|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
MX384291B
(es)
|
2013-02-20 |
2025-03-14 |
Regeneron Pharma |
Modificación genética de ratas.
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
DK3456831T3
(da)
|
2013-04-16 |
2021-09-06 |
Regeneron Pharma |
Målrettet modifikation af rottegenom
|
|
MX374532B
(es)
*
|
2013-06-17 |
2025-03-06 |
Broad Inst Inc |
Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos.
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
WO2015073978A2
(en)
|
2013-11-15 |
2015-05-21 |
Avellino Lab Usa, Inc. |
Methods for multiplex detection of alleles associated with ophthalmic conditions
|
|
KR102170502B1
(ko)
|
2013-12-11 |
2020-10-28 |
리제너론 파마슈티칼스 인코포레이티드 |
게놈의 표적화된 변형을 위한 방법 및 조성물
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
US11028388B2
(en)
*
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
ES2745769T3
(es)
|
2014-03-10 |
2020-03-03 |
Editas Medicine Inc |
Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3122880B1
(en)
|
2014-03-26 |
2021-05-05 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
TWI716367B
(zh)
*
|
2014-10-31 |
2021-01-21 |
麻省理工學院 |
用於常間回文重複序列叢集(crispr)之大量平行組合性基因學
|
|
KR102531016B1
(ko)
|
2014-11-21 |
2023-05-10 |
리제너론 파마슈티칼스 인코포레이티드 |
쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
|
|
EP3224381B1
(en)
|
2014-11-25 |
2019-09-04 |
The Brigham and Women's Hospital, Inc. |
Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
CA2969619A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
US10196613B2
(en)
|
2014-12-19 |
2019-02-05 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
WO2016130600A2
(en)
|
2015-02-09 |
2016-08-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
KR102888521B1
(ko)
|
2015-04-06 |
2025-11-19 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
|
CA2981716C
(en)
|
2015-04-10 |
2022-04-12 |
Feldan Bio Inc. |
Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same
|
|
JP2018522249A
(ja)
|
2015-04-24 |
2018-08-09 |
エディタス・メディシン、インコーポレイテッド |
Cas9分子/ガイドrna分子複合体の評価
|
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
AU2016279077A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
WO2017004261A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
CN108350446A
(zh)
*
|
2015-07-02 |
2018-07-31 |
约翰霍普金斯大学 |
基于crispr/cas9的治疗
|
|
US10456452B2
(en)
|
2015-07-02 |
2019-10-29 |
Poseida Therapeutics, Inc. |
Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles
|
|
CN108025074A
(zh)
*
|
2015-07-25 |
2018-05-11 |
哈比卜·弗罗斯特 |
用于为癌症和其他病理状态提供治疗或治愈的系统、装置和方法
|
|
EP4512819A3
(en)
|
2015-08-12 |
2025-08-06 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
|
WO2017035416A2
(en)
*
|
2015-08-25 |
2017-03-02 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
|
US10603363B2
(en)
*
|
2015-09-08 |
2020-03-31 |
Precision Biosciences, Inc. |
Treatment of retinitis pigmentosa using engineered meganucleases
|
|
FR3042506B1
(fr)
*
|
2015-10-16 |
2018-11-30 |
IFP Energies Nouvelles |
Outil genetique de transformation de bacteries clostridium
|
|
WO2017068077A1
(en)
|
2015-10-20 |
2017-04-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
KR101651817B1
(ko)
*
|
2015-10-28 |
2016-08-29 |
대한민국 |
Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
|
|
EP4036228A1
(en)
|
2015-11-13 |
2022-08-03 |
Avellino Lab USA, Inc. |
Methods for the treatment of corneal dystrophies
|
