PT97574A - Processo de obtencao de proteinas de superficie cd44 variaveis, sequencias do dna que as codificam, anticorpos destas proteinas, bem como a sua utilizacao no diagnostico e na terapia - Google Patents
Processo de obtencao de proteinas de superficie cd44 variaveis, sequencias do dna que as codificam, anticorpos destas proteinas, bem como a sua utilizacao no diagnostico e na terapiaInfo
- Publication number
- PT97574A PT97574A PT97574A PT9757491A PT97574A PT 97574 A PT97574 A PT 97574A PT 97574 A PT97574 A PT 97574A PT 9757491 A PT9757491 A PT 9757491A PT 97574 A PT97574 A PT 97574A
- Authority
- PT
- Portugal
- Prior art keywords
- proteins
- antibodies
- diagnosis
- therapy
- code
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4014510A DE4014510A1 (de) | 1990-05-07 | 1990-05-07 | Variante cd44-oberflaechenproteine, diese kodierende c-dna-sequenzen, antikoerper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie |
Publications (2)
Publication Number | Publication Date |
---|---|
PT97574A true PT97574A (pt) | 1992-01-31 |
PT97574B PT97574B (pt) | 1998-08-31 |
Family
ID=6405813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97574A PT97574B (pt) | 1990-05-07 | 1991-05-06 | Processo de obtencao de proteinas de superficie cd44 variaveis, sequencias do dna que as codificam, anticorpos destas proteinas, bem como a sua utilizacao no diagnostico e na terapia |
Country Status (21)
Country | Link |
---|---|
US (3) | US5506119A (pt) |
EP (1) | EP0531300B1 (pt) |
JP (1) | JP3133062B2 (pt) |
KR (1) | KR0184691B1 (pt) |
AT (1) | ATE106943T1 (pt) |
AU (1) | AU646858B2 (pt) |
BR (1) | BR1100650A (pt) |
CA (1) | CA2082382C (pt) |
DE (2) | DE4014510A1 (pt) |
DK (1) | DK0531300T3 (pt) |
FI (1) | FI106128B (pt) |
HU (1) | HU218905B (pt) |
IE (1) | IE62096B1 (pt) |
IL (3) | IL98024A (pt) |
NO (3) | NO309770B1 (pt) |
NZ (1) | NZ238056A (pt) |
PT (1) | PT97574B (pt) |
TW (1) | TW212202B (pt) |
WO (1) | WO1991017248A1 (pt) |
YU (1) | YU49126B (pt) |
ZA (1) | ZA913389B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5002873A (en) * | 1989-03-17 | 1991-03-26 | Fred Hutchinson Cancer Research Center | DNA sequence encoding a lymphocyte adhesion receptor for high endothelium |
US5443750A (en) * | 1991-01-16 | 1995-08-22 | The Procter & Gamble Company | Detergent compositions with high activity cellulase and softening clays |
DE4134982A1 (de) * | 1991-10-23 | 1993-04-29 | Kernforschungsz Karlsruhe | Verwendung von antikoerper enthaltenden praeparationen zur immunsuppression |
US5830646A (en) * | 1992-07-21 | 1998-11-03 | Isis Innovation Limited | Diagnostic method |
EP0703989B1 (en) | 1993-06-18 | 1997-11-05 | Oy Biotie Therapies | COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44v6 |
DE4320624A1 (de) * | 1993-06-22 | 1995-02-09 | Boehringer Ingelheim Int | Verfahren zur Diagnose und Analyse von Mammakarzinomen |
EP0767378A1 (de) * | 1993-06-22 | 1997-04-09 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Diagnose und Analyse von Magenkarzinomen |
DE4320623C2 (de) * | 1993-06-22 | 1997-11-20 | Boehringer Ingelheim Int | Verfahren zur Diagnose und Analyse von Adenokarzinomen |
DE4326573A1 (de) * | 1993-08-07 | 1995-02-23 | Boehringer Ingelheim Int | Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren |
DE4431297A1 (de) * | 1994-09-02 | 1996-03-07 | Boehringer Ingelheim Int | Monoklonaler Antikörper gegen CD44v6 |
DE19540515C1 (de) * | 1995-10-31 | 1997-02-06 | Boehringer Ingelheim Int | Tumortherapie durch adoptiven Transfer CD44v-spezifischer zytotoxischer T-Lymphozyten |
DE19653607A1 (de) | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Int | Verfahren zur Diagnose und Therapie von Hodgkin-Lymphomen |
DE19708713C2 (de) * | 1997-03-04 | 2002-11-28 | Boehringer Ingelheim Int | Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen |
US8048416B2 (en) * | 1999-10-08 | 2011-11-01 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US20080124327A1 (en) * | 1999-10-08 | 2008-05-29 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US8071072B2 (en) | 1999-10-08 | 2011-12-06 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US7947496B2 (en) | 1999-10-08 | 2011-05-24 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US7189397B2 (en) * | 1999-10-08 | 2007-03-13 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US20050100542A1 (en) * | 1999-10-08 | 2005-05-12 | Young David S. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US20090004103A1 (en) * | 1999-10-08 | 2009-01-01 | Young David S F | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
DE10026833A1 (de) * | 2000-05-30 | 2001-12-13 | Karlsruhe Forschzent | Verfahren zur Identifizierung von Verbindungen zur Modulierung der Aktivität eines Tumorsuppressorgens |
AU2003272511A1 (en) * | 2002-09-13 | 2004-04-30 | Dyax Corporation | Cd44-binding ligands |
