JP2021501127A5 - - Google Patents

Download PDF

Info

Publication number
JP2021501127A5
JP2021501127A5 JP2020517332A JP2020517332A JP2021501127A5 JP 2021501127 A5 JP2021501127 A5 JP 2021501127A5 JP 2020517332 A JP2020517332 A JP 2020517332A JP 2020517332 A JP2020517332 A JP 2020517332A JP 2021501127 A5 JP2021501127 A5 JP 2021501127A5
Authority
JP
Japan
Prior art keywords
compound
formula
mixture
weight
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020517332A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021501127A (ja
JP7783688B2 (ja
Filing date
Publication date
Priority claimed from PCT/CN2017/104485 external-priority patent/WO2019061324A1/en
Application filed filed Critical
Publication of JP2021501127A publication Critical patent/JP2021501127A/ja
Publication of JP2021501127A5 publication Critical patent/JP2021501127A5/ja
Priority to JP2023108094A priority Critical patent/JP2023134541A/ja
Application granted granted Critical
Publication of JP7783688B2 publication Critical patent/JP7783688B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020517332A 2017-09-29 2018-09-27 免疫調節剤の結晶形 Active JP7783688B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023108094A JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2017/104485 WO2019061324A1 (en) 2017-09-29 2017-09-29 CRYSTALLINE FORMS OF IMMUNOMODULATORS
CNPCT/CN2017/104485 2017-09-29
PCT/US2018/053052 WO2019067678A1 (en) 2017-09-29 2018-09-27 CRYSTALLINE FORMS OF IMMUNOMODULATORS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023108094A Division JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Publications (3)

Publication Number Publication Date
JP2021501127A JP2021501127A (ja) 2021-01-14
JP2021501127A5 true JP2021501127A5 (enExample) 2021-11-04
JP7783688B2 JP7783688B2 (ja) 2025-12-10

Family

ID=65900346

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020517332A Active JP7783688B2 (ja) 2017-09-29 2018-09-27 免疫調節剤の結晶形
JP2023108094A Pending JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023108094A Pending JP2023134541A (ja) 2017-09-29 2023-06-30 免疫調節剤の結晶形

Country Status (14)

Country Link
US (5) US11040948B2 (enExample)
EP (1) EP3687534A4 (enExample)
JP (2) JP7783688B2 (enExample)
KR (2) KR20200060402A (enExample)
CN (2) CN117209444A (enExample)
AU (2) AU2018341583B2 (enExample)
BR (1) BR112020006137A2 (enExample)
CA (1) CA3076013A1 (enExample)
EA (1) EA202090500A1 (enExample)
IL (2) IL315814A (enExample)
MY (1) MY201378A (enExample)
PH (1) PH12020550133A1 (enExample)
SG (1) SG11202002378XA (enExample)
WO (2) WO2019061324A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2675027T3 (es) 2013-09-06 2018-07-05 Aurigene Discovery Technologies Limited Derivados de 1,2,4-oxadiazol como inmunomoduladores
CA3220902A1 (en) 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
BR112020006669A2 (pt) * 2017-10-11 2020-09-24 Aurigene Discovery Technologies Limited formas cristalinas de 1,2,4-oxadiazol 3-substituído
MY206121A (en) 2017-11-03 2024-11-29 Aurigene Discovery Tech Ltd Dual inhibitors of tim-3 and pd-1 pathways
KR20200084333A (ko) 2017-11-06 2020-07-10 오리진 디스커버리 테크놀로지스 리미티드 면역조절을 위한 병행 요법
EP4332345A3 (en) 2018-12-20 2024-05-01 Impact Selector International, Llc Downhole tool for connecting with a conveyance line

