JP3133062B2 - 変体ｃｄ４４―表面蛋白質、これを暗号化するｄｎａ―配列、この蛋白質に対する抗体並びに診断及び治療におけるその使用 - Google Patents

変体ｃｄ４４―表面蛋白質、これを暗号化するｄｎａ―配列、この蛋白質に対する抗体並びに診断及び治療におけるその使用

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Publication number
JP3133062B2
JP3133062B2 JP03506825A JP50682591A JP3133062B2 JP 3133062 B2 JP3133062 B2 JP 3133062B2 JP 03506825 A JP03506825 A JP 03506825A JP 50682591 A JP50682591 A JP 50682591A JP 3133062 B2 JP3133062 B2 JP 3133062B2
Authority
JP
Japan
Prior art keywords
protein
cells
dna
sequence
rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP03506825A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05508309A (ja
Inventor
ヘルリッヒ，ペーター
ポンタ，ヘルムート
ギュンテルト，ウルズラ
マツク，ジークフリート
ヴェンツェル，アヒム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Publication of JPH05508309A publication Critical patent/JPH05508309A/ja
Application granted granted Critical
Publication of JP3133062B2 publication Critical patent/JP3133062B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP03506825A 1990-05-07 1991-03-30 変体ｃｄ４４―表面蛋白質、これを暗号化するｄｎａ―配列、この蛋白質に対する抗体並びに診断及び治療におけるその使用 Expired - Fee Related JP3133062B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4014510.7 1990-05-07
DE4014510A DE4014510A1 (de) 1990-05-07 1990-05-07 Variante cd44-oberflaechenproteine, diese kodierende c-dna-sequenzen, antikoerper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie

Publications (2)

Publication Number Publication Date
JPH05508309A JPH05508309A (ja) 1993-11-25
JP3133062B2 true JP3133062B2 (ja) 2001-02-05

Family

ID=6405813

Family Applications (1)

Application Number Title Priority Date Filing Date
JP03506825A Expired - Fee Related JP3133062B2 (ja) 1990-05-07 1991-03-30 変体ｃｄ４４―表面蛋白質、これを暗号化するｄｎａ―配列、この蛋白質に対する抗体並びに診断及び治療におけるその使用

Country Status (21)

