BR112019007872A2 - inibidores duplos de vista e das vias pd-1 - Google Patents

inibidores duplos de vista e das vias pd-1

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Publication number
BR112019007872A2
BR112019007872A2 BR112019007872A BR112019007872A BR112019007872A2 BR 112019007872 A2 BR112019007872 A2 BR 112019007872A2 BR 112019007872 A BR112019007872 A BR 112019007872A BR 112019007872 A BR112019007872 A BR 112019007872A BR 112019007872 A2 BR112019007872 A2 BR 112019007872A2
Authority
BR
Brazil
Prior art keywords
inhibitors
sight
relates
double
double sight
Prior art date
Application number
BR112019007872A
Other languages
English (en)
Inventor
Govindan Nair Sasikumar Pottayil
Ramachandra Muralidhara
Setty Sudarshan Naremaddepalli Seetharamaiah
Original Assignee
Aurigene Discovery Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurigene Discovery Technologies Limited filed Critical Aurigene Discovery Technologies Limited
Publication of BR112019007872A2 publication Critical patent/BR112019007872A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

a presente invenção refere-se a compostos de 1,2,4-oxadiazol 3-substituídos e seus derivados, que são úteis como supressores de imunoglobulina de domínio v de inibidores de ativação de células t (vista) ou como inibidores duplos de vista e a via de sinalização de morte celular programada 1 (pd-1). a divulgação também se refere ao tratamento de distúrbios inibindo um sinal imunossupressor induzido por vista e seus ligantes, pd-1, pd-l1 e/ou pd-l2.
BR112019007872A 2016-10-20 2017-10-18 inibidores duplos de vista e das vias pd-1 BR112019007872A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641035996 2016-10-20
PCT/IB2017/056463 WO2018073754A1 (en) 2016-10-20 2017-10-18 Dual inhibitors of vista and pd-1 pathways

Publications (1)

Publication Number Publication Date
BR112019007872A2 true BR112019007872A2 (pt) 2019-07-02

Family

ID=62019280

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019007872A BR112019007872A2 (pt) 2016-10-20 2017-10-18 inibidores duplos de vista e das vias pd-1

Country Status (14)

Country Link
US (1) US20200061030A1 (pt)
EP (1) EP3529235A4 (pt)
JP (2) JP7189870B2 (pt)
KR (1) KR20190067235A (pt)
CN (1) CN110139856A (pt)
AU (1) AU2017345500B2 (pt)
BR (1) BR112019007872A2 (pt)
CA (1) CA3040033A1 (pt)
EA (1) EA201990997A1 (pt)
IL (2) IL266042A (pt)
MX (1) MX2019004561A (pt)
PH (1) PH12019500780A1 (pt)
SG (2) SG10202010584XA (pt)
WO (1) WO2018073754A1 (pt)

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WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
JP2020536872A (ja) 2017-10-11 2020-12-17 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ ３−置換１，２，４−オキサジアゾールの結晶形態
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CA3081675A1 (en) 2017-11-06 2019-05-09 Aurigene Discovery Technologies Limited Conjoint therapies for immunomodulation
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TWI721624B (zh) 2018-10-31 2021-03-11 美商基利科學股份有限公司 經取代之6-氮雜苯并咪唑化合物
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CN113543851A (zh) 2019-03-07 2021-10-22 捷克共和国有机化学与生物化学研究所 2’3’-环二核苷酸及其前药
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PL3363790T3 (pl) * 2013-09-06 2020-07-27 Aurigene Discovery Technologies Limited Pochodne 1,2,4-oksadiazolu jako immunomodulatory
CN107427476A (zh) * 2015-03-10 2017-12-01 奥瑞基尼探索技术有限公司 作为免疫调节剂的3‑取代的‑1,2,4‑噁二唑和噻二唑化合物
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Also Published As

Publication number Publication date
SG11201903103VA (en) 2019-05-30
SG10202010584XA (en) 2020-12-30
KR20190067235A (ko) 2019-06-14
IL266042A (en) 2019-06-30
AU2017345500A1 (en) 2019-05-23
JP2019532083A (ja) 2019-11-07
EP3529235A4 (en) 2020-07-08
JP7189870B2 (ja) 2022-12-14
WO2018073754A1 (en) 2018-04-26
US20200061030A1 (en) 2020-02-27
EP3529235A1 (en) 2019-08-28
AU2017345500B2 (en) 2022-03-10
CN110139856A (zh) 2019-08-16
EA201990997A1 (ru) 2019-08-30
CA3040033A1 (en) 2018-04-26
IL287518A (en) 2021-12-01
PH12019500780A1 (en) 2019-08-05
MX2019004561A (es) 2019-08-05
NZ753204A (en) 2023-09-29
JP2022191239A (ja) 2022-12-27

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B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 271/06

Ipc: A61K 31/4245 (2006.01), A61K 31/422 (2006.01), C07

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25D Requested change of name of applicant approved

Owner name: AURIGENE ONCOLOGY LIMITED (IN)