JP2021501127A5 - - Google Patents

Download PDF

Info

Publication number
JP2021501127A5
JP2021501127A5 JP2020517332A JP2020517332A JP2021501127A5 JP 2021501127 A5 JP2021501127 A5 JP 2021501127A5 JP 2020517332 A JP2020517332 A JP 2020517332A JP 2020517332 A JP2020517332 A JP 2020517332A JP 2021501127 A5 JP2021501127 A5 JP 2021501127A5
Authority
JP
Japan
Prior art keywords
compound
formula
mixture
weight
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020517332A
Other languages
English (en)
Japanese (ja)
Other versions
JP7783688B2 (ja
JP2021501127A (ja
Filing date
Publication date
Priority claimed from PCT/CN2017/104485 external-priority patent/WO2019061324A1/en
Application filed filed Critical
Publication of JP2021501127A publication Critical patent/JP2021501127A/ja
Publication of JP2021501127A5 publication Critical patent/JP2021501127A5/ja
Priority to JP2023108094A priority Critical patent/JP2023134541A/ja
Application granted granted Critical
Publication of JP7783688B2 publication Critical patent/JP7783688B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020517332A 2017-09-29 2018-09-27 免疫調節剤の結晶形 Active JP7783688B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023108094A JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/104485 2017-09-29
PCT/CN2017/104485 WO2019061324A1 (en) 2017-09-29 2017-09-29 CRYSTALLINE FORMS OF IMMUNOMODULATORS
PCT/US2018/053052 WO2019067678A1 (en) 2017-09-29 2018-09-27 CRYSTALLINE FORMS OF IMMUNOMODULATORS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023108094A Division JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Publications (3)

Publication Number Publication Date
JP2021501127A JP2021501127A (ja) 2021-01-14
JP2021501127A5 true JP2021501127A5 (enExample) 2021-11-04
JP7783688B2 JP7783688B2 (ja) 2025-12-10

Family

ID=65900346

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020517332A Active JP7783688B2 (ja) 2017-09-29 2018-09-27 免疫調節剤の結晶形
JP2023108094A Pending JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023108094A Pending JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Country Status (14)

Country Link
US (5) US11040948B2 (enExample)
EP (1) EP3687534A4 (enExample)
JP (2) JP7783688B2 (enExample)
KR (2) KR20240115921A (enExample)
CN (2) CN111163772A (enExample)
AU (2) AU2018341583B2 (enExample)
BR (1) BR112020006137A2 (enExample)
CA (1) CA3076013A1 (enExample)
EA (1) EA202090500A1 (enExample)
IL (2) IL315814A (enExample)
MY (1) MY201378A (enExample)
PH (1) PH12020550133A1 (enExample)
SG (1) SG11202002378XA (enExample)
WO (2) WO2019061324A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24362B1 (es) 2013-09-06 2018-10-04 Aurigene Discovery Tech Ltd Derivados de 1,2,4-oxadiazol como inmunomoduladores
MX384444B (es) 2015-03-10 2025-03-14 Aurigene Discovery Tech Ltd Compuestos de 1,2,4-oxadiazol y tiadiazol como inmunomoduladores
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
BR112020006669A2 (pt) 2017-10-11 2020-09-24 Aurigene Discovery Technologies Limited formas cristalinas de 1,2,4-oxadiazol 3-substituído
KR20200083503A (ko) 2017-11-03 2020-07-08 오리진 디스커버리 테크놀로지스 리미티드 Tim-3 경로와 pd-1 경로의 이중 저해제
EA202090749A1 (ru) 2017-11-06 2020-08-19 Ориджен Дискавери Текнолоджис Лимитед Способы совместной терапии для иммуномодуляции
AU2019429201A1 (en) 2018-12-20 2021-07-08 Impact Selector International, Llc Downhole tool for connecting with a conveyance line