Country Link
US (3) US5506119A (2)
EP (1) EP0531300B1 (2)
JP (1) JP3133062B2 (2)
KR (1) KR0184691B1 (2)
AT (1) ATE106943T1 (2)
AU (1) AU646858B2 (2)
BR (1) BR1100650A (2)
CA (1) CA2082382C (2)
DE (2) DE4014510A1 (2)
DK (1) DK0531300T3 (2)
FI (1) FI106128B (2)
HU (1) HU218905B (2)
IE (1) IE62096B1 (2)
IL (3) IL98024A (2)
NO (3) NO309770B1 (2)
NZ (1) NZ238056A (2)
PT (1) PT97574B (2)
TW (1) TW212202B (2)
WO (1) WO1991017248A1 (2)
YU (1) YU49126B (2)
ZA (1) ZA913389B (2)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002873A (en) * 1989-03-17 1991-03-26 Fred Hutchinson Cancer Research Center DNA sequence encoding a lymphocyte adhesion receptor for high endothelium
US5443750A (en) * 1991-01-16 1995-08-22 The Procter & Gamble Company Detergent compositions with high activity cellulase and softening clays
DE4134982A1 (de) * 1991-10-23 1993-04-29 Kernforschungsz Karlsruhe Verwendung von antikoerper enthaltenden praeparationen zur immunsuppression
EP0651822B1 (en) * 1992-07-21 1996-04-17 Isis Innovation Limited Diagnostic method
EP0703989B1 (en) * 1993-06-18 1997-11-05 Oy Biotie Therapies COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44v6
DE4320624A1 (de) * 1993-06-22 1995-02-09 Boehringer Ingelheim Int Verfahren zur Diagnose und Analyse von Mammakarzinomen
EP0767378A1 (de) * 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Diagnose und Analyse von Magenkarzinomen
DE4320623C2 (de) * 1993-06-22 1997-11-20 Boehringer Ingelheim Int Verfahren zur Diagnose und Analyse von Adenokarzinomen
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
DE4431297A1 (de) * 1994-09-02 1996-03-07 Boehringer Ingelheim Int Monoklonaler Antikörper gegen CD44v6
DE19540515C1 (de) * 1995-10-31 1997-02-06 Boehringer Ingelheim Int Tumortherapie durch adoptiven Transfer CD44v-spezifischer zytotoxischer T-Lymphozyten
DE19653607A1 (de) 1996-12-20 1998-06-25 Boehringer Ingelheim Int Verfahren zur Diagnose und Therapie von Hodgkin-Lymphomen
DE19708713C2 (de) * 1997-03-04 2002-11-28 Boehringer Ingelheim Int Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen
US8071072B2 (en) 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8048416B2 (en) 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20080124327A1 (en) * 1999-10-08 2008-05-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
DE10026833A1 (de) * 2000-05-30 2001-12-13 Karlsruhe Forschzent Verfahren zur Identifizierung von Verbindungen zur Modulierung der Aktivität eines Tumorsuppressorgens
US20040110933A1 (en) * 2002-09-13 2004-06-10 Dyax Corporation CD44-binding ligands
DK2886126T3 (en) 2013-12-23 2017-09-18 Exchange Imaging Tech Gmbh Nanoparticle conjugated to CD44-binding peptides
CN109608537B (zh) * 2018-12-12 2020-09-15 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p2及其应用
CN109608536B (zh) * 2018-12-12 2020-09-15 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p3及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
US5108904A (en) * 1990-03-26 1992-04-28 Alan Landay CD44 as a marker for HIV infection

Also Published As

Publication number Publication date
NO924234L (no) 1993-01-04
HU218905B (hu) 2000-12-28
DK0531300T3 (da) 1994-10-10
IE911526A1 (en) 1991-11-20
IL134982A (en) 2004-05-12
FI106128B (fi) 2000-11-30
EP0531300B1 (de) 1994-06-08
PT97574A (pt) 1992-01-31
DE4014510A1 (de) 1991-11-14
NO980293L (no) 1993-01-04
CA2082382C (en) 2008-09-30
NO20001668D0 (no) 2000-03-31
NO980293D0 (no) 1998-01-23
DE59101889D1 (de) 1994-07-14
IL134982A0 (en) 2001-05-20
IL98024A (en) 2001-06-14
NO20001668L (no) 1993-05-06
BR1100650A (pt) 2000-08-08
US5885575A (en) 1999-03-23
NO310661B1 (no) 2001-08-06
NO317154B1 (no) 2004-08-30
YU49126B (sh) 2004-03-12
FI925043A0 (fi) 1992-11-06
ATE106943T1 (de) 1994-06-15
NZ238056A (en) 1993-01-27
NO309770B1 (no) 2001-03-26
AU646858B2 (en) 1994-03-10
YU79491A (sh) 1994-06-10
IE62096B1 (en) 1995-01-11
PT97574B (pt) 1998-08-31
ZA913389B (en) 1992-03-25
CA2082382A1 (en) 1991-11-08
KR0184691B1 (ko) 1999-04-01
NO924234D0 (no) 1992-11-04
HU9203449D0 (en) 1993-01-28
AU7565991A (en) 1991-11-27
FI925043L (fi) 1992-11-06
JPH05508309A (ja) 1993-11-25
US5506119A (en) 1996-04-09
US5760178A (en) 1998-06-02
TW212202B (2) 1993-09-01
HUT63652A (en) 1993-09-28
EP0531300A1 (de) 1993-03-17
IL98024A0 (en) 1992-06-21
WO1991017248A1 (de) 1991-11-14

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