JP2004529874A5 - - Google Patents
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- Publication number
- JP2004529874A5 JP2004529874A5 JP2002563877A JP2002563877A JP2004529874A5 JP 2004529874 A5 JP2004529874 A5 JP 2004529874A5 JP 2002563877 A JP2002563877 A JP 2002563877A JP 2002563877 A JP2002563877 A JP 2002563877A JP 2004529874 A5 JP2004529874 A5 JP 2004529874A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- hydrogen bond
- hydrophobic group
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 37
- 239000001257 hydrogen Substances 0.000 claims 37
- 239000000370 acceptor Substances 0.000 claims 33
- 125000001165 hydrophobic group Chemical group 0.000 claims 33
- 125000004429 atom Chemical group 0.000 claims 23
- 102100027995 Collagenase 3 Human genes 0.000 claims 16
- 108050005238 Collagenase 3 Proteins 0.000 claims 16
- 125000006413 ring segment Chemical group 0.000 claims 16
- 239000003446 ligand Substances 0.000 claims 11
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 125000005647 linker group Chemical group 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 230000007850 degeneration Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 201000008482 osteoarthritis Diseases 0.000 claims 3
- 208000028169 periodontal disease Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 230000008856 allosteric binding Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26882101P | 2001-02-14 | 2001-02-14 | |
| PCT/IB2002/000447 WO2002064080A2 (en) | 2001-02-14 | 2002-02-13 | Matrix metalloproteinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529874A JP2004529874A (ja) | 2004-09-30 |
| JP2004529874A5 true JP2004529874A5 (https=) | 2005-07-21 |
Family
ID=23024626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563877A Abandoned JP2004529874A (ja) | 2001-02-14 | 2002-02-13 | マトリックスメタロプロテイナーゼ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20030078276A1 (https=) |
| EP (1) | EP1361873A4 (https=) |
| JP (1) | JP2004529874A (https=) |
| AR (1) | AR033859A1 (https=) |
| AU (1) | AU2002228302A1 (https=) |
| BR (1) | BR0207864A (https=) |
| CA (1) | CA2437643A1 (https=) |
| HN (1) | HN2002000037A (https=) |
| MX (1) | MXPA03007250A (https=) |
| PA (1) | PA8539301A1 (https=) |
| PE (1) | PE20020873A1 (https=) |
| PY (1) | PY0202788A (https=) |
| SV (1) | SV2002000874A (https=) |
| UY (1) | UY27174A1 (https=) |
| WO (1) | WO2002064080A2 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| DOP2002000334A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz |
| EP1368323B1 (en) | 2001-02-14 | 2010-06-30 | Warner-Lambert Company LLC | Pyrimidine matrix metalloproteinase inhibitors |
| MXPA03005870A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibirores de benzotiadiazina de metaloproteinasas de la matriz. |
| PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
| DOP2002000332A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
| US20040006205A1 (en) * | 2001-04-03 | 2004-01-08 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| EP1434585A1 (en) | 2001-10-12 | 2004-07-07 | Warner-Lambert Company LLC | Alkyne matrix metalloproteinase inhibitors |
| WO2003033478A1 (en) * | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkynylated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitors |
| US6962922B2 (en) * | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| WO2004007469A1 (en) * | 2002-07-12 | 2004-01-22 | Warner-Lambert Company Llc | New alkynylated quinazolin compounds as mmp-13 inhibitors |
| WO2003076416A1 (en) * | 2002-03-08 | 2003-09-18 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US20040006077A1 (en) * | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
| WO2004006913A1 (en) * | 2002-07-17 | 2004-01-22 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
| MXPA05000638A (es) * | 2002-07-17 | 2005-03-31 | Warner Lambert Co | Combinacion de un inhibidor alquino alosterico de metaloproteinasa-13 de matriz con un inhibidor selectivo de ciclooxigenasa-2 que no es celecoxib o valdecoxib. |
