JP2022176979A5 - - Google Patents

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JP2022176979A5
JP2022176979A5 JP2022131443A JP2022131443A JP2022176979A5 JP 2022176979 A5 JP2022176979 A5 JP 2022176979A5 JP 2022131443 A JP2022131443 A JP 2022131443A JP 2022131443 A JP2022131443 A JP 2022131443A JP 2022176979 A5 JP2022176979 A5 JP 2022176979A5
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formula
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crystal
mixture
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JP2022131443A 2015-10-02 2022-08-22 β-ニコチンアミドモノヌクレオチドの結晶形態 Pending JP2022176979A (ja)

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JP2024111468A JP2024161353A (ja) 2015-10-02 2024-07-11 β-ニコチンアミドモノヌクレオチドの結晶形態

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US201562236657P 2015-10-02 2015-10-02
US62/236,657 2015-10-02
JP2020205773A JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態

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JP2022176979A JP2022176979A (ja) 2022-11-30
JP2022176979A5 true JP2022176979A5 (enExample) 2023-10-02

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JP2018516685A Pending JP2018534265A (ja) 2015-10-02 2016-09-30 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2020205773A Pending JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2022131443A Pending JP2022176979A (ja) 2015-10-02 2022-08-22 β-ニコチンアミドモノヌクレオチドの結晶形態
JP2024111468A Pending JP2024161353A (ja) 2015-10-02 2024-07-11 β-ニコチンアミドモノヌクレオチドの結晶形態

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JP2020205773A Pending JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態

