|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
|
US5844092A
(en)
|
1994-03-18 |
1998-12-01 |
Genentech, Inc. |
Human TRK receptors and neurotrophic factor inhibitors
|
|
CA2412494C
(en)
|
2000-06-22 |
2012-10-23 |
Genentech, Inc. |
Agonist anti-trk-c monoclonal antibodies
|
|
ES2325440T3
(es)
|
2003-02-20 |
2009-09-04 |
Smithkline Beecham Corporation |
Compuestos de pirimidina.
|
|
MY141220A
(en)
|
2003-11-17 |
2010-03-31 |
Astrazeneca Ab |
Pyrazole derivatives as inhibitors of receptor tyrosine kinases
|
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
PE20060664A1
(es)
|
2004-09-15 |
2006-08-04 |
Novartis Ag |
Amidas biciclicas como inhibidores de cinasa
|
|
DE102005003687A1
(de)
|
2005-01-26 |
2006-07-27 |
Sphingo Tec Gmbh |
Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
|
|
US20080287437A1
(en)
|
2005-05-16 |
2008-11-20 |
Astrazeneca Ab |
Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
|
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
|
UA95244C2
(ru)
|
2005-06-22 |
2011-07-25 |
Плексикон, Инк. |
Соединения и способ модулирования активности киназ, и показания для их применения
|
|
WO2007022999A1
(en)
|
2005-08-25 |
2007-03-01 |
Creabilis Therapeutics S.P.A. |
Polymer conjugates of k-252a and derivatives thereof
|
|
WO2007026720A1
(ja)
|
2005-08-31 |
2007-03-08 |
Taisho Pharmaceutical Co., Ltd. |
縮環ピラゾール誘導体
|
|
SG10202003901UA
(en)
|
2005-12-13 |
2020-05-28 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
|
|
BRPI0709680B8
(pt)
|
2006-03-27 |
2021-05-25 |
Nerviano Medical Sciences Srl |
derivados de pirrol, tiofeno e furano substituídos por piridil e piridimil como inibidores de quinase
|
|
DK2526933T3
(en)
|
2006-09-22 |
2015-05-18 |
Pharmacyclics Inc |
Inhibitors of Bruton's tyrosine kinase
|
|
WO2008079909A1
(en)
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
JP2010514695A
(ja)
|
2006-12-21 |
2010-05-06 |
プレキシコン，インコーポレーテッド |
キナーゼ調節のための化合物および方法およびそのための適応症
|
|
PE20121126A1
(es)
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
|
EA019524B1
(ru)
|
2007-05-04 |
2014-04-30 |
Айрм Ллк |
СОЕДИНЕНИЯ И КОМПОЗИЦИИ КАК ИНГИБИТОРЫ КИНАЗЫ с-kit И PDGFR
|
|
KR20150036210A
(ko)
|
2007-06-13 |
2015-04-07 |
인사이트 코포레이션 |
야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
AU2008273889B2
(en)
|
2007-07-09 |
2012-03-08 |
Astrazeneca Ab |
Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
|
|
WO2009012283A1
(en)
|
2007-07-17 |
2009-01-22 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
MY150032A
(en)
|
2007-07-19 |
2013-11-29 |
Merck Sharp & Dohme |
Heterocyclic amide compounds as protein kinase inhibitors
|
|
PT2176231T
(pt)
|
2007-07-20 |
2016-12-09 |
Nerviano Medical Sciences Srl |
Derivados de indazol substituídos activos como inibidores de quinases
|
|
EP2214706A1
(en)
|
2007-10-23 |
2010-08-11 |
Novartis AG |
Use of trkb antibodies for the treatment of respiratory disorders
|
|
WO2009071480A2
(en)
|
2007-12-04 |
2009-06-11 |
Nerviano Medical Sciences S.R.L. |
Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
|
|
PE20091326A1
(es)
|
2008-01-17 |
2009-09-18 |
Irm Llc |
Anticuerpos anti-trkb mejorados
|
|
EP2254886B1
(en)
|
2008-03-28 |
2016-05-25 |
Nerviano Medical Sciences S.r.l. |
3,4-dihydro-2h-pyrazino[1,2-a]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
WO2009143018A2
(en)
|
2008-05-19 |
2009-11-26 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
ES2554513T3
(es)
|
2008-05-23 |
2015-12-21 |
Novartis Ag |
Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa
|
|
JP5767965B2
(ja)
|
2008-06-10 |
2015-08-26 |
プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． |
キナーゼを調節する５ｈ−ピロロ［２，３−ｂ］ピラジン誘導体、およびその適応症
|
|
NZ603525A
(en)
|
2008-06-27 |
2015-02-27 |
Celgene Avilomics Res Inc |
Pyrimidine based compound and uses thereof
|
|
EP2323664B1
(en)
|
2008-07-29 |
2015-01-07 |
Nerviano Medical Sciences S.r.l. |
Use of a cdk inhibitor for the treatment of glioma
|
|
JP5746032B2
(ja)
|
2008-09-19 |
2015-07-08 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
３，４−ジヒドロ−２Ｈ−ピロロ［１，２−ａ］ピラジン−１−オン誘導体
|
|
WO2010033941A1
(en)
|
2008-09-22 |
2010-03-25 |
Array Biopharma Inc. |
Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
|
|
MY169791A
(en)
|
2008-10-22 |
2019-05-15 |
Array Biopharma Inc |
Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors
|
|
WO2010058006A1
(en)
|
2008-11-24 |
2010-05-27 |
Nerviano Medical Sciences S.R.L. |
Cdk inhibitor for the treatment of mesothelioma
|
|
JO3265B1
(ar)
|
2008-12-09 |
2018-09-16 |
Novartis Ag |
مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
|
|
TWI720517B
(zh)
|
2009-01-15 |
2021-03-01 |
美商英塞特公司 |
製造ｊａｋ抑制劑之方法及相關中間化合物
|
|
WO2010111527A1
(en)
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
SI2432472T1
(sl)
|
2009-05-22 |
2019-11-29 |
Incyte Holdings Corp |
3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
|
|
US8546413B2
(en)
|
2009-06-15 |
2013-10-01 |
Nerviano Medical Sciences S.R.L. |
Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
EA021478B1
(ru)
|
2009-10-09 |
2015-06-30 |
Инсайт Корпорейшн |
ГИДРОКСИЛЬНЫЕ, КЕТО И ГЛЮКУРОНИДНЫЕ ПРОИЗВОДНЫЕ 3-(4-(7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1Н-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА
|
|
WO2011092120A1
(en)
|
2010-01-29 |
2011-08-04 |
Nerviano Medical Sciences S.R.L. |
6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
ME03376B
(me)
|
2010-05-20 |
2020-01-20 |
Array Biopharma Inc |
Makrociklička jedinjenja kао inhibiтori trk kinaze
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
WO2012101029A1
(en)
|
2011-01-26 |
2012-08-02 |
Nerviano Medical Sciences S.R.L. |
Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
|
|
EP2668190B1
(en)
|
2011-01-26 |
2016-08-17 |
Nerviano Medical Sciences S.r.l. |
Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
|
|
US9624213B2
(en)
|
2011-02-07 |
2017-04-18 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CN103403002B
(zh)
|
2011-02-24 |
2016-06-22 |
内尔维阿诺医学科学有限公司 |
作为激酶抑制剂的噻唑基苯基-苯磺酰氨基衍生物
|
|
MA34969B1
(fr)
|
2011-02-25 |
2014-03-01 |
Irm Llc |
Composes et compositions en tant qu inibiteurs de trk
|
|
EP2702055A1
(en)
|
2011-04-11 |
2014-03-05 |
Nerviano Medical Sciences S.r.l. |
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
|
|
JP5970537B2
(ja)
|
2011-04-19 |
2016-08-17 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害薬として活性な置換ピリミジニル−ピロール
|
|
PT2707359T
(pt)
|
2011-05-12 |
2017-01-09 |
Nerviano Medical Sciences Srl |
Derivados de indazol substituídos ativos como inibidores de quinase
|
|
CA2835835C
(en)
|
2011-05-13 |
2019-04-02 |
Array Biopharma Inc. |
Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors
|
|
JP6016915B2
(ja)
|
2011-07-28 |
2016-10-26 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤として活性なアルキニル置換ピリミジニルピロール
|
|
US9145418B2
(en)
|
2011-10-07 |
2015-09-29 |
Nerviano Medical Sciences S.R.L. |
Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
|
|
JP6063945B2
(ja)
|
2011-10-07 |
2017-01-18 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤としての４−アルキル置換３，４−ジヒドロピロロ［１，２−ａ］ピラジン−１（２Ｈ）−オン誘導体
|
|
EP2779833A4
(en)
|
2011-11-14 |
2015-03-18 |
Tesaro Inc |
MODULATION OF SPECIFIC TYROSINE KINASES
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
ES2575604T3
(es)
|
2012-01-13 |
2016-06-29 |
Bristol-Myers Squibb Company |
Compuestos de piridilo sustituidos con tiazolilo o tiadiazolilo útiles como inhibidores cinasa
|
|
US20130195797A1
(en)
*
|
2012-01-31 |
2013-08-01 |
Vertex Pharmaceuticals Incorporated |
High potency formulations of vx-950
|
|
TW201350479A
(zh)
|
2012-04-26 |
2013-12-16 |
Ono Pharmaceutical Co |
Ｔｒｋ阻害化合物
|
|
ES2751944T3
(es)
|
2012-05-23 |
2020-04-02 |
Nerviano Medical Sciences Srl |
Proceso para la preparación de N-[5-(3,5-difluoro-bencil)-1H-indazol-3-il]-4-(4-metil-piperazin-1-il)-2-(tetrahidro-piran-4-ilamino)-benzamida
|
|
TWI585088B
(zh)
|
2012-06-04 |
2017-06-01 |
第一三共股份有限公司 |
作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
RS58514B1
(sr)
|
2012-06-13 |
2019-04-30 |
Incyte Holdings Corp |
Supstituisana triciklična jedinjenja kao inhibitori fgfr
|
|
WO2014011902A1
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
SG11201500125QA
(en)
|
2012-07-11 |
2015-02-27 |
Blueprint Medicines Corp |
Inhibitors of the fibroblast growth factor receptor
|
|
BR112015002152B1
(pt)
|
2012-08-02 |
2021-04-27 |
Nerviano Medical Sciences S.R.L. |
Compostos de pirróis substituídos ativos como inibidores de quinases, processo para a preparação de tais compostos, composição farmacêutica, método in vitro para a inibição da atividade de proteínas quinases da família jak e produto compreendendo os referidos compostos
|
|
SI2892900T1
(en)
|
2012-09-10 |
2018-01-31 |
Principia Biopharma Inc. |
Pyrazolopyrimidine compounds as kinase inhibitors
|
|
WO2014055928A2
(en)
|
2012-10-04 |
2014-04-10 |
University Of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
|
ES2755772T3
(es)
|
2012-11-07 |
2020-04-23 |
Nerviano Medical Sciences Srl |
Pirimidinil y piridinilpirrolopiridinonas sustituidas, proceso para su preparación y su uso como inhibidores de cinasas
|
|
KR20150086308A
(ko)
|
2012-11-12 |
2015-07-27 |
이그니타, 인코포레이티드 |
벤다무스틴 유도체 및 그의 사용 방법
|
|
WO2014078328A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
US9822118B2
(en)
|
2012-11-13 |
2017-11-21 |
Array Biopharma Inc. |
Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
WO2014078378A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
WO2014078372A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
WO2014078417A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
WO2014078325A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
MX374242B
(es)
|
2012-11-13 |
2025-03-05 |
Array Biopharma Inc |
Compuestos de n-pirrolidinil, n' -pirazolil-urea, tiourea, guanidina y cianoguanidina como inhibidores de trka cinasa.
|
|
RS55593B1
(sr)
|
2012-11-13 |
2017-06-30 |
Array Biopharma Inc |
Jedinjenja biciklične uree, tiouree, guanidina i cijanoguanidina korisna za lečenje bola
|
|
WO2014078331A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
US9981959B2
(en)
|
2012-11-13 |
2018-05-29 |
Array Biopharma Inc. |
Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
CN103848810A
(zh)
|
2012-11-30 |
2014-06-11 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
|
AU2014219855B2
(en)
|
2013-02-19 |
2017-09-28 |
Ono Pharmaceutical Co., Ltd. |
Trk-inhibiting compound
|
|
US9617282B2
(en)
|
2013-03-15 |
2017-04-11 |
Biogen Ma Inc. |
Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases
|
|
WO2014160521A1
(en)
|
2013-03-15 |
2014-10-02 |
Blueprint Medicines Corporation |
Piperazine derivatives and their use as kit modulators
|
|
EP2997030B1
(en)
|
2013-05-14 |
2017-08-09 |
Nerviano Medical Sciences S.R.L. |
Pyrrolo[2,3-d]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors
|
|
CN105228983A
(zh)
|
2013-05-30 |
2016-01-06 |
普莱希科公司 |
用于激酶调节的化合物及其适应症
|
|
TWI648272B
(zh)
|
2013-06-25 |
2019-01-21 |
美商必治妥美雅史谷比公司 |
經取代之四氫咔唑及咔唑甲醯胺化合物
|
|
WO2015002894A1
(en)
|
2013-07-02 |
2015-01-08 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
EP3027654B1
(en)
|
2013-07-30 |
2019-09-25 |
Blueprint Medicines Corporation |
Pik3c2g fusions
|
|
EP3628749A1
(en)
|
2013-07-30 |
2020-04-01 |
Blueprint Medicines Corporation |
Ntrk2 fusions
|
|
RS58361B1
(sr)
|
2013-07-31 |
2019-03-29 |
Merck Patent Gmbh |
Piridini, pirimidini i pirazini, kao inhibitori btk i njihova upotreba
|
|
KR101879422B1
(ko)
|
2013-09-18 |
2018-07-17 |
베이징 한미 파마슈티컬 컴퍼니 리미티드 |
Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물
|
|
KR102272792B1
(ko)
|
2013-09-30 |
2021-07-05 |
광저우 이노케어 파마 테크 씨오., 엘티디. |
Ｂｔｋ의 치환된 니코틴이미드 저해제 및 그의 제조 방법 및 암, 염증 및 자가면역 질환에의 용도
|
|
WO2015058129A1
(en)
|
2013-10-17 |
2015-04-23 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
SI3057969T1
(sl)
|
2013-10-17 |
2018-10-30 |
Blueprint Medicines Corporation |
Sestavki, uporabni za zdravljenje motenj, povezanih s KIT
|
|
RS63405B1
(sr)
|
2013-10-25 |
2022-08-31 |
Blueprint Medicines Corp |
Inhibitori receptora faktora rasta fibroblasta
|
|
EA201690746A1
(ru)
*
|
2013-10-25 |
2016-12-30 |
Фармасайкликс Элэлси |
Лечение с применением ингибиторов тирозинкиназы брутона и иммунотерапии
|
|
WO2015068856A1
(en)
|
2013-11-08 |
2015-05-14 |
Takeda Pharmaceutical Company Limited |
Pyrazole for the treatment autoimmune disorders
|
|
US9382246B2
(en)
|
2013-12-05 |
2016-07-05 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
AU2014362231B2
(en)
|
2013-12-11 |
2019-04-04 |
Biogen Ma Inc. |
Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
|
|
EP3079683A4
(en)
|
2013-12-13 |
2017-12-20 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
|
CA2932353A1
(en)
|
2013-12-13 |
2015-06-18 |
Steven P. Treon |
Methods to treat lymphoplasmacytic lymphoma
|
|
LT3466955T
(lt)
|
2014-01-13 |
2021-02-25 |
Aurigene Discovery Technologies Limited |
Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas
|
|
US9695165B2
(en)
|
2014-01-15 |
2017-07-04 |
Blueprint Medicines Corporation |
Inhibitors of the fibroblast growth factor receptor
|
|
ES2933350T3
(es)
|
2014-01-24 |
2023-02-06 |
Turning Point Therapeutics Inc |
Macrociclos de diarilo como moduladores de proteína quinasas
|
|
TWI672141B
(zh)
|
2014-02-20 |
2019-09-21 |
美商醫科泰生技 |
投予ｒｏｓ１突變癌細胞之分子
|
|
US20170044621A1
(en)
|
2014-04-18 |
2017-02-16 |
Blueprint Medicines Corporation |
Met fusions
|
|
WO2015161274A1
(en)
|
2014-04-18 |
2015-10-22 |
Blueprint Medicines Corporation |
Pik3ca fusions
|
|
MA40434B1
(fr)
|
2014-05-15 |
2019-09-30 |
Array Biopharma Inc |
1-((3s,4r)-4-(3-fluorophényl)-1-(2-méthoxyéthyl)pyrrolidin-3-yl)-3-(4-méthyl-3-(2-méthylpyrimidin-5-yl)-1-phényl-1h-pyrazol-5-yl)urée comme inhibiteur de la kinase trka
|
|
EP3155118A1
(en)
|
2014-06-10 |
2017-04-19 |
Blueprint Medicines Corporation |
Pkn1 fusions
|
|
WO2015191666A2
(en)
|
2014-06-10 |
2015-12-17 |
Blueprint Medicines Corporation |
Raf1 fusions
|
|
US9949971B2
(en)
|
2014-06-17 |
2018-04-24 |
Acerta Pharma B.V. |
Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor
|
|
US10370724B2
(en)
|
2014-07-17 |
2019-08-06 |
Blueprint Medicines Corporation |
PRKC fusions
|
|
US10370725B2
(en)
|
2014-07-17 |
2019-08-06 |
Blueprint Medicines Corporation |
FGR fusions
|
|
WO2016011144A1
(en)
|
2014-07-17 |
2016-01-21 |
Blueprint Medicines Corporation |
Tert fusions
|
|
US9688680B2
(en)
|
2014-08-04 |
2017-06-27 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
KR20170033358A
(ko)
|
2014-08-07 |
2017-03-24 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나아제 저해제의 신규한 제제
|
|
US10399959B2
(en)
|
2014-08-18 |
2019-09-03 |
Ono Pharmaceutical Co., Ltd. |
Acid-addition salt of Trk-inhibiting compound
|
|
US9969749B2
(en)
|
2014-09-30 |
2018-05-15 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
|
CN106922146B
(zh)
|
2014-10-02 |
2020-05-26 |
豪夫迈·罗氏有限公司 |
用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
|
|
PE20190710A1
(es)
|
2014-10-24 |
2019-05-17 |
Bristol Myers Squibb Co |
Compuestos de indol carboxamida utiles como inhibidores de cinasas
|
|
MX2017005060A
(es)
|
2014-10-24 |
2017-07-05 |
Bristol Myers Squibb Co |
Compuestos atropisomeros triciclicos.
|
|
KR102562866B1
(ko)
|
2014-11-14 |
2023-08-04 |
네르비아노 메디칼 사이언시스 에스.알.엘. |
단백질 키나아제 억제제로서의 6-아미노-7-바이사이클로-7-데아자-퓨린 유도체
|
|
CN113354649B
(zh)
|
2014-11-16 |
2024-12-10 |
阵列生物制药公司 |
一种新的晶型
|
|
EP3221700B1
(en)
|
2014-11-18 |
2022-06-22 |
Blueprint Medicines Corporation |
Prkacb fusions
|
|
WO2016106628A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
RU2730016C2
(ru)
|
2015-02-05 |
2020-08-14 |
Мерк Патент Гмбх |
Макроциклические соединения в качестве irak1/4 ингибиторов и их применение
|
|
US9717745B2
(en)
|
2015-03-19 |
2017-08-01 |
Zhejiang DTRM Biopharma Co. Ltd. |
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
|
|
WO2016161571A1
(en)
|
2015-04-08 |
2016-10-13 |
Merck Sharp & Dohme Corp. |
Indazole and azaindazole btk inhibitors
|
|
WO2016161570A1
(en)
