CA2932478A1 - Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing - Google Patents

Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing Download PDF

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Publication number
CA2932478A1
CA2932478A1 CA2932478A CA2932478A CA2932478A1 CA 2932478 A1 CA2932478 A1 CA 2932478A1 CA 2932478 A CA2932478 A CA 2932478A CA 2932478 A CA2932478 A CA 2932478A CA 2932478 A1 CA2932478 A1 CA 2932478A1
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Prior art keywords
sequence
cas9
tracr
crispr
target
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CA2932478A
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English (en)
French (fr)
Inventor
Le Cong
David Benjamin Turitz Cox
Matthias Heidenreich
Randall Jeffrey Platt
Lukasz SWIECH
Feng Zhang
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Massachusetts Institute of Technology
Broad Institute Inc
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Massachusetts Institute of Technology
Broad Institute Inc
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
    • C12N9/226—Class 2 CAS enzyme complex, e.g. single CAS protein
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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CA2932478A 2013-12-12 2014-12-12 Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing Pending CA2932478A1 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201361915153P 2013-12-12 2013-12-12
US201361915215P 2013-12-12 2013-12-12
US201361915145P 2013-12-12 2013-12-12
US201361915176P 2013-12-12 2013-12-12
US201361915192P 2013-12-12 2013-12-12
US201361915107P 2013-12-12 2013-12-12
US201361915148P 2013-12-12 2013-12-12
US61/915,153 2013-12-12
US61/915,145 2013-12-12
US61/915,148 2013-12-12
US61/915,176 2013-12-12
US61/915,215 2013-12-12
US61/915,107 2013-12-12
US61/915,192 2013-12-12
PCT/US2014/070127 WO2015089462A1 (en) 2013-12-12 2014-12-12 Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing

Publications (1)

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CA2932478A1 true CA2932478A1 (en) 2015-06-18

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CA2932478A Pending CA2932478A1 (en) 2013-12-12 2014-12-12 Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing

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US (2) US11407985B2 (https=)
EP (2) EP3079725B1 (https=)
JP (3) JP7103750B2 (https=)
KR (2) KR102805572B1 (https=)
CN (3) CN111206032B (https=)
AU (5) AU2014361781B2 (https=)
BR (1) BR112016013201B1 (https=)
CA (1) CA2932478A1 (https=)
DK (1) DK3079725T3 (https=)
ES (1) ES2765481T3 (https=)
IL (3) IL316141A (https=)
MX (2) MX374529B (https=)
SG (1) SG10201804976YA (https=)
WO (1) WO2015089462A1 (https=)
ZA (1) ZA201603714B (https=)

Cited By (2)

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WO2018051347A1 (en) * 2016-09-14 2018-03-22 Yeda Research And Development Co. Ltd. Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens
CN109804069A (zh) * 2016-09-23 2019-05-24 ProQR治疗上市公司Ⅱ 治疗眼部疾病的反义寡核苷酸

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US9828582B2 (en) 2013-03-19 2017-11-28 Duke University Compositions and methods for the induction and tuning of gene expression
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MX374532B (es) * 2013-06-17 2025-03-06 Broad Inst Inc Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos.
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
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CN106459995B (zh) 2013-11-07 2020-02-21 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
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US11028388B2 (en) * 2014-03-05 2021-06-08 Editas Medicine, Inc. CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
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US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
TWI716367B (zh) * 2014-10-31 2021-01-21 麻省理工學院 用於常間回文重複序列叢集（ｃｒｉｓｐｒ）之大量平行組合性基因學
KR102531016B1 (ko) 2014-11-21 2023-05-10 리제너론 파마슈티칼스 인코포레이티드 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
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