JP2022097516A5 - - Google Patents
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- JP2022097516A5 JP2022097516A5 JP2022066559A JP2022066559A JP2022097516A5 JP 2022097516 A5 JP2022097516 A5 JP 2022097516A5 JP 2022066559 A JP2022066559 A JP 2022066559A JP 2022066559 A JP2022066559 A JP 2022066559A JP 2022097516 A5 JP2022097516 A5 JP 2022097516A5
- Authority
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- Prior art keywords
- cells
- cell
- pluripotent stem
- pluripotency
- feeder
- Prior art date
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- 210000004027 cell Anatomy 0.000 claims 42
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 35
- 238000000034 method Methods 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 12
- 239000003112 inhibitor Substances 0.000 claims 11
- 102000001267 GSK3 Human genes 0.000 claims 7
- 108060006662 GSK3 Proteins 0.000 claims 7
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 7
- 239000011435 rock Substances 0.000 claims 7
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 6
- 108010083123 CDX2 Transcription Factor Proteins 0.000 claims 5
- 102000006277 CDX2 Transcription Factor Human genes 0.000 claims 5
- 102100031196 Choriogonadotropin subunit beta 3 Human genes 0.000 claims 5
- 101000776619 Homo sapiens Choriogonadotropin subunit beta 3 Proteins 0.000 claims 5
- 101000819088 Homo sapiens Transcription factor GATA-6 Proteins 0.000 claims 5
- 102100021382 Transcription factor GATA-6 Human genes 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000014509 gene expression Effects 0.000 claims 5
- 229940124647 MEK inhibitor Drugs 0.000 claims 4
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 4
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 4
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 4
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
- 210000005260 human cell Anatomy 0.000 claims 4
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 3
- 230000008672 reprogramming Effects 0.000 claims 3
- 102100022464 5'-nucleotidase Human genes 0.000 claims 2
- 108010005465 AC133 Antigen Proteins 0.000 claims 2
- 102000005908 AC133 Antigen Human genes 0.000 claims 2
- -1 CD31 Proteins 0.000 claims 2
- 102100037904 CD9 antigen Human genes 0.000 claims 2
- 102100037241 Endoglin Human genes 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 2
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 2
- 101000599862 Homo sapiens Intercellular adhesion molecule 3 Proteins 0.000 claims 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 2
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 2
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 2
- 102100025304 Integrin beta-1 Human genes 0.000 claims 2
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 2
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 2
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 2
- 102100040120 Prominin-1 Human genes 0.000 claims 2
- 108091005735 TGF-beta receptors Proteins 0.000 claims 2
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 2
- 239000006285 cell suspension Substances 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 230000005283 ground state Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- 102000018918 Activin Receptors Human genes 0.000 claims 1
- 108010052946 Activin Receptors Proteins 0.000 claims 1
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical compound CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000031448 Genomic Instability Diseases 0.000 claims 1
- 210000001766 X chromosome Anatomy 0.000 claims 1
- 108091007416 X-inactive specific transcript Proteins 0.000 claims 1
- 108091035715 XIST (gene) Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 230000032823 cell division Effects 0.000 claims 1
- 230000003833 cell viability Effects 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000013028 medium composition Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000007420 reactivation Effects 0.000 claims 1
- 108091006082 receptor inhibitors Proteins 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023113157A JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2024219417A JP2025039573A (ja) | 2010-12-22 | 2024-12-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426369P | 2010-12-22 | 2010-12-22 | |
| US61/426,369 | 2010-12-22 | ||
| US201161496991P | 2011-06-14 | 2011-06-14 | |
| US61/496,991 | 2011-06-14 | ||
| JP2020054166A JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020054166A Division JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023113157A Division JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022097516A JP2022097516A (ja) | 2022-06-30 |
| JP2022097516A5 true JP2022097516A5 (enExample) | 2023-01-19 |
| JP7350127B2 JP7350127B2 (ja) | 2023-09-25 |
Family
ID=46314809
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546290A Active JP6182456B2 (ja) | 2010-12-22 | 2011-12-19 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2017103182A Active JP6682474B2 (ja) | 2010-12-22 | 2017-05-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2020054166A Active JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2022066559A Active JP7350127B2 (ja) | 2010-12-22 | 2022-04-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2023113157A Active JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2024219417A Pending JP2025039573A (ja) | 2010-12-22 | 2024-12-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546290A Active JP6182456B2 (ja) | 2010-12-22 | 2011-12-19 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2017103182A Active JP6682474B2 (ja) | 2010-12-22 | 2017-05-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2020054166A Active JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023113157A Active JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2024219417A Pending JP2025039573A (ja) | 2010-12-22 | 2024-12-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9732319B2 (enExample) |
| EP (1) | EP2655601A4 (enExample) |
| JP (6) | JP6182456B2 (enExample) |
| KR (6) | KR20200113286A (enExample) |
| CN (3) | CN114164167B (enExample) |
| AU (1) | AU2011349446C1 (enExample) |
| CA (1) | CA2822638C (enExample) |
| WO (1) | WO2012087965A2 (enExample) |
Families Citing this family (84)
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| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| SG173492A1 (en) | 2009-02-03 | 2011-09-29 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| KR20200113286A (ko) | 2010-12-22 | 2020-10-06 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| US10428309B2 (en) * | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| US10273459B2 (en) | 2011-12-01 | 2019-04-30 | New York Stem Cell Foundation | Automated system for producing induced pluripotent stem cells or differentiated cells |
| JP6433902B2 (ja) * | 2013-01-04 | 2018-12-05 | 国立大学法人京都大学 | 初期化幹細胞 |
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| WO2014117146A1 (en) * | 2013-01-28 | 2014-07-31 | Rutgers, The State University Of New Jersey | Growth matrices for stem cell propagation in vitro and in tissue regeneration |
| SG11201506520TA (en) * | 2013-02-18 | 2015-09-29 | Univ Health Network | Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells |
| WO2014200114A1 (en) * | 2013-06-11 | 2014-12-18 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US20160115447A1 (en) * | 2013-06-11 | 2016-04-28 | President And Fellows Of Harvard College | Compositions and methods for improving induced neuron generation |
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| CN103667349B (zh) * | 2013-11-15 | 2017-02-15 | 安徽农业大学 | 一种高效获取猪诱导性多能干细胞的方法 |
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| CN105441384B (zh) * | 2014-09-26 | 2021-01-05 | 北京大学 | 一种制备动物和人类原始多潜能干细胞的方法，试剂盒及用途 |
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