JP2022062045A5 - - Google Patents

Info

Publication number

JP2022062045A5

JP2022062045A5 JP2022003408A JP2022003408A JP2022062045A5 JP 2022062045 A5 JP2022062045 A5 JP 2022062045A5 JP 2022003408 A JP2022003408 A JP 2022003408A JP 2022003408 A JP2022003408 A JP 2022003408A JP 2022062045 A5 JP2022062045 A5 JP 2022062045A5

Authority

JP

Japan

Prior art keywords

use according

agent

atropine

ophthalmic composition

stabilized ophthalmic

Prior art date

2022-01-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 18
• 239000003795 chemical substances by application Substances 0.000 claims 10
• 229930003347 Atropine Natural products 0.000 claims 8
• RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims 8
• HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 claims 8
• 229960000396 atropine Drugs 0.000 claims 8
• RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims 8
• 229960002028 atropine sulfate Drugs 0.000 claims 8
• 239000003755 preservative agent Substances 0.000 claims 6
• 239000000872 buffer Substances 0.000 claims 5
• 230000002335 preservative effect Effects 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 239000012929 tonicity agent Substances 0.000 claims 3
• 230000015556 catabolic process Effects 0.000 claims 2
• 239000002738 chelating agent Substances 0.000 claims 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 2
• 239000007857 degradation product Substances 0.000 claims 2
• 238000006731 degradation reaction Methods 0.000 claims 2
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000004515 progressive myopia Effects 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
• ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
• 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
• 229920002413 Polyhexanide Polymers 0.000 claims 1
• 239000008351 acetate buffer Substances 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 229960000686 benzalkonium chloride Drugs 0.000 claims 1
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
• 150000001642 boronic acid derivatives Chemical group 0.000 claims 1
• 239000007853 buffer solution Substances 0.000 claims 1
• 239000006172 buffering agent Substances 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 229960003431 cetrimonium Drugs 0.000 claims 1
• RLGQACBPNDBWTB-UHFFFAOYSA-N cetyltrimethylammonium ion Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)C RLGQACBPNDBWTB-UHFFFAOYSA-N 0.000 claims 1
• 229960004926 chlorobutanol Drugs 0.000 claims 1
• 239000007979 citrate buffer Substances 0.000 claims 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
• 239000003889 eye drop Substances 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• -1 halogen salt Chemical class 0.000 claims 1
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
• 235000019799 monosodium phosphate Nutrition 0.000 claims 1
• 230000004379 myopia Effects 0.000 claims 1
• 208000001491 myopia Diseases 0.000 claims 1
• 125000005430 oxychloro group Chemical group 0.000 claims 1
• 239000008363 phosphate buffer Substances 0.000 claims 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
• 229960004919 procaine Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
• 229960001922 sodium perborate Drugs 0.000 claims 1
• YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims 1