JP2018188440A5 - - Google Patents
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- Publication number
- JP2018188440A5 JP2018188440A5 JP2018091739A JP2018091739A JP2018188440A5 JP 2018188440 A5 JP2018188440 A5 JP 2018188440A5 JP 2018091739 A JP2018091739 A JP 2018091739A JP 2018091739 A JP2018091739 A JP 2018091739A JP 2018188440 A5 JP2018188440 A5 JP 2018188440A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- atropine
- ophthalmic
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 35
- 229930003347 Atropine Natural products 0.000 claims description 27
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims description 27
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 27
- 229960000396 atropine Drugs 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 14
- 238000009472 formulation Methods 0.000 claims description 12
- 239000000872 buffer Substances 0.000 claims description 8
- VBSTXRUAXCTZBQ-UHFFFAOYSA-N 1-hexyl-4-phenylpiperazine Chemical compound C1CN(CCCCCC)CCN1C1=CC=CC=C1 VBSTXRUAXCTZBQ-UHFFFAOYSA-N 0.000 claims description 3
- JACRWUWPXAESPB-QMMMGPOBSA-N Tropic acid Natural products OC[C@H](C(O)=O)C1=CC=CC=C1 JACRWUWPXAESPB-QMMMGPOBSA-N 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 13
- 239000002738 chelating agent Substances 0.000 claims 7
- 239000004034 viscosity adjusting agent Substances 0.000 claims 7
- 239000007864 aqueous solution Substances 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 239000007853 buffer solution Substances 0.000 claims 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 229940061607 dibasic sodium phosphate Drugs 0.000 claims 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000011146 sterile filtration Methods 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 claims 1
- 150000003628 tricarboxylic acids Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
- 229910052805 deuterium Inorganic materials 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 1
- 229920006237 degradable polymer Polymers 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000005445 isotope effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000002911 mydriatic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000004515 progressive myopia Effects 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762505027P | 2017-05-11 | 2017-05-11 | |
| US62/505,027 | 2017-05-11 |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129396A Division JP6865476B2 (ja) | 2017-05-11 | 2019-07-11 | 眼科用アトロピン組成物 |
| JP2019129403A Division JP6681502B2 (ja) | 2017-05-11 | 2019-07-11 | 貯蔵安定性液体低用量アトロピン眼科用製剤を調製する方法 |
| JP2019129405A Division JP6681503B2 (ja) | 2017-05-11 | 2019-07-11 | 近視の治療用の治療キット、および、近視の治療のための薬剤の製造におけるアトロピンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018188440A JP2018188440A (ja) | 2018-11-29 |
| JP2018188440A5 true JP2018188440A5 (https=) | 2019-02-07 |
| JP6557379B2 JP6557379B2 (ja) | 2019-08-07 |
Family
ID=64096170
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018091739A Active JP6557379B2 (ja) | 2017-05-11 | 2018-05-10 | アトロピン医薬組成物 |
| JP2019129405A Active JP6681503B2 (ja) | 2017-05-11 | 2019-07-11 | 近視の治療用の治療キット、および、近視の治療のための薬剤の製造におけるアトロピンの使用 |
| JP2019129396A Active JP6865476B2 (ja) | 2017-05-11 | 2019-07-11 | 眼科用アトロピン組成物 |
| JP2019129403A Active JP6681502B2 (ja) | 2017-05-11 | 2019-07-11 | 貯蔵安定性液体低用量アトロピン眼科用製剤を調製する方法 |