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
|
KR102787119B1
(ko)
|
2015-11-30 |
2025-03-27 |
듀크 유니버시티 |
유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
|
|
WO2017099494A1
(ko)
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
|
SG10201913266UA
(en)
*
|
2015-12-11 |
2020-02-27 |
Massachusetts Eye & Ear Infirmary |
Materials and methods for delivering nucleic acids to cochlear and vestibular cells
|
|
WO2017136520A1
(en)
*
|
2016-02-04 |
2017-08-10 |
President And Fellows Of Harvard College |
Mitochondrial genome editing and regulation
|
|
US20190032088A1
(en)
*
|
2016-02-26 |
2019-01-31 |
Cellectis |
Micelle based system nuclease encapsulation for in-vivo gene editing
|
|
WO2017160662A1
(en)
*
|
2016-03-12 |
2017-09-21 |
The Regents Of The University Of California |
Biodegradable vectors for efficient rna delivery
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US12011488B2
(en)
|
2016-03-23 |
2024-06-18 |
The Regents Of The University Of California |
Methods of treating mitochondrial disorders
|
|
CN109476716A
(zh)
|
2016-03-23 |
2019-03-15 |
加利福尼亚大学董事会 |
治疗线粒体障碍的方法
|
|
US11512311B2
(en)
|
2016-03-25 |
2022-11-29 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency
|
|
WO2017175072A1
(en)
*
|
2016-04-08 |
2017-10-12 |
Feldan Bio Inc. |
Peptide shuttle based gene disruption
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
US11773410B2
(en)
*
|
2016-04-13 |
2023-10-03 |
University Of Massachusetts |
Repairing compound heterozygous recessive mutations by allele exchange
|
|
US11213594B2
(en)
|
2016-04-29 |
2022-01-04 |
Poseida Therapeutics, Inc. |
Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids
|
|
CN113831407B
(zh)
|
2016-05-20 |
2024-06-11 |
瑞泽恩制药公司 |
用于使用多个引导rna来破坏免疫耐受性的方法
|
|
CN109906271A
(zh)
*
|
2016-06-03 |
2019-06-18 |
国家医疗保健研究所 |
编码Cas9核酸酶的核酸的饮食控制的表达及其用途
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US11882815B2
(en)
*
|
2016-06-15 |
2024-01-30 |
University Of Massachusetts |
Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
|
|
EP4484443A3
(en)
*
|
2016-06-29 |
2025-03-26 |
CRISPR Therapeutics AG |
Materials and methods for treatment of friedreich ataxia and other related disorders
|
|
US12595478B2
(en)
|
2016-06-29 |
2026-04-07 |
The Broad Institute, Inc. |
Crispr-Cas systems having destabilization domain
|
|
KR20190039703A
(ko)
*
|
2016-07-05 |
2019-04-15 |
더 존스 홉킨스 유니버시티 |
Crispr/cas9-기반 조성물 및 망막 변성을 치료하기 위한 방법
|
|
JP7490211B2
(ja)
|
2016-07-19 |
2024-05-27 |
デューク ユニバーシティ |
Cpf1に基づくゲノム編集の治療適用
|
|
EP3492096A4
(en)
*
|
2016-07-28 |
2020-04-15 |
Institute for Basic Science |
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF EYE DISEASES WITH CAS9 PROTEINS AND GUIDE RNA
|
|
BR112019001887A2
(pt)
|
2016-08-02 |
2019-07-09 |
Editas Medicine Inc |
composições e métodos para o tratamento de doença associada a cep290
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
EP4485466A3
(en)
|
2016-08-17 |
2025-04-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
SG11201901306XA
(en)
*
|
2016-08-19 |
2019-03-28 |
Toolgen Inc |
Artificially engineered angiogenesis regulatory system
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
WO2018051347A1
(en)
*
|
2016-09-14 |
2018-03-22 |
Yeda Research And Development Co. Ltd. |
Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens
|
|
GB201616202D0
(en)
*
|
2016-09-23 |
2016-11-09 |
Proqr Therapeutics Ii Bv |
