JP2023036708A5 - - Google Patents
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- Publication number
- JP2023036708A5 JP2023036708A5 JP2022199092A JP2022199092A JP2023036708A5 JP 2023036708 A5 JP2023036708 A5 JP 2023036708A5 JP 2022199092 A JP2022199092 A JP 2022199092A JP 2022199092 A JP2022199092 A JP 2022199092A JP 2023036708 A5 JP2023036708 A5 JP 2023036708A5
- Authority
- JP
- Japan
- Prior art keywords
- citrate
- crystals
- crystal
- degrees
- peaks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013078 crystal Substances 0.000 claims 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 17
- 238000000634 powder X-ray diffraction Methods 0.000 claims 9
- 230000001747 exhibiting effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000001860 citric acid derivatives Chemical class 0.000 claims 2
- 238000000113 differential scanning calorimetry Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000001757 thermogravimetry curve Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024174009A JP2025020120A (ja) | 2018-08-31 | 2024-10-03 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862725805P | 2018-08-31 | 2018-08-31 | |
| US62/725,805 | 2018-08-31 | ||
| US16/517,369 | 2019-07-19 | ||
| US16/517,369 US10562930B1 (en) | 2018-08-31 | 2019-07-19 | Salts and crystal forms of GABAA positive allosteric modulator |
| PCT/US2019/049103 WO2020047434A1 (en) | 2018-08-31 | 2019-08-30 | Salts and crystal forms of gabaa positive allosteric modulator |
| JP2020517339A JP7199739B2 (ja) | 2018-08-31 | 2019-08-30 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517339A Division JP7199739B2 (ja) | 2018-08-31 | 2019-08-30 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024174009A Division JP2025020120A (ja) | 2018-08-31 | 2024-10-03 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023036708A JP2023036708A (ja) | 2023-03-14 |
| JP2023036708A5 true JP2023036708A5 (https=) | 2023-06-15 |
Family
ID=69528249
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517339A Active JP7199739B2 (ja) | 2018-08-31 | 2019-08-30 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
| JP2022199092A Pending JP2023036708A (ja) | 2018-08-31 | 2022-12-14 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
| JP2024174009A Pending JP2025020120A (ja) | 2018-08-31 | 2024-10-03 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517339A Active JP7199739B2 (ja) | 2018-08-31 | 2019-08-30 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024174009A Pending JP2025020120A (ja) | 2018-08-31 | 2024-10-03 | Ｇａｂａａの正のアロステリックモジュレーターの塩及び結晶形態 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10562930B1 (https=) |
| EP (2) | EP3710465B1 (https=) |
| JP (3) | JP7199739B2 (https=) |
| KR (1) | KR102845326B1 (https=) |
| CN (1) | CN113473991B (https=) |
| AU (1) | AU2019333310B8 (https=) |
| BR (1) | BR112021003727A2 (https=) |
| CA (1) | CA3111193A1 (https=) |
| IL (1) | IL281143B2 (https=) |
| MA (1) | MA50921A (https=) |
| MX (1) | MX2021002382A (https=) |
| TW (2) | TWI823999B (https=) |
| WO (1) | WO2020047434A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117024501A (zh) * | 2014-10-16 | 2023-11-10 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| US10562930B1 (en) | 2018-08-31 | 2020-02-18 | Praxis Precision Medicines, Inc. | Salts and crystal forms of GABAA positive allosteric modulator |
| MX2021006985A (es) * | 2018-12-14 | 2021-09-08 | Praxis Prec Medicines Inc | Metodos para el tratamiento de la depresión. |
| EP4125921A1 (en) | 2020-03-25 | 2023-02-08 | Sage Therapeutics, Inc. | Use of agents for treatment of respiratory conditions |
| WO2022006541A1 (en) * | 2020-07-02 | 2022-01-06 | Praxis Precision Medicines, Inc. | Methods for the treatment of adjustment disorder |
| EP4294819A4 (en) | 2021-02-18 | 2024-12-18 | Praxis Precision Medicines, Inc. | GABA-A POSITIVE ALLOSTERIC MODULATOR HEMI-CITRATE SALTS AND CORRESPONDING CRYSTALLINE FORM |
