ZA202201784B - Salt and crystal form of compound having agonistic activity to s1p5 receptor - Google Patents
Salt and crystal form of compound having agonistic activity to s1p5 receptorInfo
- Publication number
- ZA202201784B ZA202201784B ZA2022/01784A ZA202201784A ZA202201784B ZA 202201784 B ZA202201784 B ZA 202201784B ZA 2022/01784 A ZA2022/01784 A ZA 2022/01784A ZA 202201784 A ZA202201784 A ZA 202201784A ZA 202201784 B ZA202201784 B ZA 202201784B
- Authority
- ZA
- South Africa
- Prior art keywords
- receptor
- salt
- compound
- crystal form
- agonistic activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962889091P | 2019-08-20 | 2019-08-20 | |
| PCT/JP2020/031326 WO2021033729A1 (ja) | 2019-08-20 | 2020-08-19 | Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA202201784B true ZA202201784B (en) | 2024-02-28 |
Family
ID=74660224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2022/01784A ZA202201784B (en) | 2019-08-20 | 2022-02-10 | Salt and crystal form of compound having agonistic activity to s1p5 receptor |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12459890B2 (https=) |
| EP (1) | EP4019496B1 (https=) |
| JP (1) | JP7409383B2 (https=) |
| KR (1) | KR102930707B1 (https=) |
| CN (1) | CN114302873A (https=) |
| BR (1) | BR112022002632A2 (https=) |
| CA (1) | CA3150303A1 (https=) |
| ES (1) | ES2983098T3 (https=) |
| IL (1) | IL290432A (https=) |
| MX (1) | MX2022001820A (https=) |
| MY (1) | MY207001A (https=) |
| PH (1) | PH12022550319A1 (https=) |
| TW (1) | TWI859303B (https=) |
| WO (1) | WO2021033729A1 (https=) |
| ZA (1) | ZA202201784B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3757091T (pt) * | 2018-02-22 | 2024-09-11 | Ono Pharmaceutical Co | Ácido 1-[[(3s)-3-metil-6-(4,4,4-trifluorobutoxi)-3,4-di-hidronaftalen-2-il]metil]azetidino-3-carboxílico com atividade agonista do recetor s1p5 para o tratamento de doenças neurodegenerativas e cancro |
| AU2022291768A1 (en) | 2021-06-16 | 2023-11-30 | Celgene Corporation | Azetidinyl compounds comprising a carboxylic acid group for the treatment of neurodegenerative diseases |
| EP4633736A1 (en) * | 2022-12-16 | 2025-10-22 | Celgene Corporation | Heterocyclic compounds as modulators of s1p5 |
| WO2025119254A1 (en) * | 2023-12-06 | 2025-06-12 | Ono Pharmaceutical Co., Ltd. | Method for preparing dihydronaphthalene derivative |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| GB8725118D0 (en) * | 1987-10-27 | 1987-12-02 | Ciba Geigy Ag | Rifamycin derivatives |
| JP2005020882A (ja) | 2003-06-25 | 2005-01-20 | Matsushita Electric Works Ltd | モータアクチュエータ装置 |
| US7825109B2 (en) | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
| KR20110140139A (ko) | 2003-08-29 | 2011-12-30 | 오노 야꾸힝 고교 가부시키가이샤 | Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도 |
| JP2006064757A (ja) | 2004-08-24 | 2006-03-09 | Systec Kyowa:Kk | ディスプレイ固定用スタンド |
| BRPI0519012A2 (pt) * | 2004-12-13 | 2008-12-23 | Ono Pharmaceutical Co | derivado do Ácido aminocarboxÍlico e seu uso medicinal |
| JP2009526073A (ja) | 2006-02-09 | 2009-07-16 | ユニバーシティ オブ バージニア パテント ファンデーション | 二環式スフィンゴシン−１−リン酸受容体アナログ |
| ME00529B (me) * | 2006-06-12 | 2011-10-10 | Novartis Ag | Polimorfi n-hidroksi-3-[4-[[[2-(-metil-1h-indol-3-il)etil]amino]fenil]-2e-2-propenamida |
| UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
| EA034451B1 (ru) | 2011-02-07 | 2020-02-10 | Байоджен Ма Инк. | Модуляторы s1p |
| EP3228615B1 (en) * | 2014-12-04 | 2021-01-20 | ONO Pharmaceutical Co., Ltd. | Dihydronaphthalene derivatives useful in the treatment of s1p5-mediated diseases |
| EP3409658B9 (en) | 2016-01-29 | 2024-07-17 | ONO Pharmaceutical Co., Ltd. | Tetrahydronaphthalene derivative |
| PT3757091T (pt) * | 2018-02-22 | 2024-09-11 | Ono Pharmaceutical Co | Ácido 1-[[(3s)-3-metil-6-(4,4,4-trifluorobutoxi)-3,4-di-hidronaftalen-2-il]metil]azetidino-3-carboxílico com atividade agonista do recetor s1p5 para o tratamento de doenças neurodegenerativas e cancro |
| TW202114983A (zh) * | 2019-08-20 | 2021-04-16 | 日商小野藥品工業股份有限公司 | Ｓ１ｐ媒介疾病的預防及／或治療劑 |
