JP2021501789A5 - - Google Patents

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JP2021501789A5
JP2021501789A5 JP2020524864A JP2020524864A JP2021501789A5 JP 2021501789 A5 JP2021501789 A5 JP 2021501789A5 JP 2020524864 A JP2020524864 A JP 2020524864A JP 2020524864 A JP2020524864 A JP 2020524864A JP 2021501789 A5 JP2021501789 A5 JP 2021501789A5
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Japan
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alkyl
disease
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independently
halo
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JP2020524864A
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JP2021501789A (ja
JP7337790B2 (ja
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Priority claimed from PCT/US2018/058949 external-priority patent/WO2019090069A1/en
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JP2020524864A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7337790B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580726P 2017-11-02 2017-11-02
US62/580,726 2017-11-02
US201862643059P 2018-03-14 2018-03-14
US62/643,059 2018-03-14
PCT/US2018/058949 WO2019090069A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501789A JP2021501789A (ja) 2021-01-21
JP2021501789A5 true JP2021501789A5 (enExample) 2021-12-09
JP7337790B2 JP7337790B2 (ja) 2023-09-04

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JP2020524864A Active JP7337790B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

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US (2) US20200361941A1 (enExample)
EP (1) EP3704094A1 (enExample)
JP (1) JP7337790B2 (enExample)
KR (1) KR20200096918A (enExample)
CN (1) CN112189008A (enExample)
AU (2) AU2018358346A1 (enExample)
BR (1) BR112020008841A2 (enExample)
CA (1) CA3080801A1 (enExample)
CL (1) CL2020001184A1 (enExample)
CO (1) CO2020006227A2 (enExample)
CR (1) CR20200243A (enExample)
EC (1) ECSP20027553A (enExample)
IL (1) IL274368B2 (enExample)
MX (1) MX2020004551A (enExample)
PE (1) PE20210040A1 (enExample)
PH (1) PH12020550524A1 (enExample)
RU (1) RU2020117927A (enExample)
SG (1) SG11202003985YA (enExample)
TW (1) TWI818929B (enExample)
UY (1) UY37956A (enExample)
WO (1) WO2019090069A1 (enExample)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
JP2019530678A (ja) 2016-09-18 2019-10-24 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Yap1のoct4との相互作用を標的とするyap1阻害剤
CN111094233B (zh) 2017-08-09 2024-03-15 戴纳立制药公司 化合物、组合物及方法
PT3676297T (pt) 2017-09-01 2023-08-29 Denali Therapeutics Inc Compostos, composições e métodos
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
RU2020122711A (ru) 2017-12-13 2022-01-17 ПРАКСИС БАЙОТЕК ЭлЭлСи Ингибиторы пути интегрированной реакции на стресс
EA202092174A1 (ru) 2018-03-14 2021-01-15 Х. Ли Моффитт Кэнсер Сентер Энд Рисерч Инститьют, Инк. Ингибиторы yap1, которые нацелены на взаимодействие yap1 с oct4
SG11202011014VA (en) 2018-06-05 2020-12-30 Praxis Biotech LLC Inhibitors of integrated stress response pathway
JP2021529814A (ja) * 2018-07-09 2021-11-04 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 化学化合物
TWI832295B (zh) * 2018-10-11 2024-02-11 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
CA3129609A1 (en) 2019-02-13 2020-08-20 Denali Therapeutics Inc. Eukaryotic initiation factor 2b modulators
EA202192900A1 (ru) 2019-04-23 2022-03-18 Эвотек Интернешнл Гмбх Модуляторы пути интегрированной реакции на стресс
AU2020261234A1 (en) 2019-04-23 2021-11-11 Evotec International Gmbh Modulators of the integrated stress response pathway
AU2020266592A1 (en) * 2019-04-30 2021-12-02 Abbvie Inc. Substituted cyclolakyls as modulators of the integrated stress pathway
CA3142748A1 (en) 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway
IL291665B2 (en) * 2019-09-27 2025-07-01 Univ Texas Inhibitors of receptor interacting protein kinase i for the treatment of disease
KR20220133252A (ko) 2020-01-28 2022-10-04 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절자
JP2023517944A (ja) 2020-03-11 2023-04-27 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合的ストレス応答経路の調節因子
WO2021211742A1 (en) * 2020-04-14 2021-10-21 The General Hospital Corporation Use of gcn2 inhibitors in treating mitochondrial myopathies and diseases associated with mitochondrial dysfunction
MX2023002269A (es) * 2020-08-26 2023-05-16 Vertex Pharma Inhibidores de apol1 y metodos para usar los mismos.
US20230391763A1 (en) 2020-10-22 2023-12-07 Evotec International Gmbh Modulators of the integrated stress response pathway
AU2021366303A1 (en) 2020-10-22 2023-06-22 Evotec International Gmbh Modulators of the integrated stress response pathway
CA3195290A1 (en) * 2020-10-22 2022-04-28 Holly Victoria Atton Modulators of the integrated stress response pathway
AU2024291624A1 (en) * 2023-07-14 2025-11-20 Shenzhen Zhongge Biological Technology Co., Ltd. Compound, pharmaceutical composition comprising same, and use thereof
KR20250122004A (ko) * 2024-02-05 2025-08-13 재단법인 대구경북첨단의료산업진흥재단 신규한 eIF2B 작용제 및 이를 포함하는 대사질환 예방 또는 치료용 조성물
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

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FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
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