| AU2003281169A1 (en) * | 2002-07-17 | 2004-02-02 | Warner-Lambert Company Llc | Combination of an allosteric carboxylic inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
| BR0312708A (pt) * | 2002-07-17 | 2005-04-26 | Warner Lambert Co | Combinação de um inibidor alcina alostérico de metaloproteinase-13 de matriz com celecoxib ou valdecoxib |
| BR0312943A (pt) * | 2002-07-17 | 2005-07-12 | Warner Lambert Co | Combinação de um inibidor alostérico de matriz metaloproteinase-13 com um inibidor seletivo de ciclooxigenase-2 que não é celecoxib ou valdecoxib |
| CA2497658A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Chromone derivatives as matrix metalloproteinase inhibitors |
| WO2004014378A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors |
| AU2003249535A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 1,6-fused uracil derivatives as matrix metalloproteinase inhibitors |
| AU2003249477A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
| AU2003249539A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors |
| BR0313724A (pt) * | 2002-08-13 | 2005-06-28 | Warner Lambert Co | Derivados de azaisoquinolina como inibidores de metaloproteinase de matriz |
| AU2003253186A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
| MXPA05001603A (es) | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados monociclicos como inhibidores de metaloproteinasa de matriz. |
| WO2004014923A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
| WO2004014869A2 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 5,6-fused 3,4-dihydropyrimidine-2-one derivatives as matrix metalloproteinase inhibitors |
| ES2283851T3 (es) * | 2002-08-13 | 2007-11-01 | Warner-Lambert Company Llc | Derivados de pirimidin-2,4-diona como inhibidores de las metaloproteinasas de matriz. |
| BR0313727A (pt) * | 2002-08-13 | 2005-07-12 | Warner Lambert Co | Derivados de isoquinolina como inibidores de metaloproteinase da matriz |
| PA8578101A1 (es) * | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
| WO2004014375A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
| AU2003250482A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Phthalimide derivatives as matrix metalloproteinase inhibitors |
| AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| US7166609B2 (en) | 2002-11-02 | 2007-01-23 | Sanofi-Aventis Deutschland Gmbh | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases |
| US20040142950A1 (en) * | 2003-01-17 | 2004-07-22 | Bunker Amy Mae | Amide and ester matrix metalloproteinase inhibitors |
| WO2005002585A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
| EP2287326A1 (en) | 2003-08-08 | 2011-02-23 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| WO2005016926A1 (en) * | 2003-08-19 | 2005-02-24 | Warner-Lambert Company Llc | Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors |
| EP1657238A4 (en) * | 2003-08-22 | 2008-12-03 | Takeda Pharmaceutical | CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE |
| ATE530165T1 (de) * | 2003-11-14 | 2011-11-15 | Baxter Int | Alpha1-antitrypsin-zusammensetzungen und behandlungsverfahren unter verwendung dieser zusammensetzungen |
| US20060247231A1 (en) * | 2003-12-18 | 2006-11-02 | Warner-Lambert Company Llc | Amide and ester matrix metalloproteinase inhibitors |
| EP1737499A4 (en) | 2004-03-09 | 2009-07-22 | Arriva Pharmaceuticals Inc | TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE BY INHALATION OF LOW DOSES OF A PROTEASE HEMMER |
| US20070105768A1 (en) * | 2004-11-10 | 2007-05-10 | Rajiv Nayar | Dry recombinant human alpha 1-antitrypsin formulation |
| MX2007006790A (es) | 2004-12-07 | 2007-08-15 | Toyama Chemical Co Ltd | Novedosos derivado de acido antranilico o sal del mismo. |
| ES2395952T3 (es) * | 2005-03-16 | 2013-02-18 | Toyama Chemical Co., Ltd. | Nuevo derivado del ácido antranílico o una sal del mismo |
| CA2612176C (en) | 2005-06-14 | 2015-02-17 | Aska Pharmaceutical Co., Ltd. | Dihydrothieno[2,3-d]pyramidine-6-carboxylic acid derivatives as pde9 inhibitors |