| JP2021056894A Active JP7332179B2 (ja) | 2017-05-11 | 2021-03-30 | 眼科用アトロピン組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129405A Active JP6681503B2 (ja) | 2017-05-11 | 2019-07-11 | 近視の治療用の治療キット、および、近視の治療のための薬剤の製造におけるアトロピンの使用 |
| JP2019129396A Active JP6865476B2 (ja) | 2017-05-11 | 2019-07-11 | 眼科用アトロピン組成物 |
| JP2019129403A Active JP6681502B2 (ja) | 2017-05-11 | 2019-07-11 | 貯蔵安定性液体低用量アトロピン眼科用製剤を調製する方法 |
| JP2021056894A Active JP7332179B2 (ja) | 2017-05-11 | 2021-03-30 | 眼科用アトロピン組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (14) | US10251875B2 (https=) |
| EP (2) | EP3970694A1 (https=) |
| JP (5) | JP6557379B2 (https=) |
| KR (1) | KR102281667B1 (https=) |
| CN (1) | CN110621298B (https=) |
| AU (1) | AU2018265257B2 (https=) |
| CA (1) | CA3063228C (https=) |
| CL (1) | CL2019003228A1 (https=) |
| CO (1) | CO2019012893A2 (https=) |
| CY (1) | CY1124880T1 (https=) |
| ES (1) | ES2901140T3 (https=) |
| HR (1) | HRP20212019T1 (https=) |
| HU (1) | HUE056595T2 (https=) |
| LT (1) | LT3548000T (https=) |
| MX (1) | MX392558B (https=) |
| PH (1) | PH12019502701A1 (https=) |
| PL (1) | PL3548000T3 (https=) |
| PT (1) | PT3548000T (https=) |
| RS (1) | RS62817B1 (https=) |
| RU (1) | RU2745603C1 (https=) |
| SG (1) | SG11201910085UA (https=) |
| SI (1) | SI3548000T1 (https=) |
| WO (1) | WO2018209051A1 (https=) |
Families Citing this family (34)
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| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| HK1248570A1 (zh) | 2015-05-29 | 2018-10-19 | 西德奈克西斯公司 | D2o稳定化的药物制剂 |
| ES2929368T3 (es) | 2016-05-25 | 2022-11-28 | Singapore Health Serv Pte Ltd | Composición acuosa que contiene atropina |
| RU2745603C1 (ru) | 2017-05-11 | 2021-03-29 | Невакар Инк. | Фармацевтические композиции атропина |
| JP7227163B2 (ja) | 2017-06-10 | 2023-02-21 | アイノビア，インコーポレイティド | 流体を取扱い、目に流体を送出するための方法および装置 |
| US11554115B2 (en) * | 2018-03-14 | 2023-01-17 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Quinoline derivative for treatment of triple-negative breast cancer |
| WO2019216395A1 (ja) * | 2018-05-11 | 2019-11-14 | 千寿製薬株式会社 | 眼科用組成物 |
| CN114557955B (zh) * | 2018-09-25 | 2024-06-18 | 沈阳兴齐眼药股份有限公司 | 药物组合物、其制备方法和用途 |
| WO2020219707A1 (en) * | 2019-04-24 | 2020-10-29 | Allergan, Inc. | Compositions and methods for treatment of ocular conditions |
| WO2021001806A1 (en) * | 2019-07-04 | 2021-01-07 | Ocular Discovery Ltd. | Stable dipyridamole formulations with reduced impurities |
| WO2021119513A1 (en) | 2019-12-11 | 2021-06-17 | Eyenovia, Inc. | Systems and devices for delivering fluids to the eye and methods of use |
| JP2023505841A (ja) * | 2019-12-16 | 2023-02-13 | シドネキシス，インク． | Ｄ２ｏを含む眼科用組成物 |
| CN110917133A (zh) * | 2019-12-23 | 2020-03-27 | 河北科技大学 | 一种治疗近视的滴眼剂及其制备方法 |
| MX2022013037A (es) * | 2020-05-05 | 2022-11-09 | Procter & Gamble | Composiciones para el cuidado bucal que comprenden acido dicarboxilico. |
| CN111821259A (zh) * | 2020-07-14 | 2020-10-27 | 艾尔健康眼药(辽宁)有限公司 | 一种眼用药物组合物 |
| CN111840221A (zh) * | 2020-08-25 | 2020-10-30 | 安徽博诺美科生物医药有限公司 | 一种硫酸阿托品滴眼液 |
| WO2022130033A1 (en) * | 2020-12-17 | 2022-06-23 | Sun Pharmaceutical Industries Limited | An aqueous sterile solution of atropine for ophthalmic use |
| US20240156724A1 (en) * | 2021-03-16 | 2024-05-16 | Vyluma Inc. | Multi-Dose Container for Ophthalmic Compositions |