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US (6) US10392415B2 (enExample)
EP (2) EP3355895A4 (enExample)
JP (4) JP2018534265A (enExample)
KR (1) KR102779733B1 (enExample)
CN (1) CN108697722B (enExample)
AU (1) AU2016331918B2 (enExample)
BR (1) BR112018006243A2 (enExample)
CA (1) CA3000744C (enExample)
EA (1) EA037104B1 (enExample)
GB (1) GB2542881B (enExample)
IL (1) IL258276B (enExample)
MX (1) MX390064B (enExample)
WO (1) WO2017059249A1 (enExample)
ZA (1) ZA201802657B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016302005B2 (en) 2015-08-05 2021-03-04 Metro International Biotech, Llc Nicotinamide mononucleotide derivatives and their uses
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
WO2016188092A1 (zh) * 2015-12-11 2016-12-01 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的保健品中的应用及其保健品
CN106659729A (zh) * 2015-12-11 2017-05-10 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的药物中的应用及其药物
WO2018047715A1 (ja) * 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β-ニコチンアミドモノヌクレオチドの結晶及びその製造方法
EP3538099A4 (en) 2016-11-11 2020-06-17 The Queen's University of Belfast EFFICIENT AND SCALABLE SYNTHESIS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS OF THEM, ADENYLYDINUCLEOTIDE CONJUGATES THEREOF AND NEW-WAY CRYSTALS
EP3554285A4 (en) 2016-11-29 2021-01-20 University of Iowa Research Foundation USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
EP3624808A4 (en) * 2017-05-18 2021-03-03 Elysium Health, Inc. PROCEDURES AND COMPOSITIONS FOR IMPROVED SLEEP
WO2019152416A1 (en) 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
US10654883B2 (en) 2018-05-15 2020-05-19 Jumpstart Fertility Pty Ltd Inorganic salts of nicotinic acid mononucleotide as anti-aging agents
CN109674808A (zh) * 2019-01-30 2019-04-26 四川大学 β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途
CN109939120B (zh) * 2019-03-01 2020-01-31 北京慧宝源生物技术股份有限公司 含烟酰胺单核苷酸和罗汉果苷的组合物及其应用
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN112823778B (zh) * 2019-11-21 2024-06-14 百瑞全球有限公司 毛发护理组合物及其制备方法
CN113121628A (zh) * 2019-12-30 2021-07-16 尚科生物医药(上海)有限公司 一种无定型烟酰胺单核苷酸的制备方法
JP7648026B2 (ja) * 2020-03-27 2025-03-18 オリエンタル酵母工業株式会社 β-ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物を含む組成物、並びにその品質評価方法および酵素反応性の判定方法
KR20220160611A (ko) * 2020-03-30 2022-12-06 오리엔탈고우보고오교가부시끼가이샤 줄기세포의 염색체 안정화제
FR3110836B1 (fr) * 2020-05-29 2023-06-16 Nuvamid Utilisation de NMN pour réduire l’immunodépression et l’immunosénescence
CN111588729A (zh) * 2020-06-16 2020-08-28 无锡脑镁素生物医药科技有限公司 β-烟酰胺单核苷酸在预防脱发或促进毛发生长产品中的应用
CN112538101B (zh) * 2020-08-13 2026-02-03 常州博海威医药科技股份有限公司 一种β烟酰胺单核苷酸的新晶型及其制备方法和用途
CN112076204A (zh) * 2020-09-29 2020-12-15 深圳雾件科技有限公司 一种烟酰胺单核苷酸在运动神经元修复的应用
CN114349809A (zh) * 2020-10-13 2022-04-15 华东理工大学 β-烟酰胺单核苷酸的晶型A及其制备方法
US20230416291A1 (en) * 2020-11-27 2023-12-28 Mirailab Bioscience Inc. HIGH-PURITY ß-NICOTINAMIDE MONONUCLEOTIDE (NMN) AND METHOD FOR PRODUCING SAME
CN112694505A (zh) * 2020-12-30 2021-04-23 音芙医药科技(上海)有限公司 一种高密度的nmn的制备方法
EP4322932A4 (en) * 2021-04-13 2025-01-15 Animal Biosciences, Inc. Formulations of nicotinic acid derivatives and flavonoid polyphenols and uses thereof
IL308577A (en) 2021-05-27 2024-01-01 Metro Int Biotech Llc Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use
CN113912653B (zh) * 2021-06-04 2024-04-23 天津大学 一种提高β-烟酰胺单核苷酸结晶粉末松堆密度的方法
CN113402575B (zh) * 2021-06-18 2022-04-22 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸共晶体的方法
CN113292619B (zh) * 2021-06-18 2022-04-22 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸-异烟碱共晶体及其组合物
WO2023077503A1 (zh) * 2021-11-08 2023-05-11 邦泰生物工程(深圳)有限公司 一种提高烟酰胺单核苷酸晶体的堆密度的方法及其晶体
CN114129509B (zh) * 2021-12-03 2023-12-01 药酚享科技(北京)有限公司 一种保湿性nmn亲水凝胶剂及其制备方法
CN114214270B (zh) * 2021-12-17 2023-11-24 中国农业科学院北京畜牧兽医研究所 一种调控冷冻牛卵母细胞的发育能力的方法及其应用
CN114213486A (zh) * 2021-12-31 2022-03-22 浙江拓普药业股份有限公司 一种西兰花中烟酰胺单核苷酸的提取纯化方法
CN114540283B (zh) * 2022-01-27 2023-10-20 中国农业科学院北京畜牧兽医研究所 用于牛体外胚胎生产的高效玻璃化冷冻方法
WO2024251966A1 (en) 2023-06-07 2024-12-12 Bohan & Co As. Crystalline reduced nicotinamide mononucleotide (nmnh) and process thereof
WO2025004768A1 (ja) * 2023-06-29 2025-01-02 株式会社カネカ 結晶性複合体、及びその製造方法、並びに組成物

