JP2023519890A - 免疫状態の処置のためのｍｋ２経路阻害剤の経口組成物 - Google Patents

免疫状態の処置のためのｍｋ２経路阻害剤の経口組成物 Download PDF

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JP2023519890A
JP2023519890A JP2022558423A JP2022558423A JP2023519890A JP 2023519890 A JP2023519890 A JP 2023519890A JP 2022558423 A JP2022558423 A JP 2022558423A JP 2022558423 A JP2022558423 A JP 2022558423A JP 2023519890 A JP2023519890 A JP 2023519890A
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ウォルター スミス
ジョセフ モナハン
エドワード ヘルリーゲル
デヴィッド ゴードン
ハイディ ホープ
ジョン ロバート スプリンガー
ゲイリー エイ デクレシェンツォ
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アクラリス セラピューティクス，インコーポレイテッド
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2022558423A 2020-03-27 2021-03-26 免疫状態の処置のためのｍｋ２経路阻害剤の経口組成物 Pending JP2023519890A (ja)

Applications Claiming Priority (31)

Application Number Priority Date Filing Date Title
US202063000746P 2020-03-27 2020-03-27
US63/000,746 2020-03-27
US202063015241P 2020-04-24 2020-04-24
US63/015,241 2020-04-24
US202063018954P 2020-05-01 2020-05-01
US63/018,954 2020-05-01
US202063022301P 2020-05-08 2020-05-08
US202063022298P 2020-05-08 2020-05-08
US63/022,301 2020-05-08
US63/022,298 2020-05-08
US202063024160P 2020-05-13 2020-05-13
US63/024,160 2020-05-13
US202063053903P 2020-07-20 2020-07-20
US63/053,903 2020-07-20
US202063076689P 2020-09-10 2020-09-10
US63/076,689 2020-09-10
US202063126173P 2020-12-16 2020-12-16
US63/126,173 2020-12-16
US202063128523P 2020-12-21 2020-12-21
US63/128,523 2020-12-21
US202163136080P 2021-01-11 2021-01-11
US63/136,080 2021-01-11
US202163136967P 2021-01-13 2021-01-13
US63/136,967 2021-01-13
US202163138672P 2021-01-18 2021-01-18
US63/138,672 2021-01-18
US202163140116P 2021-01-21 2021-01-21
US63/140,116 2021-01-21
US202163149230P 2021-02-13 2021-02-13
US63/149,230 2021-02-13
PCT/US2021/024482 WO2021195562A1 (en) 2020-03-27 2021-03-26 Oral compositions of mk2 pathway inhibitor for treatment of immune conditions

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JP2023519890A true JP2023519890A (ja) 2023-05-15
JP2023519890A5 JP2023519890A5 (https=) 2024-04-04

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JP2022558423A Pending JP2023519890A (ja) 2020-03-27 2021-03-26 免疫状態の処置のためのｍｋ２経路阻害剤の経口組成物
JP2022558424A Pending JP2023519891A (ja) 2020-03-27 2021-03-26 置換ピリジノン－ピリジニル化合物のプロセス、組成物、および結晶形態

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JP2022558424A Pending JP2023519891A (ja) 2020-03-27 2021-03-26 置換ピリジノン－ピリジニル化合物のプロセス、組成物、および結晶形態

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US (4) US20230149400A1 (https=)
EP (2) EP4132524A4 (https=)
JP (2) JP2023519890A (https=)
KR (2) KR20220161396A (https=)
CN (4) CN119235863A (https=)
AU (2) AU2021244255A1 (https=)
BR (1) BR112022019349A2 (https=)
CA (2) CA3172088A1 (https=)
IL (1) IL296054A (https=)
MX (2) MX2022011748A (https=)
PH (2) PH12022552321A1 (https=)
WO (3) WO2021195507A1 (https=)

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