ES2571437T3 - Proceso en un solo reactor para preparar pemetrexed disódico - Google Patents

Proceso en un solo reactor para preparar pemetrexed disódico

Info

Publication number
ES2571437T3
ES2571437T3 ES12826654T ES12826654T ES2571437T3 ES 2571437 T3 ES2571437 T3 ES 2571437T3 ES 12826654 T ES12826654 T ES 12826654T ES 12826654 T ES12826654 T ES 12826654T ES 2571437 T3 ES2571437 T3 ES 2571437T3
Authority
ES
Spain
Prior art keywords
salts
pemetrexed
single reactor
pemetrexed disodium
reactor process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12826654T
Other languages
English (en)
Inventor
Tuncer Aslan
Ender Kosak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOCAK FARMA ILAC VE KIMYA SAN AS
Original Assignee
KOCAK FARMA ILAC VE KIMYA SAN AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOCAK FARMA ILAC VE KIMYA SAN AS filed Critical KOCAK FARMA ILAC VE KIMYA SAN AS
Application granted granted Critical
Publication of ES2571437T3 publication Critical patent/ES2571437T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso eficiente para preparar pemetrexed o sus sales metálicas a partir de ésteres dialquílicos de pemetrexed o sales de los mismos, el cual comprende: a- disolver o suspender un éster dialquílico de pemetrexed o sales del mismo en agua o en una mezcla de agua/alcohol; b- desalinizar e hidrolizar los grupos éster usando hidróxido de metal; c- adicionar sales metálicas hidrosolubles después de ajustar el pH; y d- aislar las sales de pemetrexed de la mezcla mediante filtración.
ES12826654T 2011-12-29 2012-12-14 Proceso en un solo reactor para preparar pemetrexed disódico Active ES2571437T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2011/13223A TR201113223A2 (tr) 2011-12-29 2011-12-29 Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem.
PCT/TR2012/000213 WO2013100872A1 (en) 2011-12-29 2012-12-14 One pot process for preparing pemetrexed disodium

Publications (1)

Publication Number Publication Date
ES2571437T3 true ES2571437T3 (es) 2016-05-25

Family

ID=47003823

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12826654T Active ES2571437T3 (es) 2011-12-29 2012-12-14 Proceso en un solo reactor para preparar pemetrexed disódico

Country Status (7)

Country Link
US (1) US8952153B2 (es)
EP (1) EP2797920B1 (es)
JP (1) JP5883514B2 (es)
ES (1) ES2571437T3 (es)
RU (1) RU2577251C2 (es)
TR (1) TR201113223A2 (es)
WO (1) WO2013100872A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115608309B (zh) * 2022-10-17 2023-10-20 连云港贵科药业有限公司 一种高纯度培美曲塞二钠的生产方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136101A (en) 1978-02-03 1979-01-23 American Cyanamid Company Process for preparing dialkyl (p-aminobenzoyl) glutamates
EP2322526A1 (en) * 2006-08-14 2011-05-18 Sicor, Inc. Crystalline form of pemetrexed diacid and process for the preparation thereof
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
CA2762190A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase
TW201118098A (en) 2009-08-13 2011-06-01 Reddy S Lab Liimited Dr Processes for preparing pemetrexed

Also Published As

Publication number Publication date
US20140309420A1 (en) 2014-10-16
EP2797920A1 (en) 2014-11-05
TR201113223A2 (tr) 2012-06-21
EP2797920B1 (en) 2016-02-24
JP5883514B2 (ja) 2016-03-15
WO2013100872A1 (en) 2013-07-04
RU2014111291A (ru) 2015-09-27
RU2577251C2 (ru) 2016-03-10
JP2015503557A (ja) 2015-02-02
US8952153B2 (en) 2015-02-10

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ES2571437T3 (es) Proceso en un solo reactor para preparar pemetrexed disódico