| EP4088713A1 (en) * | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| EP4088714A1 (en) * | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| CN113440486B (zh) * | 2021-06-02 | 2022-12-20 | 苏州欧康维视生物科技有限公司 | 一种用于预防或治疗眼科疾病的滴眼剂组合物及其制备方法 |
| JP2024531836A (ja) * | 2021-09-13 | 2024-08-29 | オウプーシーファン ファーマシューティカル テクノロジー カンパニー リミテッド | アトロピン点眼液及びその調製方法 |
| WO2023086878A1 (en) * | 2021-11-10 | 2023-05-19 | Visus Therapeutics, Inc. | Carbachol formulations to enhance anti-presbyopia effects |
| CN114129511A (zh) * | 2021-12-07 | 2022-03-04 | 河南润弘制药股份有限公司 | 一种具有改进稳定性的硫酸阿托品注射液 |
| WO2023152642A1 (en) * | 2022-02-08 | 2023-08-17 | Avaca Pharma Private Limited | Ophthalmic compositions and methods thereof |
| US20230277521A1 (en) * | 2022-03-07 | 2023-09-07 | Harrow Ip, Llc | Extended-release pharmaceutical compositions for treating eye conditions |
| CN114569551A (zh) * | 2022-03-21 | 2022-06-03 | 杭州赫尔斯科技有限公司 | 阿托品滴眼液及其制备方法 |
| WO2023201315A2 (en) * | 2022-04-14 | 2023-10-19 | TearClear Corp. | Ophthalmic agent in preservative removal device |
| CN115177584A (zh) * | 2022-07-14 | 2022-10-14 | 成都市海通药业有限公司 | 一种硫酸阿托品注射液的制备方法 |
| WO2024091789A1 (en) * | 2022-10-26 | 2024-05-02 | Vyluma Inc. | Childhood atropine for myopia progression |
| CN115998692A (zh) * | 2023-02-15 | 2023-04-25 | 苏州欧康维视生物科技有限公司 | 一种阿托品药物产品及其用途 |
| WO2025146828A1 (ja) * | 2024-01-05 | 2025-07-10 | ロート製薬株式会社 | 眼科組成物 |
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| US20070254914A1 (en) | 2006-05-01 | 2007-11-01 | Non-Profit Organization Chang Gung Memorial Hospital | Low-concentration atropine solution for preventing myopia progression and preparing method thereof |
| JP2007308398A (ja) * | 2006-05-17 | 2007-11-29 | Chang Gung Memorial Hospital | 目薬、及びその製造方法 |
| NZ584275A (en) * | 2007-10-08 | 2012-06-29 | Fovea Pharmaceuticals | Aqueous cyclosporine ophthalmic formulations |
| US8883214B2 (en) | 2009-01-13 | 2014-11-11 | The Regents Of The University Of California | Implantable delivery vehicle for ocular delivery of muscarinic antagonists |
| EP2464387A4 (en) | 2009-08-12 | 2013-05-15 | Seros Medical Llc | DEUTERATED WATER SOLUTION AND RIBOFLAVIN FOR EXTENDED OXYGEN SINGULET LIFETIME IN THE TREATMENT OF OCULAR TISSUE AND METHOD OF USE |
| WO2012161655A1 (en) | 2011-05-23 | 2012-11-29 | Singapore Health Services Pte Ltd | Composition and/or method for reducing and/or preventing myopia progression comprising atropine |
| CN105007918B (zh) | 2013-01-31 | 2018-06-15 | 千寿制药株式会社 | 稳定的水性液体制剂 |
| CA2911298C (en) | 2013-05-06 | 2019-09-17 | Kaohsiung Chang Gung Memorial Hospital | A pharmaceutical composition comprising atropine and nsaid for treating myopia |
| EP3057575B1 (en) * | 2013-10-15 | 2021-09-08 | Pharmathen S.A. | Preservative free pharmaceutical compositions for ophthalmic administration |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US20160009705A1 (en) | 2014-06-24 | 2016-01-14 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016172712A2 (en) * | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
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| US10010502B2 (en) | 2015-05-19 | 2018-07-03 | Amorphex Therapeutics Llc | Device that delivers a sustained low-dose of a myopia-suppressing drug, while preserving pupillary function and accommodation |
| KR102667598B1 (ko) | 2015-06-18 | 2024-05-20 | 렌즈 테라퓨틱스 인코포레이티드 | 눈의 굴절 이상 치료 및 원거리 시력 개선용 조성물 및 방법 |
