AR075900A1 - Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores. - Google Patents
Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores.Info
- Publication number
- AR075900A1 AR075900A1 ARP100100895A ARP100100895A AR075900A1 AR 075900 A1 AR075900 A1 AR 075900A1 AR P100100895 A ARP100100895 A AR P100100895A AR P100100895 A ARP100100895 A AR P100100895A AR 075900 A1 AR075900 A1 AR 075900A1
- Authority
- AR
- Argentina
- Prior art keywords
- dioxo
- phosphonic
- acid
- diazabicyclo
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
Abstract
Reivindicacion 1: Un proceso para la preparacion de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico, que comprende: hacer reaccionar 1,3-diaminopropano con dialquilvinilfosfonato para formar éster dialquílico del ácido N-(3-aminopropil)aminoetanfosfonico; hacer reaccionar el éster dialquílico del ácido N-(3-aminopropil)aminoetanfosfonico con 3,4-dialcoxi-3-ciclobuten-1,2-diona para formar éster dialquílico del ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico; e hidrolizar el éster dialquílico del ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico para formar el ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfonico; con la condicion de que (a) el paso de reaccion de 1,3-diaminopropano con dialquilvinilfosfonato se lleve a cabo sustancialmente en ausencia de solvente exogeno; y/o (b) el paso de reaccion del éster dialquílico del ácido N-(3-aminopropil)aminoetanfosfonico con 3,4-dialcoxi-3-ciclobuten-1,2-diona se lleve a cabo en un solvente aprotico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16151309P | 2009-03-19 | 2009-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR075900A1 true AR075900A1 (es) | 2011-05-04 |
Family
ID=42227623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100895A AR075900A1 (es) | 2009-03-19 | 2010-03-19 | Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20120116074A1 (es) |
EP (1) | EP2408790A1 (es) |
JP (1) | JP2012521352A (es) |
KR (1) | KR20110139274A (es) |
CN (1) | CN102356087A (es) |
AR (1) | AR075900A1 (es) |
AU (1) | AU2010226479A1 (es) |
BR (1) | BRPI1009900A2 (es) |
CA (1) | CA2754390A1 (es) |
MX (1) | MX2011009716A (es) |
WO (1) | WO2010108063A1 (es) |
ZA (1) | ZA201107412B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2247962B1 (en) * | 2008-02-25 | 2014-04-09 | Koninklijke Philips N.V. | Iso-plane backbone for radiation detectors |
WO2010121133A2 (en) * | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
KR101474063B1 (ko) * | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ct 조영제 |
WO2015085005A1 (en) * | 2013-12-03 | 2015-06-11 | The General Hospital Corporation | Molecular imaging probes |
US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
KR102612882B1 (ko) | 2017-05-05 | 2023-12-11 | 센터 포 프로브 디벨롭먼트 앤드 커머셜리제이션 | 이관능성 킬레이트 및 그의 용도의 약동학적 증진 |
CN110891614A (zh) | 2017-05-05 | 2020-03-17 | 融合制药公司 | Igf-1r单克隆抗体及其用途 |
US20220296196A1 (en) * | 2019-12-09 | 2022-09-22 | Sino Canada Health Institute Inc. | Method for Monitoring PET Readout Positions Using MRI Fiducials |
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US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
JPH05503072A (ja) | 1989-08-28 | 1993-05-27 | ザ・ゼネラル・ホスピタル・コーポレーション | 診断用nmr映像化の為のヒドロキシ―アリール金属キレート |
US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
US5168103A (en) | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
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CA2185653C (en) | 1994-03-16 | 2009-01-13 | Kathleen M. Miller | Stabilization of peptides and proteins for radiopharmaceutical use |
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BR9811807A (pt) * | 1997-08-01 | 2000-08-15 | American Home Prod | Processo para a preparação de ácido [2-(8,9)-dioxo-2,6-diazabiciclo-[5.2.0]-non-1(7)-en-2-il)-etil] fosfÈnico |
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-
2010
- 2010-03-19 KR KR1020117024351A patent/KR20110139274A/ko not_active Application Discontinuation
- 2010-03-19 WO PCT/US2010/027908 patent/WO2010108063A1/en active Application Filing
- 2010-03-19 BR BRPI1009900A patent/BRPI1009900A2/pt not_active Application Discontinuation
- 2010-03-19 MX MX2011009716A patent/MX2011009716A/es not_active Application Discontinuation
- 2010-03-19 CN CN2010800119434A patent/CN102356087A/zh active Pending
- 2010-03-19 AU AU2010226479A patent/AU2010226479A1/en not_active Abandoned
- 2010-03-19 US US13/256,777 patent/US20120116074A1/en not_active Abandoned
- 2010-03-19 JP JP2012500984A patent/JP2012521352A/ja not_active Withdrawn
- 2010-03-19 AR ARP100100895A patent/AR075900A1/es not_active Application Discontinuation
- 2010-03-19 EP EP10710739A patent/EP2408790A1/en not_active Withdrawn
- 2010-03-19 CA CA2754390A patent/CA2754390A1/en not_active Abandoned
- 2010-04-16 US US13/256,795 patent/US9200017B2/en active Active
-
2011
- 2011-10-10 ZA ZA2011/07412A patent/ZA201107412B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20110139274A (ko) | 2011-12-28 |
AU2010226479A1 (en) | 2011-09-22 |
EP2408790A1 (en) | 2012-01-25 |
JP2012521352A (ja) | 2012-09-13 |
WO2010108063A1 (en) | 2010-09-23 |
BRPI1009900A2 (pt) | 2016-03-15 |
MX2011009716A (es) | 2011-10-17 |
US9200017B2 (en) | 2015-12-01 |
US20120077958A1 (en) | 2012-03-29 |
CA2754390A1 (en) | 2010-09-23 |
ZA201107412B (en) | 2012-07-25 |
US20120116074A1 (en) | 2012-05-10 |
CN102356087A (zh) | 2012-02-15 |
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Legal Events
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FA | Abandonment or withdrawal |