RS63486B1 - Oftalmološki sastavi koji obuhvataju muskarinski antagonist i deuterisanu vodu - Google Patents

Oftalmološki sastavi koji obuhvataju muskarinski antagonist i deuterisanu vodu

Info

Publication number
RS63486B1
RS63486B1 RS20220765A RSP20220765A RS63486B1 RS 63486 B1 RS63486 B1 RS 63486B1 RS 20220765 A RS20220765 A RS 20220765A RS P20220765 A RSP20220765 A RS P20220765A RS 63486 B1 RS63486 B1 RS 63486B1
Authority
RS
Serbia
Prior art keywords
ophthalmic compositions
muscarinic antagonist
deuterated water
deuterated
water
Prior art date
Application number
RS20220765A
Other languages
English (en)
Inventor
Gregory I Ostrow
Kenneth J Widder
David S Baker
Original Assignee
Sydnexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54868660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS63486(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sydnexis Inc filed Critical Sydnexis Inc
Publication of RS63486B1 publication Critical patent/RS63486B1/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RS20220765A 2014-06-24 2015-06-23 Oftalmološki sastavi koji obuhvataju muskarinski antagonist i deuterisanu vodu RS63486B1 (sr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201462016502P 2014-06-24 2014-06-24
US201462096433P 2014-12-23 2014-12-23
US201562151926P 2015-04-23 2015-04-23
US14/726,139 US9421199B2 (en) 2014-06-24 2015-05-29 Ophthalmic composition
PCT/US2015/037249 WO2015200361A1 (en) 2014-06-24 2015-06-23 Ophthalmic composition
EP15811865.3A EP3160471B1 (en) 2014-06-24 2015-06-23 Ophthalmic compositions comprising a muscarinic antagonist and deuterated water

Publications (1)

Publication Number Publication Date
RS63486B1 true RS63486B1 (sr) 2022-09-30

Family

ID=54868660

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20220765A RS63486B1 (sr) 2014-06-24 2015-06-23 Oftalmološki sastavi koji obuhvataju muskarinski antagonist i deuterisanu vodu

Country Status (20)