Antisense oligonucleotides for the treatment of eye deisease
|
|
US12499971B2
(en)
|
2016-09-28 |
2025-12-16 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
CN110291100B
(zh)
|
2016-10-12 |
2024-06-11 |
费尔丹生物公司 |
用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂,其用途、与其相关的方法和试剂盒
|
|
US9982267B2
(en)
|
2016-10-12 |
2018-05-29 |
Feldan Bio Inc. |
Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
|
|
US11629170B2
(en)
|
2016-10-12 |
2023-04-18 |
Feldan Bio Inc. |
Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
|
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
CN110139654A
(zh)
*
|
2016-11-03 |
2019-08-16 |
优美佳生物技术有限公司 |
用于细胞重编程的方法和组合物
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
KR101917287B1
(ko)
|
2016-12-19 |
2018-11-13 |
한국과학기술연구원 |
자가-조립식 리보뉴클레오단백질 나노입자
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
EP3565608A4
(en)
*
|
2017-01-05 |
2020-12-16 |
Rutgers, The State University of New Jersey |
TARGETED GENE EDITING PLATFORM INDEPENDENT OF BICATENARY DNA BREAKAGE AND ITS USES
|
|
JP7215716B2
(ja)
*
|
2017-01-13 |
2023-01-31 |
学校法人自治医科大学 |
肝臓ゲノム上の凝固関連因子遺伝子を破壊するためのaavベクター
|
|
WO2018145111A1
(en)
*
|
2017-02-06 |
2018-08-09 |
Children's Medical Center Corporation |
Materials and methods for delivering nucleic acids to cochlear and vestibular cells
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018147343A1
(en)
*
|
2017-02-07 |
2018-08-16 |
Edigene Corporation |
Method of treating diseases associated with elevated kras expression using crispr-gndm system
|
|
WO2018164457A1
(ko)
*
|
2017-03-06 |
2018-09-13 |
기초과학연구원 |
C2cL 엔도뉴클레아제를 포함하는 유전체 교정용 조성물 및 이를 이용한 유전체 교정 방법
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
JP2020511141A
(ja)
*
|
2017-03-15 |
2020-04-16 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新規Cas13bオルソログCRISPR酵素及び系
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
US12331319B2
(en)
|
2017-04-12 |
2025-06-17 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
US12590288B2
(en)
|
2017-04-12 |
2026-03-31 |
The Broad Institute, Inc. |
Method of treating an inflammatory disease by administering an agent which binds a surface receptor on a tuft cell that induces an ILC class 2 inflammatory response
|
|
EP3610266A4
(en)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
TUMOR SIGNATURE OF METASTASIS, COMPOSITIONS OF SUBSTANCES AND USES THEREOF
|
|
WO2018191750A2
(en)
|
2017-04-14 |
2018-10-18 |
The Broad Institute Inc. |
Novel delivery of large payloads
|
|
US12208140B2
(en)
|
2017-04-21 |
2025-01-28 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
JOP20190257A1
(ar)
*
|
2017-04-28 |
2019-10-28 |
Novartis Ag |
مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
EP3622092A4
(en)
|
2017-05-11 |
2021-06-23 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11866697B2
(en)
|
2017-05-18 |
2024-01-09 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
CN118581154A
(zh)
*
|
2017-06-02 |
2024-09-03 |
国家健康与医学研究院 |
用于遗传障碍的基因疗法的基因组编辑手段和结合病毒载体的基因疗法
|
|
CA3102054A1
(en)
|
2017-06-05 |
2018-12-13 |
Fred Hutchinson Cancer Research Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
WO2018232356A1
(en)
|
2017-06-15 |
2018-12-20 |
The Regents Of The University Of California |
Targeted non-viral dna insertions
|
|
JP7123982B2
(ja)
*
|
2017-06-15 |
2022-08-23 |
ツールゲン インコーポレイテッド |
肝臓において目的のタンパク質を発現するためのプラットフォーム
|
|