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3227725A (en) 1962-04-17 1966-01-04 Union Carbide Corp Certain 3,5-disubstituted 1,2,4-oxadiazole compounds
TW201311B (enExample) 1991-06-17 1993-03-01 Hoffmann La Roche
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
WO2001014557A1 (en) 1999-08-23 2001-03-01 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
BR0208637A (pt) 2001-04-02 2004-12-07 Wyeth Corp Pd-1, um receptor para b7-4, e usos dos mesmos
US7794710B2 (en) 2001-04-20 2010-09-14 Mayo Foundation For Medical Education And Research Methods of enhancing T cell responsiveness
CA2466279A1 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
GB0204159D0 (en) 2002-02-22 2002-04-10 British Biotech Pharm Metalloproteinase inhibitors
US7595048B2 (en) 2002-07-03 2009-09-29 Ono Pharmaceutical Co., Ltd. Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
BR0316880A (pt) 2002-12-23 2005-10-25 Wyeth Corp Anticorpos contra pd-1 e usos dos mesmos
US7569578B2 (en) 2003-12-05 2009-08-04 Bristol-Meyers Squibb Company Heterocyclic anti-migraine agents
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1593671A1 (en) 2004-03-05 2005-11-09 Graffinity Pharmaceuticals AG DPP-IV inhibitors
JP5065908B2 (ja) 2004-12-24 2012-11-07 プロシディオン・リミテッド Gタンパク質結合受容体作動薬
EP2439273B1 (en) 2005-05-09 2019-02-27 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
WO2006133216A2 (en) 2005-06-06 2006-12-14 Smithkline Beecham Corporation 4-substituted arylamine derivatives and their use in pharmaceutical compositions
WO2007075749A2 (en) 2005-12-20 2007-07-05 Merck & Co., Inc. Niacin receptor agonists, compositions containing such compounds and methods of treatment
CN101484433A (zh) 2006-02-15 2009-07-15 艾博特公司 新的乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
US20080021026A1 (en) 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
AU2007300542B2 (en) * 2006-09-25 2012-05-17 Ptc Therapeutics, Inc. Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
CN101842095B (zh) 2007-07-02 2015-06-24 于明 肿瘤治疗的配方,方法和靶目标
US7868001B2 (en) 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
AU2009217356B2 (en) 2008-02-22 2012-05-03 Irm Llc Heterocyclic compounds and compositions as c-kit and PDGFR kinase inhibitors
WO2010033701A2 (en) 2008-09-19 2010-03-25 Genzyme Corporation Inhibitors of sphingosine kinase 1
WO2010051447A1 (en) 2008-10-30 2010-05-06 Elixir Pharmaceuticals, Inc. Sulfonamide containing compounds and uses thereof
US8217149B2 (en) 2008-12-09 2012-07-10 Genentech, Inc. Anti-PD-L1 antibodies, compositions and articles of manufacture
LT3279215T (lt) 2009-11-24 2020-04-10 Medimmune Limited Tiksliniai surišantys agentai prieš b7-h1
US20130022629A1 (en) 2010-01-04 2013-01-24 Sharpe Arlene H Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
WO2011137587A1 (en) 2010-05-06 2011-11-10 Hutchison Medipharma Limited Cytokine inhibitors
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
WO2012129564A2 (en) 2011-03-24 2012-09-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome chymotrypsin-like inhibition using pi-1833 analogs
CN103732238A (zh) 2011-06-08 2014-04-16 奥瑞基尼探索技术有限公司 用于免疫调节的治疗性化合物
TWI547493B (zh) 2011-09-27 2016-09-01 諾華公司 作為突變idh之抑制劑之3-嘧啶-4-基-唑啶-2-酮
CN104159911A (zh) 2012-03-07 2014-11-19 奥瑞基尼探索技术有限公司 作为免疫调节剂的模拟肽化合物
JP2015512910A (ja) 2012-03-29 2015-04-30 オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited ヒトpd1のbcループに由来する免疫調節性環状化合物
CN107892719B (zh) 2012-10-04 2022-01-14 达纳-法伯癌症研究所公司 人单克隆抗-pd-l1抗体和使用方法
EP3763810A3 (en) 2012-10-10 2021-07-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
AR093984A1 (es) 2012-12-21 2015-07-01 Merck Sharp & Dohme Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
EP2943487B1 (en) 2013-01-09 2016-11-16 Gilead Sciences, Inc. 5-membered heteroaryls and their use as antiviral agents
WO2014141104A1 (en) 2013-03-14 2014-09-18 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
WO2014147586A1 (en) 2013-03-22 2014-09-25 Novartis Ag 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh
ES2675027T3 (es) 2013-09-06 2018-07-05 Aurigene Discovery Technologies Limited Derivados de 1,2,4-oxadiazol como inmunomoduladores
SG11201601679TA (en) * 2013-09-06 2016-04-28 Aurigene Discovery Tech Ltd 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
PT3702373T (pt) 2013-09-13 2022-09-27 Beigene Switzerland Gmbh Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico
GB2516515B8 (en) 2013-12-04 2016-10-05 Intelligent Growth Solutions Ltd Automated arrangement to grow plants under lighting in a vertical tower
US10174012B2 (en) * 2014-11-04 2019-01-08 The University Of Kansas LKB1-AMPK activators for therapeutic use in polycystic kidney disease
SG11201706902SA (en) 2015-03-10 2017-09-28 Aurigene Discovery Tech Ltd 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
JP2018507885A (ja) 2015-03-10 2018-03-22 オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited 免疫調節剤としての1,3,4−オキサジアゾールおよびチアジアゾール化合物
CA3220902A1 (en) 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
BR112018008891A8 (pt) 2015-11-03 2019-02-26 Janssen Biotech Inc anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos
WO2018047143A1 (en) 2016-09-12 2018-03-15 Aurigene Discovery Technologies Limited Vista signaling pathway inhibitory compounds useful as immunomodulators
WO2018051254A1 (en) 2016-09-14 2018-03-22 Aurigene Discovery Technologies Limited Cyclic substituted-1,2,4-oxadiazole compounds as immunomodulators
KR20190067235A (ko) 2016-10-20 2019-06-14 오리진 디스커버리 테크놀로지스 리미티드 Vista 및 pd-1 경로의 이중 억제제
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
BR112020006669A2 (pt) 2017-10-11 2020-09-24 Aurigene Discovery Technologies Limited formas cristalinas de 1,2,4-oxadiazol 3-substituído
MY206121A (en) 2017-11-03 2024-11-29 Aurigene Discovery Tech Ltd Dual inhibitors of tim-3 and pd-1 pathways
KR20200084333A (ko) 2017-11-06 2020-07-10 오리진 디스커버리 테크놀로지스 리미티드 면역조절을 위한 병행 요법