| CA2627497C (en) * | 2005-10-28 | 2014-10-14 | Takeda Pharmaceutical Company Limited | Heterocyclic amide compound and use thereof |
| CA2685753A1 (en) * | 2007-05-09 | 2008-11-20 | Neuromed Pharmaceuticals Ltd. | Bicyclic pyrimidine derivatives as calcium channel blockers |
| EP2240178A4 (en) * | 2007-12-19 | 2011-10-26 | Glaxosmithkline Llc | PROLYLHYDROXYLASEHEMMER |
| JP2011521958A (ja) | 2008-05-27 | 2011-07-28 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | Ｗｎｔタンパク質シグナル伝達阻害剤 |
| JP5657201B2 (ja) * | 2008-09-30 | 2015-01-21 | サンメディカル株式会社 | 酵素阻害作用または酵素阻害作用と抗菌作用とを有する歯科用組成物 |
| CN102627657B (zh) * | 2012-03-09 | 2015-01-07 | 苏州施亚生物科技有限公司 | 3-(4-甲氧基-苄基)-1h-嘧啶-2,4-二酮衍生物的合成方法 |
| CN103012189A (zh) * | 2012-12-20 | 2013-04-03 | 天津理工大学 | 具有抗血小板聚集作用的酰胺类化合物及其制备和应用 |
| KR20160065957A (ko) * | 2013-10-07 | 2016-06-09 | 바이엘 파마 악티엔게젤샤프트 | 시클릭 티에노우라실-카르복스아미드 및 그의 용도 |
| WO2016184313A1 (zh) | 2015-05-20 | 2016-11-24 | 南京明德新药研发股份有限公司 | 羟基嘌呤类化合物及其应用 |
| EP3299371B1 (en) * | 2015-05-20 | 2021-08-25 | Guangdong Raynovent Biotech Co., Ltd. | Hydroxyl purine compounds and use thereof |
| CN109593066B (zh) * | 2018-12-21 | 2020-06-19 | 上海交通大学 | 一种用于治疗肠道细菌感染的叶酸拮抗剂及其制备与应用 |
| US11919895B2 (en) * | 2019-10-25 | 2024-03-05 | Saint Louis University | GPR183 antagonists for the treatment of pain |
| CN115197225B (zh) * | 2021-09-03 | 2023-04-11 | 贵州大学 | 一种五元杂环并喹唑啉酮类化合物及其制备方法 |
| CN113773277B (zh) * | 2021-09-18 | 2023-12-05 | 兰州大学 | 一种4h-1,2,4-苯并噻二嗪-1,1-二氧化物衍生物的合成方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US129672A (en) * | 1872-07-23 | Improvement in heating-stoves | ||
| US156069A (en) * | 1874-10-20 | Improvement in lithographic printing-presses | ||
| US193377A (en) * | 1877-07-24 | Improvement in bee-hives | ||
| US151558A (en) * | 1874-06-02 | Improvement in the modes of machine-sewing | ||
| US151555A (en) * | 1874-06-02 | Improvement in street-railway switches | ||
| US130278A (en) * | 1872-08-06 | Improvement in pipe-tongs | ||
| US156061A (en) * | 1874-10-20 | Improvement in boot and shoe nails | ||
| US161000A (en) * | 1875-03-23 | Improvement in millstone-bushes | ||
| US4172A (en) * | 1845-09-02 | Coal-breaker | ||
| US144274A (en) * | 1873-11-04 | Improvement in self-closing telegraph-keys | ||
| US3655679A (en) * | 1969-06-25 | 1972-04-11 | Merck & Co Inc | Certain aryl pyridine carboxylic acid derivatives |
| US5521181A (en) * | 1995-01-27 | 1996-05-28 | Abbott Laboratories | Bicyclic substituted hexahydrobenz[e]isoindole α-1 adrenergic antagonists |
| US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| KR20000057444A (ko) * | 1996-12-09 | 2000-09-15 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 심기능부전 및 심실확장의 치료 및 예방 방법 |
| MXPA03005870A (es) * | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibirores de benzotiadiazina de metaloproteinasas de la matriz. |
-
2002
- 2002-02-08 PA PA20028539301A patent/PA8539301A1/es unknown
- 2002-02-13 UY UY27174A patent/UY27174A1/es not_active Application Discontinuation
- 2002-02-13 CA CA002437643A patent/CA2437643A1/en not_active Abandoned
- 2002-02-13 JP JP2002563877A patent/JP2004529874A/ja not_active Abandoned
- 2002-02-13 SV SV2002000874A patent/SV2002000874A/es not_active Application Discontinuation
- 2002-02-13 BR BR0207864-3A patent/BR0207864A/pt not_active IP Right Cessation
- 2002-02-13 MX MXPA03007250A patent/MXPA03007250A/es unknown
- 2002-02-13 PE PE2002000116A patent/PE20020873A1/es not_active Application Discontinuation
- 2002-02-13 HN HN2002000037A patent/HN2002000037A/es unknown
- 2002-02-13 AU AU2002228302A patent/AU2002228302A1/en not_active Abandoned
- 2002-02-13 EP EP02710275A patent/EP1361873A4/en not_active Withdrawn
- 2002-02-13 US US10/075,069 patent/US20030078276A1/en not_active Abandoned
- 2002-02-13 AR ARP020100472A patent/AR033859A1/es not_active Application Discontinuation
- 2002-02-13 PY PY200200202788A patent/PY0202788A/es unknown
- 2002-02-13 WO PCT/IB2002/000447 patent/WO2002064080A2/en not_active Ceased
-
2004
- 2004-04-29 US US10/835,619 patent/US20050004126A1/en not_active Abandoned
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