KR102761791B1
(ko)
|
2017-06-26 |
2025-02-05 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법
|
|
US20200123567A1
(en)
|
2017-06-26 |
2020-04-23 |
Samira Kiani |
A universal platform to enhance crispr-based gene editing for in vivo therapies
|
|
US11773407B2
(en)
*
|
2017-06-26 |
2023-10-03 |
Arizona Board Of Regents On Behalf Of Arizona State University |
CRISPR logic circuits for safer and controllable gene therapies
|
|
US20210154326A1
(en)
*
|
2017-06-26 |
2021-05-27 |
Arizona Board Of Regents On Behalf Of Arizona State University |
CRISPR-Based Synthetic Gene Circuits as Next Generation Gene Therapy of Inner Ear
|
|
KR102007457B1
(ko)
*
|
2017-06-30 |
2019-08-05 |
동국대학교 산학협력단 |
Cas9 단백질, 가이드 RNA 및 양친매성 펩타이드를 포함하는 나노복합체 및 이의 용도
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
US12105089B2
(en)
|
2017-07-17 |
2024-10-01 |
The Broad Institute, Inc. |
Cell atlas of the healthy and ulcerative colitis human colon
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
BR102017016440A2
(pt)
|
2017-07-31 |
2019-03-19 |
Universidade Federal Do Rio Grande Do Sul |
Composição para terapia gênica do sistema nervoso central, processo de obtenção e uso da mesma
|
|
CA3074202A1
(en)
*
|
2017-08-28 |
2019-03-07 |
Wisconsin Alumni Research Foundation |
Nanocapsules for delivering ribonucleoproteins
|
|
EP3675913A4
(en)
*
|
2017-08-28 |
2021-06-02 |
University of Florida Research Foundation, Incorporated |
Methods and compositions for treating cone-rod retinal dystrophy
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
AU2018338318B2
(en)
*
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
CN110832596B
(zh)
*
|
2017-10-16 |
2021-03-26 |
因美纳有限公司 |
基于深度学习的深度卷积神经网络训练方法
|
|
CA3079681A1
(en)
|
2017-10-20 |
2019-04-25 |
Fred Hutchinson Cancer Research Center |
Systems and methods to produce b cells genetically modified to express selected antibodies
|
|
CN111867635A
(zh)
*
|
2017-10-20 |
2020-10-30 |
法国国家卫生及研究医学协会 |
包括视网膜下递送治疗有效量的重组aav9衍生载体的在对象的视锥细胞光感受器中表达目的多核苷酸的方法
|
|
JP7101419B2
(ja)
|
2017-10-27 |
2022-07-15 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
内因性t細胞受容体の標的置換
|
|
EP3707258A1
(en)
*
|
2017-11-06 |
2020-09-16 |
Editas Medicine, Inc. |
Methods, compositions and components for crispr-cas9 editing of cblb in t cells for immunotherapy
|
|
GB2568255A
(en)
*
|
2017-11-08 |
2019-05-15 |
Evox Therapeutics Ltd |
Exosomes comprising RNA therapeutics
|
|
US12221720B2
(en)
|
2017-11-13 |
2025-02-11 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
CA3082450A1
(en)
*
|
2017-11-21 |
2019-05-31 |
Crispr Therapeutics Ag |
Materials and methods for treatment of autosomal dominant retinitis pigmentosa
|
|
CA3084185A1
(en)
*
|
2017-12-06 |
2019-06-13 |
Generation Bio Co. |
Gene editing using a modified closed-ended dna (cedna)
|
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
AU2018393050A1
(en)
*
|
2017-12-21 |
2020-06-18 |
Bayer Healthcare Llc |
Materials and methods for treatment of Usher Syndrome Type 2A
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
EP3740580A4
(en)
|
2018-01-19 |
2021-10-20 |
Duke University |
GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYONTS
|
|
CN109507429A
(zh)
*
|
2018-02-14 |
2019-03-22 |
复旦大学 |
基于CRISPR/cas9和过氧化物酶APEX2系统识别分析特异性位点相互作用蛋白的方法
|
|
EP3762040A4
(en)
|
2018-03-05 |
2022-01-05 |
Children's Medical Center Corporation |