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201389A (en) 1962-09-24 1965-08-17 Kyowa Hakko Kogyo Kk Method for preparing ribonucleoside-5'-phosphates or their salts from ribonucleosides
US3451997A (en) 1965-11-30 1969-06-24 Kyowa Hakko Kogyo Kk Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
US4411995A (en) 1981-09-28 1983-10-25 Massachusetts Institute Of Technology Synthesis of nicotinamide cofactors
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
ATE391492T1 (de) 1997-07-29 2008-04-15 Alcon Lab Inc Ophthalmische zusammensetzungen enthaltend galaktomannanpolymere und borat
EP1051167A1 (en) 1998-01-29 2000-11-15 Sepracor, Inc. Pharmaceutical uses of optically pure (-) -bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
RS51031B (sr) 2001-04-30 2010-10-31 Trommsdorff Gmbh & Co.Kg.Arzneimittel Farmaceutski aktivni estri uridina
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US20040224039A1 (en) 2003-02-12 2004-11-11 Donald Brucker Compositions and methods for the treatment of diseases and disorder associated with oxidative damage
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
ES2593113T3 (es) 2003-08-07 2016-12-05 Allergan, Inc. Composiciones para el suministro de agentes terapéuticos en los ojos y métodos para obtener y usar los mismos
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
EP1727546A4 (en) 2003-10-31 2008-07-09 Robarts Res Inst METHOD AND FORMULATIONS FOR THE PROTECTION OF CELLS AND FOR THE TREATMENT OF ILLNESSES AND SUFFERING THROUGH OPTIMIZATION OF INTRA-CELLULAR NAD CONCENTRATION
PT1755391E (pt) 2004-06-04 2016-02-03 Univ Washington Métodos e composições para o tratamento de neuropatias
AU2006218403A1 (en) 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
US20070149466A1 (en) 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
JP5063878B2 (ja) 2005-08-30 2012-10-31 扶桑薬品工業株式会社 硫化水素塩を含有する消化器系疾患の予防/治療用組成物
US20080020413A1 (en) * 2006-03-29 2008-01-24 Columbia University Crystalline visfatin and methods therefor
CA2646674A1 (en) 2006-04-20 2007-11-01 Fred Hutchinson Cancer Research Center Use of chalcogenides for treating shock and other adverse conditions
US20080318892A1 (en) 2006-04-28 2008-12-25 John Geoffrey Pickering Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of nad
WO2007136744A1 (en) * 2006-05-19 2007-11-29 The Johns Hopkins University Crystal structure of a substrate complex of nampt/pbef/visfatin
EP2124985A4 (en) * 2007-01-26 2011-06-08 Univ Washington METHOD AND COMPOSITIONS FOR TREATING NERVOUS ELEMENTS
CN101497638B (zh) 2008-01-30 2012-09-26 中国科学院大连化学物理研究所 一种nad+类似物及其合成和应用
US11219696B2 (en) 2008-12-19 2022-01-11 Nationwide Children's Hospital Delivery of polynucleotides using recombinant AAV9
CN101601679B (zh) 2009-03-17 2011-08-10 中国人民解放军第二军医大学 一种烟酰胺单核苷酸的应用
US20100297079A1 (en) 2009-05-20 2010-11-25 Chimerix, Inc. Compounds, compositions and methods for treating viral infection
KR20110061909A (ko) * 2009-12-02 2011-06-10 삼성전자주식회사 도펀트로 도핑된 그라펜 및 이를 이용한 소자
WO2011130595A2 (en) 2010-04-15 2011-10-20 Sirtris Pharmaceuticals, Inc. Sirtuin activators and activation assays
US8481711B2 (en) 2010-07-06 2013-07-09 Hidenori Kamanishi Neurite outgrowth agent
WO2012031196A1 (en) 2010-09-03 2012-03-08 Forma Therapeutics, Inc. 4- { [ ( pyridin- 3 - yl -methyl) aminocarbonyl] amino} benzene - sulfone derivatives as nampt inhibitors for therapy of diseases such as cancer
US9676721B2 (en) 2010-09-03 2017-06-13 Forma Tm, Llc Compounds and compositions for the inhibition of NAMPT
AU2011295725B2 (en) 2010-09-03 2015-03-26 Forma Tm, Llc. Novel compounds and compositions for the inhibition of NAMPT
WO2012094343A1 (en) 2011-01-05 2012-07-12 Trilink Biotechnologies Chemically substituted thermosensitive probes and cofactors for hot start ligation
US20140065099A1 (en) 2011-02-15 2014-03-06 Ecole Polytechnique Federale De Lausanne (Epfl) Methods of Treating Mitochondrial Dysfunction
US20120107888A1 (en) 2011-02-17 2012-05-03 Qteros, Inc. Modulation of fermentation products through vitamin supplementation
