JP3174405B2 - ８−ビニル−および８−エチニル−キノロン−カルボン酸類 - Google Patents

８−ビニル−および８−エチニル−キノロン−カルボン酸類

Info

Publication number
JP3174405B2
JP3174405B2 JP21245092A JP21245092A JP3174405B2 JP 3174405 B2 JP3174405 B2 JP 3174405B2 JP 21245092 A JP21245092 A JP 21245092A JP 21245092 A JP21245092 A JP 21245092A JP 3174405 B2 JP3174405 B2 JP 3174405B2
Authority
JP
Japan
Prior art keywords
methyl
hydrogen
oxo
dihydro
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP21245092A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05262738A (ja
Inventor
ウベ・ペーターゼン
トーマス・ヒムラー
トーマス・シエンケ
アンドレアス・クレプス
クラウス・グローエ
クラウス−デイーター・ブレム
カール・ゲオルク・メツツガー
ライナー・エンデルマン
ハンス−ヨアヒム・ツアイラー
Original Assignee
バイエル・アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイエル・アクチエンゲゼルシヤフト filed Critical バイエル・アクチエンゲゼルシヤフト
Publication of JPH05262738A publication Critical patent/JPH05262738A/ja
Application granted granted Critical
Publication of JP3174405B2 publication Critical patent/JP3174405B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)
  • Pyridine Compounds (AREA)
JP21245092A 1991-07-19 1992-07-17 ８−ビニル−および８−エチニル−キノロン−カルボン酸類 Expired - Fee Related JP3174405B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4123918.0 1991-07-19
DE4123918A DE4123918A1 (de) 1991-07-19 1991-07-19 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren

Publications (2)

Publication Number Publication Date
JPH05262738A JPH05262738A (ja) 1993-10-12
JP3174405B2 true JP3174405B2 (ja) 2001-06-11

Family

ID=6436512

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21245092A Expired - Fee Related JP3174405B2 (ja) 1991-07-19 1992-07-17 ８−ビニル−および８−エチニル−キノロン−カルボン酸類

Country Status (22)

Country Link
EP (1) EP0523512B1 (enExample)
JP (1) JP3174405B2 (enExample)
KR (1) KR100240608B1 (enExample)
AT (1) ATE147733T1 (enExample)
AU (1) AU658901B2 (enExample)
CA (1) CA2073993A1 (enExample)
CZ (1) CZ282037B6 (enExample)
DE (2) DE4123918A1 (enExample)
DK (1) DK0523512T3 (enExample)
ES (1) ES2097835T3 (enExample)
FI (1) FI103043B (enExample)
GR (1) GR3022305T3 (enExample)
HU (1) HU219910B (enExample)
IE (1) IE80557B1 (enExample)
IL (1) IL102520A (enExample)
MX (1) MX9204110A (enExample)
NO (1) NO302886B1 (enExample)
PL (1) PL171910B1 (enExample)
RU (1) RU2077533C1 (enExample)
SK (1) SK279221B6 (enExample)
TW (1) TW201309B (enExample)
ZA (1) ZA925351B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4230804A1 (de) * 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4418510A1 (de) * 1994-05-27 1995-11-30 Bayer Ag 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate
DE4425659A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
PL186737B1 (pl) * 1996-02-23 2004-02-27 Bayer Ag Kwasy 8-cyjano-1-cyklopropylo-7-/2, 8-diazabicyklo [ 4.3.0 ] nonan-8-ylo/-6-fluoro-1,4-dihydro-4-okso-3-chinolinokarboksylowe i ich pochodne, sposób ich wytwarzania, środki medyczne je zawierające i ich zastosowanie do wytwarzania środków medycznychi antybakteryjnych
PT897919E (pt) * 1996-04-19 2004-11-30 Wakunaga Pharma Co Ltd Novos derivados do acido piridonacarboxilico ou seus sais e agentes anti-bacterianos contendo-os como ingrediente activo
WO1998024781A1 (en) * 1996-12-04 1998-06-11 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
CN1264837C (zh) 1997-09-15 2006-07-19 普罗克特和甘保尔公司 喹诺酮抗微生物剂、其组合物和应用
PL1666477T3 (pl) 2003-09-10 2013-11-29 Kyorin Seiyaku Kk Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
WO2007037303A1 (ja) * 2005-09-28 2007-04-05 Daiichi Sankyo Company, Limited テトラ置換－５－アザスピロ[２．４]へプタン誘導体の製法およびその光学活性中間体
ES2366150T3 (es) 2006-03-28 2011-10-17 Warner Chilcott Company, Llc Malatos de polimorfos de ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinocarboxílico.
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
JP5322927B2 (ja) 2007-05-24 2013-10-23 杏林製薬株式会社 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
CN112074514B (zh) 2018-05-09 2024-10-29 礼蓝动物保健有限公司 新的喹啉衍生物
RU2757741C1 (ru) * 2021-03-01 2021-10-21 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Производное ципрофлоксацина, обладающее антибактериальной активностью в отношении антибиотикоустойчивых штаммов микроорганизмов

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123536A (en) * 1977-12-14 1978-10-31 Warner-Lambert Company Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US5047538A (en) * 1990-04-12 1991-09-10 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents

Also Published As

Publication number Publication date
NO922639D0 (no) 1992-07-03
KR100240608B1 (ko) 2000-03-02
SK219192A3 (en) 1998-08-05
FI103043B1 (fi) 1999-04-15
MX9204110A (es) 1993-08-01
DE4123918A1 (de) 1993-01-21
PL171910B1 (pl) 1997-06-30
CZ219192A3 (en) 1993-02-17
SK279221B6 (sk) 1998-08-05
KR930002320A (ko) 1993-02-22
AU658901B2 (en) 1995-05-04
DK0523512T3 (da) 1997-06-30
AU1966392A (en) 1993-01-21
EP0523512A1 (de) 1993-01-20
HUT61741A (en) 1993-03-01
NO302886B1 (no) 1998-05-04
CZ282037B6 (cs) 1997-04-16
ZA925351B (en) 1993-04-28
FI923268L (fi) 1993-01-20
FI103043B (fi) 1999-04-15
IE80557B1 (en) 1998-09-23
IL102520A (en) 1997-07-13
IE922348A1 (en) 1993-01-27
IL102520A0 (en) 1993-01-14
EP0523512B1 (de) 1997-01-15
RU2077533C1 (ru) 1997-04-20
ES2097835T3 (es) 1997-04-16
JPH05262738A (ja) 1993-10-12
CA2073993A1 (en) 1993-01-20
HU9202349D0 (en) 1992-10-28
HU219910B (hu) 2001-09-28
DE59207880D1 (de) 1997-02-27
PL295331A1 (en) 1993-07-12
GR3022305T3 (en) 1997-04-30
ATE147733T1 (de) 1997-02-15
NO922639L (no) 1993-01-20
FI923268A0 (fi) 1992-07-16
TW201309B (enExample) 1993-03-01

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Legal Events

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LAPS Cancellation because of no payment of annual fees