COMPOSITIONS AND METHODS OF ADMINISTRATION OF NUCLEIC ACIDS TO COCHLEAR AND VESTIBULAR CELLS
|
|
WO2019173728A1
(en)
*
|
2018-03-09 |
2019-09-12 |
Lee Hye Young |
Crispr-nanoparticles and methods of use in brain disorders
|
|
KR102907245B1
(ko)
|
2018-03-14 |
2026-01-05 |
에디타스 메디신, 인코포레이티드 |
혈색소병증 치료를 위한 시스템 및 방법
|
|
US20190284553A1
(en)
*
|
2018-03-15 |
2019-09-19 |
KSQ Therapeutics, Inc. |
Gene-regulating compositions and methods for improved immunotherapy
|
|
BR112020019079A2
(pt)
|
2018-03-23 |
2020-12-29 |
Massachusetts Eye And Ear Infirmary |
Abordagem de salto de éxon mediada por crispr/cas9 para síndrome de usher associada a ush2a
|
|
EP3773520A4
(en)
*
|
2018-04-09 |
2021-12-22 |
Orgenesis Inc. |
BIOXOMES AND REDOXOMES PARTICLES, PROCESS AND COMPOSITION
|
|
WO2019204585A1
(en)
|
2018-04-19 |
2019-10-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
|
KR20210039983A
(ko)
*
|
2018-04-24 |
2021-04-12 |
리간달 인코포레이티드 |
게놈 편집을 위한 방법 및 조성물
|
|
HUE059223T2
(hu)
|
2018-04-24 |
2022-10-28 |
Kws Saat Se & Co Kgaa |
Jobb emészthetõségû növények és marker haplotípusok
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
JP2021522787A
(ja)
*
|
2018-04-30 |
2021-09-02 |
オレゴン ヘルス アンド サイエンス ユニバーシティ |
遺伝子治療の方法
|
|
US20190336585A1
(en)
*
|
2018-05-03 |
2019-11-07 |
John Lawrence Mee |
Method for sustainable human cognitive enhancement
|
|
US20210393796A1
(en)
*
|
2018-05-03 |
2021-12-23 |
Cognigenics, Inc. |
Methods for sustainable human cognitive enhancement
|
|
WO2019213660A2
(en)
|
2018-05-04 |
2019-11-07 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
AU2019265019B2
(en)
|
2018-05-11 |
2025-11-06 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
KR20250133482A
(ko)
*
|
2018-05-11 |
2025-09-05 |
빔 테라퓨틱스, 인크. |
프로그래밍가능한 염기 편집기 시스템을 이용하여 단일 뉴클레오티드 다형성을 편집하는 방법
|
|
CN108588050B
(zh)
*
|
2018-05-14 |
2021-06-25 |
北京艾克伦医疗科技有限公司 |
Dna聚合酶以及核酸检测方法和试剂盒
|
|
CN108587998B
(zh)
*
|
2018-05-17 |
2021-05-18 |
浙江大学 |
一种外泌体、外泌体的制备方法及其在制备皮肤浅表性肿瘤的药物中的应用
|
|
US20190359985A1
(en)
*
|
2018-05-22 |
2019-11-28 |
John Lawrence Mee |
Adjustable method for sustainable human cognitive enhancement
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CN108707627A
(zh)
*
|
2018-05-31 |
2018-10-26 |
深圳市免疫基因治疗研究院 |
一种mld慢病毒载体、慢病毒及其制备方法和应用
|
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
WO2020051223A1
(en)
|
2018-09-04 |
2020-03-12 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods for organ specific delivery of nucleic acids
|
|
US12357580B2
(en)
|
2018-06-19 |
2025-07-15 |
The Board Of Regents Of The University Of Texas System |
Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
|
|
US20190390193A1
(en)
*
|
2018-06-23 |
2019-12-26 |
John Lawrence Mee |
Reversible method for sustainable human cognitive enhancement
|
|
US20220000988A1
(en)
*
|
2018-06-23 |
2022-01-06 |
John Lawrence Mee |
Reversible method for sustainable human cognitive enhancement
|
|
WO2020006036A1
(en)
|
2018-06-26 |
2020-01-02 |
Massachusetts Institute Of Technology |
Crispr effector system based amplification methods, systems, and diagnostics
|
|
EP3814519A1
(en)
|
2018-06-26 |
2021-05-05 |
The Broad Institute, Inc. |
Crispr/cas and transposase based amplification compositions, systems and methods
|
|
IL260445B
(en)
*
|
2018-07-05 |
2019-08-29 |
Lempo Therapeutics Ltd |
Methods and compositions for modulating myeloperoxidase (mpo) expression
