KR102930707B1 - S1p5 수용체 작동 활성을 갖는 화합물의 염 및 결정형 - Google Patents

S1p5 수용체 작동 활성을 갖는 화합물의 염 및 결정형

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Publication number
KR102930707B1
KR102930707B1 KR1020227004458A KR20227004458A KR102930707B1 KR 102930707 B1 KR102930707 B1 KR 102930707B1 KR 1020227004458 A KR1020227004458 A KR 1020227004458A KR 20227004458 A KR20227004458 A KR 20227004458A KR 102930707 B1 KR102930707 B1 KR 102930707B1
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South Korea
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compound
powder
crystal
ray diffraction
diffraction spectrum
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Korean (ko)
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KR20220050886A (ko
Inventor
슈헤이 오타니
다카유키 후지토
나오코 이무라
히데오미 기지마
스테판 디 페어런트
멜라니 재넬 베빌
코트니 에스 존슨
트래비스 리 휴스턴
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오노 야꾸힝 고교 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020227004458A 2019-08-20 2020-08-19 S1p5 수용체 작동 활성을 갖는 화합물의 염 및 결정형 Active KR102930707B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962889091P 2019-08-20 2019-08-20
US62/889,091 2019-08-20
PCT/JP2020/031326 WO2021033729A1 (ja) 2019-08-20 2020-08-19 Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形

Publications (2)

Publication Number Publication Date
KR20220050886A KR20220050886A (ko) 2022-04-25
KR102930707B1 true KR102930707B1 (ko) 2026-02-24

Family

ID=74660224

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227004458A Active KR102930707B1 (ko) 2019-08-20 2020-08-19 S1p5 수용체 작동 활성을 갖는 화합물의 염 및 결정형

Country Status (16)

Country Link
US (1) US12459890B2 (https=)
EP (1) EP4019496B1 (https=)
JP (1) JP7409383B2 (https=)
KR (1) KR102930707B1 (https=)
CN (1) CN114302873A (https=)
AU (1) AU2020334489C1 (https=)
BR (1) BR112022002632A2 (https=)
CA (1) CA3150303A1 (https=)
ES (1) ES2983098T3 (https=)
IL (1) IL290432A (https=)
MX (1) MX2022001820A (https=)
MY (1) MY207001A (https=)
PH (1) PH12022550319A1 (https=)
TW (1) TWI859303B (https=)
WO (1) WO2021033729A1 (https=)
ZA (1) ZA202201784B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE068382T2 (hu) * 2018-02-22 2024-12-28 Ono Pharmaceutical Co SIP5-receptor-agonista aktivitással rendelkezõ 1[[(3S)-3-metil-6-(4(4,4-trifluorbutoxi)-3,4-dihidronaftalen-2-il]metil]azetidin-3-karbonsav neurodegeneratív rendellenességek és rák kezelésére
US11919879B2 (en) 2021-06-16 2024-03-05 Celgene Corporation Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases
KR20250114133A (ko) * 2022-12-16 2025-07-28 셀진 코포레이션 S1p5의 조정제로서의 헤테로시클릭 화합물
WO2025119254A1 (en) 2023-12-06 2025-06-12 Ono Pharmaceutical Co., Ltd. Method for preparing dihydronaphthalene derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019163917A1 (ja) 2018-02-22 2019-08-29 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物

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NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
GB8725118D0 (en) * 1987-10-27 1987-12-02 Ciba Geigy Ag Rifamycin derivatives
JP2005020882A (ja) 2003-06-25 2005-01-20 Matsushita Electric Works Ltd モータアクチュエータ装置
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
EP1661881B1 (en) 2003-08-29 2014-12-17 Ono Pharmaceutical Co., Ltd. Compound capable of binding s1p receptor and pharmaceutical use thereof
JP2006064757A (ja) 2004-08-24 2006-03-09 Systec Kyowa:Kk ディスプレイ固定用スタンド
EP2592066B1 (en) 2004-12-13 2014-12-03 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medical use thereof
AU2007212193A1 (en) 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
EP2086930A2 (en) * 2006-06-12 2009-08-12 Novartis AG Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
UA113507C2 (xx) 2011-02-07 2017-02-10 Модулятори s1p
ES2852724T3 (es) 2014-12-04 2021-09-14 Ono Pharmaceutical Co Derivados de dihidronaftaleno útiles en el tratamiento de enfermedades mediadas por S1P5
ES2975689T3 (es) 2016-01-29 2024-07-11 Ono Pharmaceutical Co Derivado de tetrahidronaftaleno
TW202114983A (zh) * 2019-08-20 2021-04-16 日商小野藥品工業股份有限公司 Ｓ１ｐ媒介疾病的預防及／或治療劑

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019163917A1 (ja) 2018-02-22 2019-08-29 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物

Also Published As

Publication number Publication date
IL290432A (en) 2022-04-01
CA3150303A1 (en) 2021-02-25
US20220289675A1 (en) 2022-09-15
EP4019496B1 (en) 2024-06-05
JP7409383B2 (ja) 2024-01-09
MX2022001820A (es) 2022-03-17
PH12022550319A1 (en) 2022-12-19
TWI859303B (zh) 2024-10-21
ES2983098T3 (es) 2024-10-22
AU2020334489A1 (en) 2022-03-03
AU2020334489B2 (en) 2025-10-30
AU2020334489C1 (en) 2026-03-26
US12459890B2 (en) 2025-11-04
NZ785003A (en) 2024-09-27
BR112022002632A2 (pt) 2022-05-03
JPWO2021033729A1 (https=) 2021-02-25
KR20220050886A (ko) 2022-04-25
ZA202201784B (en) 2024-02-28
MY207001A (en) 2025-01-23
CN114302873A (zh) 2022-04-08
EP4019496A4 (en) 2023-01-11
EP4019496A1 (en) 2022-06-29
TW202114984A (zh) 2021-04-16
WO2021033729A1 (ja) 2021-02-25

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