JP3889708B2 - Ｃ型肝炎トリペプチド阻害剤 - Google Patents

Ｃ型肝炎トリペプチド阻害剤 Download PDF

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Publication number
JP3889708B2
JP3889708B2 JP2002561494A JP2002561494A JP3889708B2 JP 3889708 B2 JP3889708 B2 JP 3889708B2 JP 2002561494 A JP2002561494 A JP 2002561494A JP 2002561494 A JP2002561494 A JP 2002561494A JP 3889708 B2 JP3889708 B2 JP 3889708B2
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JP
Japan
Prior art keywords
compound
mmol
alkyl
phenyl
nmr
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Expired - Fee Related
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JP2002561494A
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Japanese (ja)
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JP2004538251A (ja
JP2004538251A5 (https=
Inventor
ジェフリー・アレン・キャンベル
アンドリュー・グッド
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treating Waste Gases (AREA)
JP2002561494A 2000-11-20 2001-11-20 Ｃ型肝炎トリペプチド阻害剤 Expired - Fee Related JP3889708B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24996800P 2000-11-20 2000-11-20
PCT/US2001/045145 WO2002060926A2 (en) 2000-11-20 2001-11-20 Hepatitis c tripeptide inhibitors

Publications (3)

Publication Number Publication Date
JP2004538251A JP2004538251A (ja) 2004-12-24
JP2004538251A5 JP2004538251A5 (https=) 2005-06-30
JP3889708B2 true JP3889708B2 (ja) 2007-03-07

Family

ID=22945765

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002561494A Expired - Fee Related JP3889708B2 (ja) 2000-11-20 2001-11-20 Ｃ型肝炎トリペプチド阻害剤

Country Status (14)

Country Link
US (1) US6872805B2 (https=)
EP (1) EP1337550B1 (https=)
JP (1) JP3889708B2 (https=)
CN (1) CN100391967C (https=)
AT (1) ATE327246T1 (https=)
AU (1) AU2002248147B2 (https=)
BR (1) BR0115447A (https=)
CA (1) CA2429359A1 (https=)
DE (1) DE60119968T2 (https=)
ES (1) ES2263687T3 (https=)
HU (1) HUP0500456A3 (https=)
MX (1) MXPA03004299A (https=)
PE (1) PE20020707A1 (https=)
WO (1) WO2002060926A2 (https=)

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* Cited by examiner, † Cited by third party
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