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
EP3827076A1
(en)
|
2018-07-26 |
2021-06-02 |
Uniwersytet Jagiellonski |
In vivo delivery system of the genome dna modifying enzymes and the use thereof
|
|
CN112888461A
(zh)
*
|
2018-07-26 |
2021-06-01 |
株式会社图尔金 |
抗凝因子的基因编辑
|
|
CA3108281A1
(en)
*
|
2018-08-03 |
2020-02-06 |
Beam Therapeutics Inc. |
Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
|
|
JP2021532815A
(ja)
|
2018-08-07 |
2021-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新規Cas12b酵素およびシステム
|
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
US12421507B2
(en)
|
2018-08-20 |
2025-09-23 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of CRISPR-CAS9
|
|
EP3846857A4
(en)
*
|
2018-09-04 |
2022-10-12 |
The Board Of Regents Of The University Of Texas System |
COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS
|
|
CN109402115B
(zh)
*
|
2018-09-06 |
2024-02-02 |
广州普世利华科技有限公司 |
靶向Rett突变基因RNA的gRNA及Rett突变基因的检测方法、检测试剂盒
|
|
WO2020051507A1
(en)
|
2018-09-06 |
2020-03-12 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
EP3847254A4
(en)
|
2018-09-07 |
2022-08-10 |
Beam Therapeutics Inc. |
COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
|
|
WO2020051562A2
(en)
|
2018-09-07 |
2020-03-12 |
Beam Therapeutics Inc. |
Compositions and methods for improving base editing
|
|
WO2020056170A1
(en)
|
2018-09-12 |
2020-03-19 |
Fred Hutchinson Cancer Research Center |
Reducing cd33 expression to selectively protect therapeutic cells
|
|
AU2019343045A1
(en)
|
2018-09-18 |
2021-05-13 |
Vnv Newco Inc. |
ARC-based capsids and uses thereof
|
|
US20210355492A1
(en)
*
|
2018-09-21 |
2021-11-18 |
City University Of Hong Kong |
Cargo loaded extracellular vesicles
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
US20220411783A1
(en)
|
2018-10-12 |
2022-12-29 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
CN109957568B
(zh)
*
|
2018-10-16 |
2024-02-02 |
广州普世利华科技有限公司 |
用于靶向HBB RNA的gRNA及基于C2c2的HBB突变检测方法、检测试剂盒
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
WO2020097370A2
(en)
|
2018-11-08 |
2020-05-14 |
Triton Algae Innovations, Inc. |
Methods for overproducing protoporphyrin ix in algae and compositions therefrom
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
AU2019396520A1
(en)
*
|
2018-12-12 |
2021-05-27 |
Flagship Pioneering Innovations V, Inc. |
Anellosomes for delivering secreted therapeutic modalities
|
|
US20220028491A1
(en)
*
|
2018-12-13 |
2022-01-27 |
The General Hospital Corporation |
Biologically informed and accurate sequence alignment
|
|
CN111321171A
(zh)
*
|
2018-12-14 |
2020-06-23 |
江苏集萃药康生物科技有限公司 |
一种应用CRISPR/Cas9介导ES打靶技术制备基因打靶动物模型的方法
|
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
CN113544266A
(zh)
|
2018-12-17 |
2021-10-22 |
博德研究所 |
Crispr相关转座酶系统和其使用方法
|
|
EP3897745A1
(en)
*
|
2018-12-23 |
2021-10-27 |
CSL Behring LLC |
Haematopoietic stem cell-gene therapy for wiskott-aldrich syndrome
|
|
KR102386498B1
(ko)
*
|
2018-12-27 |
2022-04-15 |
한양대학교 산학협력단 |
Crispr-cas를 기반으로 하는 유전자 교정용 조성물
|
|
WO2020139031A1
(ko)
*
|
2018-12-27 |
2020-07-02 |
한양대학교 산학협력단 |
Crispr-cas를 기반으로 하는 유전자 교정용 조성물
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CN120174005A
(zh)
|
2019-02-13 |
2025-06-20 |
比姆医疗股份有限公司 |
具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
|
|
CA3130515A1
(en)
*
|
2019-02-25 |