Country Link
US (11) US9421199B2 (sr)
EP (3) EP3160471B1 (sr)
JP (4) JP6678362B2 (sr)
KR (3) KR20210116688A (sr)
CN (3) CN110638749A (sr)
BR (1) BR112016030368B1 (sr)
CA (1) CA2953363C (sr)
DK (1) DK3160471T3 (sr)
ES (1) ES2924243T3 (sr)
HR (1) HRP20220972T1 (sr)
HU (1) HUE059521T2 (sr)
IL (1) IL249643B (sr)
LT (1) LT3160471T (sr)
PL (1) PL3160471T3 (sr)
PT (1) PT3160471T (sr)
RS (1) RS63486B1 (sr)
SG (3) SG11201610682UA (sr)
SI (1) SI3160471T1 (sr)
TW (3) TWI763620B (sr)
WO (1) WO2015200361A1 (sr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3050298A1 (en) 2012-08-24 2014-02-27 Sun Pharma Global Fze Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and polyalkoxylated alcohol for use in the treatment of ocular conditions
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
US11382909B2 (en) 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
US10010502B2 (en) 2015-05-19 2018-07-03 Amorphex Therapeutics Llc Device that delivers a sustained low-dose of a myopia-suppressing drug, while preserving pupillary function and accommodation
EP3302426A4 (en) 2015-05-29 2018-12-05 Sydnexis, Inc. D2o stabilized pharmaceutical formulations
EP3423076B1 (en) 2016-02-29 2024-04-17 Sun Pharmaceutical Industries Limited Topical cyclosporine-containing formulations and uses thereof
JP7095873B2 (ja) * 2016-04-11 2022-07-05 ユニバーシティ・オブ・キャンベラ レボドパ、抗酸化剤及び水性担体を含む眼科用組成物
AR108591A1 (es) * 2016-05-25 2018-09-05 Singapore Health Serv Pte Ltd Composición acuosa que contiene atropina
AU2018224426B2 (en) * 2017-02-21 2023-05-18 Singapore Health Services Pte Ltd Composition and method for preventing or delaying onset of myopia comprising atropine
JP7016880B2 (ja) * 2017-03-23 2022-02-07 シンガポール ヘルス サービシーズ ピーティーイー リミテッド チオトロピウムを有効成分として含有する近視予防、近視治療および/または近視進行抑制剤
IL299297B1 (en) 2017-03-27 2024-04-01 Regeneron Pharma Sterilization method
WO2018209051A1 (en) 2017-05-11 2018-11-15 Nevakar Inc. Atropine pharmaceutical compositions
JP7227163B2 (ja) 2017-06-10 2023-02-21 アイノビア,インコーポレイティド 流体を取扱い、目に流体を送出するための方法および装置
KR102654048B1 (ko) * 2017-07-20 2024-04-03 세인다 파마슈티컬 광저우 코포레이션 근시 치료용 조성물 및 방법
MX2020005217A (es) * 2017-11-21 2020-11-24 Sydnexis Inc Composicion oftalmica y dispositivo de administracion de la misma.
CA3087622A1 (en) 2018-01-05 2019-07-11 University Of Utah Research Foundation Treatment of myopic progression
CN114533652A (zh) * 2018-09-25 2022-05-27 沈阳兴齐眼科医院有限公司 药物组合物、其制备方法和用途
CN109157503B (zh) * 2018-09-25 2019-08-16 沈阳兴齐眼药股份有限公司 防治nitm的药物组合物及其医药用途
EP3701938B8 (en) 2019-03-01 2024-02-21 Medivis S.R.L. Ophthalmic formulations based on atropine
WO2020219707A1 (en) * 2019-04-24 2020-10-29 Allergan, Inc. Compositions and methods for treatment of ocular conditions
KR102308566B1 (ko) * 2019-05-28 2021-10-05 서울대학교병원 녹내장 안약의 약물이상반응 진단 키트
AU2020311441A1 (en) * 2019-07-11 2022-02-03 University Of Utah Research Foundation Multi-agent ocular formulations and treatment methods
US20220411482A1 (en) * 2019-11-15 2022-12-29 Silk Technologies, Ltd. Stable formulations of silk-derived protein
EP4076469A4 (en) * 2019-12-16 2024-03-06 Sydnexis, Inc. OPHTHALMIC COMPOSITIONS WITH D20
CN111821259A (zh) * 2020-07-14 2020-10-27 艾尔健康眼药(辽宁)有限公司 一种眼用药物组合物
US11850249B2 (en) 2020-10-05 2023-12-26 Somerset Therapeutics, Llc Methods of efficiently reducing intraocular pressure
KR102245533B1 (ko) * 2020-11-02 2021-04-28 주식회사 지게차코리아 운송수단용 림 및 이의 제조방법
CA3210064A1 (en) * 2021-01-28 2022-08-04 Glaukos Corporation Formulations
WO2022169959A1 (en) * 2021-02-04 2022-08-11 Sydnexis, Inc. Ophthalmic compositions for presbyopia
WO2022172089A1 (en) * 2021-02-12 2022-08-18 I Optima Ltd. Compound, method and system for ophthalmic surgery
EP4308080A1 (en) * 2021-03-16 2024-01-24 Vyluma Inc. Multi-dose container for ophthalmic compositions
EP4088713A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
EP4088714A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
WO2023081891A2 (en) * 2021-11-05 2023-05-11 Calm Water Therapeutics Llc Methods for using bioadhesive and steric interactions of copolymers with at least two moieties to minimize adverse effects mediated by external influences on cell, tissue, organ system, and organism biology
WO2023172240A1 (en) * 2022-03-07 2023-09-14 Harrow Ip, Llc Extended-release pharmaceutical compositions for treating eye conditions
US20230277521A1 (en) * 2022-03-07 2023-09-07 Harrow Ip, Llc Extended-release pharmaceutical compositions for treating eye conditions
WO2023171989A1 (ko) * 2022-03-11 2023-09-14 주식회사 메디치바이오 안질환 예방 또는 치료용 약학 조성물
WO2023215407A2 (en) * 2022-05-03 2023-11-09 Iview Therapeutics, Inc. Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases
US20240033260A1 (en) * 2022-07-26 2024-02-01 The Chinese University Of Hong Kong Low-concentration atropine for myopia prevention (lamp-2) study
WO2024091789A1 (en) * 2022-10-26 2024-05-02 Vyluma Inc. Childhood atropine for myopia progression