| ES2929368T3 (es) | 2016-05-25 | 2022-11-28 | Singapore Health Serv Pte Ltd | Composición acuosa que contiene atropina |
| RU2745603C1 (ru) * | 2017-05-11 | 2021-03-29 | Невакар Инк. | Фармацевтические композиции атропина |
| US11191751B1 (en) | 2020-10-08 | 2021-12-07 | Ads Therapeutics Llc | Topical ophthalmological atropine free base compositions |
-
2018
- 2018-05-10 RU RU2019139290A patent/RU2745603C1/ru active
- 2018-05-10 ES ES18798073T patent/ES2901140T3/es active Active
- 2018-05-10 LT LTEPPCT/US2018/032017T patent/LT3548000T/lt unknown
- 2018-05-10 MX MX2019013218A patent/MX392558B/es unknown
- 2018-05-10 EP EP21205568.5A patent/EP3970694A1/en active Pending
- 2018-05-10 WO PCT/US2018/032017 patent/WO2018209051A1/en not_active Ceased
- 2018-05-10 PT PT187980735T patent/PT3548000T/pt unknown
- 2018-05-10 HU HUE18798073A patent/HUE056595T2/hu unknown
- 2018-05-10 KR KR1020197036249A patent/KR102281667B1/ko active Active
- 2018-05-10 PL PL18798073T patent/PL3548000T3/pl unknown
- 2018-05-10 HR HRP20212019TT patent/HRP20212019T1/hr unknown
- 2018-05-10 EP EP18798073.5A patent/EP3548000B1/en active Active
- 2018-05-10 US US15/976,279 patent/US10251875B2/en active Active
- 2018-05-10 CN CN201880031247.6A patent/CN110621298B/zh active Active
- 2018-05-10 AU AU2018265257A patent/AU2018265257B2/en active Active
- 2018-05-10 SI SI201830521T patent/SI3548000T1/sl unknown
- 2018-05-10 SG SG11201910085U patent/SG11201910085UA/en unknown
- 2018-05-10 RS RS20211580A patent/RS62817B1/sr unknown
- 2018-05-10 CA CA3063228A patent/CA3063228C/en active Active
- 2018-05-10 JP JP2018091739A patent/JP6557379B2/ja active Active
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2019
- 2019-02-20 US US16/280,405 patent/US10583132B2/en active Active
- 2019-02-20 US US16/280,669 patent/US10576074B2/en not_active Ceased
- 2019-02-20 US US16/280,384 patent/US10568875B2/en active Active
- 2019-02-20 US US16/280,552 patent/US11071732B2/en active Active
- 2019-02-20 US US16/280,585 patent/US10610525B2/en active Active
- 2019-07-11 JP JP2019129405A patent/JP6681503B2/ja active Active
- 2019-07-11 JP JP2019129396A patent/JP6865476B2/ja active Active
- 2019-07-11 JP JP2019129403A patent/JP6681502B2/ja active Active
- 2019-11-11 CL CL2019003228A patent/CL2019003228A1/es unknown
- 2019-11-18 CO CONC2019/0012893A patent/CO2019012893A2/es unknown
- 2019-11-28 PH PH12019502701A patent/PH12019502701A1/en unknown
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2020
- 2020-07-20 US US16/933,642 patent/US11464769B2/en active Active
- 2020-08-31 US US17/007,900 patent/US11730728B2/en active Active
- 2020-08-31 US US17/007,816 patent/US11730727B2/en active Active
- 2020-09-09 US US17/016,186 patent/US11707458B2/en active Active
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2021
- 2021-01-11 US US17/145,589 patent/US11642338B2/en active Active
- 2021-03-30 JP JP2021056894A patent/JP7332179B2/ja active Active
- 2021-12-23 CY CY20211101132T patent/CY1124880T1/el unknown
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2022
- 2022-03-02 US US17/685,286 patent/USRE50040E1/en active Active
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2023
- 2023-06-28 US US18/343,636 patent/US12036217B2/en active Active
-
2024
- 2024-06-26 US US18/755,212 patent/US20240342154A1/en active Pending
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