DK2886126T3 (en) | 2013-12-23 | 2017-09-18 | Exchange Imaging Tech Gmbh | Nanoparticle conjugated to CD44-binding peptides |
CN109608537B (zh) * | 2018-12-12 | 2020-09-15 | 深圳市龙华区人民医院 | 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p2及其应用 |
CN109608536B (zh) * | 2018-12-12 | 2020-09-15 | 深圳市龙华区人民医院 | 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p3及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753894A (en) * | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
US5108904A (en) * | 1990-03-26 | 1992-04-28 | Alan Landay | CD44 as a marker for HIV infection |
-
1990
- 1990-05-07 DE DE4014510A patent/DE4014510A1/de not_active Withdrawn
-
1991
- 1991-03-30 CA CA002082382A patent/CA2082382C/en not_active Expired - Lifetime
- 1991-03-30 DE DE59101889T patent/DE59101889D1/de not_active Expired - Lifetime
- 1991-03-30 DK DK91906994.8T patent/DK0531300T3/da active
- 1991-03-30 WO PCT/EP1991/000614 patent/WO1991017248A1/de active IP Right Grant
- 1991-03-30 HU HU9203449A patent/HU218905B/hu unknown
- 1991-03-30 AU AU75659/91A patent/AU646858B2/en not_active Ceased
- 1991-03-30 KR KR1019920702741A patent/KR0184691B1/ko not_active IP Right Cessation
- 1991-03-30 EP EP91906994A patent/EP0531300B1/de not_active Expired - Lifetime
- 1991-03-30 US US07/946,497 patent/US5506119A/en not_active Expired - Lifetime
- 1991-03-30 AT AT91906994T patent/ATE106943T1/de not_active IP Right Cessation
- 1991-03-30 JP JP03506825A patent/JP3133062B2/ja not_active Expired - Fee Related
- 1991-05-02 IL IL9802491A patent/IL98024A/en not_active IP Right Cessation
- 1991-05-02 IL IL13498291A patent/IL134982A/en not_active IP Right Cessation
- 1991-05-06 IE IE152691A patent/IE62096B1/en unknown
- 1991-05-06 PT PT97574A patent/PT97574B/pt not_active IP Right Cessation
- 1991-05-06 ZA ZA913389A patent/ZA913389B/xx unknown
- 1991-05-06 NZ NZ238056A patent/NZ238056A/xx unknown
- 1991-05-06 TW TW080103527A patent/TW212202B/zh active
- 1991-05-07 YU YU79491A patent/YU49126B/sh unknown
-
1992
- 1992-11-04 NO NO924234A patent/NO309770B1/no unknown
- 1992-11-06 FI FI925043A patent/FI106128B/fi not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/478,882 patent/US5885575A/en not_active Expired - Lifetime
- 1995-06-07 US US08/483,322 patent/US5760178A/en not_active Expired - Lifetime
-
1997
- 1997-05-07 BR BR1100650-1A patent/BR1100650A/pt active IP Right Grant
-
1998
- 1998-01-23 NO NO19980293A patent/NO317154B1/no unknown
-
2000
- 2000-03-09 IL IL13498200A patent/IL134982A0/xx active IP Right Grant
- 2000-03-31 NO NO20001668A patent/NO310661B1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT97574A (pt) | Processo de obtencao de proteinas de superficie cd44 variaveis, sequencias do dna que as codificam, anticorpos destas proteinas, bem como a sua utilizacao no diagnostico e na terapia | |
ATE80660T1 (de) | Verfahren zur herstellung eines polypeptides. | |
BR9507618A (pt) | Frações polipeptidicas solúveis da proteína lag-3 processo de produção composição terapêutica anticorpos anti-idiotipo | |
ES2147178T3 (es) | Dominio de union a cd2 del antigeno 3 asociado con la funcion linfocitica. | |
ES2068907T3 (es) | Secuencias de nucleotidos que codifican una proteina con actividad ureasica. | |
ATE106454T1 (de) | Kennzeichnung und nachweis von mit autoimmunkrankheiten assoziierten sequenzen. | |
DE3587422D1 (de) | Fuer ein hirudinaehnliches protein kodierende dns-sequenz und verfahren zur herstellung eines solchen proteins. | |
ATE135371T1 (de) | Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis | |
ATE212059T1 (de) | Methoden zur identifizierung heterofunktionaler fusionsproteine | |
DE69233463D1 (de) | Expression und reinigung von kloniertem humanen alpha-fetoprotein | |
ATE121754T1 (de) | Vakzine gegen bordetella. | |
NO930428D0 (no) | Proteinstrukturen til plantetoksingelonin | |
DE3881023D1 (de) | Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten. | |
SE8904007D0 (sv) | Monoklona antikroppar och diagnostiseringsmetod | |
ATE188997T1 (de) | Klonierung von malaria-spezifischen dna- sequenzen:isolierung des gens für das 140 kd protein | |
DE68917520D1 (de) | Verfahren und Systeme zur Herstellung von HIV-Antigenen. | |
ATE290549T1 (de) | Ing2, ein mit iaps assoziiertes zellzyklusprotein,sowie zusammensetzungen, verfahren und verwendungen | |
ATE88639T1 (de) | Antigenisches peptid der 28kd proteingruppe aus s. mansoni und sein verfahren zur isolierung, monoklonale antikoerper, die mindestens ein epitop dieses peptids erkennen und verwendungen fuer die induzierung der synthese von neutralisierenden antikoerpern. | |
ATE91303T1 (de) | Verfahren zur herstellung von peptiden durch spezifische spaltung von gentechnisch gewonnenen fusionsproteinen mit collagenasen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19911004 |
|
FG3A | Patent granted, date of granting |
Effective date: 19980519 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20061120 |