| WO2022177718A1 (en) | 2021-02-18 | 2022-08-25 | Sage Therapeutics, Inc. | Use of neuroactive steroid for treatment of sexual dysfunction |
| WO2022231309A1 (ko) | 2021-04-27 | 2022-11-03 | 경북대학교 산학협력단 | 저분자 콜라겐을 유효성분으로 포함하는 근감소증의 예방 또는 개선용 식품 조성물 및 약학적 조성물 |
| WO2023159035A1 (en) | 2022-02-16 | 2023-08-24 | Sage Therapeutics, Inc. | Neuroactive steroids for treatment of cns-related disorders |
| WO2023164386A1 (en) * | 2022-02-28 | 2023-08-31 | Sage Therapeutics, Inc. | Neuroactive steroids for treatment of gastrointestinal diseases or conditions |
| EP4514357A4 (en) * | 2022-04-26 | 2026-04-29 | Praxis Prec Medicines Inc | METHODS OF TREATING NEUROLOGICAL DISORDERS |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69435286D1 (de) * | 1993-05-24 | 2010-05-20 | Purdue Pharma Ltd | Verfahren und zusammensetzungen zum hervorrufen von schlaf |
| US5939545A (en) | 1994-02-14 | 1999-08-17 | Cocensys, Inc. | Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series |
| ATE284895T1 (de) * | 1995-06-06 | 2005-01-15 | Euro Celtique Sa | Neuroaktive steroide der androstan- und pregnanreihe |
| US6780853B1 (en) | 1995-06-06 | 2004-08-24 | Euro-Celtique S.A. | Neuroactive steroids of the androstane and pregnane series |
| WO1998005337A1 (en) | 1996-08-01 | 1998-02-12 | Cocensys, Inc. | Use of gaba and nmda receptor ligands for the treatment of migraine headache |
| UA73736C2 (en) * | 1999-04-29 | 2005-09-15 | Euro Celtic S A | Method for alleviating or preventing insomnia and inducing anesthesia |
| CN1688288A (zh) * | 2002-08-05 | 2005-10-26 | 巴克斯特国际公司 | 具有多晶型控制的亚微米粒度颗粒的制备和新多晶型伊曲康唑 |
| WO2004072079A1 (en) | 2003-02-11 | 2004-08-26 | Pfizer Limited | Hydrated and anhydrous sildenafil hemi-citrate compound |
| WO2005007600A2 (en) | 2003-07-11 | 2005-01-27 | Eisai Co., Ltd. | Novel methods using aminobenzoic acid compounds |
| AU2004265101B2 (en) | 2003-08-14 | 2009-06-11 | F. Hoffmann-La Roche Ag | Gabanergic modulators |
| WO2005105822A2 (en) | 2004-04-23 | 2005-11-10 | Euro-Celtique S.A. | 3-alpha-hydroxy 21-n- heteroaryl-pregnane derivatives for modulation of brain excitability and a process for the production thereof |
| US20060074059A1 (en) | 2004-08-26 | 2006-04-06 | Goliber Philip A | Isomorphic crystalline habits of 3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha-pregnane-20-one |
| ATE538797T1 (de) * | 2005-06-09 | 2012-01-15 | Euro Celtique Sa | Pharmazeutische zusammensetzungen mit neuroaktivem steroid und verwendungen davon |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| AU2007229866A1 (en) | 2006-03-22 | 2007-10-04 | Mount Sinai School Of Medicine | Intranasal administration of ketamine to treat depression |
| US20090074677A1 (en) | 2007-01-08 | 2009-03-19 | Duke University | Neuroactive steroid compositions and methods of use therefor |
| MX2011011156A (es) * | 2009-04-23 | 2011-11-04 | Theravance Inc | COMPUESTOS DIAMIDA QUE TIENE ACTIVIDAD COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS Y COMO AGONISTAS DE LOS RECEPTORES ANDRENERGICOS ß2. |
| CA2789654A1 (en) * | 2010-02-24 | 2011-09-01 | Ramot At Tel-Aviv University Ltd. | Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same |
| US20130252924A1 (en) * | 2010-11-11 | 2013-09-26 | Akron Molecules Gmbh | Compounds and Methods for Treating Pain |
| US20140315992A1 (en) | 2011-07-07 | 2014-10-23 | The Children's Hospital Of Philadelphia | Genetic Alterations Associated with Autism and the Autistic Phenotype and Methods of Use Thereof for the Diagnosis and Treatment of Autism |
| HRP20180487T1 (hr) | 2013-07-24 | 2018-05-04 | Commissariat à l'énergie atomique et aux énergies alternatives | Upotreba flekainida kao anti-koneksinskog sredstva i metoda za potenciranje učinaka psihotropnog lijeka |
