JPWO2021033729A5 - - Google Patents
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- JPWO2021033729A5 JPWO2021033729A5 JP2021540972A JP2021540972A JPWO2021033729A5 JP WO2021033729 A5 JPWO2021033729 A5 JP WO2021033729A5 JP 2021540972 A JP2021540972 A JP 2021540972A JP 2021540972 A JP2021540972 A JP 2021540972A JP WO2021033729 A5 JPWO2021033729 A5 JP WO2021033729A5
- Authority
- JP
- Japan
- Prior art keywords
- diffraction
- crystal
- powder
- peak
- crystal according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013078 crystal Substances 0.000 claims 31
- 238000000634 powder X-ray diffraction Methods 0.000 claims 17
- 238000001228 spectrum Methods 0.000 claims 16
- 238000000113 differential scanning calorimetry Methods 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 9
- 102100029802 Sphingosine 1-phosphate receptor 5 Human genes 0.000 claims 4
- 101710155451 Sphingosine 1-phosphate receptor 5 Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- XKYTZMBQIKKIIW-ZDUSSCGKSA-N 1-[[(3S)-3-methyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid Chemical compound C[C@H]1Cc2cc(OCCCC(F)(F)F)ccc2C=C1CN1CC(C1)C(O)=O XKYTZMBQIKKIIW-ZDUSSCGKSA-N 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940035637 spectrum-4 Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962889091P | 2019-08-20 | 2019-08-20 | |
| US62/889,091 | 2019-08-20 | ||
| PCT/JP2020/031326 WO2021033729A1 (ja) | 2019-08-20 | 2020-08-19 | Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021033729A1 JPWO2021033729A1 (https=) | 2021-02-25 |
| JPWO2021033729A5 true JPWO2021033729A5 (https=) | 2022-09-14 |
| JP7409383B2 JP7409383B2 (ja) | 2024-01-09 |
Family
ID=74660224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021540972A Active JP7409383B2 (ja) | 2019-08-20 | 2020-08-19 | Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US12459890B2 (https=) |
| EP (1) | EP4019496B1 (https=) |
| JP (1) | JP7409383B2 (https=) |
| KR (1) | KR102930707B1 (https=) |
| CN (1) | CN114302873A (https=) |
| AU (1) | AU2020334489C1 (https=) |
| BR (1) | BR112022002632A2 (https=) |
| CA (1) | CA3150303A1 (https=) |
| ES (1) | ES2983098T3 (https=) |
| IL (1) | IL290432A (https=) |
| MX (1) | MX2022001820A (https=) |
| MY (1) | MY207001A (https=) |
| PH (1) | PH12022550319A1 (https=) |
| TW (1) | TWI859303B (https=) |
| WO (1) | WO2021033729A1 (https=) |
| ZA (1) | ZA202201784B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE068382T2 (hu) * | 2018-02-22 | 2024-12-28 | Ono Pharmaceutical Co | SIP5-receptor-agonista aktivitással rendelkezõ 1[[(3S)-3-metil-6-(4(4,4-trifluorbutoxi)-3,4-dihidronaftalen-2-il]metil]azetidin-3-karbonsav neurodegeneratív rendellenességek és rák kezelésére |
| US11919879B2 (en) | 2021-06-16 | 2024-03-05 | Celgene Corporation | Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases |
| KR20250114133A (ko) * | 2022-12-16 | 2025-07-28 | 셀진 코포레이션 | S1p5의 조정제로서의 헤테로시클릭 화합물 |
| WO2025119254A1 (en) | 2023-12-06 | 2025-06-12 | Ono Pharmaceutical Co., Ltd. | Method for preparing dihydronaphthalene derivative |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| GB8725118D0 (en) * | 1987-10-27 | 1987-12-02 | Ciba Geigy Ag | Rifamycin derivatives |
| JP2005020882A (ja) | 2003-06-25 | 2005-01-20 | Matsushita Electric Works Ltd | モータアクチュエータ装置 |
| CN1874991A (zh) | 2003-08-29 | 2006-12-06 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
| EP1661881B1 (en) | 2003-08-29 | 2014-12-17 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding s1p receptor and pharmaceutical use thereof |
| JP2006064757A (ja) | 2004-08-24 | 2006-03-09 | Systec Kyowa:Kk | ディスプレイ固定用スタンド |
| EP2592066B1 (en) | 2004-12-13 | 2014-12-03 | Ono Pharmaceutical Co., Ltd. | Aminocarboxylic acid derivative and medical use thereof |
| AU2007212193A1 (en) | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
| EP2086930A2 (en) * | 2006-06-12 | 2009-08-12 | Novartis AG | Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide |
| UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
| UA113507C2 (xx) | 2011-02-07 | 2017-02-10 | Модулятори s1p | |
| ES2852724T3 (es) | 2014-12-04 | 2021-09-14 | Ono Pharmaceutical Co | Derivados de dihidronaftaleno útiles en el tratamiento de enfermedades mediadas por S1P5 |
| ES2975689T3 (es) | 2016-01-29 | 2024-07-11 | Ono Pharmaceutical Co | Derivado de tetrahidronaftaleno |
| HUE068382T2 (hu) * | 2018-02-22 | 2024-12-28 | Ono Pharmaceutical Co | SIP5-receptor-agonista aktivitással rendelkezõ 1[[(3S)-3-metil-6-(4(4,4-trifluorbutoxi)-3,4-dihidronaftalen-2-il]metil]azetidin-3-karbonsav neurodegeneratív rendellenességek és rák kezelésére |
| TW202114983A (zh) * | 2019-08-20 | 2021-04-16 | 日商小野藥品工業股份有限公司 | Ｓ１ｐ媒介疾病的預防及／或治療劑 |
-
2020
- 2020-08-19 CN CN202080056980.0A patent/CN114302873A/zh active Pending
- 2020-08-19 PH PH1/2022/550319A patent/PH12022550319A1/en unknown
- 2020-08-19 MY MYPI2022000691A patent/MY207001A/en unknown
- 2020-08-19 BR BR112022002632A patent/BR112022002632A2/pt unknown
- 2020-08-19 TW TW109128245A patent/TWI859303B/zh active
- 2020-08-19 AU AU2020334489A patent/AU2020334489C1/en active Active
- 2020-08-19 JP JP2021540972A patent/JP7409383B2/ja active Active
- 2020-08-19 EP EP20854718.2A patent/EP4019496B1/en active Active
- 2020-08-19 KR KR1020227004458A patent/KR102930707B1/ko active Active
- 2020-08-19 CA CA3150303A patent/CA3150303A1/en active Pending
- 2020-08-19 ES ES20854718T patent/ES2983098T3/es active Active
- 2020-08-19 WO PCT/JP2020/031326 patent/WO2021033729A1/ja not_active Ceased
- 2020-08-19 MX MX2022001820A patent/MX2022001820A/es unknown
- 2020-08-19 US US17/634,505 patent/US12459890B2/en active Active
-
2022
- 2022-02-08 IL IL290432A patent/IL290432A/en unknown
- 2022-02-10 ZA ZA2022/01784A patent/ZA202201784B/en unknown
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