KR102845326B1 - Gabaa 양성 알로스테릭 조절인자의 염 및 결정 형태 - Google Patents

Gabaa 양성 알로스테릭 조절인자의 염 및 결정 형태

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Publication number
KR102845326B1
KR102845326B1 KR1020217009437A KR20217009437A KR102845326B1 KR 102845326 B1 KR102845326 B1 KR 102845326B1 KR 1020217009437 A KR1020217009437 A KR 1020217009437A KR 20217009437 A KR20217009437 A KR 20217009437A KR 102845326 B1 KR102845326 B1 KR 102845326B1
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KR
South Korea
Prior art keywords
compound
exhibits
peaks
xrpd
salt
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Application number
KR1020217009437A
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English (en)
Korean (ko)
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KR20210054546A (ko
Inventor
넬슨 비. 올리비에
키란 레디
가브리엘 마르티네즈 보텔라
매그너스 론
폴 에이. 라스카
Original Assignee
프락시스 프리시젼 메디신즈, 인크.
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Publication of KR20210054546A publication Critical patent/KR20210054546A/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
KR1020217009437A 2018-08-31 2019-08-30 Gabaa 양성 알로스테릭 조절인자의 염 및 결정 형태 Active KR102845326B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862725805P 2018-08-31 2018-08-31
US62/725,805 2018-08-31
US16/517,369 2019-07-19
US16/517,369 US10562930B1 (en) 2018-08-31 2019-07-19 Salts and crystal forms of GABAA positive allosteric modulator
PCT/US2019/049103 WO2020047434A1 (en) 2018-08-31 2019-08-30 Salts and crystal forms of gabaa positive allosteric modulator

Publications (2)

Publication Number Publication Date
KR20210054546A KR20210054546A (ko) 2021-05-13
KR102845326B1 true KR102845326B1 (ko) 2025-08-12

Family

ID=69528249

Family Applications (1)

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KR1020217009437A Active KR102845326B1 (ko) 2018-08-31 2019-08-30 Gabaa 양성 알로스테릭 조절인자의 염 및 결정 형태

Country Status (13)

Country Link
US (4) US10562930B1 (https=)
EP (2) EP3710465B1 (https=)
JP (3) JP7199739B2 (https=)
KR (1) KR102845326B1 (https=)
CN (1) CN113473991B (https=)
AU (1) AU2019333310B8 (https=)
BR (1) BR112021003727A2 (https=)
CA (1) CA3111193A1 (https=)
IL (1) IL281143B2 (https=)
MA (1) MA50921A (https=)
MX (1) MX2021002382A (https=)
TW (2) TWI850138B (https=)
WO (1) WO2020047434A1 (https=)

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KR20220157426A (ko) 2020-03-25 2022-11-29 세이지 테라퓨틱스, 인크. 호흡기 병태의 치료를 위한 작용제의 용도
WO2022006541A1 (en) * 2020-07-02 2022-01-06 Praxis Precision Medicines, Inc. Methods for the treatment of adjustment disorder
WO2022177718A1 (en) 2021-02-18 2022-08-25 Sage Therapeutics, Inc. Use of neuroactive steroid for treatment of sexual dysfunction
JP2024506942A (ja) * 2021-02-18 2024-02-15 プラクシス プレシジョン メディシンズ， インコーポレイテッド Ｇａｂａ－ａポジティブアロステリック調節物質のヘミ－クエン酸塩およびその結晶形態
US20240207366A1 (en) 2021-04-27 2024-06-27 Kyungpook National University Industry-Academic Cooperation Foundation Food composition and pharmaceutical composition for preventing or alleviating sarcopenia, containing low-molecular-weight collagen as active ingredient
WO2023159035A1 (en) 2022-02-16 2023-08-24 Sage Therapeutics, Inc. Neuroactive steroids for treatment of cns-related disorders
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Also Published As

Publication number Publication date
IL281143B1 (en) 2024-12-01
KR20210054546A (ko) 2021-05-13
MA50921A (fr) 2020-09-23
JP2021504297A (ja) 2021-02-15
BR112021003727A2 (pt) 2021-05-25
US10927141B2 (en) 2021-02-23
CN113473991B (zh) 2025-12-26
MX2021002382A (es) 2021-08-11
AU2019333310A1 (en) 2021-04-08
US20220024967A1 (en) 2022-01-27
EP3710465A1 (en) 2020-09-23
US20240140985A1 (en) 2024-05-02
CA3111193A1 (en) 2020-03-05
US10562930B1 (en) 2020-02-18
IL281143B2 (en) 2025-04-01
US20200071350A1 (en) 2020-03-05
AU2019333310B2 (en) 2024-11-21
TWI850138B (zh) 2024-07-21
AU2019333310A8 (en) 2025-04-17
US20200255471A1 (en) 2020-08-13
EP3710465B1 (en) 2024-08-14
TW202408461A (zh) 2024-03-01
IL281143A (en) 2021-04-29
AU2019333310B8 (en) 2025-04-17
TW202024108A (zh) 2020-07-01
JP2025020120A (ja) 2025-02-12
EP3710465A4 (en) 2020-09-23
CN113473991A (zh) 2021-10-01
JP7199739B2 (ja) 2023-01-06
WO2020047434A1 (en) 2020-03-05
EP4458357A3 (en) 2024-12-18
TWI823999B (zh) 2023-12-01
JP2023036708A (ja) 2023-03-14
EP4458357A2 (en) 2024-11-06
US12404297B2 (en) 2025-09-02

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