DK0523512T3 - 8-Vinyl- og 8-ethynyl-quinoloncarboxylsyrer - Google Patents

8-Vinyl- og 8-ethynyl-quinoloncarboxylsyrer

Info

Publication number
DK0523512T3
DK0523512T3 DK92111454.2T DK92111454T DK0523512T3 DK 0523512 T3 DK0523512 T3 DK 0523512T3 DK 92111454 T DK92111454 T DK 92111454T DK 0523512 T3 DK0523512 T3 DK 0523512T3
Authority
DK
Denmark
Prior art keywords
ethynyl
vinyl
carboxylic acids
quinolone carboxylic
quinolone
Prior art date
Application number
DK92111454.2T
Other languages
Danish (da)
English (en)
Inventor
Klaus Dr Grohe
Andreas Dr Krebs
Hans-Joachim Dr Zeiler
Thomas Dr Himmler
Thomas Dr Schenke
Uwe Dr Petersen
Klaus Klaus-Dieter Dr Bremm
Karl Georg Dr Metzger
Rainer Dr Endermann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0523512T3 publication Critical patent/DK0523512T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)
  • Pyridine Compounds (AREA)
DK92111454.2T 1991-07-19 1992-07-06 8-Vinyl- og 8-ethynyl-quinoloncarboxylsyrer DK0523512T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4123918A DE4123918A1 (de) 1991-07-19 1991-07-19 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren

Publications (1)

Publication Number Publication Date
DK0523512T3 true DK0523512T3 (da) 1997-06-30

Family

ID=6436512

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92111454.2T DK0523512T3 (da) 1991-07-19 1992-07-06 8-Vinyl- og 8-ethynyl-quinoloncarboxylsyrer

Country Status (22)

Country Link
EP (1) EP0523512B1 (enExample)
JP (1) JP3174405B2 (enExample)
KR (1) KR100240608B1 (enExample)
AT (1) ATE147733T1 (enExample)
AU (1) AU658901B2 (enExample)
CA (1) CA2073993A1 (enExample)
CZ (1) CZ282037B6 (enExample)
DE (2) DE4123918A1 (enExample)
DK (1) DK0523512T3 (enExample)
ES (1) ES2097835T3 (enExample)
FI (1) FI103043B (enExample)
GR (1) GR3022305T3 (enExample)
HU (1) HU219910B (enExample)
IE (1) IE80557B1 (enExample)
IL (1) IL102520A (enExample)
MX (1) MX9204110A (enExample)
NO (1) NO302886B1 (enExample)
PL (1) PL171910B1 (enExample)
RU (1) RU2077533C1 (enExample)
SK (1) SK279221B6 (enExample)
TW (1) TW201309B (enExample)
ZA (1) ZA925351B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4230804A1 (de) * 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4418510A1 (de) * 1994-05-27 1995-11-30 Bayer Ag 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate
DE4425659A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
TR199801493T2 (xx) * 1996-02-23 1998-10-21 Bayer Aktiengesellschaft �ste�e g�re ikame edilen 8-siyano-1-siklopropil-7-(2,8-diazabisiklo(4.3.0) nonan-8il)-6-fl�oro-1,4-dihidro-4-okso-3-kinolinkarboksilik asitler ve bunlar�n t�revleri.
JP3484703B2 (ja) 1996-04-19 2004-01-06 湧永製薬株式会社 新規ピリドンカルボン酸誘導体又はその塩並びに該物質を有効成分とする抵抗剤
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
SK286420B6 (sk) 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
WO2005026147A1 (ja) 2003-09-10 2005-03-24 Kyorin Pharmaceutical Co., Ltd. 7−(4−置換−3−シクロプロピルアミノメチル−1−ピロリジニル)キノロンカルボン酸誘導体
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
JP5073497B2 (ja) * 2005-09-28 2012-11-14 第一三共株式会社 テトラ置換−5−アザスピロ[2.4]へプタン誘導体の製法およびその光学活性中間体
PT2001862E (pt) 2006-03-28 2011-07-20 Warner Chilcott Co Llc Sais de malato e polimorfos do ácido (3s,5s)-7-[3- amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro- 8-metoxi-4-oxo-3-quinolinocarboxílico
EP1999125A2 (en) 2006-03-28 2008-12-10 The Procter and Gamble Company A coupling process for preparing quinolone intermediates
US8222407B2 (en) 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
PT3790874T (pt) * 2018-05-09 2023-05-31 Bayer Animal Health Gmbh Derivados de quinolina antelmínticos
RU2757741C1 (ru) * 2021-03-01 2021-10-21 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Производное ципрофлоксацина, обладающее антибактериальной активностью в отношении антибиотикоустойчивых штаммов микроорганизмов

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123536A (en) * 1977-12-14 1978-10-31 Warner-Lambert Company Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US5047538A (en) * 1990-04-12 1991-09-10 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents

Also Published As

Publication number Publication date
HU219910B (hu) 2001-09-28
MX9204110A (es) 1993-08-01
PL295331A1 (en) 1993-07-12
NO922639D0 (no) 1992-07-03
DE59207880D1 (de) 1997-02-27
AU1966392A (en) 1993-01-21
TW201309B (enExample) 1993-03-01
NO302886B1 (no) 1998-05-04
FI103043B1 (fi) 1999-04-15
ATE147733T1 (de) 1997-02-15
HU9202349D0 (en) 1992-10-28
AU658901B2 (en) 1995-05-04
HUT61741A (en) 1993-03-01
NO922639L (no) 1993-01-20
ZA925351B (en) 1993-04-28
DE4123918A1 (de) 1993-01-21
ES2097835T3 (es) 1997-04-16
JPH05262738A (ja) 1993-10-12
CZ282037B6 (cs) 1997-04-16
FI923268L (fi) 1993-01-20
IL102520A (en) 1997-07-13
PL171910B1 (pl) 1997-06-30
FI923268A0 (fi) 1992-07-16
GR3022305T3 (en) 1997-04-30
CA2073993A1 (en) 1993-01-20
FI103043B (fi) 1999-04-15
IE80557B1 (en) 1998-09-23
IL102520A0 (en) 1993-01-14
KR100240608B1 (ko) 2000-03-02
IE922348A1 (en) 1993-01-27
JP3174405B2 (ja) 2001-06-11
SK219192A3 (en) 1998-08-05
EP0523512A1 (de) 1993-01-20
SK279221B6 (sk) 1998-08-05
CZ219192A3 (en) 1993-02-17
RU2077533C1 (ru) 1997-04-20
EP0523512B1 (de) 1997-01-15
KR930002320A (ko) 1993-02-22

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