AR082888A1 (es) 2011-05-04 2013-01-16 Forma Therapeutics Inc Compuestos de piridina para la inhibicion de nampt
US20120328526A1 (en) 2011-06-27 2012-12-27 University Of Maryland, Baltimore Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof
EP3345901A3 (en) 2011-06-29 2018-09-12 President and Fellows of Harvard College Small molecules as antiaging agents
ES2620612T3 (es) 2012-03-02 2017-06-29 Genentech, Inc. Derivados de sulfóxidos y sulfonas de piridinilo y pirimidinilo
ES2620668T3 (es) 2012-03-02 2017-06-29 Genentech, Inc. Derivados de amidas y sulfonamidas amido espirocíclicas
US10696692B2 (en) 2012-03-02 2020-06-30 Forma Tm, Llc Amido-benzyl sulfone and sulfoxide derivates
WO2013127268A1 (en) 2012-03-02 2013-09-06 Genentech,Inc. Amido-benzyl sulfone and sulfonamide derivatives
WO2013130943A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Alkyl-and di-substituted amido-benzyl sulfonamide derivatives
JP6289460B2 (ja) 2012-07-16 2018-03-07 コーネル ユニヴァーシティー 難聴を治療するためのニコチンアミドリボシド
US9877981B2 (en) * 2012-10-09 2018-01-30 President And Fellows Of Harvard College NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
CN102876759A (zh) * 2012-10-29 2013-01-16 尚科生物医药(上海)有限公司 尼克酰胺腺嘌呤二核苷酸的制备方法
WO2014074715A1 (en) 2012-11-07 2014-05-15 Genentech, Inc. Cyclopropyl amide derivatives
WO2014111906A1 (en) 2013-01-21 2014-07-24 Ecole Polytechnique Federale De Lausanne (Epfl) Bioluminescence imaging of small biomolecules
EP2968306B1 (en) 2013-03-15 2023-06-07 Washington University Administration of nicotinamide mononucleotide in the treatment of dry eye
US20140271355A1 (en) 2013-03-15 2014-09-18 Sabre Intellectual Property Holdings Llc Apparatus and process for focused gas phase application of biocide
GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
US20160287621A1 (en) 2013-11-06 2016-10-06 President And Fellows Of Harvard College Biological production of nad precursors and analogs
AU2014348672A1 (en) 2013-11-12 2016-06-02 Ortho-Nutra, Llc Theacrine-based supplement and method of use thereof
US10398701B2 (en) 2013-11-12 2019-09-03 Ortho-Nutra, Llc Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine
US20160279161A1 (en) 2013-11-14 2016-09-29 Newsouth Innovation Pty Limited Senescence and senescence associated secretory phenotype
CN104367587B (zh) 2013-12-06 2018-06-29 中国人民解放军第二军医大学 烟酰胺单核苷酸在制备促脑缺血后神经再生药物中的应用
US20150258052A1 (en) 2014-03-13 2015-09-17 Salk Institute For Biological Studies Methods of using fexaramine and agents that increase sympathetic nervous system activity to promote browning of white adipose tissue
JP2017511304A (ja) 2014-03-13 2017-04-20 ソーク インスティチュート フォー バイオロジカル スタディーズ フェキサラミン類似体ならびに作製方法および使用方法
US10301268B2 (en) 2014-03-13 2019-05-28 The Salk Institute For Biological Studies Analogs of fexaramine and methods of making and using
WO2015186068A1 (en) 2014-06-02 2015-12-10 Glaxosmithkline Intellectual Property (No.2) Limited Preparation and use of crystalline beta-d-nicotinamide riboside
WO2015187649A1 (en) 2014-06-03 2015-12-10 Sulfagenix, Inc. Methods and compositions for treating nitric oxide deficiency disorders and related conditions
RU2016149767A (ru) 2014-06-06 2018-07-16 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Аналоги никотинамидрибозида и фармацевтические композиции и их применение
CN106715454B (zh) 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
US10653782B2 (en) 2014-11-25 2020-05-19 Nortwestern University Retroviral particles expressing Sirt1 embedded within PPCN
AU2015362283B2 (en) 2014-12-09 2020-07-30 Amorepacific Corporation Composition for activating longevity gene
CA2978069C (en) 2015-03-09 2021-10-12 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
CN104817604B (zh) 2015-03-16 2017-08-04 邦泰生物工程(深圳)有限公司 一种β‑烟酰胺单核苷酸的纯化方法
US20180051253A1 (en) 2015-03-18 2018-02-22 The Regents Of The University Of California Methods of preventing and reversing stem cell aging
CA2987986A1 (en) 2015-06-04 2016-12-08 Chromadex, Inc. Selective solvent free phosphorylation
US20180177703A1 (en) 2015-06-25 2018-06-28 N.V. Perricone Llc Niacinamide Mononucleotide Formulations For Skin Aging