2020-09-03 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease-related methods and compositions for treating rho-associated autosomal-dominant retinitis pigmentosa (adrp)
|
|
US20220047618A1
(en)
*
|
2019-02-28 |
2022-02-17 |
Regeneron Pharmaceuticals, Inc. |
Adeno-associated virus vectors for the delivery of therapeutics
|
|
WO2020181193A1
(en)
*
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
|
US12534714B2
(en)
|
2019-03-18 |
2026-01-27 |
The Broad Institute, Inc. |
Type VII CRISPR proteins and systems
|
|
WO2020191233A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
SG11202110613SA
(en)
*
|
2019-03-27 |
2021-10-28 |
Res Inst Nationwide Childrens Hospital |
Generation of chimeric antigen receptor (car)-primary nk cells for cancer immunotherapy using a combination of cas9/rnp and aav viruses
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CA3040645A1
(en)
|
2019-04-18 |
2020-10-18 |
Feldan Bio Inc. |
Peptide-based non-proteinaceous cargo delivery
|
|
CN110129368B
(zh)
*
|
2019-04-22 |
2021-03-09 |
中国科学院脑科学与智能技术卓越创新中心 |
一种感染支持细胞和毛细胞的aav载体
|
|
WO2020229533A1
(en)
|
2019-05-13 |
2020-11-19 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
|
WO2020236972A2
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
WO2020243661A1
(en)
|
2019-05-31 |
2020-12-03 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
CN110241098B
(zh)
*
|
2019-06-05 |
2021-04-30 |
复旦大学 |
酿脓链球菌的CRISPR核酸酶SpCas9的截短型高特异性变异体及其应用
|
|
WO2020252455A1
(en)
|
2019-06-13 |
2020-12-17 |
The General Hospital Corporation |
Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
|
|
CN112143701A
(zh)
*
|
2019-06-26 |
2020-12-29 |
中国科学院脑科学与智能技术卓越创新中心 |
基于rna定点编辑的抑制脉络膜新生血管形成的方法及试剂
|
|
SG11202111943UA
(en)
|
2019-07-02 |
2021-11-29 |
Hutchinson Fred Cancer Res |
Recombinant ad35 vectors and related gene therapy improvements
|
|
US20230033299A1
(en)
*
|
2019-07-30 |
2023-02-02 |
NxGen Medicine Inc. |
Methods of Treating Pain Conditions and Compositions Related Thereto
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
EP4013868A4
(en)
*
|
2019-08-16 |
2023-08-23 |
The Jackson Laboratory |
LIVE CELL IMAGING OF NON-REPETITIVE GENOMIC LOCI
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
EP4034138A4
(en)
|
2019-09-27 |
2024-07-31 |
Beam Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
EP4045522A1
(en)
|
2019-10-17 |
2022-08-24 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
|
US12521451B2
(en)
*
|
2019-11-08 |
2026-01-13 |
Regeneron Pharmaceuticals, Inc. |
CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy
|
|
CN111001044A
(zh)
*
|
2019-12-30 |
2020-04-14 |
上海申淇医疗科技有限公司 |
一种药物球囊、其涂覆药物的制备及药物球囊的制备方法
|
|
KR102152189B1
(ko)
|
2020-02-11 |
2020-09-04 |
재단법인 아산사회복지재단 |
T 세포 내 표적 위치로의 t 세포 수용체 삽입을 위한 재조합벡터 및 이를 이용한 t 세포 내 표적 위치로의 t 세포 수용체 삽입용 조성물
|
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
|
AU2021257213A1
(en)
*
|
2020-04-17 |
2022-11-03 |
Nevada Research & Innovation Corporation |
CRISPR-inhibition for facioscapulohumeral muscular dystrophy
|
|
IL297761A
(en)
|
2020-05-08 |
2022-12-01 |
Broad Inst Inc |
Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence
|
|
GB202007199D0
(en)
*
|
2020-05-15 |
2020-07-01 |
Oxford Biomedica Ltd |
Viral vector production
|
|
AR122206A1
(es)
|
2020-05-29 |
2022-08-24 |
Kws Saat Se & Co Kgaa |
Inducción de haploides en plantas
|
|
CA3189601A1
(en)
|
2020-07-24 |
2022-01-27 |
The General Hospital Corporation |
