JP2021501786A5 - - Google Patents

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Publication number
JP2021501786A5
JP2021501786A5 JP2020524813A JP2020524813A JP2021501786A5 JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5 JP 2020524813 A JP2020524813 A JP 2020524813A JP 2020524813 A JP2020524813 A JP 2020524813A JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5
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JP
Japan
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alkyl
och
disease
independently
halo
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Pending
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JP2020524813A
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English (en)
Japanese (ja)
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JP2021501786A (ja
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Publication date
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Priority claimed from PCT/US2018/058957 external-priority patent/WO2019090076A1/en
Publication of JP2021501786A publication Critical patent/JP2021501786A/ja
Publication of JP2021501786A5 publication Critical patent/JP2021501786A5/ja
Pending legal-status Critical Current

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JP2020524813A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Pending JP2021501786A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580742P 2017-11-02 2017-11-02
US62/580,742 2017-11-02
US201862643063P 2018-03-14 2018-03-14
US62/643,063 2018-03-14
PCT/US2018/058957 WO2019090076A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (2)

Publication Number Publication Date
JP2021501786A JP2021501786A (ja) 2021-01-21
JP2021501786A5 true JP2021501786A5 (enExample) 2021-12-09

Family

ID=64564980

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524813A Pending JP2021501786A (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (20)

Country Link
US (2) US20200345727A1 (enExample)
EP (1) EP3710428B1 (enExample)
JP (1) JP2021501786A (enExample)
KR (1) KR20200096522A (enExample)
CN (1) CN112204009B (enExample)
AU (2) AU2018360857A1 (enExample)
BR (1) BR112020008839A2 (enExample)
CA (1) CA3080806A1 (enExample)
CL (1) CL2020001167A1 (enExample)
CO (1) CO2020006248A2 (enExample)
EC (1) ECSP20026381A (enExample)
IL (1) IL274369B2 (enExample)
MX (1) MX2020004555A (enExample)
PE (1) PE20210396A1 (enExample)
PH (1) PH12020550523A1 (enExample)
RU (1) RU2020117900A (enExample)
SG (1) SG11202003982QA (enExample)
TW (1) TWI797186B (enExample)
UY (1) UY37957A (enExample)
WO (1) WO2019090076A1 (enExample)

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IL301709B2 (en) 2017-08-09 2025-07-01 Denali Therapeutics Inc Compounds, compositions and methods
TW201920129A (zh) 2017-09-01 2019-06-01 美商戴納立製藥公司 化合物、組合物及方法
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
JP2021508336A (ja) 2017-12-13 2021-03-04 プラクシス バイオテック エルエルシー 統合的ストレス応答経路の阻害剤
WO2019178401A1 (en) 2018-03-14 2019-09-19 H. Lee Moffitt Cancer Center And Research Institute, Inc. Yap1 inhibitors that target the interaction of yap1 with oct4
US11166942B2 (en) 2018-06-05 2021-11-09 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
BR112021013924A2 (pt) 2019-01-18 2021-09-21 Astrazeneca Ab Inibidores de pcsk9 e métodos de uso do mesmo
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
CR20210426A (es) 2019-02-13 2021-09-30 Denali Therapeutics Inc Compuestos, composiciones y métodos
EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
WO2020216766A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
AR118836A1 (es) * 2019-04-30 2021-11-03 Calico Life Sciences Llc Moduladores de la vía de tensión integrada
JP2022536663A (ja) 2019-06-12 2022-08-18 プラクシス バイオテック エルエルシー 統合的ストレス応答経路のモジュレーター
US20230029266A1 (en) * 2019-11-05 2023-01-26 Dermira, Inc. MrgprX2 Antagonists for the Treatment of Inflammatory Disorders
CA3162526A1 (en) 2020-01-28 2021-08-05 Christopher John Brown Modulators of the integrated stress response pathway
KR20220151635A (ko) 2020-03-11 2022-11-15 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절제
CN113754541B (zh) * 2020-06-02 2025-01-03 深圳湾实验室 靶向eb病毒核抗原蛋白的小分子抑制剂、制备方法及其应用
ES2997335T3 (en) 2020-10-22 2025-02-17 Evotec Int Gmbh Modulators of the integrated stress response pathway
CA3195290A1 (en) 2020-10-22 2022-04-28 Holly Victoria Atton Modulators of the integrated stress response pathway
MX2023004677A (es) 2020-10-22 2023-05-24 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
TW202241857A (zh) 2020-12-18 2022-11-01 美商戴納立製藥公司 化合物之固體形式
TW202329937A (zh) 2021-12-03 2023-08-01 美商英塞特公司 雙環胺ck12抑制劑
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
EP4480477A4 (en) * 2022-02-15 2025-06-18 Kanaph Therapeutics Inc. Pharmaceutical composition for treating cancer, comprising anticancer agent and novel compound having inhibitory activity with respect to prostaglandin e2 receptors
CN114614096B (zh) * 2022-02-24 2024-03-08 复旦大学 一种快充型电解液及其在锂离子电池中的应用
PE20250789A1 (es) * 2022-03-30 2025-03-14 Escient Pharmaceuticals Inc Derivados de quinolina como moduladores del receptor x2 de la proteina g relacionados con mas y productos relacionados
WO2023211854A1 (en) * 2022-04-25 2023-11-02 Praxis Precision Medicines, Inc. Kcnt1 inhibitors comprising a thiazole core and methods of use
JP2025514140A (ja) * 2022-04-25 2025-05-02 プラクシス プレシジョン メディシンズ, インコーポレイテッド ピラゾールコアを含むkcnt1阻害剤及び使用方法
CN115368263B (zh) * 2022-09-01 2024-05-17 南开大学 一种肉桂酸酰胺衍生物的合成及其制药应用
CN121263408A (zh) * 2023-07-14 2026-01-02 深圳众格生物科技有限公司 一种化合物、包含其的药物组合物及其用途

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