AU2016302005B2 (en) 2015-08-05 2021-03-04 Metro International Biotech, Llc Nicotinamide mononucleotide derivatives and their uses
TW201713774A (zh) 2015-08-06 2017-04-16 Kohjin Life Sciences Co Ltd 含有β-菸鹼醯胺單核苷酸的酵母萃取物及其製造方法
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
KR20180063179A (ko) 2015-10-07 2018-06-11 조엘 후이젠가 인간의 노화에 따른 노쇠의 방어 및 회복을 위한 생체 경로의 복구
WO2017079195A1 (en) 2015-11-02 2017-05-11 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
US10654882B2 (en) 2015-12-21 2020-05-19 Showa Denko K.K. Nicotinamide mononucleotide derivative and salt thereof, method for producing same, topical skin preparation, cosmetic and food additive
EP3187180A1 (en) 2015-12-28 2017-07-05 Ludwig-Maximilians-Universität München Adenosylhomocysteinase binding substances for medical use
WO2017145151A1 (en) 2016-02-23 2017-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (nr) and cosmetic composition comprising (nr and a phosphate-binding agent
US10000520B2 (en) 2016-03-16 2018-06-19 ChromaDex Inc. B-vitamin and amino acid conjugates ofnicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
MX393076B (es) 2016-04-20 2025-03-24 Chromadex Inc Uso de derivados de ribósido de ácido nicotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores que incrementan nad+
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
WO2018023207A1 (zh) 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
WO2018023208A1 (zh) 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
CN108026130B (zh) 2016-07-30 2021-04-02 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
WO2018023205A1 (zh) 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种烟酰胺单核苷酸的纯化方法
WO2018023209A1 (zh) 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
WO2018023210A1 (zh) 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
WO2018047715A1 (ja) * 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β-ニコチンアミドモノヌクレオチドの結晶及びその製造方法
EP3512158B1 (en) 2016-09-09 2021-08-18 Nec Corporation Transmitting device, receiving device, quantum key distribution method, and quantum key distribution program for quantum key distribution system
ES2955713T3 (es) 2016-09-13 2023-12-05 Megumi Tanaka Agente de mejora de la función visual, y método para mejorar la función visual
US20200009170A1 (en) 2016-09-13 2020-01-09 Megumi Tanaka Sleep display agent property and method for improving sleep disorders
EP3538099A4 (en) 2016-11-11 2020-06-17 The Queen's University of Belfast EFFICIENT AND SCALABLE SYNTHESIS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS OF THEM, ADENYLYDINUCLEOTIDE CONJUGATES THEREOF AND NEW-WAY CRYSTALS
US20190328761A1 (en) 2016-12-21 2019-10-31 Newsouth Innovations Pty Limited Methods for enhancing vascular density
CN106755209B (zh) 2016-12-29 2021-07-23 苏州汉酶生物技术有限公司 一种酶法制备β-烟酰胺单核苷酸的方法
WO2018132833A1 (en) 2017-01-13 2018-07-19 The Regents Of The University Of Colorado, A Body Corporate Methods for treating hypertension and arterial stiffness
KR102520690B1 (ko) 2017-01-31 2023-04-10 오리엔탈고우보고오교가부시끼가이샤 다분화능성 줄기세포 증식 촉진제
JP6920071B2 (ja) 2017-02-16 2021-08-18 ワシントン・ユニバーシティWashington University アディポネクチン分泌向上剤
JP7182289B2 (ja) 2017-04-05 2022-12-02 コーネル ユニヴァーシティー β-ニコチネートエステルヌクレオチドおよびその調製プロセス
CA3071561A1 (en) 2017-07-31 2019-02-07 Newsouth Innovations Pty Limited Methods for increasing fertility
WO2019152416A1 (en) 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
US20210388018A1 (en) 2018-10-01 2021-12-16 Cornell University Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof
KR20210108400A (ko) 2018-12-10 2021-09-02 크로마덱스 아이엔씨. 니코티노일 리보사이드 및 이의 유도체의 결정질 형태 및 이의 제조 방법
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
WO2020197882A1 (en) 2019-03-22 2020-10-01 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
EP4153323A1 (fr) 2020-05-20 2023-03-29 Nuvamid SA Compositions cosmetiques anti-age comprenant du nmn
IL308577A (en) 2021-05-27 2024-01-01 Metro Int Biotech Llc Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use

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