Similar Documents

Publication Publication Date Title
JP2021501127A5 (enExample)
JP2022176979A5 (enExample)
JP6081763B2 (ja) ダサチニブ多形体およびその調製プロセス
JP6025861B2 (ja) カバジタキセルの結晶形およびこれを調製するための方法
JP2005503386A5 (enExample)
KR101604501B1 (ko) N-[2-(다이에틸아미노)에틸]-5-[(5-플루오로-1,2-다이하이드로-2-옥소-3h-인돌-3-일리덴)메틸]-2,4-다이메틸-1h-피롤-3-카복스아미드의 결정 형태 및 이의 제조 방법
CN101679218A (zh) 晶体米诺环素碱及其制备方法
JP2005522503A (ja) N−(トランス−4−イソプロピルシクロヘキシルカルボニル)−d−フェニルアラニンの結晶形
JP2018528199A5 (enExample)
CN107635969B (zh) 恩杂鲁胺结晶形式的制造方法
EP3414256B1 (en) Purification process involving amine salt of obeticholic acid
KR102266680B1 (ko) 벨리노스테트의 다형태 및 이의 제조 방법
JP2020530473A (ja) ロキサデュスタットの多形および共結晶
IL315814A (en) Crystalline forms of immunomodulators
CN104011035A (zh) 卡巴他赛的晶型和用于制备其的方法
JP2020536872A5 (enExample)
WO2016107289A1 (zh) 制备索非布韦晶型6的方法
US20180273499A1 (en) Salts and solid state forms of vortioxetine
JP2004520446A5 (enExample)
JP2019172635A (ja) アジルサルタン微細結晶の製造方法
EP2621889B1 (en) Process for making fingolimod hydrochloride crystals
WO2018008219A1 (ja) アジルサルタン中間体、アジルサルタン、及びこれらの製造方法
JP6198269B2 (ja) オルメサルタンメドキソミルの製造方法
WO2017131218A1 (ja) アジルサルタン及びその製造方法
CN109890794B (zh) 纯化1-(4-氯苯基)吡唑-3-醇的方法