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382124B1 (en) 1958-07-18 1994-10-04 Rohm & Haas Process for preparing macroreticular resins, copolymers and products of said process
BE624258A (sr) 1961-10-31
DE1518819B1 (de) 1965-04-03 1969-12-04 Basf Ag Loesungsvermittler fuer pharmazeutische Zwecke
SE352811B (sr) 1971-06-04 1973-01-15 Pharmacia Ab
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4255415A (en) * 1978-11-22 1981-03-10 Schering Corporation Polyvinyl alcohol ophthalmic gel
US4952586A (en) 1982-08-27 1990-08-28 The Regents Of The University Of California Edrophonium-atropine composition and therapeutic uses thereof
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
DE3644984A1 (de) 1986-07-01 1988-07-07 Eberhardt Schlueter Patrone oder ampulle fuer eine injektionsvorrichtung sowie selbsttaetige injektionsvorrichtung
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US4852582A (en) 1987-09-11 1989-08-01 Pell Donald M Method and kit for measuring the effectiveness of bronchodilators
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
IL85312A (en) 1988-02-03 1991-08-16 Israel State Injectable pharmaceutical compositions having improved stability
JP2617508B2 (ja) * 1988-02-05 1997-06-04 エーザイ株式会社 安定なジフェンヒドラミン含有水溶液
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
FR2638428B1 (fr) 1988-10-28 1990-12-28 Transphyto Sa Conditionnement pour liquides a epurer
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5496471A (en) 1990-01-08 1996-03-05 Ciba-Geigy Corporation Apparatus for removing components from solutions
US5259998A (en) 1991-10-04 1993-11-09 Chiron Ophthalmics, Inc. Method for casting dissolvable ophthalmic shields in a mold
US5492689A (en) 1991-11-19 1996-02-20 The Center For Innovative Technology Combined virustatic antimediator (COVAM) treatment of common colds
US5716952A (en) 1992-03-18 1998-02-10 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
US5505953A (en) 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US5260000A (en) 1992-08-03 1993-11-09 Bausch & Lomb Incorporated Process for making silicone containing hydrogel lenses
FR2702660B1 (fr) 1993-03-17 1995-05-24 Karl Simpson Compositions thérapeutiques stabilisées et leur procédé de préparation.
US5840770A (en) 1993-08-24 1998-11-24 Hill Medical Corporation Method of killing tumor cells
US5490938A (en) 1993-12-20 1996-02-13 Biopolymerix, Inc. Liquid dispenser for sterile solutions
KR100374098B1 (ko) 1994-04-08 2003-06-09 아트릭스 라보라토리스, 인코포레이션 조절된방출이식편형성에적합한액체전달조성물
GB2293100A (en) 1994-09-15 1996-03-20 Medeva Europ Ltd Pharmaceutical compositions with deuterium oxide
CZ285636B6 (cs) 1995-02-07 1999-10-13 Ústav Makromolekulární Chemie Av Čr Nové lékové formy pro farmaka aplikovaná v očním lékařství s prolongovanou účinností a způsob jejich výroby
AU7528696A (en) 1995-10-31 1997-05-22 Merck & Co., Inc. Muscarine antagonists
FR2742357B1 (fr) 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
CA2250780A1 (en) 1996-04-10 1997-10-16 The Regents Of The University Of California Correction of genetic defects using chemical chaperones
