458 B2 JP 4064458B2 JP 52354396 A JP52354396 A JP 52354396A JP 52354396 A JP52354396 A JP 52354396A JP 4064458 B2 JP4064458 B2 JP 4064458B2
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Japan
Prior art keywords
phenyl
contrast agent
pharmaceutically acceptable
imaging contrast
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP52354396A
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English (en)
Japanese (ja)
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JPH10513445A (ja
Inventor
トーマス ジェイ． マックマーリー，
弘直 佐治木
ダニエル エム． スコット，
ランドール ビー． ローファー，
Original Assignee
エピックス ファーマシューティカルズ，インコーポレイテッド
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Publication of JPH10513445A publication Critical patent/JPH10513445A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
JP52354396A 1995-02-01 1996-01-16 延長された血液保持を有する診断画像造影剤 Expired - Fee Related JP4064458B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38231795A 1995-02-01 1995-02-01
US08/382,317 1995-02-01
PCT/US1996/000164 WO1996023526A2 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2002369062A Division JP2004026793A (ja) 1995-02-01 2002-12-19 延長された血液保持を有する診断画像造影剤

Publications (2)

Publication Number Publication Date
JPH10513445A JPH10513445A (ja) 1998-12-22
JP4064458B2 true JP4064458B2 (ja) 2008-03-19

Family

ID=23508434

Family Applications (4)

Application Number Title Priority Date Filing Date
JP52354396A Expired - Fee Related JP4064458B2 (ja) 1995-02-01 1996-01-16 延長された血液保持を有する診断画像造影剤
JP2002369062A Withdrawn JP2004026793A (ja) 1995-02-01 2002-12-19 延長された血液保持を有する診断画像造影剤
JP2006225515A Withdrawn JP2006342181A (ja) 1995-02-01 2006-08-22 延長された血液保持を有する診断画像造影剤
JP2008095587A Expired - Fee Related JP4950110B2 (ja) 1995-02-01 2008-04-01 延長された血液保持を有する診断画像造影剤

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2002369062A Withdrawn JP2004026793A (ja) 1995-02-01 2002-12-19 延長された血液保持を有する診断画像造影剤
JP2006225515A Withdrawn JP2006342181A (ja) 1995-02-01 2006-08-22 延長された血液保持を有する診断画像造影剤
JP2008095587A Expired - Fee Related JP4950110B2 (ja) 1995-02-01 2008-04-01 延長された血液保持を有する診断画像造影剤

Country Status (25)

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