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3227725A (en) 1962-04-17 1966-01-04 Union Carbide Corp Certain 3,5-disubstituted 1,2,4-oxadiazole compounds
TW201311B (enExample) 1991-06-17 1993-03-01 Hoffmann La Roche
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
WO2001014557A1 (en) 1999-08-23 2001-03-01 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
JP2004533226A (ja) 2001-04-02 2004-11-04 ワイス B7−4に対するpd−1、aレセプター、およびその使用
AU2002258941A1 (en) 2001-04-20 2002-11-05 Mayo Foundation For Medical Education And Research Methods of enhancing cell responsiveness
CA2466279A1 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
GB0204159D0 (en) 2002-02-22 2002-04-10 British Biotech Pharm Metalloproteinase inhibitors
EP2206517B1 (en) 2002-07-03 2023-08-02 Ono Pharmaceutical Co., Ltd. Immunopotentiating compositions comprising anti-PD-L1 antibodies
CN1753912B (zh) 2002-12-23 2011-11-02 惠氏公司 抗pd-1抗体及其用途
TW200524601A (en) 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1593671A1 (en) 2004-03-05 2005-11-09 Graffinity Pharmaceuticals AG DPP-IV inhibitors
WO2006067532A1 (en) 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor agonists
ES2720160T3 (es) 2005-05-09 2019-07-18 Ono Pharmaceutical Co Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas
JP2008546643A (ja) 2005-06-06 2008-12-25 スミスクライン ビーチャム コーポレーション 4−置換アリールアミン誘導体および医薬組成物におけるその使用
AU2006331731A1 (en) 2005-12-20 2007-07-05 Merck Sharp & Dohme Corp. Niacin receptor agonists, compositions containing such compounds and methods of treatment
US8748627B2 (en) 2006-02-15 2014-06-10 Abbvie Inc. Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
WO2008011557A2 (en) 2006-07-20 2008-01-24 Borchardt Allen J Heteroaryl inhibitors of rho kinase
CL2007002743A1 (es) * 2006-09-25 2008-07-11 Pct Therapeutics Inc Soc Organ Forma cristalina del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico; composicion farmaceutica que comprende a dicha forma cristalina; y su uso para modular la terminacion prematura de traslado o decaimiento de marn, tales como carcicoma.
JP5191537B2 (ja) 2007-06-18 2013-05-08 エム・エス・ディー・オス・ベー・フェー ヒトのプログラムされたデスレセプターpd−1に対する抗体
WO2009006555A2 (en) 2007-07-02 2009-01-08 Yu, Ming Methods, composition, targets for combinational cancer treatments
US7868001B2 (en) 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
BRPI0908849A2 (pt) 2008-02-22 2015-08-25 Irm Llc Composto e composições como c-kit e inibidores de pdgfr quinase
WO2010033701A2 (en) 2008-09-19 2010-03-25 Genzyme Corporation Inhibitors of sphingosine kinase 1
EP2349266A4 (en) 2008-10-30 2012-06-06 Elixir Pharmaceuticals Inc Sulphonamide-containing compounds and their uses
HUE065752T2 (hu) 2008-12-09 2024-06-28 Hoffmann La Roche Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére
PT2504364T (pt) 2009-11-24 2017-11-14 Medimmune Ltd Agentes de ligação direcionados contra b7-h1
US20130022629A1 (en) 2010-01-04 2013-01-24 Sharpe Arlene H Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
WO2011137587A1 (en) 2010-05-06 2011-11-10 Hutchison Medipharma Limited Cytokine inhibitors
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
WO2012129564A2 (en) 2011-03-24 2012-09-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome chymotrypsin-like inhibition using pi-1833 analogs
CN103732238A (zh) 2011-06-08 2014-04-16 奥瑞基尼探索技术有限公司 用于免疫调节的治疗性化合物
EP2771337B1 (en) 2011-09-27 2017-08-02 Novartis AG 3-(pyrimidin-4-yl)-oxazolidin-2-ones as inhibitors of mutant idh
CN104159911A (zh) 2012-03-07 2014-11-19 奥瑞基尼探索技术有限公司 作为免疫调节剂的模拟肽化合物
CN104245726A (zh) 2012-03-29 2014-12-24 奥瑞基尼探索技术有限公司 来自人pd1的bc环的免疫调节环状化合物
CA2886433C (en) 2012-10-04 2022-01-04 Dana-Farber Cancer Institute, Inc. Human monoclonal anti-pd-l1 antibodies and methods of use
AU2013329186B2 (en) 2012-10-10 2019-02-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
AR093984A1 (es) 2012-12-21 2015-07-01 Merck Sharp & Dohme Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
JP5941598B2 (ja) 2013-01-09 2016-06-29 ギリアード サイエンシーズ, インコーポレイテッド 5員ヘテロアリールおよびそれらの抗ウイルス剤としての使用
WO2014141104A1 (en) 2013-03-14 2014-09-18 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
WO2014147586A1 (en) 2013-03-22 2014-09-25 Novartis Ag 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh
HRP20181251T1 (hr) * 2013-09-06 2018-10-05 Aurigene Discovery Technologies Limited Derivati 1,3,4-oksadiazola i 1,3,4-tiadiazola kao imunomodulatori
CU24362B1 (es) 2013-09-06 2018-10-04 Aurigene Discovery Tech Ltd Derivados de 1,2,4-oxadiazol como inmunomoduladores
JP6623353B2 (ja) 2013-09-13 2019-12-25 ベイジーン スウィッツァーランド ゲーエムベーハー 抗pd−1抗体並びにその治療及び診断のための使用
GB2516515B8 (en) 2013-12-04 2016-10-05 Intelligent Growth Solutions Ltd Automated arrangement to grow plants under lighting in a vertical tower
US10174012B2 (en) * 2014-11-04 2019-01-08 The University Of Kansas LKB1-AMPK activators for therapeutic use in polycystic kidney disease
CA2979145A1 (en) 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 1,3,4-oxadiazole and thiadiazole compounds as immunomodulators
WO2016142886A2 (en) 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
MX384444B (es) * 2015-03-10 2025-03-14 Aurigene Discovery Tech Ltd Compuestos de 1,2,4-oxadiazol y tiadiazol como inmunomoduladores
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
SMT202200118T1 (it) 2015-11-03 2022-05-12 Janssen Biotech Inc Anticorpi che legano specificamente pd-1 e loro usi
WO2018047143A1 (en) 2016-09-12 2018-03-15 Aurigene Discovery Technologies Limited Vista signaling pathway inhibitory compounds useful as immunomodulators
WO2018051254A1 (en) 2016-09-14 2018-03-22 Aurigene Discovery Technologies Limited Cyclic substituted-1,2,4-oxadiazole compounds as immunomodulators
MX2019004561A (es) 2016-10-20 2019-08-05 Aurigene Discovery Tech Ltd Inhibidores dobles del supresor de inmunoglobulina del dominio v de la activacion de linfocitos t (vista) y las vias de muerte programada 1 (pd-1).
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
BR112020006669A2 (pt) 2017-10-11 2020-09-24 Aurigene Discovery Technologies Limited formas cristalinas de 1,2,4-oxadiazol 3-substituído
KR20200083503A (ko) 2017-11-03 2020-07-08 오리진 디스커버리 테크놀로지스 리미티드 Tim-3 경로와 pd-1 경로의 이중 저해제
EA202090749A1 (ru) 2017-11-06 2020-08-19 Ориджен Дискавери Текнолоджис Лимитед Способы совместной терапии для иммуномодуляции

