CN110129368B - 一种感染支持细胞和毛细胞的aav载体 - Google Patents
一种感染支持细胞和毛细胞的aav载体 Download PDFInfo
- Publication number
- CN110129368B CN110129368B CN201910324597.8A CN201910324597A CN110129368B CN 110129368 B CN110129368 B CN 110129368B CN 201910324597 A CN201910324597 A CN 201910324597A CN 110129368 B CN110129368 B CN 110129368B
- Authority
- CN
- China
- Prior art keywords
- aav
- gene
- cells
- hearing
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (15)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910324597.8A CN110129368B (zh) | 2019-04-22 | 2019-04-22 | 一种感染支持细胞和毛细胞的aav载体 |
PCT/CN2020/081210 WO2020215968A1 (zh) | 2019-04-22 | 2020-03-25 | 一种高效感染支持细胞和毛细胞的aav载体 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910324597.8A CN110129368B (zh) | 2019-04-22 | 2019-04-22 | 一种感染支持细胞和毛细胞的aav载体 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110129368A CN110129368A (zh) | 2019-08-16 |
CN110129368B true CN110129368B (zh) | 2021-03-09 |
Family
ID=67570671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910324597.8A Active CN110129368B (zh) | 2019-04-22 | 2019-04-22 | 一种感染支持细胞和毛细胞的aav载体 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN110129368B (zh) |
WO (1) | WO2020215968A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110129368B (zh) * | 2019-04-22 | 2021-03-09 | 中国科学院脑科学与智能技术卓越创新中心 | 一种感染支持细胞和毛细胞的aav载体 |
CN111349148A (zh) * | 2020-03-13 | 2020-06-30 | 辉大(上海)生物科技有限公司 | 一种腺相关病毒载体及其用途 |
CN113584082B (zh) * | 2021-06-22 | 2023-07-25 | 复旦大学附属眼耳鼻喉科医院 | CRISPR/Cas9基因编辑系统及其在制备治疗遗传性感音神经性聋的药物中的应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104869987A (zh) * | 2012-09-07 | 2015-08-26 | 麻省眼耳医院 | 用于再生毛细胞和/或支持细胞的方法及组合物 |
CN106061510A (zh) * | 2013-12-12 | 2016-10-26 | 布罗德研究所有限公司 | 用于基因组编辑的crispr‑cas系统和组合物的递送、用途和治疗应用 |
WO2017189753A1 (en) * | 2016-04-26 | 2017-11-02 | Massachusetts Eye And Ear Infirmary | Isl1-based gene therapy to treat hearing loss |
CN111349148A (zh) * | 2020-03-13 | 2020-06-30 | 辉大(上海)生物科技有限公司 | 一种腺相关病毒载体及其用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1755400A2 (en) * | 2004-06-18 | 2007-02-28 | The University Of Montana | Aav mediated gene delivery to cochlear cells |
EP3984550A1 (en) * | 2015-12-11 | 2022-04-20 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
EP3407901B1 (en) * | 2016-01-29 | 2021-07-21 | Massachusetts Eye & Ear Infirmary | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
CN109082402B (zh) * | 2018-08-06 | 2021-08-17 | 复旦大学 | 一种aav-dj型腺相关病毒体外高效感染类器官的用途 |
CN110129368B (zh) * | 2019-04-22 | 2021-03-09 | 中国科学院脑科学与智能技术卓越创新中心 | 一种感染支持细胞和毛细胞的aav载体 |
-
2019
- 2019-04-22 CN CN201910324597.8A patent/CN110129368B/zh active Active
-
2020
- 2020-03-25 WO PCT/CN2020/081210 patent/WO2020215968A1/zh active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104869987A (zh) * | 2012-09-07 | 2015-08-26 | 麻省眼耳医院 | 用于再生毛细胞和/或支持细胞的方法及组合物 |
CN106061510A (zh) * | 2013-12-12 | 2016-10-26 | 布罗德研究所有限公司 | 用于基因组编辑的crispr‑cas系统和组合物的递送、用途和治疗应用 |
WO2017189753A1 (en) * | 2016-04-26 | 2017-11-02 | Massachusetts Eye And Ear Infirmary | Isl1-based gene therapy to treat hearing loss |
CN111349148A (zh) * | 2020-03-13 | 2020-06-30 | 辉大(上海)生物科技有限公司 | 一种腺相关病毒载体及其用途 |
Also Published As
Publication number | Publication date |
---|---|
CN110129368A (zh) | 2019-08-16 |
WO2020215968A1 (zh) | 2020-10-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20230212605A1 (en) | Adeno-associated virus vector and use thereof | |
CN110129368B (zh) | 一种感染支持细胞和毛细胞的aav载体 | |
EP2829285B1 (en) | Recombinant lentiviral vector preparation | |
McDougald et al. | SIRT1 and NRF2 gene transfer mediate distinct neuroprotective effects upon retinal ganglion cell survival and function in experimental optic neuritis | |
US20130012450A1 (en) | Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For The Treatment Of Dermatology Related Genetic Diseases | |
CN109528653B (zh) | 具有基因编辑功能的膜性囊泡及其制备方法、药物组合物和用途 | |
CN110917362A (zh) | 核酸输送的区室化方法及其组合物和应用 | |
JPH04504125A (ja) | 脊椎動物における外因性ポリヌクレオチド配列の発現 | |
EA024878B1 (ru) | Ген, кодирующий мутантную глюкокиназу человека, отличающуюся увеличенной стабильностью, и его применение для контроля глюкозы в крови или предупреждения и лечения нарушений углеводного обмена | |
Ildefonso et al. | Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation | |
TWI794699B (zh) | 一種質體組合及其在製備經修飾的免疫細胞中的應用 | |
JP2015199751A (ja) | 貧血および赤血球機能不全を治療するためのlcatの使用 | |
JPWO2014142235A1 (ja) | 微小胞及びその製造方法 | |
JP2021522278A (ja) | ライソゾーム病を改善するための、レンチウイルスベクターが形質導入されたt−rapa細胞の使用 | |
WO2020223933A1 (zh) | 高效感染支持细胞的aav突变体 | |
CN111909246B (zh) | 高效感染支持细胞的aav突变体 | |
CN115252760B (zh) | 一种广谱抗冠状病毒的制剂及其制备方法 | |
CN111686124B (zh) | miR-486-3p在制备治疗SAH导致的神经炎症产品中的应用 | |
CN116925192A (zh) | 一种融合型腺相关病毒及其应用 | |
JP2023540130A (ja) | リプログラミング用機能性断片、組み合わせ、およびその用途 | |
DE602004013165T2 (de) | Chimärisches vektorsystem | |
WO2023078099A1 (zh) | 一种用于治疗神经损伤疾病的基因药物 | |
WO2024066780A1 (zh) | 一种融合型新型腺相关病毒及其应用 | |
WO2023143366A1 (zh) | 变异型腺相关病毒及其在疾病治疗中的应用 | |
CN114642668B (zh) | 拉坦前列素的药物新用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20190816 Assignee: Huida (Shanghai) Biotechnology Co., Ltd. Assignor: Shanghai Institute of life Sciences, Chinese Academy of Sciences Contract record no.: X2019310000011 Denomination of invention: A kind of AAV carrier of efficient infection sertoli cell and hair cell License type: Common License Record date: 20190919 |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200519 Address after: 200031 No. 320, Yueyang Road, Shanghai, Xuhui District Applicant after: Center for excellence and innovation of brain science and intelligent technology, Chinese Academy of Sciences Address before: 200031 Yueyang Road, Shanghai, No. 319, No. Applicant before: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant |