JP2023519891A5 - - Google Patents
Info
- Publication number
- JP2023519891A5 JP2023519891A5 JP2022558424A JP2022558424A JP2023519891A5 JP 2023519891 A5 JP2023519891 A5 JP 2023519891A5 JP 2022558424 A JP2022558424 A JP 2022558424A JP 2022558424 A JP2022558424 A JP 2022558424A JP 2023519891 A5 JP2023519891 A5 JP 2023519891A5
- Authority
- JP
- Japan
- Prior art keywords
- approximately
- compound
- pharmaceutical composition
- crystalline form
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063000746P | 2020-03-27 | 2020-03-27 | |
| US63/000,746 | 2020-03-27 | ||
| US202063015241P | 2020-04-24 | 2020-04-24 | |
| US63/015,241 | 2020-04-24 | ||
| US202063018954P | 2020-05-01 | 2020-05-01 | |
| US63/018,954 | 2020-05-01 | ||
| US202063022301P | 2020-05-08 | 2020-05-08 | |
| US202063022298P | 2020-05-08 | 2020-05-08 | |
| US63/022,301 | 2020-05-08 | ||
| US63/022,298 | 2020-05-08 | ||
| US202063024160P | 2020-05-13 | 2020-05-13 | |
| US63/024,160 | 2020-05-13 | ||
| US202063053903P | 2020-07-20 | 2020-07-20 | |
| US63/053,903 | 2020-07-20 | ||
| US202063076689P | 2020-09-10 | 2020-09-10 | |
| US63/076,689 | 2020-09-10 | ||
| US202063126173P | 2020-12-16 | 2020-12-16 | |
| US63/126,173 | 2020-12-16 | ||
| US202063128523P | 2020-12-21 | 2020-12-21 | |
| US63/128,523 | 2020-12-21 | ||
| US202163136080P | 2021-01-11 | 2021-01-11 | |
| US63/136,080 | 2021-01-11 | ||
| US202163136967P | 2021-01-13 | 2021-01-13 | |
| US63/136,967 | 2021-01-13 | ||
| US202163138672P | 2021-01-18 | 2021-01-18 | |
| US63/138,672 | 2021-01-18 | ||
| US202163140116P | 2021-01-21 | 2021-01-21 | |
| US63/140,116 | 2021-01-21 | ||
| US202163149230P | 2021-02-13 | 2021-02-13 | |
| US63/149,230 | 2021-02-13 | ||
| PCT/US2021/024316 WO2021195475A1 (en) | 2020-03-27 | 2021-03-26 | Process, compositions, and crystalline forms of substituted pyridinone-pyridinyl compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023519891A JP2023519891A (ja) | 2023-05-15 |
| JP2023519891A5 true JP2023519891A5 (https=) | 2024-03-29 |
Family
ID=77890611
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558423A Pending JP2023519890A (ja) | 2020-03-27 | 2021-03-26 | 免疫状態の処置のためのmk2経路阻害剤の経口組成物 |
| JP2022558424A Pending JP2023519891A (ja) | 2020-03-27 | 2021-03-26 | 置換ピリジノン-ピリジニル化合物のプロセス、組成物、および結晶形態 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558423A Pending JP2023519890A (ja) | 2020-03-27 | 2021-03-26 | 免疫状態の処置のためのmk2経路阻害剤の経口組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20230149400A1 (https=) |
| EP (2) | EP4132524A4 (https=) |
| JP (2) | JP2023519890A (https=) |
| KR (2) | KR20220161396A (https=) |
| CN (4) | CN119235863A (https=) |
| AU (2) | AU2021244255A1 (https=) |
| BR (1) | BR112022019349A2 (https=) |
| CA (2) | CA3172088A1 (https=) |
| IL (1) | IL296054A (https=) |
| MX (2) | MX2022011748A (https=) |
| PH (2) | PH12022552321A1 (https=) |
| WO (3) | WO2021195507A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220161396A (ko) | 2020-03-27 | 2022-12-06 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 치환된 피리디논-피리디닐 화합물의 제조, 조성물, 및 결정형 |
| KR20230044446A (ko) * | 2020-07-24 | 2023-04-04 | 브리스톨-마이어스 스큅 컴퍼니 | 급성 호흡기 장애의 치료 방법 |
| EP4247380A4 (en) * | 2020-11-23 | 2025-03-05 | Aclaris Therapeutics, Inc. | PROCESSES FOR THE SYNTHESIS OF SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS |
| BR112023019861A2 (pt) | 2021-03-31 | 2023-11-07 | Xinthera Inc | Inibidores de mk2 e usos dos mesmos |
| EP4367099A4 (en) | 2021-07-09 | 2025-06-04 | Xinthera, Inc. | Pyridinone mk2 inhibitors and uses thereof |
| WO2023125708A1 (zh) * | 2021-12-29 | 2023-07-06 | 上海美悦生物科技发展有限公司 | 一种p38 MAPK/MK2通路调节剂及其组合物、制备方法和用途 |
| CN116396274B (zh) * | 2022-01-06 | 2025-11-11 | 深圳信立泰药业股份有限公司 | 一种取代的联吡啶酮类化合物及其制备方法与应用 |
| CN116444493A (zh) * | 2022-01-14 | 2023-07-18 | 上海翰森生物医药科技有限公司 | 含双并环类衍生物、其制备方法和应用 |
| WO2023150709A2 (en) * | 2022-02-04 | 2023-08-10 | Aclaris Therapeutics, Inc. | Methods of synthesizing deuterated substituted pyridinone-pyridinyl compounds |
| EP4593823A1 (en) * | 2022-09-30 | 2025-08-06 | Abbvie Inc. | Methods of treating hidradenitis suppurativa |
| TW202428271A (zh) * | 2022-11-16 | 2024-07-16 | 大陸商上海美悦生物科技發展有限公司 | 吡啶氮氧化物類衍生物及其藥物組合物、製備方法和用途 |
| KR20240078816A (ko) | 2022-11-28 | 2024-06-04 | 주식회사 엘지에너지솔루션 | 에이징 시스템 |
| EP4650347A1 (en) | 2023-01-13 | 2025-11-19 | Shanghai Meiyue Biotech Development Co., Ltd. | Phenyl-substituted heteroaryl compound and pharmaceutical composition comprising same, preparation method therefor and use thereof |
| JP2026504073A (ja) * | 2023-01-13 | 2026-02-03 | プールベグ ファーマ(ユーケー) リミテッド | がん免疫療法関連サイトカイン放出症候群の軽減のための医薬品および方法 |
| WO2025093869A1 (en) * | 2023-11-01 | 2025-05-08 | Poolbeg Pharma (UK) Limited | P38 map kinase inhibitor for use in the treatment of inflammation |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JP2002526482A (ja) | 1998-09-18 | 2002-08-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | p38のインヒビター |
| JP2003500403A (ja) | 1999-05-21 | 2003-01-07 | サイオス,インコーポレーテッド | p38キナーゼのインヒビターとしてのインドール型誘導体 |
| EP1248869A2 (en) * | 2000-01-07 | 2002-10-16 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| EP1341782A2 (en) | 2000-11-20 | 2003-09-10 | Scios Inc. | Inhibitors of p38 kinase |
| US7314752B2 (en) | 2001-07-19 | 2008-01-01 | Common Sense, Ltd. | Secretion-monitoring article |
| ATE448784T1 (de) | 2002-02-14 | 2009-12-15 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| US7304061B2 (en) | 2002-04-26 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic inhibitors of ERK2 and uses thereof |
| GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
| CA2498111A1 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
| US7183287B2 (en) | 2003-04-03 | 2007-02-27 | Pharmacia Corporation | Substituted pyrimidinones |
| US20070167621A1 (en) | 2003-04-03 | 2007-07-19 | Pharmacia Corporation | Substituted pyrimidinones |
| CL2004002050A1 (es) | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
| US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
| GB0402653D0 (en) * | 2004-02-06 | 2004-03-10 | Cyclacel Ltd | Compounds |
| JP2005255675A (ja) | 2004-02-09 | 2005-09-22 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| CN1976915A (zh) | 2004-02-11 | 2007-06-06 | 史密丝克莱恩比彻姆公司 | Hiv整合酶抑制剂 |
| US7936407B2 (en) | 2005-02-24 | 2011-05-03 | Samsung Electronics Co., Ltd. | Array substrate, method of manufacturing the same, display panel having the same, and liquid crystal display apparatus having the same |
| BRPI0607913A2 (pt) | 2005-04-08 | 2010-03-23 | Eisai R&D Man Co Ltd | agente terapÊutico para discinesia |
| TW200740755A (en) | 2005-07-13 | 2007-11-01 | Bayer Cropscience Sa | Dihalogenation of N,O-disubstituted hydroxypyridones and their uses |
| WO2007081901A2 (en) | 2006-01-05 | 2007-07-19 | The Scripps Research Institute | Pyrimidinone derivatives as protein kinase inhibitors |
| UY30378A1 (es) | 2006-06-02 | 2008-01-02 | Janssen Pharmaceutica Nv | Nuevos derivados de piridinona n-aril y n-heteroaril sustituidos para usar en enfermedades mediadas por mch-1 |
| ES2426780T3 (es) | 2006-07-14 | 2013-10-25 | Amgen Inc. | Compuestos de piridona sustituidos con alquino y métodos de uso |
| KR20090085117A (ko) | 2006-11-24 | 2009-08-06 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로모노시클릭 화합물 및 이의 용도 |
| BRPI0720049A2 (pt) | 2006-12-07 | 2014-01-07 | Novartis Ag | Derivados de piridina utilizados como inibidores de xiap |
| US20110130403A1 (en) * | 2007-03-14 | 2011-06-02 | Ranbaxy Laboratories Limited | Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors |
| WO2008153942A1 (en) | 2007-06-06 | 2008-12-18 | Xcovery, Inc. | Kinase inhibitor compounds |
| EA016595B1 (ru) | 2007-07-17 | 2012-06-29 | Бристол-Маерс Сквибб Компани | Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения |
| US9187426B2 (en) | 2008-06-27 | 2015-11-17 | Novartis Ag | Organic compounds |
| EP2334673A1 (en) * | 2008-08-29 | 2011-06-22 | Amgen Inc. | PYRIDO[3,2-d]PYRIDAZINE-2(1H)-ONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF |
| JP5466759B2 (ja) | 2009-05-28 | 2014-04-09 | ノバルティス アーゲー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
| US8618299B2 (en) | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
| US9073925B2 (en) | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| AU2010302420B2 (en) * | 2009-10-02 | 2013-07-04 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| SI2648516T1 (sl) | 2010-12-06 | 2019-01-31 | Aclaris Therapeutics, Inc. | Substituirane spojine piridinon-piridinila |
| US9056110B2 (en) | 2011-12-06 | 2015-06-16 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
| HUE054178T2 (hu) * | 2013-06-07 | 2021-08-30 | Aclaris Therapeutics Inc | Metil/fluor-piridinil-metoxi-szubsztituált piridinon-piridinil-vegyületek és fluor-pirimidinil-metoxi-szubsztituált piridinon-piridinil-vegyületek |
| WO2015161908A1 (en) * | 2014-03-11 | 2015-10-29 | Ludwig-Maximilians-Universität München | Non-immunosuppressive cyclophilin inhibitors for the treatment of coronavirus infections |
| WO2017048702A1 (en) * | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| EP3720436A4 (en) | 2017-12-06 | 2021-06-02 | Lin Bioscience, Pty Ltd. | TUBULIN INHIBITORS |
| JP2022542434A (ja) | 2019-07-31 | 2022-10-03 | アクラリス セラピューティクス,インコーポレイテッド | 重水素化mk2経路阻害剤およびその使用方法 |
| US20230087078A1 (en) | 2020-03-02 | 2023-03-23 | Washington University | Compositions and methods for the treatment of pancreatic cancer |
| KR20220161396A (ko) | 2020-03-27 | 2022-12-06 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 치환된 피리디논-피리디닐 화합물의 제조, 조성물, 및 결정형 |
-
2021
- 2021-03-26 KR KR1020227037292A patent/KR20220161396A/ko not_active Withdrawn
- 2021-03-26 JP JP2022558423A patent/JP2023519890A/ja active Pending
- 2021-03-26 CN CN202411432060.0A patent/CN119235863A/zh active Pending
- 2021-03-26 IL IL296054A patent/IL296054A/en unknown
- 2021-03-26 PH PH1/2022/552321A patent/PH12022552321A1/en unknown
- 2021-03-26 PH PH1/2022/552263A patent/PH12022552263A1/en unknown
- 2021-03-26 JP JP2022558424A patent/JP2023519891A/ja active Pending
- 2021-03-26 BR BR112022019349A patent/BR112022019349A2/pt not_active Application Discontinuation
- 2021-03-26 AU AU2021244255A patent/AU2021244255A1/en not_active Abandoned
- 2021-03-26 CN CN202411390540.5A patent/CN119454711A/zh active Pending
- 2021-03-26 WO PCT/US2021/024376 patent/WO2021195507A1/en not_active Ceased
- 2021-03-26 US US17/907,516 patent/US20230149400A1/en active Pending
- 2021-03-26 CA CA3172088A patent/CA3172088A1/en active Pending
- 2021-03-26 EP EP21776610.4A patent/EP4132524A4/en not_active Withdrawn
- 2021-03-26 CA CA3172203A patent/CA3172203A1/en active Pending
- 2021-03-26 KR KR1020227037183A patent/KR20220161390A/ko not_active Withdrawn
- 2021-03-26 MX MX2022011748A patent/MX2022011748A/es unknown
- 2021-03-26 MX MX2022011755A patent/MX2022011755A/es unknown
- 2021-03-26 CN CN202180037711.4A patent/CN115666566A/zh active Pending
- 2021-03-26 WO PCT/US2021/024316 patent/WO2021195475A1/en not_active Ceased
- 2021-03-26 US US17/214,532 patent/US11844801B2/en active Active
- 2021-03-26 WO PCT/US2021/024482 patent/WO2021195562A1/en not_active Ceased
- 2021-03-26 EP EP21775856.4A patent/EP4125891A4/en not_active Withdrawn
- 2021-03-26 CN CN202180032410.2A patent/CN115484952B/zh not_active Expired - Fee Related
- 2021-03-26 AU AU2021244609A patent/AU2021244609A1/en not_active Abandoned
-
2023
- 2023-11-08 US US18/504,778 patent/US12370195B2/en active Active
-
2025
- 2025-06-25 US US19/249,611 patent/US20250387393A1/en active Pending
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