Similar Documents

Publication Publication Date Title
JP2021501127A5 (enExample)
JP2022176979A5 (enExample)
JP6025861B2 (ja) カバジタキセルの結晶形およびこれを調製するための方法
KR101604501B1 (ko) N-[2-(다이에틸아미노)에틸]-5-[(5-플루오로-1,2-다이하이드로-2-옥소-3h-인돌-3-일리덴)메틸]-2,4-다이메틸-1h-피롤-3-카복스아미드의 결정 형태 및 이의 제조 방법
CN101679218A (zh) 晶体米诺环素碱及其制备方法
JP2018528199A5 (enExample)
JP2005522503A (ja) N−(トランス−4−イソプロピルシクロヘキシルカルボニル)−d−フェニルアラニンの結晶形
CN107635969B (zh) 恩杂鲁胺结晶形式的制造方法
JP2020530473A (ja) ロキサデュスタットの多形および共結晶
EP3414256B1 (en) Purification process involving amine salt of obeticholic acid
KR102266680B1 (ko) 벨리노스테트의 다형태 및 이의 제조 방법
IL315814A (en) Crystalline forms of immunomodulators
CN104011035A (zh) 卡巴他赛的晶型和用于制备其的方法
JP2020536872A5 (enExample)
WO2016107289A1 (zh) 制备索非布韦晶型6的方法
US20180273499A1 (en) Salts and solid state forms of vortioxetine
JP2004520446A5 (enExample)
JP2019172635A (ja) アジルサルタン微細結晶の製造方法
EP2621889B1 (en) Process for making fingolimod hydrochloride crystals
WO2018008219A1 (ja) アジルサルタン中間体、アジルサルタン、及びこれらの製造方法
JP6198269B2 (ja) オルメサルタンメドキソミルの製造方法
WO2017131218A1 (ja) アジルサルタン及びその製造方法
CN109890794B (zh) 纯化1-(4-氯苯基)吡唑-3-醇的方法
JPWO2023058645A5 (enExample)
JP6577938B2 (ja) セフジトレンピボキシルの新規結晶形態およびその製造方法