Enhanced virus-like particles and methods of use thereof for delivery to cells
|
|
CN114250228A
(zh)
*
|
2020-09-22 |
2022-03-29 |
广州瑞风生物科技有限公司 |
靶向CTGF基因的gRNA及其应用
|
|
WO2022067034A1
(en)
*
|
2020-09-24 |
2022-03-31 |
Albert Einstein College Of Medicine |
Attb cell line, transgenic cell lines derived therefrom, and methods of making the same
|
|
CA3196831A1
(en)
|
2020-09-25 |
2022-03-31 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
|
CN113057969A
(zh)
*
|
2021-03-09 |
2021-07-02 |
吴志新 |
一种间充质干细胞对儿童自闭症临床应用实验方法
|
|
CN113181376B
(zh)
*
|
2021-03-17 |
2022-11-29 |
复旦大学附属眼耳鼻喉科医院 |
Htra2基因表达抑制剂在预防获得性感音神经性聋中的应用
|
|
CN113667734B
(zh)
*
|
2021-07-16 |
2022-05-24 |
四川大学华西医院 |
Shank3片段序列甲基化检测试剂在制备精神分裂症诊断试剂盒中的用途
|
|
WO2023006933A1
(en)
|
2021-07-30 |
2023-02-02 |
KWS SAAT SE & Co. KGaA |
Plants with improved digestibility and marker haplotypes
|
|
JP2024534945A
(ja)
|
2021-09-10 |
2024-09-26 |
アジレント・テクノロジーズ・インク |
化学修飾を有するプライム編集のためのガイドrna
|
|
JP2024537991A
(ja)
|
2021-10-14 |
2024-10-18 |
アーセナル バイオサイエンシズ インコーポレイテッド |
共発現されるshRNAと論理ゲートシステムとを有する免疫細胞
|
|
EP4441232A2
(en)
*
|
2021-12-01 |
2024-10-09 |
Shape Therapeutics Inc. |
Functional aav capsids for intravitreal administration
|
|
WO2023143609A1
(en)
*
|
2022-01-30 |
2023-08-03 |
Edigene Therapeutics (Beijing) Inc. |
Methods for nucleic acid editing to alter apoe4 function
|
|
CN115487315B
(zh)
*
|
2022-04-20 |
2023-08-04 |
暨南大学 |
治疗亨廷顿病的药物
|
|
CN115029346B
(zh)
*
|
2022-04-22 |
2024-01-02 |
复旦大学附属眼耳鼻喉科医院 |
用于靶向敲降Htra2转录本的sgRNA、CRISPR/CasRx系统及应用
|
|
CA3265393A1
(en)
|
2022-08-26 |
2024-02-29 |
KWS SAAT SE & Co. KGaA |
USE OF PAIRED GENES FOR HYBRID SELECTION
|
|
WO2024112036A1
(ko)
*
|
2022-11-21 |
2024-05-30 |
고려대학교 산학협력단 |
Cas9 단백질을 이용한 고효율 어댑터 연결 반응에서 어댑터 이합체의 제거 방법
|
|
CN116515908B
(zh)
*
|
2023-04-03 |
2024-04-26 |
苏州启辰生物科技有限公司 |
Rpe65基因编辑模型犬的建立方法
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
WO2024253957A1
(en)
|
2023-06-07 |
2024-12-12 |
Northwestern University |
Targeting autoimmunity-associated t cells through regulation of transcription factors
|
|
CN121729237A
(zh)
*
|
2023-06-30 |
2026-03-24 |
武田药品工业株式会社 |
Htt阻遏物及其用途
|
|
WO2025027136A1
(en)
|
2023-08-01 |
2025-02-06 |
ETH Zürich |
Single-cell crispr-screening of multiple gene perturbations in vivo
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025184403A2
(en)
*
|
2024-02-29 |
2025-09-04 |
Memorial Sloan-Kettering Cancer Center |
Cell penetrating peptides and methods including the same
|
|
WO2025196502A1
(en)
|
2024-03-20 |
2025-09-25 |
North Carolina Agricultural & Technical State University |
Choline kinase inhibitors as a therapeutic treatment for obesity
|
|
US20260022380A1
(en)
|
2024-06-10 |
2026-01-22 |
Northwestern University |
Genetic modulators of kras protein expression and their uses
|
|
WO2026047626A1
(en)
|
2024-08-30 |
2026-03-05 |
Inceptor Bio, Llc |
Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy
|
|
WO2026060399A2
(en)
|
2024-09-16 |
2026-03-19 |
Northwestern University |
T cell lymphoma mutations, compositions, and uses to enhance engineered t cell therapies
|
|
WO2026060398A2
(en)
|
2024-09-16 |
2026-03-19 |
Northwestern University |
B cell lymphoma mutations, compositions, and uses to enhance engineered t cell therapies
|
|
CN119745798B
(zh)
*
|
2024-11-07 |
2025-10-31 |
河北中琨生物工程有限责任公司 |
搭载siCCR5的工程化脐带干细胞外泌体、制备方法及其在治疗阿尔茨海默症上的应用
|