US6270954B1 (en) 1996-04-10 2001-08-07 The Regents Of The University Of California Correction of genetic defects using chemical chaperones
US20030157187A1 (en) 1996-12-02 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory diseases
US20040136915A1 (en) 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing atropine
FR2770843B1 (fr) 1997-11-13 2000-01-14 Lavipharm Lab Association prolamines-lipides polaires vegetaux, son procede de preparation et ses applications
US6149670A (en) 1999-03-11 2000-11-21 Alsius Corporation Method and system for treating cardiac arrest using hypothermia
US5976499A (en) 1998-09-04 1999-11-02 Johns Hopkins University Macroscopic sweat test for cystic fibrosis
IN185228B (sr) 1999-02-03 2000-12-09 Bakulesh Mafatlal Dr Khamar
WO2000069470A2 (en) 1999-05-17 2000-11-23 Aesgen, Inc. Improved cellular uptake of bioactive agents
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
US6218428B1 (en) 2000-04-28 2001-04-17 Emil Chynn Ophthalmic composition
CN1323595A (zh) 2000-05-11 2001-11-28 朱卫国 用于青光眼的药物组合物
US20050251254A1 (en) 2000-06-02 2005-11-10 Brady Daniel G Method of implanting accommodating intraocular lenses
US20030195179A1 (en) 2000-08-25 2003-10-16 Shirou Sawa Aqueous suspension preparations
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
MXPA03010655A (es) 2001-05-25 2007-06-22 Valley Forge Pharmaceuticals I Gel oft??lmico de pirenzepina.
CN1206988C (zh) 2002-05-10 2005-06-22 刘继东 硫酸阿托品眼用凝胶
JP2007502823A (ja) 2003-08-15 2007-02-15 キューエルティー・ユーエスエイ・インコーポレーテッド 接着性および生体侵食性の経粘膜薬物送達システム
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
WO2005072656A1 (en) 2004-01-27 2005-08-11 Osteotech, Inc. Stabilized bone graft
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US8313763B2 (en) 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
US7659260B2 (en) 2005-01-14 2010-02-09 Eddie Francis Kadrmas Tamponade compositions and methods for retinal repair
US9238003B2 (en) 2005-02-04 2016-01-19 Auburn University Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules
EP1848749B1 (en) 2005-02-04 2018-10-31 Auburn University Contact drug delivery system
CN1939534B (zh) 2005-09-27 2010-12-01 长春金赛药业股份有限公司 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂
GB2423711B (en) * 2005-10-24 2007-02-14 Fortune Apex Dev Ltd Method for preparing a pharmaceutical composition with enhanced mucoadhesion
WO2007053747A2 (en) 2005-11-01 2007-05-10 President And Fellows Of Harvard College Modulating endoplasmic reticulum stress in the treatment of tuberous sclerosis
US7767217B2 (en) 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
CN101049287A (zh) * 2006-04-07 2007-10-10 财团法人长庚纪念医院 抑制近视度数增加的低浓度阿托平眼药剂及其制造方法
US20070254914A1 (en) * 2006-05-01 2007-11-01 Non-Profit Organization Chang Gung Memorial Hospital Low-concentration atropine solution for preventing myopia progression and preparing method thereof
JP2007308398A (ja) * 2006-05-17 2007-11-29 Chang Gung Memorial Hospital 目薬、及びその製造方法
US7691099B2 (en) 2006-07-12 2010-04-06 Ntk Enterprises, Inc. Deuterated ocular solutions for LTK and other surgical eye procedures
