MX2019004561A - Inhibidores dobles del supresor de inmunoglobulina del dominio v de la activacion de linfocitos t (vista) y las vias de muerte programada 1 (pd-1). - Google Patents

Inhibidores dobles del supresor de inmunoglobulina del dominio v de la activacion de linfocitos t (vista) y las vias de muerte programada 1 (pd-1).

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Publication number
MX2019004561A
MX2019004561A MX2019004561A MX2019004561A MX2019004561A MX 2019004561 A MX2019004561 A MX 2019004561A MX 2019004561 A MX2019004561 A MX 2019004561A MX 2019004561 A MX2019004561 A MX 2019004561A MX 2019004561 A MX2019004561 A MX 2019004561A
Authority
MX
Mexico
Prior art keywords
vista
pathways
dual inhibitors
inhibitors
relates
Prior art date
Application number
MX2019004561A
Other languages
English (en)
Inventor
Ramachandra Muralidhara
Govindan Nair Sasikumar Pottayil
Setty Sudarshan Naremaddepalli Seetharamaiah
Original Assignee
Aurigene Discovery Tech Ltd
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Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of MX2019004561A publication Critical patent/MX2019004561A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente descripción hace referencia a compuestos de 1,2,4-oxadiazol 3-substituidos y sus derivados, que son útiles como inhibidores del supresor de inmunoglobulina del dominio V de la activación de linfocitos T (VISTA) o como inhibidores dobles del VISTA y la vía de señalización de la muerte celular programada 1 (PD-1). La descripción también hace referencia al tratamiento de trastornos mediante la inhibición de una señal inmunosupresora inducida por el VISTA y sus ligandos, PD-1, PD-L1 y/o PD-L2.
MX2019004561A 2016-10-20 2017-10-18 Inhibidores dobles del supresor de inmunoglobulina del dominio v de la activacion de linfocitos t (vista) y las vias de muerte programada 1 (pd-1). MX2019004561A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641035996 2016-10-20
PCT/IB2017/056463 WO2018073754A1 (en) 2016-10-20 2017-10-18 Dual inhibitors of vista and pd-1 pathways

Publications (1)

Publication Number Publication Date
MX2019004561A true MX2019004561A (es) 2019-08-05

Family

ID=62019280

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019004561A MX2019004561A (es) 2016-10-20 2017-10-18 Inhibidores dobles del supresor de inmunoglobulina del dominio v de la activacion de linfocitos t (vista) y las vias de muerte programada 1 (pd-1).
MX2023007973A MX2023007973A (es) 2016-10-20 2019-04-17 Inhibidores dobles del supresor de inmunoglobulina del dominio v de la activacion de linfocitos t (vista) y las vias de muerte programada 1 (pd-1).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023007973A MX2023007973A (es) 2016-10-20 2019-04-17 Inhibidores dobles del supresor de inmunoglobulina del dominio v de la activacion de linfocitos t (vista) y las vias de muerte programada 1 (pd-1).

Country Status (14)

Country Link
US (1) US20200061030A1 (es)
EP (1) EP3529235A4 (es)
JP (2) JP7189870B2 (es)
KR (1) KR20190067235A (es)
CN (1) CN110139856A (es)
AU (1) AU2017345500B2 (es)
BR (1) BR112019007872A2 (es)
CA (1) CA3040033A1 (es)
EA (1) EA201990997A1 (es)
IL (2) IL266042A (es)
MX (2) MX2019004561A (es)
PH (1) PH12019500780A1 (es)
SG (2) SG10202010584XA (es)
WO (1) WO2018073754A1 (es)

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PL3041827T3 (pl) 2013-09-06 2018-09-28 Aurigene Discovery Tech Limited Pochodne 1,2,4-oksadiazolu jako immunomodulatory
AU2016230793B2 (en) 2015-03-10 2021-03-25 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
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WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
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WO2019087087A1 (en) 2017-11-03 2019-05-09 Aurigene Discovery Technologies Limited Dual inhibitors of tim-3 and pd-1 pathways
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PL3041827T3 (pl) * 2013-09-06 2018-09-28 Aurigene Discovery Tech Limited Pochodne 1,2,4-oksadiazolu jako immunomodulatory
SG11201706902SA (en) * 2015-03-10 2017-09-28 Aurigene Discovery Tech Ltd 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
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Also Published As

Publication number Publication date
US20200061030A1 (en) 2020-02-27
PH12019500780A1 (en) 2019-08-05
AU2017345500B2 (en) 2022-03-10
EP3529235A1 (en) 2019-08-28
IL287518A (en) 2021-12-01
EA201990997A1 (ru) 2019-08-30
BR112019007872A2 (pt) 2019-07-02
WO2018073754A1 (en) 2018-04-26
JP7189870B2 (ja) 2022-12-14
CN110139856A (zh) 2019-08-16
SG10202010584XA (en) 2020-12-30
AU2017345500A1 (en) 2019-05-23
CA3040033A1 (en) 2018-04-26
KR20190067235A (ko) 2019-06-14
SG11201903103VA (en) 2019-05-30
JP2022191239A (ja) 2022-12-27
EP3529235A4 (en) 2020-07-08
IL266042A (en) 2019-06-30
NZ753204A (en) 2023-09-29
MX2023007973A (es) 2023-07-18
JP2019532083A (ja) 2019-11-07

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