| WO2016015653A1 (zh) * | 2014-08-01 | 2016-02-04 | 江苏豪森药业股份有限公司 | C-Met抑制剂结晶型游离碱或其结晶型酸式盐及其制备方法和应用 |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| CN117024501A (zh) | 2014-10-16 | 2023-11-10 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| US10391105B2 (en) | 2016-09-09 | 2019-08-27 | Marinus Pharmaceuticals Inc. | Methods of treating certain depressive disorders and delirium tremens |
| US10420773B2 (en) | 2017-09-26 | 2019-09-24 | Ovid Therapeutics Inc. | Methods of treating developmental disorders and/or seizure disorders with etifoxine |
| MY204493A (en) | 2017-11-10 | 2024-08-30 | Marinus Pharmaceuticals Inc | Ganaxolone for use in treating genetic epileptic disorders |
| US10562930B1 (en) | 2018-08-31 | 2020-02-18 | Praxis Precision Medicines, Inc. | Salts and crystal forms of GABAA positive allosteric modulator |
| MX2021006985A (es) | 2018-12-14 | 2021-09-08 | Praxis Prec Medicines Inc | Metodos para el tratamiento de la depresión. |
| MX2021007142A (es) | 2018-12-17 | 2021-08-11 | Intra Cellular Therapies Inc | Compuestos organicos. |
| US20220125803A1 (en) | 2019-03-04 | 2022-04-28 | Praxis Precision Medicines, Inc. | Methods for the treatment of perimenopause and menopause |
| WO2020185710A1 (en) | 2019-03-08 | 2020-09-17 | Alairion, Inc. | Method for treating sleep fragmentation disorders using neurosteroid positive allosteric modulators of the gabaa receptor |
| US20220265666A1 (en) | 2019-08-02 | 2022-08-25 | Praxis Precision Medicines, Inc. | Methods of treating substance abuse disorder, dyspnea, tinnitus, and child and adolescent depression |
| JP2022552808A (ja) | 2019-10-02 | 2022-12-20 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | Ｇａｂａ－ａ受容体陽性アロステリック調節因子と、ｎｍｄａ拮抗薬、ｎｍｄａ陰性アロステリック調節因子、またはｎｍｄａ部分作動薬との組み合わせ |
| WO2021168106A1 (en) | 2020-02-18 | 2021-08-26 | Praxis Precision Medicines, Inc. | Deuterated neurosteroid |
| WO2022006541A1 (en) | 2020-07-02 | 2022-01-06 | Praxis Precision Medicines, Inc. | Methods for the treatment of adjustment disorder |
| JP2023539125A (ja) | 2020-08-20 | 2023-09-13 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| EP4294819A4 (en) | 2021-02-18 | 2024-12-18 | Praxis Precision Medicines, Inc. | GABA-A POSITIVE ALLOSTERIC MODULATOR HEMI-CITRATE SALTS AND CORRESPONDING CRYSTALLINE FORM |
| EP4329751A4 (en) | 2021-04-26 | 2025-03-19 | Praxis Precision Medicines, Inc. | Methods of treatment with neuroactive steroids |
| WO2023159094A2 (en) | 2022-02-16 | 2023-08-24 | Praxis Precision Medicines, Inc. | PROCESS OF MAKING 3α-HYDROXY-3β-METHOXYMETHYL-21-(1'- IMIDAZOLYL)-5α-PREGNAN-20-ONE |
| EP4514357A4 (en) | 2022-04-26 | 2026-04-29 | Praxis Prec Medicines Inc | METHODS OF TREATING NEUROLOGICAL DISORDERS |
-
2019
- 2019-07-19 US US16/517,369 patent/US10562930B1/en active Active
- 2019-08-30 CN CN201980071246.9A patent/CN113473991B/zh active Active
- 2019-08-30 MA MA050921A patent/MA50921A/fr unknown
- 2019-08-30 TW TW108131297A patent/TWI823999B/zh active
- 2019-08-30 EP EP19842855.9A patent/EP3710465B1/en active Active
- 2019-08-30 EP EP24194131.9A patent/EP4458357A3/en active Pending
- 2019-08-30 CA CA3111193A patent/CA3111193A1/en active Pending
- 2019-08-30 BR BR112021003727-6A patent/BR112021003727A2/pt unknown
- 2019-08-30 TW TW112141287A patent/TWI850138B/zh active
- 2019-08-30 KR KR1020217009437A patent/KR102845326B1/ko active Active
- 2019-08-30 MX MX2021002382A patent/MX2021002382A/es unknown
- 2019-08-30 JP JP2020517339A patent/JP7199739B2/ja active Active
- 2019-08-30 AU AU2019333310A patent/AU2019333310B8/en active Active
- 2019-08-30 WO PCT/US2019/049103 patent/WO2020047434A1/en not_active Ceased
- 2019-08-30 IL IL281143A patent/IL281143B2/en unknown
- 2019-11-27 US US16/698,057 patent/US10927141B2/en active Active
-
2021
- 2021-01-07 US US17/143,602 patent/US20220024967A1/en not_active Abandoned
-
2022
- 2022-12-14 JP JP2022199092A patent/JP2023036708A/ja active Pending
-
2023
- 2023-12-05 US US18/529,117 patent/US12404297B2/en active Active
-
2024
- 2024-10-03 JP JP2024174009A patent/JP2025020120A/ja active Pending
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