US7745665B2 (en) 2007-06-04 2010-06-29 Auspex Pharmaceuticals, Inc. Substituted phenethylamines
CN101327216A (zh) 2007-06-22 2008-12-24 肖正连 一种硫酸阿托品眼用即型凝胶
MX2010003774A (es) * 2007-10-08 2010-04-27 Fovea Pharmaceuticals Sa Formulaciones oftalmicas acuosas.
US7815605B2 (en) 2007-11-28 2010-10-19 Souter Steve R Emergency medication pump injection system
CN101468214A (zh) * 2007-12-27 2009-07-01 上海华捷视医疗设备有限公司 一种眼科手术用重水及其制备方法
ES2459198T3 (es) 2008-04-20 2014-05-08 D2 Bioscience Group Ltd Utilización de óxido de deuterio como inhibidor de elastasa
AU2009325061B2 (en) 2008-12-11 2014-05-29 Children's Medical Center Corporation Contact lens drug delivery device
DE102009003942A1 (de) 2009-01-07 2010-07-08 D2O Biosience Group Ltd., Hamilton Verwendung von Deuteriumoxid zur Behandlung Virus-basierter Erkrankungen des Auges
US8883214B2 (en) 2009-01-13 2014-11-11 The Regents Of The University Of California Implantable delivery vehicle for ocular delivery of muscarinic antagonists
TW201043211A (en) 2009-03-31 2010-12-16 Johnson & Johnson Vision Care Inc Punctal plugs
EP2464387A4 (en) * 2009-08-12 2013-05-15 Seros Medical Llc DEUTERATED WATER SOLUTION AND RIBOFLAVIN FOR EXTENDED OXYGEN SINGULET LIFETIME IN THE TREATMENT OF OCULAR TISSUE AND METHOD OF USE
FR2950036B1 (fr) 2009-09-11 2011-12-16 Rexam Pharma La Verpilliere Dispositif de distribution de liquide
FR2952040B1 (fr) 2009-10-29 2011-12-30 Rexam Pharma La Verpilliere Dispositif de distribution de liquide sous forme de gouttes
WO2011098578A2 (en) 2010-02-12 2011-08-18 Bioneer A/S Liposome system for ocular administration
KR20130111932A (ko) * 2010-04-30 2013-10-11 세로스 메디컬, 엘엘씨 조합 방식을 이용하여 안구 조직을 치료하는 방법 및 장치
TWI424663B (zh) 2010-07-01 2014-01-21 Joy Ride Tech Co Ltd A motor with heat pipe
AU2011278934B2 (en) 2010-07-15 2015-02-26 Eyenovia, Inc. Drop generating device
JP2013531044A (ja) 2010-07-15 2013-08-01 コリンシアン オフサルミック,インコーポレイティド 点眼薬送達
TW201217533A (en) 2010-08-04 2012-05-01 Bayer Pharma AG Genomics of actinoplanes utahensis
WO2012111029A2 (en) * 2011-02-18 2012-08-23 M/S. Appasamy Associates Ophthalmic composition for enabling dilation of pupils
JP2014506935A (ja) 2011-03-03 2014-03-20 アラーガン インコーポレイテッド シリコーンベースの非水系眼科製剤
US20140088199A1 (en) 2011-04-05 2014-03-27 Optosolve Llp Ophthalmic treatments
TWI632914B (zh) 2011-05-12 2018-08-21 遠景生物製藥股份有限公司 具有類固醇類或非類固醇抗發炎藥之安定的普維酮-碘(Povidone-Iodine)組合物
WO2012161655A1 (en) 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine
TW201302244A (zh) 2011-07-08 2013-01-16 Univ Nat Chiao Tung 載藥型隱形眼鏡及其製備方法
EP2785335B8 (en) 2011-11-29 2017-08-02 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and pharmaceutical compositions for the treatment of darier disease
US20170304152A1 (en) 2012-02-01 2017-10-26 Certa Dose, Inc. Apparatuses, methods, and systems for delivering medication using medication kits
US9814729B2 (en) 2012-03-14 2017-11-14 The Regents Of The University Of California Nerve agent antidotes
JP6360039B2 (ja) 2012-05-03 2018-07-18 カラ ファーマシューティカルズ インコーポレイテッド 複数の被覆された粒子を含む組成物、医薬組成物、医薬製剤、及び当該粒子の形成方法