-
2020
- 2020-08-19 MX MX2022001820A patent/MX2022001820A/es unknown
- 2020-08-19 US US17/634,505 patent/US12459890B2/en active Active
- 2020-08-19 BR BR112022002632A patent/BR112022002632A2/pt unknown
- 2020-08-19 EP EP20854718.2A patent/EP4019496B1/en active Active
- 2020-08-19 PH PH1/2022/550319A patent/PH12022550319A1/en unknown
- 2020-08-19 CN CN202080056980.0A patent/CN114302873A/zh active Pending
- 2020-08-19 JP JP2021540972A patent/JP7409383B2/ja active Active
- 2020-08-19 TW TW109128245A patent/TWI859303B/zh active
- 2020-08-19 ES ES20854718T patent/ES2983098T3/es active Active
- 2020-08-19 KR KR1020227004458A patent/KR102930707B1/ko active Active
- 2020-08-19 MY MYPI2022000691A patent/MY207001A/en unknown
- 2020-08-19 CA CA3150303A patent/CA3150303A1/en active Pending
- 2020-08-19 WO PCT/JP2020/031326 patent/WO2021033729A1/ja not_active Ceased
-
2022
- 2022-02-08 IL IL290432A patent/IL290432A/en unknown
- 2022-02-10 ZA ZA2022/01784A patent/ZA202201784B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI859303B (zh) | 2024-10-21 |
| TW202114984A (zh) | 2021-04-16 |
| MY207001A (en) | 2025-01-23 |
| EP4019496A4 (en) | 2023-01-11 |
| CN114302873A (zh) | 2022-04-08 |
| US20220289675A1 (en) | 2022-09-15 |
| AU2020334489C1 (en) | 2026-03-26 |
| EP4019496A1 (en) | 2022-06-29 |
| JP7409383B2 (ja) | 2024-01-09 |
| JPWO2021033729A1 (https=) | 2021-02-25 |
| WO2021033729A1 (ja) | 2021-02-25 |
| ES2983098T3 (es) | 2024-10-22 |
| US12459890B2 (en) | 2025-11-04 |
| MX2022001820A (es) | 2022-03-17 |
| KR20220050886A (ko) | 2022-04-25 |
| AU2020334489A1 (en) | 2022-03-03 |
| BR112022002632A2 (pt) | 2022-05-03 |
| KR102930707B1 (ko) | 2026-02-24 |
| AU2020334489B2 (en) | 2025-10-30 |
| IL290432A (en) | 2022-04-01 |
| PH12022550319A1 (en) | 2022-12-19 |
| EP4019496B1 (en) | 2024-06-05 |
| CA3150303A1 (en) | 2021-02-25 |
| NZ785003A (en) | 2024-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202201784B (en) | Salt and crystal form of compound having agonistic activity to s1p5 receptor | |
| PT4058151T (pt) | Novo sal de composto de terfenilo | |
| SG11202109438TA (en) | A salt and crystal form of a fak inhibitor | |
| IL277326A (en) | Polymorphs of calcium salts that suppress dihydroureoate dehydrogenase, and methods for their production | |
| MA40067A (fr) | Sels de chlorhydrate de n-(cyanométhyl)-4-(2-(4-morpholinophénylamino)pyrimidin-4-yl)benzamide | |
| IL319797B1 (en) | Method for synthesizing a furoimidazopyridine compound, a crystalline form of a furoimidazopyridine compound, and a crystalline form of a salt thereof | |
| HUE067428T2 (hu) | 5-MEO-DMT kristályos hidrobromidsója | |
| IL293584B1 (en) | Synthesis of compounds to promote hair growth | |
| IL276656A (en) | Compounds with S1P5 receptor agonistic activity | |
| SG11202106210QA (en) | Salt of syk inhibitor and crystalline form thereof | |
| PT3424930T (pt) | Cristal de um composto com atividade inibidora de jak | |
| IL285219A (en) | A crystal of the compound diarylthiohydantoin | |
| MA53162A (fr) | Sel de xinafoate d'un composé inhibiteur de jak | |
| IL274274A (en) | Salt form and crystal form of compound as FGFR4 inhibitor and method of their preparation | |
| HUE071923T2 (hu) | Az S-oxprenolol sói | |
| IL304419A (en) | salt crystals | |
| EP3936189A4 (en) | SALT OF A PENTACYCLIC COMPOUND AND CRYSTALS THEREOF | |
| EP2698371A4 (en) | NEW VERBUNDADDITIONSALZ AGAINST THROMBOCYTES | |
| IL288158A (en) | Crystalline salt forms of n-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide | |
| EP2592080A4 (en) | CRYSTAL OF A CONDENSED PYRIDINE COMPOUND SALT | |
| EP4438606A4 (en) | NEW CRYSTALLINE FORM OF A NUCLEOSIDE COMPOUND AND ITS SALT | |
| GB2603328B (en) | Process for the synthesis of elagolix sodium salt and intermediates of said process | |
| SG11202009262VA (en) | Salts of compounds and crystals thereof | |
| IL277578A (en) | New salt forms of URAT-1 inhibitors | |
| EP3845534A4 (en) | SALT FORM AND CRYSTALLINE FORM OF A NEW AZATRICYCLIC COMPOUND AND USE THEREOF |