DK0531300T3 - Variant-CD44-overfladeproteiner, DNA-sekvenser, som koder herfor, antistoffer mod disse proteiner samt deres anvendelse til diagnostik og terapi - Google Patents

Variant-CD44-overfladeproteiner, DNA-sekvenser, som koder herfor, antistoffer mod disse proteiner samt deres anvendelse til diagnostik og terapi

Info

Publication number
DK0531300T3
DK0531300T3 DK91906994.8T DK91906994T DK0531300T3 DK 0531300 T3 DK0531300 T3 DK 0531300T3 DK 91906994 T DK91906994 T DK 91906994T DK 0531300 T3 DK0531300 T3 DK 0531300T3
Authority
DK
Denmark
Prior art keywords
variant
proteins
antibodies
diagnostics
therapy
Prior art date
Application number
DK91906994.8T
Other languages
English (en)
Inventor
Peter Herrlich
Helmut Ponta
Ursula Guenthert
Siegfried Matzku
Achim Wenzel
Original Assignee
Deutsches Krebsforsch
Kernforschungsz Karlsruhe
Univ Karlsruhe Tech Hochschule
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Kernforschungsz Karlsruhe, Univ Karlsruhe Tech Hochschule filed Critical Deutsches Krebsforsch
Application granted granted Critical
Publication of DK0531300T3 publication Critical patent/DK0531300T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91906994.8T 1990-05-07 1991-03-30 Variant-CD44-overfladeproteiner, DNA-sekvenser, som koder herfor, antistoffer mod disse proteiner samt deres anvendelse til diagnostik og terapi DK0531300T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4014510A DE4014510A1 (de) 1990-05-07 1990-05-07 Variante cd44-oberflaechenproteine, diese kodierende c-dna-sequenzen, antikoerper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie

Publications (1)

Publication Number Publication Date
DK0531300T3 true DK0531300T3 (da) 1994-10-10

Family

ID=6405813

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91906994.8T DK0531300T3 (da) 1990-05-07 1991-03-30 Variant-CD44-overfladeproteiner, DNA-sekvenser, som koder herfor, antistoffer mod disse proteiner samt deres anvendelse til diagnostik og terapi

Country Status (21)