AU2013257830A1 (en) 2012-05-11 2014-11-20 Cipla Limited Pharmaceutical composition
AU2013262986A1 (en) 2012-05-14 2015-01-22 Eyenovia, Inc. Laminar flow droplet generator device and methods of use
EA201492094A1 (ru) 2012-05-15 2015-04-30 Айновиа, Инк. Эжекторные устройства, способы, возбудители и схемы для них
US20150297800A1 (en) 2012-07-03 2015-10-22 Sio2 Medical Products, Inc. SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS
US9827250B2 (en) * 2012-07-31 2017-11-28 Johnson & Johnson Vision Care, Inc. Lens incorporating myopia control optics and muscarinic agents
CA3050298A1 (en) 2012-08-24 2014-02-27 Sun Pharma Global Fze Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and polyalkoxylated alcohol for use in the treatment of ocular conditions
US9498035B2 (en) 2012-12-21 2016-11-22 Coopervision International Holding Company, Lp Silicone hydrogel contact lenses for sustained release of beneficial polymers
WO2014140105A1 (en) 2013-03-13 2014-09-18 D2 Bioscience Group Ltd. Materials and compositions for dental cements and filler materials
US20160018671A1 (en) 2013-03-29 2016-01-21 Onefocus Technology, Llc Drug delivery from contact lenses with a fluidic module
ES2871116T3 (es) 2013-05-06 2021-10-28 Kaohsiung Chang Gung Memorial Hospital Composición farmacéutica de un AINE y atropina
AR096330A1 (es) 2013-05-17 2015-12-23 Incyte Corp Derivados del bipirazol como inhibidores jak
US9089562B2 (en) 2013-08-28 2015-07-28 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
US9320709B2 (en) 2013-08-28 2016-04-26 Presbyopia Therapies Llc Storage stable compositions and methods for the treatment of refractive errors of the eye
DE102013218802B4 (de) 2013-09-19 2018-06-28 Aero Pump Gmbh Abgabevorrichtung für Fluide aus einem Fluidbehälter
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US20160009705A1 (en) 2014-06-24 2016-01-14 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
JP6660939B2 (ja) 2014-08-13 2020-03-11 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 点眼剤からの保存剤除去
US11382909B2 (en) 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
DE102015104646B3 (de) 2015-03-26 2016-06-30 Aero Pump Gmbh Abgabevorrichtung für ein Fluid
EP3302426A4 (en) 2015-05-29 2018-12-05 Sydnexis, Inc. D2o stabilized pharmaceutical formulations
AR108591A1 (es) 2016-05-25 2018-09-05 Singapore Health Serv Pte Ltd Composición acuosa que contiene atropina
JP7033789B2 (ja) 2016-06-29 2022-03-11 オトノミー,インク. トリグリセリド耳用製剤とその使用
ES2968453T3 (es) 2016-09-19 2024-05-09 Mexichem Fluor Sa De Cv Composición farmacéutica que comprende glicopirrolato
AU2018224426B2 (en) 2017-02-21 2023-05-18 Singapore Health Services Pte Ltd Composition and method for preventing or delaying onset of myopia comprising atropine
WO2018209051A1 (en) 2017-05-11 2018-11-15 Nevakar Inc. Atropine pharmaceutical compositions
KR102654048B1 (ko) 2017-07-20 2024-04-03 세인다 파마슈티컬 광저우 코포레이션 근시 치료용 조성물 및 방법
MX2020005217A (es) 2017-11-21 2020-11-24 Sydnexis Inc Composicion oftalmica y dispositivo de administracion de la misma.
EP4076469A4 (en) 2019-12-16 2024-03-06 Sydnexis, Inc. OPHTHALMIC COMPOSITIONS WITH D20

