AR075900A1 - Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores. - Google Patents

Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores.

Info

Publication number
AR075900A1
AR075900A1 ARP100100895A ARP100100895A AR075900A1 AR 075900 A1 AR075900 A1 AR 075900A1 AR P100100895 A ARP100100895 A AR P100100895A AR P100100895 A ARP100100895 A AR P100100895A AR 075900 A1 AR075900 A1 AR 075900A1
Authority
AR
Argentina
Prior art keywords
dioxo
phosphonic
acid
diazabicyclo
ethyl
Prior art date
Application number
ARP100100895A
Other languages
English (en)
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of AR075900A1 publication Critical patent/AR075900A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Reivindicacion 1: Un proceso para la preparacion de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico, que comprende: hacer reaccionar 1,3-diaminopropano con dialquilvinilfosfonato para formar éster dialquílico del ácido N-(3-aminopropil)aminoetanfosfonico; hacer reaccionar el éster dialquílico del ácido N-(3-aminopropil)aminoetanfosfonico con 3,4-dialcoxi-3-ciclobuten-1,2-diona para formar éster dialquílico del ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico; e hidrolizar el éster dialquílico del ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico para formar el ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico; con la condicion de que (a) el paso de reaccion de 1,3-diaminopropano con dialquilvinilfosfonato se lleve a cabo sustancialmente en ausencia de solvente exogeno; y/o (b) el paso de reaccion del éster dialquílico del ácido N-(3-aminopropil)aminoetanfosfonico con 3,4-dialcoxi-3-ciclobuten-1,2-diona se lleve a cabo en un solvente aprotico.
ARP100100895A 2009-03-19 2010-03-19 Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores. AR075900A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16151309P 2009-03-19 2009-03-19

Publications (1)

Publication Number Publication Date
AR075900A1 true AR075900A1 (es) 2011-05-04

Family

ID=42227623

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100895A AR075900A1 (es) 2009-03-19 2010-03-19 Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores.

Country Status (12)

Country Link
US (2) US20120116074A1 (es)
EP (1) EP2408790A1 (es)
JP (1) JP2012521352A (es)
KR (1) KR20110139274A (es)
CN (1) CN102356087A (es)
AR (1) AR075900A1 (es)
AU (1) AU2010226479A1 (es)
BR (1) BRPI1009900A2 (es)
CA (1) CA2754390A1 (es)
MX (1) MX2011009716A (es)
WO (1) WO2010108063A1 (es)
ZA (1) ZA201107412B (es)

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Also Published As

Publication number Publication date
JP2012521352A (ja) 2012-09-13
EP2408790A1 (en) 2012-01-25
MX2011009716A (es) 2011-10-17
CA2754390A1 (en) 2010-09-23
AU2010226479A1 (en) 2011-09-22
US20120077958A1 (en) 2012-03-29
ZA201107412B (en) 2012-07-25
KR20110139274A (ko) 2011-12-28
BRPI1009900A2 (pt) 2016-03-15
CN102356087A (zh) 2012-02-15
WO2010108063A1 (en) 2010-09-23
US9200017B2 (en) 2015-12-01
US20120116074A1 (en) 2012-05-10

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