JPWO2021033729A5 - - Google Patents
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- JPWO2021033729A5 JPWO2021033729A5 JP2021540972A JP2021540972A JPWO2021033729A5 JP WO2021033729 A5 JPWO2021033729 A5 JP WO2021033729A5 JP 2021540972 A JP2021540972 A JP 2021540972A JP 2021540972 A JP2021540972 A JP 2021540972A JP WO2021033729 A5 JPWO2021033729 A5 JP WO2021033729A5
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- JP
- Japan
- Prior art keywords
- diffraction
- crystal
- powder
- peak
- crystal according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013078 crystal Substances 0.000 claims 31
- 238000000634 powder X-ray diffraction Methods 0.000 claims 17
- 238000001228 spectrum Methods 0.000 claims 16
- 238000000113 differential scanning calorimetry Methods 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 9
- 102100029802 Sphingosine 1-phosphate receptor 5 Human genes 0.000 claims 4
- 101710155451 Sphingosine 1-phosphate receptor 5 Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- XKYTZMBQIKKIIW-ZDUSSCGKSA-N 1-[[(3S)-3-methyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid Chemical compound C[C@H]1Cc2cc(OCCCC(F)(F)F)ccc2C=C1CN1CC(C1)C(O)=O XKYTZMBQIKKIIW-ZDUSSCGKSA-N 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940035637 spectrum-4 Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962889091P | 2019-08-20 | 2019-08-20 | |
| US62/889,091 | 2019-08-20 | ||
| PCT/JP2020/031326 WO2021033729A1 (ja) | 2019-08-20 | 2020-08-19 | Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021033729A1 JPWO2021033729A1 (https=) | 2021-02-25 |
| JPWO2021033729A5 true JPWO2021033729A5 (https=) | 2022-09-14 |
| JP7409383B2 JP7409383B2 (ja) | 2024-01-09 |
Family
ID=74660224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021540972A Active JP7409383B2 (ja) | 2019-08-20 | 2020-08-19 | Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12459890B2 (https=) |
| EP (1) | EP4019496B1 (https=) |
| JP (1) | JP7409383B2 (https=) |
| KR (1) | KR102930707B1 (https=) |
| CN (1) | CN114302873A (https=) |
| BR (1) | BR112022002632A2 (https=) |
| CA (1) | CA3150303A1 (https=) |
| ES (1) | ES2983098T3 (https=) |
| IL (1) | IL290432A (https=) |
| MX (1) | MX2022001820A (https=) |
| MY (1) | MY207001A (https=) |
| PH (1) | PH12022550319A1 (https=) |
| TW (1) | TWI859303B (https=) |
| WO (1) | WO2021033729A1 (https=) |
| ZA (1) | ZA202201784B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3757091T (pt) * | 2018-02-22 | 2024-09-11 | Ono Pharmaceutical Co | Ácido 1-[[(3s)-3-metil-6-(4,4,4-trifluorobutoxi)-3,4-di-hidronaftalen-2-il]metil]azetidino-3-carboxílico com atividade agonista do recetor s1p5 para o tratamento de doenças neurodegenerativas e cancro |
| AU2022291768A1 (en) | 2021-06-16 | 2023-11-30 | Celgene Corporation | Azetidinyl compounds comprising a carboxylic acid group for the treatment of neurodegenerative diseases |
| EP4633736A1 (en) * | 2022-12-16 | 2025-10-22 | Celgene Corporation | Heterocyclic compounds as modulators of s1p5 |
| WO2025119254A1 (en) * | 2023-12-06 | 2025-06-12 | Ono Pharmaceutical Co., Ltd. | Method for preparing dihydronaphthalene derivative |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| GB8725118D0 (en) * | 1987-10-27 | 1987-12-02 | Ciba Geigy Ag | Rifamycin derivatives |
| JP2005020882A (ja) | 2003-06-25 | 2005-01-20 | Matsushita Electric Works Ltd | モータアクチュエータ装置 |
| US7825109B2 (en) | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
| KR20110140139A (ko) | 2003-08-29 | 2011-12-30 | 오노 야꾸힝 고교 가부시키가이샤 | Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도 |
| JP2006064757A (ja) | 2004-08-24 | 2006-03-09 | Systec Kyowa:Kk | ディスプレイ固定用スタンド |
| BRPI0519012A2 (pt) * | 2004-12-13 | 2008-12-23 | Ono Pharmaceutical Co | derivado do Ácido aminocarboxÍlico e seu uso medicinal |
| JP2009526073A (ja) | 2006-02-09 | 2009-07-16 | ユニバーシティ オブ バージニア パテント ファンデーション | 二環式スフィンゴシン−１−リン酸受容体アナログ |
| ME00529B (me) * | 2006-06-12 | 2011-10-10 | Novartis Ag | Polimorfi n-hidroksi-3-[4-[[[2-(-metil-1h-indol-3-il)etil]amino]fenil]-2e-2-propenamida |
| UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
| EA034451B1 (ru) | 2011-02-07 | 2020-02-10 | Байоджен Ма Инк. | Модуляторы s1p |
| EP3228615B1 (en) * | 2014-12-04 | 2021-01-20 | ONO Pharmaceutical Co., Ltd. | Dihydronaphthalene derivatives useful in the treatment of s1p5-mediated diseases |
| EP3409658B9 (en) | 2016-01-29 | 2024-07-17 | ONO Pharmaceutical Co., Ltd. | Tetrahydronaphthalene derivative |
| PT3757091T (pt) * | 2018-02-22 | 2024-09-11 | Ono Pharmaceutical Co | Ácido 1-[[(3s)-3-metil-6-(4,4,4-trifluorobutoxi)-3,4-di-hidronaftalen-2-il]metil]azetidino-3-carboxílico com atividade agonista do recetor s1p5 para o tratamento de doenças neurodegenerativas e cancro |
| TW202114983A (zh) * | 2019-08-20 | 2021-04-16 | 日商小野藥品工業股份有限公司 | Ｓ１ｐ媒介疾病的預防及／或治療劑 |
-
2020
- 2020-08-19 MX MX2022001820A patent/MX2022001820A/es unknown
- 2020-08-19 US US17/634,505 patent/US12459890B2/en active Active
- 2020-08-19 BR BR112022002632A patent/BR112022002632A2/pt unknown
- 2020-08-19 EP EP20854718.2A patent/EP4019496B1/en active Active
- 2020-08-19 PH PH1/2022/550319A patent/PH12022550319A1/en unknown
- 2020-08-19 CN CN202080056980.0A patent/CN114302873A/zh active Pending
- 2020-08-19 JP JP2021540972A patent/JP7409383B2/ja active Active
- 2020-08-19 TW TW109128245A patent/TWI859303B/zh active
- 2020-08-19 ES ES20854718T patent/ES2983098T3/es active Active
- 2020-08-19 KR KR1020227004458A patent/KR102930707B1/ko active Active
- 2020-08-19 MY MYPI2022000691A patent/MY207001A/en unknown
- 2020-08-19 CA CA3150303A patent/CA3150303A1/en active Pending
- 2020-08-19 WO PCT/JP2020/031326 patent/WO2021033729A1/ja not_active Ceased
-
2022
- 2022-02-08 IL IL290432A patent/IL290432A/en unknown
- 2022-02-10 ZA ZA2022/01784A patent/ZA202201784B/en unknown
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