Also Published As

Publication number Publication date
US11596625B2 (en) 2023-03-07
EP3160471B1 (en) 2022-06-01
US20150366854A1 (en) 2015-12-24
KR20200001612A (ko) 2020-01-06
US20180042911A1 (en) 2018-02-15
EP3160471A1 (en) 2017-05-03
JP2017522292A (ja) 2017-08-10
IL249643A0 (en) 2017-02-28
TW202412797A (zh) 2024-04-01
SG11201610682UA (en) 2017-01-27
US10076515B2 (en) 2018-09-18
JP2024050526A (ja) 2024-04-10
PL3160471T3 (pl) 2022-09-26
CN110638749A (zh) 2020-01-03
US20240165098A1 (en) 2024-05-23
KR102506109B1 (ko) 2023-03-03
US20160339007A1 (en) 2016-11-24
CN106572998B (zh) 2019-11-08
SG10201707617VA (en) 2017-10-30
US11883390B2 (en) 2024-01-30
US9421199B2 (en) 2016-08-23
TWI763620B (zh) 2022-05-11
US9770447B2 (en) 2017-09-26
SG10201913976SA (en) 2020-03-30
US20230092957A1 (en) 2023-03-23
EP4115884A1 (en) 2023-01-11
US20180193326A1 (en) 2018-07-12
ES2924243T3 (es) 2022-10-05
BR112016030368B1 (pt) 2022-11-01
CN106572998A (zh) 2017-04-19
EP3689350A1 (en) 2020-08-05
KR20170018962A (ko) 2017-02-20
US11896588B2 (en) 2024-02-13
KR20210116688A (ko) 2021-09-27
US20190298707A1 (en) 2019-10-03
US20230091109A1 (en) 2023-03-23
US20230093205A1 (en) 2023-03-23
US20190091213A1 (en) 2019-03-28
WO2015200361A1 (en) 2015-12-30
JP2020097599A (ja) 2020-06-25
US20210059998A1 (en) 2021-03-04
US10842787B2 (en) 2020-11-24
TW202237110A (zh) 2022-10-01
LT3160471T (lt) 2022-11-10
JP6678362B2 (ja) 2020-04-08
SI3160471T1 (sl) 2022-10-28
BR112016030368A2 (pt) 2018-07-17
JP2022062045A (ja) 2022-04-19
US10864208B2 (en) 2020-12-15
CA2953363A1 (en) 2015-12-30
HRP20220972T1 (hr) 2022-11-25
DK3160471T3 (da) 2022-08-15
US11890277B2 (en) 2024-02-06
IL249643B (en) 2021-10-31
PT3160471T (pt) 2022-08-09
CN115192520A (zh) 2022-10-18
CA2953363C (en) 2024-02-27
US10201534B2 (en) 2019-02-12
TW201613588A (en) 2016-04-16
HUE059521T2 (hu) 2022-11-28
JP7505888B2 (ja) 2024-06-25
EP3160471A4 (en) 2018-04-04

Similar Documents

Publication Publication Date Title
RS63486B1 (sr) Oftalmološki sastavi koji obuhvataju muskarinski antagonist i deuterisanu vodu
IL280791A (en) Deuterium compounds and their use
HK1249893A1 (zh) 氘代vx-661
HK1256980A1 (zh) 氘化化合物和其用途
PL3102634T3 (pl) Miękkie i przezroczyste kopolimery odporne na uderzenia
ZA201703805B (en) Low water dentifrice compositions
IL251059B (en) Arimoclomol formulation
ZA201703804B (en) Cleansing compositions
HK1250015A1 (zh) 鎮咳藥組合物和方法
GB201407079D0 (en) Complete flood protection
IL251590A0 (en) Ophthalmic preparations
ZA201703701B (en) Ophthalmic composition
HUE048374T2 (hu) Permetezhetõ fájdalomcsillapító készítmények
GB201413538D0 (en) Ophthalmic compositions and uses thereof
GB201508876D0 (en) Sanitary protection
GB201407024D0 (en) Dental caddy
GB201404391D0 (en) Novel compositions having use in therapy