JP2021501786A5 - - Google Patents

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Publication number
JP2021501786A5
JP2021501786A5 JP2020524813A JP2020524813A JP2021501786A5 JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5 JP 2020524813 A JP2020524813 A JP 2020524813A JP 2020524813 A JP2020524813 A JP 2020524813A JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5
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JP
Japan
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alkyl
och
disease
independently
halo
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Pending
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JP2020524813A
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English (en)
Japanese (ja)
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JP2021501786A (ja
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Publication date
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Priority claimed from PCT/US2018/058957 external-priority patent/WO2019090076A1/en
Publication of JP2021501786A publication Critical patent/JP2021501786A/ja
Publication of JP2021501786A5 publication Critical patent/JP2021501786A5/ja
Pending legal-status Critical Current

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JP2020524813A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Pending JP2021501786A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580742P 2017-11-02 2017-11-02
US62/580,742 2017-11-02
US201862643063P 2018-03-14 2018-03-14
US62/643,063 2018-03-14
PCT/US2018/058957 WO2019090076A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (2)

Publication Number Publication Date
JP2021501786A JP2021501786A (ja) 2021-01-21
JP2021501786A5 true JP2021501786A5 (enExample) 2021-12-09

Family

ID=64564980

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524813A Pending JP2021501786A (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (20)

Country Link
US (2) US20200345727A1 (enExample)
EP (1) EP3710428A1 (enExample)
JP (1) JP2021501786A (enExample)
KR (1) KR20200096522A (enExample)
CN (1) CN112204009B (enExample)
AU (1) AU2018360857A1 (enExample)
BR (1) BR112020008839A2 (enExample)
CA (1) CA3080806A1 (enExample)
CL (1) CL2020001167A1 (enExample)
CO (1) CO2020006248A2 (enExample)
EC (1) ECSP20026381A (enExample)
IL (1) IL274369B2 (enExample)
MX (1) MX2020004555A (enExample)
PE (1) PE20210396A1 (enExample)
PH (1) PH12020550523A1 (enExample)
RU (1) RU2020117900A (enExample)
SG (1) SG11202003982QA (enExample)
TW (1) TWI797186B (enExample)
UY (1) UY37957A (enExample)
WO (1) WO2019090076A1 (enExample)

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JP2019530678A (ja) 2016-09-18 2019-10-24 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Yap1のoct4との相互作用を標的とするyap1阻害剤
CN111094233B (zh) 2017-08-09 2024-03-15 戴纳立制药公司 化合物、组合物及方法
PT3676297T (pt) 2017-09-01 2023-08-29 Denali Therapeutics Inc Compostos, composições e métodos
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
RU2020122711A (ru) 2017-12-13 2022-01-17 ПРАКСИС БАЙОТЕК ЭлЭлСи Ингибиторы пути интегрированной реакции на стресс
EA202092174A1 (ru) 2018-03-14 2021-01-15 Х. Ли Моффитт Кэнсер Сентер Энд Рисерч Инститьют, Инк. Ингибиторы yap1, которые нацелены на взаимодействие yap1 с oct4
SG11202011014VA (en) 2018-06-05 2020-12-30 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TWI832295B (zh) 2018-10-11 2024-02-11 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
EA202191890A1 (ru) 2019-01-18 2022-02-03 Астразенека Аб Ингибиторы pcsk9 и способы их применения
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
CA3129609A1 (en) 2019-02-13 2020-08-20 Denali Therapeutics Inc. Eukaryotic initiation factor 2b modulators
AU2020261234A1 (en) 2019-04-23 2021-11-11 Evotec International Gmbh Modulators of the integrated stress response pathway
EA202192900A1 (ru) 2019-04-23 2022-03-18 Эвотек Интернешнл Гмбх Модуляторы пути интегрированной реакции на стресс
AU2020266592A1 (en) * 2019-04-30 2021-12-02 Abbvie Inc. Substituted cyclolakyls as modulators of the integrated stress pathway
CA3142748A1 (en) 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway
CN114845709B (zh) * 2019-11-05 2024-10-01 德米拉公司 用于治疗炎性病症的mrgprx2拮抗剂
KR20220133252A (ko) 2020-01-28 2022-10-04 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절자
JP2023517944A (ja) 2020-03-11 2023-04-27 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合的ストレス応答経路の調節因子
CN113754541B (zh) * 2020-06-02 2025-01-03 深圳湾实验室 靶向eb病毒核抗原蛋白的小分子抑制剂、制备方法及其应用
AU2021366303A1 (en) 2020-10-22 2023-06-22 Evotec International Gmbh Modulators of the integrated stress response pathway
US20230391763A1 (en) 2020-10-22 2023-12-07 Evotec International Gmbh Modulators of the integrated stress response pathway
CA3195290A1 (en) 2020-10-22 2022-04-28 Holly Victoria Atton Modulators of the integrated stress response pathway
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors
JP2025508381A (ja) * 2022-02-15 2025-03-26 カナプ セラピューティクス インコーポレイテッド プロスタグランジンe2受容体を阻害する新規化合物及び抗がん薬を含む、がんを治療するための医薬組成物
CN114614096B (zh) * 2022-02-24 2024-03-08 复旦大学 一种快充型电解液及其在锂离子电池中的应用
JP2025514140A (ja) * 2022-04-25 2025-05-02 プラクシス プレシジョン メディシンズ, インコーポレイテッド ピラゾールコアを含むkcnt1阻害剤及び使用方法
WO2023211854A1 (en) * 2022-04-25 2023-11-02 Praxis Precision Medicines, Inc. Kcnt1 inhibitors comprising a thiazole core and methods of use
CN115368263B (zh) * 2022-09-01 2024-05-17 南开大学 一种肉桂酸酰胺衍生物的合成及其制药应用
AU2024291624A1 (en) * 2023-07-14 2025-11-20 Shenzhen Zhongge Biological Technology Co., Ltd. Compound, pharmaceutical composition comprising same, and use thereof

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US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
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PT2861566T (pt) * 2012-06-13 2017-02-08 Hoffmann La Roche Novos diazaspirocicloalcanos e azaspirocicloalcanos
AU2014233520B2 (en) * 2013-03-15 2019-02-21 The Regents Of The University Of California Modulators of the eIF2alpha pathway
WO2015038778A1 (en) * 2013-09-11 2015-03-19 The Brigham And Women's Hospital, Inc. SUBSTITUTED UREA EIF2α KINASE ACTIVATORS
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