Country Link
US (3) US5506119A (da)
EP (1) EP0531300B1 (da)
JP (1) JP3133062B2 (da)
KR (1) KR0184691B1 (da)
AT (1) ATE106943T1 (da)
AU (1) AU646858B2 (da)
BR (1) BR1100650A (da)
CA (1) CA2082382C (da)
DE (2) DE4014510A1 (da)
DK (1) DK0531300T3 (da)
FI (1) FI106128B (da)
HU (1) HU218905B (da)
IE (1) IE62096B1 (da)
IL (3) IL134982A (da)
NO (3) NO309770B1 (da)
NZ (1) NZ238056A (da)
PT (1) PT97574B (da)
TW (1) TW212202B (da)
WO (1) WO1991017248A1 (da)
YU (1) YU49126B (da)
ZA (1) ZA913389B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002873A (en) * 1989-03-17 1991-03-26 Fred Hutchinson Cancer Research Center DNA sequence encoding a lymphocyte adhesion receptor for high endothelium
US5443750A (en) * 1991-01-16 1995-08-22 The Procter & Gamble Company Detergent compositions with high activity cellulase and softening clays
DE4134982A1 (de) * 1991-10-23 1993-04-29 Kernforschungsz Karlsruhe Verwendung von antikoerper enthaltenden praeparationen zur immunsuppression
DE69302276T2 (de) * 1992-07-21 1996-09-19 Isis Innovation Diagnostische Methode
JPH08511419A (ja) 1993-06-18 1996-12-03 ヤルカネン、シルパ 組成物およびＣＤ４４ｖ６に対するモノクローナル抗体を用いる診断方法
DE4320623C2 (de) * 1993-06-22 1997-11-20 Boehringer Ingelheim Int Verfahren zur Diagnose und Analyse von Adenokarzinomen
EP0767378A1 (de) * 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Diagnose und Analyse von Magenkarzinomen
DE4320624A1 (de) * 1993-06-22 1995-02-09 Boehringer Ingelheim Int Verfahren zur Diagnose und Analyse von Mammakarzinomen
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
DE4431297A1 (de) * 1994-09-02 1996-03-07 Boehringer Ingelheim Int Monoklonaler Antikörper gegen CD44v6
DE19540515C1 (de) * 1995-10-31 1997-02-06 Boehringer Ingelheim Int Tumortherapie durch adoptiven Transfer CD44v-spezifischer zytotoxischer T-Lymphozyten
DE19653607A1 (de) 1996-12-20 1998-06-25 Boehringer Ingelheim Int Verfahren zur Diagnose und Therapie von Hodgkin-Lymphomen
DE19708713C2 (de) * 1997-03-04 2002-11-28 Boehringer Ingelheim Int Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen
US20080124327A1 (en) * 1999-10-08 2008-05-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8048416B2 (en) 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8071072B2 (en) 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
DE10026833A1 (de) * 2000-05-30 2001-12-13 Karlsruhe Forschzent Verfahren zur Identifizierung von Verbindungen zur Modulierung der Aktivität eines Tumorsuppressorgens
AU2003272511A1 (en) * 2002-09-13 2004-04-30 Dyax Corporation Cd44-binding ligands
PL2886126T3 (pl) 2013-12-23 2017-11-30 Exchange Imaging Technologies Gmbh Nanocząstka sprzężona z peptydami wiążącymi CD44
CN109608537B (zh) * 2018-12-12 2020-09-15 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p2及其应用
CN109608536B (zh) * 2018-12-12 2020-09-15 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p3及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
US5108904A (en) * 1990-03-26 1992-04-28 Alan Landay CD44 as a marker for HIV infection

Also Published As

Publication number Publication date
NO924234L (no) 1993-01-04
FI925043A0 (fi) 1992-11-06
AU646858B2 (en) 1994-03-10
NO20001668D0 (no) 2000-03-31
IL98024A0 (en) 1992-06-21
YU49126B (sh) 2004-03-12
NZ238056A (en) 1993-01-27
NO924234D0 (no) 1992-11-04
NO980293D0 (no) 1998-01-23
DE4014510A1 (de) 1991-11-14
EP0531300A1 (de) 1993-03-17
TW212202B (da) 1993-09-01
US5760178A (en) 1998-06-02
NO310661B1 (no) 2001-08-06
IE62096B1 (en) 1995-01-11
WO1991017248A1 (de) 1991-11-14
HU9203449D0 (en) 1993-01-28
PT97574A (pt) 1992-01-31
FI106128B (fi) 2000-11-30
US5506119A (en) 1996-04-09
CA2082382C (en) 2008-09-30
JP3133062B2 (ja) 2001-02-05
PT97574B (pt) 1998-08-31
IE911526A1 (en) 1991-11-20
FI925043A (fi) 1992-11-06
NO317154B1 (no) 2004-08-30
IL98024A (en) 2001-06-14
KR0184691B1 (ko) 1999-04-01
IL134982A (en) 2004-05-12
NO309770B1 (no) 2001-03-26
ZA913389B (en) 1992-03-25
JPH05508309A (ja) 1993-11-25
HUT63652A (en) 1993-09-28
CA2082382A1 (en) 1991-11-08
DE59101889D1 (de) 1994-07-14
IL134982A0 (en) 2001-05-20
BR1100650A (pt) 2000-08-08
YU79491A (sh) 1994-06-10
EP0531300B1 (de) 1994-06-08
NO20001668L (no) 1993-05-06
ATE106943T1 (de) 1994-06-15
US5885575A (en) 1999-03-23
HU218905B (hu) 2000-12-28
NO980293L (no) 1993-01-04
AU7565991A (en) 1991-11-27

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