|
2015-04-08 |
2016-10-13 |
Merck Sharp & Dohme Corp. |
Azacarbazole btk inhibitors
|
|
LT3286181T
(lt)
|
2015-04-22 |
2021-04-26 |
Rigel Pharmaceuticals, Inc. |
Pirazolo junginiai ir junginių gamybos bei naudojimo būdas
|
|
TW201701879A
(zh)
|
2015-04-30 |
2017-01-16 |
拜耳製藥公司 |
Ｉｒａｋ４抑制劑組合
|
|
CA3025813A1
(en)
|
2015-05-27 |
2016-12-01 |
Gb005, Inc. |
Inhibitors of the tec kinase enzyme family
|
|
UA124090C2
(uk)
|
2015-06-03 |
2021-07-21 |
Прінсіпіа Байофарма Інк. |
Інгібітори тирозинкінази
|
|
CN108602776B
(zh)
|
2015-09-18 |
2021-12-03 |
默克专利有限公司 |
用作irak抑制剂的杂芳基化合物及其用途
|
|
US20170035881A1
(en)
|
2015-10-19 |
2017-02-09 |
Acerta Pharma B.V. |
Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor
|
|
CN114716381B
(zh)
*
|
2015-12-16 |
2025-03-11 |
洛克索肿瘤学股份有限公司 |
可用作激酶抑制剂的化合物
|
|
LT3390390T
(lt)
|
2015-12-16 |
2021-11-25 |
Boehringer Ingelheim International Gmbh |
Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui
|
|
WO2017103661A1
(en)
|
2015-12-18 |
2017-06-22 |
Edel-For-Life Sa |
Quality control assay to monitor the completeness of pathogen or targeted cell inactivation treatments in biological, foodstuff, drinks and cosmetics products
|
|
WO2017134685A2
(en)
|
2016-02-02 |
2017-08-10 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazino compounds as btk inhibitors
|
|
WO2017205769A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
US10689400B2
(en)
|
2016-07-28 |
2020-06-23 |
Turning Point Therapeutics, Inc. |
Macrocycle kinase inhibitors
|
|
EP4011882B1
(en)
|
2016-08-15 |
2025-03-05 |
Purdue Research Foundation |
4-substituted aminoisoquinoline derivatives
|
|
CN109641892B
(zh)
|
2016-08-16 |
2021-07-02 |
默克专利有限公司 |
用作可逆btk抑制剂的2-氧代-咪唑并吡啶及其用途
|
|
CA2939286A1
(en)
|
2016-08-17 |
2018-02-17 |
Pharmascience Inc. |
Spirocyclic containing compounds and pharmaceutical uses thereof
|
|
TW201811795A
(zh)
|
2016-08-24 |
2018-04-01 |
美商亞闊股份有限公司 |
胺基－吡咯并嘧啶酮化合物及其用途
|
|
JP7201586B6
(ja)
|
2016-09-08 |
2024-02-08 |
サビラ バイオサイエンシズ エルエルシー |
神経保護作用、自己免疫性ならびに癌の疾患および病状において有用な１，２－ジチオラン化合物
|
|
KR102686957B1
(ko)
|
2016-11-08 |
2024-07-22 |
주식회사 대웅제약 |
신규한 피롤로피리미딘 유도체 및 이를 포함하는 약학적 조성물
|
|
JOP20190113A1
(ar)
|
2016-11-18 |
2019-05-15 |
Biocad Joint Stock Co |
مثبطات بروتون تيروزين كيناز
|
|
CN108101905A
(zh)
|
2016-11-24 |
2018-06-01 |
中国科学院上海药物研究所 |
嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
|
|
WO2018103060A1
(en)
|
2016-12-09 |
2018-06-14 |
Janssen Pharmaceutica Nv |
Inhibitors of bruton's tyrosine kinase and methods of their use
|
|
CN106831789A
(zh)
|
2016-12-21 |
2017-06-13 |
南京亘泰医药技术有限公司 |
布鲁顿酪氨酸激酶抑制剂
|
|
UY37559A
(es)
|
2017-01-06 |
2018-05-31 |
Pharmacyclics Llc |
Pirazolo[3,4-b]piridina y pirrolo[2,3-b]piridina como inhibidores de la tirosina quinasa de bruton
|
|
CN110621316B
(zh)
|
2017-04-21 |
2024-01-26 |
Epizyme股份有限公司 |
用ehmt2抑制剂进行的组合疗法
|
|
JP7142173B2
(ja)
|
2019-12-06 |
2022-09-26 |
ロクソ オンコロジー， インコーポレイテッド |
ブルトン型チロシンキナーゼ阻害剤の投薬
|
|
TW202317099A
(zh)
|
2020-09-10 |
2023-05-01 |
美商絡速藥業公司 |
用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體
|